公开(公告)号：US06263229B1

公开(公告)日：2001-07-17

申请号：US09191563

申请日：1998-11-13

Applicant: Ergin Atalar ,  Jeffrey C. Lestio ,  Harry K. Charles, Jr. ,  Bliss G. Carkhuff ,  Paul A. Bottomley

Inventor： Ergin Atalar ,  Jeffrey C. Lestio ,  Harry K. Charles, Jr. ,  Bliss G. Carkhuff ,  Paul A. Bottomley

IPC: A61B5055

CPC classification number: G01R33/34084 ,  G01R33/34007 ,  G01R33/341 ,  G01R33/3657 ,  G01R33/3678

Abstract: The present invention provides several embodiments of methods of making magnetic resonance catheter coils which include employing a flexible electrically insulative base member, depositing an electrically conductive material on the base member in a predetermined pattern to create at least one pair of generally parallel electrically conductive coil elements which are electrically connected to each other. A catheter is provided over the coil assembly. In one embodiment, a second pair of generally parallel electrically conductive coil elements are provided in order to create a quadrature coil. In this latter embodiment, the electrically insulative base member may have the first pair of coil elements created on one surface thereof and a second pair on the other with the base member subsequently being deformed to create a tubular coil having one pair of coil elements on the outside and the other pair on the inside. In some embodiments, tuning and matching circuits and decoupling circuits may be provided. The (a) coils, (b) coil assemblies, as well as (c) catheter coils containing coil assemblies produced by these methods are also disclosed. The coils may be miniaturized so as to facilitate ready insertion within a suitable sheath, such as a probe or catheter, into a patient, including into body openings, or into blood vessels or into interior regions of the body.

Abstract translation: 本发明提供了制造磁共振导管线圈的方法的几个实施例，其包括采用柔性电绝缘基底部件，以预定图案在基底部件上沉积导电材料，以产生至少一对大致平行的导电线圈元件 它们彼此电连接。 在线圈组件上提供导管。 在一个实施例中，提供第二对大致平行的导电线圈元件以便产生正交线圈。 在后一个实施例中，电绝缘基体可以具有在其一个表面上形成的第一对线圈元件，而另一对线圈元件可以具有另一对线圈元件，而第二对线圈元件随后变形，从而形成管状线圈，该管状线圈在其上具有一对线圈元件 外面和另一对在里面。 在一些实施例中，可以提供调谐和匹配电路和去耦电路。 还公开了（a）线圈，（b）线圈组件，以及（c）包含由这些方法制造的线圈组件的导管线圈。 线圈可以被小型化，以便于在适当的护套（例如探针或导管）内容易地插入患者体内，包括进入体内开口，或进入血管或进入体内的内部区域。

公开(公告)号：US06188219B1

公开(公告)日：2001-02-13

申请号：US09236054

申请日：1999-01-22

Applicant: Scott B. Reeder ,  Ergin Atalar ,  Anthony Z. Faranesh ,  Elliot R. McVeigh

Inventor： Scott B. Reeder ,  Ergin Atalar ,  Anthony Z. Faranesh ,  Elliot R. McVeigh

IPC: G01V300

CPC classification number: G01R33/58

Abstract: The invention provides a method of magnetic resonance imaging. A magnetic resonance imaging apparatus having a plurality of gradient axes is employed. A plurality of imaging planes are employed with respect to the gradient axes. A plurality of gradient referencing pre-scans are executed for the imaging planes to provide a plurality of calibration correction values for the imaging planes. A specimen is employed with respect to the gradient axes. An imaging plane is selected with respect to the specimen, and a main magnetic field is established with respect to the specimen. Radio frequency pulses are applied to the specimen to produce magnetic resonance signals. The calibration correction values for the selected imaging plane are employed to adjust a plurality of gradient waveforms. The gradient waveforms are output as a plurality of magnetic field gradients with respect to the gradient axes. Magnetic resonance information is acquired from the magnetic resonance signals corresponding to the radio frequency pulses. The magnetic resonance information is employed to display an image of the specimen. Associated apparatus and calibration method are also disclosed.

