公开(公告)号：US20210172027A1

公开(公告)日：2021-06-10

申请号：US17178110

申请日：2021-02-17

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6853 ,  G16H50/30 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US10934594B2

公开(公告)日：2021-03-02

申请号：US16202944

申请日：2018-11-28

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6886 ,  C12Q1/6853 ,  G16H50/30 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US10648025B2

公开(公告)日：2020-05-12

申请号：US15841006

申请日：2017-12-13

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Hatim T. Allawi ,  William G. Weisburg ,  Graham P. Lidgard ,  Michael W. Kaiser ,  Abram M. Vaccaro ,  Gracie Shea

IPC: C12Q1/686 ,  C12Q1/6827 ,  C12P19/34 ,  C12N15/65 ,  C01B17/48

Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.

公开(公告)号：US20200048720A1

公开(公告)日：2020-02-13

申请号：US16665738

申请日：2019-10-28

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6858 ,  C12Q1/6827

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

公开(公告)号：US20190249263A1

公开(公告)日：2019-08-15

申请号：US16399467

申请日：2019-04-30

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

公开(公告)号：US20190161806A1

公开(公告)日：2019-05-30

申请号：US16202944

申请日：2018-11-28

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US10301680B2

公开(公告)日：2019-05-28

申请号：US14669834

申请日：2015-03-26

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David Alan Ahlquist ,  William Russell Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

公开(公告)号：US20190153510A1

公开(公告)日：2019-05-23

申请号：US16134254

申请日：2018-09-18

Applicant: Exact Sciences Development Company, LLC

Inventor： Hatim Allawi ,  Rebecca Oldham-Haltom ,  Zubin Gagrat ,  Michael Domanico ,  Graham Lidgard

IPC: C12Q1/686 ,  C12Q1/6851

Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.

公开(公告)号：US10253358B2

公开(公告)日：2019-04-09

申请号：US15033803

申请日：2014-11-04

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： Michael Domanico ,  Ilse A. Tyler ,  Brian Aizenstein ,  Hatim Allawi ,  Graham P. Lidgard

IPC: C12P19/34 ,  C12Q1/6851 ,  C12Q1/6844

Abstract: The present invention provides DNA plasmids that find use as calibrators or reference standards for calculating DNA quantities in a sample. In particular, provided herein are DNA plasmids that contain multiple control fragments, and methods of their use in DNA quantitation.

公开(公告)号：US20180251859A1

公开(公告)日：2018-09-06

申请号：US15971561

申请日：2018-05-04

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.