Abstract translation: 本发明提供一种磁共振成像方法。 采用具有多个梯度轴的磁共振成像装置。 相对于梯度轴采用多个成像平面。 对于成像平面执行多个梯度参考预扫描以为成像平面提供多个校准校正值。 相对于梯度轴使用试样。 相对于试样选择成像面，相对于试样建立主磁场。 将射频脉冲施加到样本以产生磁共振信号。 采用所选择的成像平面的校正校正值来调整多个梯度波形。 梯度波形相对于梯度轴被输出为多个磁场梯度。 从对应于射频脉冲的磁共振信号获取磁共振信息。 使用磁共振信息来显示样本的图像。 还公开了相关装置和校准方法。

公开(公告)号：US5699801A

公开(公告)日：1997-12-23

申请号：US457833

申请日：1995-06-01

Applicant: Ergin Atalar ,  Paul A. Bottomley ,  Elias A. Zerhouni

Inventor： Ergin Atalar ,  Paul A. Bottomley ,  Elias A. Zerhouni

IPC: A61B10/00 ,  A61B5/055 ,  A61B10/02 ,  A61B19/00 ,  G01R33/34

CPC classification number: G01R33/34084 ,  A61B5/055 ,  G01R33/341 ,  G01R33/3657 ,  G01R33/3678 ,  G01R33/34007

Abstract: The invention provides a method for magnetic resonance imaging and spectroscopic analysis of the interior of a specimen which includes positioning the specimen within a main magnetic field, introducing an invasive probe having an elongated receiver coil into or adjacent to the specimen with the coil having at least one pair of elongated electrical conductors, preferably, generally parallel to each other disposed within a dielectric material and having a pair of ends electrically connected to each other. RF pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the receiver coil receiving magnetic resonance signals and emitting responsive output signals which may be processed by a computer to provide image information for display in a desired manner. The method in a preferred form involves employing a flexible receiver coil which has uniform sensitivity along the coil and may be operated even when the magnetic resonance signal is in an oblique position. Tuning capacitance may be distributed along the length of the coil and/or a Faraday screen provided to minimize dielectric losses between the coil and the surrounding material of the specimen. The method may be used on a wide variety of specimens and in a preferred use is introduced into small blood vessels of a patient to facilitate determination of atherosclerotic plaque. Medical intervention procedures, such as plaque removal, may be employed generally simultaneously with the imaging of the present invention. Corresponding apparatus is provided.

Abstract translation: 本发明提供了一种用于磁共振成像和样品内部光谱分析的方法，其包括将样品定位在主磁场内，将具有细长的接收器线圈的侵入性探针引入到试样中或与样品相邻，线圈至少具有 一对细长的电导体，优选地大致彼此平行地设置在电介质材料内并且具有彼此电连接的一对端部。 将RF脉冲提供给感兴趣的区域以激励磁共振信号，梯度磁脉冲被施加到感兴趣的区域，接收器线圈接收磁共振信号并且发出可由计算机处理的响应输出信号，以提供图像信息 以期望的方式显示。 优选形式的方法涉及使用具有沿线圈的均匀灵敏度的柔性接收器线圈，并且即使当磁共振信号处于倾斜位置时也可以进行操作。 调谐电容可以沿着线圈的长度和/或法拉第屏幕分布，以最小化线圈和样品的周围材料之间的介电损耗。 该方法可以用于各种各样的样品，并且优选的用途被引入到患者的小血管中以便于确定动脉粥样硬化斑块。 医疗干预程序，例如除斑，可以与本发明的成像通常同时使用。 提供相应的设备。

公开(公告)号：US09301705B2

公开(公告)日：2016-04-05

申请号：US13341266

申请日：2011-12-30

Applicant: Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliott R. McVeigh ,  Albert Lardo ,  Hugh Caikins ,  Joao Lima

Inventor： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliott R. McVeigh ,  Albert Lardo ,  Hugh Caikins ,  Joao Lima

IPC: A61B5/05 ,  A61B5/055 ,  A61B5/00 ,  A61B18/14 ,  A61B19/00 ,  G01R33/28 ,  G01R33/34 ,  A61B17/00 ,  G01R33/48 ,  G01R33/56

CPC classification number: A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

Abstract: A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions.

Abstract translation: 使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。 组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。 组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。

公开(公告)号：US08928320B2

公开(公告)日：2015-01-06

申请号：US13425910

申请日：2012-03-21

Applicant: Emre Kopanoglu ,  Ergin Atalar

Inventor： Emre Kopanoglu ,  Ergin Atalar

IPC: G01V3/00 ,  G01R33/483 ,  G01R33/28 ,  G01R33/565

CPC classification number: G01R33/4833 ,  G01R33/288 ,  G01R33/5659

Abstract: In the acquisition of magnetic resonance data from an examination subject according to a pulse sequence that causes radiation into the examination subject of a radiated radio frequency (RF) pulse having a frequency spectrum and a slice profile with a relationship therebetween, the examination subject is substantially simultaneously, with the radiated RF pulse, to a non-linear magnetic field that alters the relationship in the radiated RF pulse between the frequency spectrum and the slice profile. The alteration of this relationship can be used, for example, to reduce the specific absorption rate (SAR) of the examination subject during the acquisition of the magnetic resonance data.

Abstract translation: 在从检查对象采集磁共振数据的过程中，根据脉冲序列，将具有频谱和切片轮廓的辐射射频（RF）脉冲的辐射引入检查对象，脉冲序列之间具有关系，检查对象基本上 同时利用辐射的RF脉冲将其转换成改变频谱和切片轮廓之间的辐射RF脉冲中的关系的非线性磁场。 例如，可以使用这种关系的改变来降低在获取磁共振数据期间检查对象的比吸收率（SAR）。

公开(公告)号：US20130271135A1

公开(公告)日：2013-10-17

申请号：US13863530

申请日：2013-04-16

Applicant: ALI CAGLAR OZEN ,  ERGIN ATALAR

Inventor： ALI CAGLAR OZEN ,  ERGIN ATALAR

IPC: G01R33/54

CPC classification number: G01R33/543 ,  G01R33/3657 ,  G01R33/4816 ,  G01R33/4824 ,  G01R33/5612

Abstract: In magnetic resonance data acquisition, decoupling between the transmit and receive coils is achieved by using a transmit array system wherein induced currents from the transmit coils cancel each other, resulting in a total of zero current in the receive coil. Forward and reversed polarized transmit coil pairs are set to cancel the individual currents of each other, or of a receive coil. Linearly polarized fields can also be used to effect the decoupling. The decoupling allows the magnetic resonance data acquisition system to be operated for concurrent excitation of the nuclear spins and reception of the resulting magnetic resonance signals.

Abstract translation: 在磁共振数据采集中，通过使用发射阵列系统来实现发射和接收线圈之间的去耦，其中来自发射线圈的感应电流彼此抵消，导致接收线圈中的总电流为零。 设置正向和反向偏振的发射线圈对以抵消彼此或接收线圈的各个电流。 线性极化场也可用于实现去耦。 解耦允许磁共振数据采集系统用于同时激励核自旋和接收所得到的磁共振信号。

公开(公告)号：US08521257B2

公开(公告)日：2013-08-27

申请号：US12225198

申请日：2007-03-14

Applicant: Louis L. Whitcomb ,  Axel Krieger ,  Robert Charles Susil ,  Gabor Fichtinger ,  Ergin Atalar ,  Iulian I. Iordachita

Inventor： Louis L. Whitcomb ,  Axel Krieger ,  Robert Charles Susil ,  Gabor Fichtinger ,  Ergin Atalar ,  Iulian I. Iordachita

IPC: A61B5/00

CPC classification number: A61B5/064 ,  A61B5/055 ,  A61B6/12 ,  A61B8/12 ,  A61B10/0241 ,  A61B34/20 ,  A61B34/25 ,  A61B34/30 ,  A61B90/11 ,  A61B90/50 ,  A61B2017/00911 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/378

Abstract: A device, system, and method for entering a medical device such as a needle into the body inside a medical imager such as a MRI scanner, CT, X-ray fluoroscopy, and ultrasound imaging, from within a body cavity (such as the rectum, vagina, or laparoscopically accessed cavity). A three degree-of-freedom mechanical device translates and rotates inside the cavity and enters a needle into the body, and steers the needle to a target point selected by the user. The device is guided by real-time images from the medical imager. Networked computers process the medical images and enable the clinician to control the motion of the mechanical device that is operated within the imager, outside of the imager or remotely from outside the imager.

Abstract translation: 一种用于将诸如针之类的医疗装置从医疗成像器（例如MRI扫描仪，CT，X射线透视和超声成像）内的体内进入体腔（例如直肠）的装置，系统和方法 ，阴道或腹腔镜腔）。 三自由度机械装置在空腔内平移和旋转，并将针进入身体，并将针转向由使用者选择的目标点。 该装置由来自医用成像器的实时图像引导。 联网的计算机处理医学图像并使临床医生能够控制在成像器内部，在成像器外部或远离成像仪外部操作的机械装置的运动。

公开(公告)号：US20120249139A1

公开(公告)日：2012-10-04

申请号：US13425910

申请日：2012-03-21

Applicant: Emre Kopanoglu ,  Ergin Atalar

Inventor： Emre Kopanoglu ,  Ergin Atalar

IPC: G01R33/54 ,  G01R33/34

CPC classification number: G01R33/4833 ,  G01R33/288 ,  G01R33/5659

Abstract: In the acquisition of magnetic resonance data from an examination subject according to a pulse sequence that causes radiation into the examination subject of a radiated radio frequency (RF) pulse having a frequency spectrum and a slice profile with a relationship therebetween, the examination subject is substantially simultaneously, with the radiated RF pulse, to a non-linear magnetic field that alters the relationship in the radiated RF pulse between the frequency spectrum and the slice profile. The alteration of this relationship can be used, for example, to reduce the specific absorption rate (SAR) of the examination subject during the acquisition of the magnetic resonance data.

Abstract translation: 在从检查对象采集磁共振数据的过程中，根据脉冲序列，将具有频谱和切片轮廓的辐射射频（RF）脉冲的辐射引入检查对象，脉冲序列之间具有关系，检查对象基本上是 同时利用辐射的RF脉冲将其转换成改变频谱和切片轮廓之间的辐射RF脉冲中的关系的非线性磁场。 例如，可以使用这种关系的改变来降低在获取磁共振数据期间检查对象的比吸收率（SAR）。

公开(公告)号：US07844319B2

公开(公告)日：2010-11-30

申请号：US10123534

申请日：2002-04-15

Applicant: Robert C. Susil ,  Gwyneth Susil ,  Ergin Atalar ,  Albert C. Lardo ,  Henry R. Halperin ,  Ronald D. Berger ,  Hugh Calkins ,  Paul Bottomley

Inventor： Robert C. Susil ,  Gwyneth Susil ,  Ergin Atalar ,  Albert C. Lardo ,  Henry R. Halperin ,  Ronald D. Berger ,  Hugh Calkins ,  Paul Bottomley

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/7203 ,  A61B18/1492 ,  A61B2018/00839 ,  A61B2090/374 ,  A61N1/086 ,  G01R33/285

Abstract: Herein is disclosed a probe, including a first electrode disposed at least partially on the probe surface, a second electrode disposed at least partially on the probe surface, a first conductor electrically coupled to the first electrode, a second conductor electrically coupled to the second electrode, and a reactive element electrically coupling the first conductor and the second conductor.

Abstract translation: 本文公开了一种探针，包括至少部分地设置在探针表面上的第一电极，至少部分地设置在探针表面上的第二电极，电耦合到第一电极的第一导体，电耦合到第二电极的第二导体 以及电耦合第一导体和第二导体的电抗元件。

公开(公告)号：US20100168555A1

公开(公告)日：2010-07-01

申请号：US12654607

申请日：2009-12-24

Applicant: Parag V. Karmarkar ,  Ergin Atalar ,  Robert J. Lederman ,  Amish N. Raval

Inventor： Parag V. Karmarkar ,  Ergin Atalar ,  Robert J. Lederman ,  Amish N. Raval

IPC: A61B5/055

CPC classification number: G01R33/286 ,  A61B90/39 ,  A61B2090/3958 ,  A61M25/00 ,  A61M2025/1079 ,  G01R33/287 ,  G01R33/34084

Abstract: Disclosed is a guide catheter that includes one or more RF antennas to enhance the visibility of the guide catheter in MR imagery. One embodiment of the guide catheter includes a loop coil at the distal end of the guide catheter and a loopless antenna between the distal end and the proximal end. By combining a loop coil and a loopless antenna on the catheter, the shaft of the catheter may be visible in MR imagery while the distal end may appear in the MR imagery more brightly than the shaft.

Abstract translation: 公开了一种引导导管，其包括一个或多个RF天线，以增强导引导管在MR图像中的可视性。 引导导管的一个实施例包括在引导导管的远端处的环形线圈和在远端和近端之间的无凹凸天线。 通过在导管上组合环形线圈和无孔天线，导管的轴可以在MR图像中可见，而远端可能比轴更明亮地出现在MR图像中。