中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

36 records (took 0.02 seconds)

    PAR-2 Agonist
    21.
    发明申请
    PAR-2 Agonist 失效
    PAR-2激动剂

    公开(公告)号：US20090215703A1

    公开(公告)日：2009-08-27

    申请号：US11909931

    申请日：2006-03-29

    Applicant: Hiroyuki Ishiwata ,  Mototsugu Kabeya ,  Toru Kanke

    Inventor： Hiroyuki Ishiwata ,  Mototsugu Kabeya ,  Toru Kanke

    IPC: A61K38/03 ,  C07K4/00 ,  A61P27/00

    CPC classification number: C07K5/0812 ,  A61K38/00 ,  C07K5/101 ,  C07K5/1016

    Abstract: The present invention relates to a pharmaceutical composition for preventing/treating conditions associated with PAR-2. The present invention also relates to a method for preventing/treating the condition using the pharmaceutical composition and use for manufacturing the pharmaceutical composition. The pharmaceutical composition comprises a compound represented by the following general formula (1), salt or solvate thereof and a pharmaceutically acceptable carrier: Ar—CO-AA1-AA2-AA3-AA4-NH—X—Y (1) wherein, Ar represents a phenyl group or an aromatic heterocyclic group optionally having substituent(s): AA1 represents a hydrophobic amino acid: AA2 represents an amino acid absent of substituent (s) having more than two carbon atoms: AA3 represents an amino acid absent of substituent(s) having more than two carbon atoms: AA4 represents a basic amino acid: X represents a straight-chain or branched bivalent saturated aliphatic hydrocarbon group having 1 to 6 carbon atoms: Y represents basic substituent (s); straight-chain, branched, or cyclic bivalent saturated aliphatic hydrocarbon group having 1 to 6 carbon atoms, or an aromatic hydrocarbon group having 6 to 10 carbon atoms. The compound represented by the general formula (1) has dramatically improved PAR-2 activation potency compared to peptide comprised of 6 amino acids (Tethered receptor agonist peptide: TRAP) in spite of reduction of the number of amino acid.

    Abstract translation: 本发明涉及用于预防/治疗与PAR-2相关的病症的药物组合物。 本发明还涉及使用药物组合物预防/治疗病症的方法以及用于制造药物组合物的方法。 药物组合物包含由以下通式（1）表示的化合物，其盐或溶剂化物和药学上可接受的载体：Ar-CO-AA1-AA2-AA3-AA4-NH-XY（1）其中Ar表示苯基 基团或任选具有取代基的芳族杂环基：AA1表示疏水性氨基酸：AA2表示不具有多于两个碳原子的取代基的氨基酸：AA3表示不具有取代基的氨基酸， 两个以上碳原子：AA4表示碱性氨基酸：X表示碳原子数1〜6的直链或支链二价饱和脂肪族烃基，Y表示碱性取代基。 具有1至6个碳原子的直链，支链或环状二价饱和脂族烃基或具有6至10个碳原子的芳族烃基。 尽管氨基酸数量的减少，但由通式（1）表示的化合物与包含6个氨基酸的肽（束缚受体激动剂肽：TRAP）相比，显着提高了PAR-2的活化效力。

    Low-pass filter capable of preventing unnecessary electromagnetic coupling
    22.
    发明申请
    Low-pass filter capable of preventing unnecessary electromagnetic coupling 失效
    低通滤波器，能够防止不必要的电磁耦合

    公开(公告)号：US20070103256A1

    公开(公告)日：2007-05-10

    申请号：US11521756

    申请日：2006-09-15

    Applicant: Hiroyuki Ishiwata

    Inventor： Hiroyuki Ishiwata

    IPC: H03H7/01

    CPC classification number: H03H7/0115 ,  H01P1/2039 ,  H03H7/1758 ,  H03H2001/0085

    Abstract: A plurality of conductive patterns constituting first, second, and third inductors are formed in a multi-layer wiring board. A fifth dielectric layer is disposed between second to fourth dielectric layers having the first inductor and a seventh dielectric layer having the second inductor. First and second electrode layers are disposed facing each other across the fifth dielectric layer so as to constitute a capacitor. The capacitor is disposed between the first and third inductors and the second inductor. The first electrode layer, i.e., one electrode of the capacitor, is a ground layer.

    Abstract translation: 构成第一，第二和第三电感器的多个导电图案形成在多层布线板中。 第五电介质层设置在具有第一电感器的第二至第四电介质层和具有第二电感器的第七电介质层之间。 第一电极层和第二电极层跨越第五电介质层彼此面对地布置以构成电容器。 电容器设置在第一和第三电感器和第二电感器之间。 第一电极层，即电容器的一个电极，是接地层。

    Diplexer
    23.
    发明申请
    Diplexer 失效
    双工器

    公开(公告)号：US20050192047A1

    公开(公告)日：2005-09-01

    申请号：US11061075

    申请日：2005-02-17

    Applicant: Hiroyuki Ishiwata ,  Takashi Tanemura ,  Akiyuki Yoshisato ,  Masami Miyazaki

    Inventor： Hiroyuki Ishiwata ,  Takashi Tanemura ,  Akiyuki Yoshisato ,  Masami Miyazaki

    IPC: H03H7/075 ,  H03H7/46 ,  H04B1/06 ,  H04B7/00 ,  H04M1/00

    CPC classification number: H03H7/463

    Abstract: A diplexer contains a common terminal connected to an antenna, a first input/output terminal for inputting/outputting signals of a plurality of high frequency bands higher than a predetermined frequency, and a second input/output terminal for inputting/outputting signals of low frequency bands lower than the predetermined frequency. Between the common terminal and the first input/output terminal, a high pass filter and a low trap circuits for attenuating the low frequency bands respectively are interposed in series, and, between the common terminal and the second input/output terminal, a low pass filter and high trap circuits for attenuating the high frequency bands respectively are interposed in series.

    Abstract translation: 双工器包括连接到天线的公共端子，用于输入/输出高于预定频率的多个高频带的信号的第一输入/输出端子和用于输入/输出低频信号的第二输入/输出端子 频带低于预定频率。 在公共端子和第一输入/输出端子之间，分别插入用于衰减低频带的高通滤波器和低陷波电路，并且在公共端子和第二输入/输出端子之间存在低通 用于衰减高频带的滤波器和高陷波电路分别串联插入。

    Bis(5-aryl-2-pyridyl) derivatives
    25.
    发明授权
    Bis(5-aryl-2-pyridyl) derivatives 失效
    双（5-芳基-2-吡啶基）衍生物

    公开(公告)号：US06706703B2

    公开(公告)日：2004-03-16

    申请号：US09893698

    申请日：2001-06-29

    Applicant: Hiroyuki Ishiwata ,  Seiichi Sato ,  Mototsugu Kabeya ,  Soichi Oda ,  Makoto Suda ,  Manabu Shibasaki

    Inventor： Hiroyuki Ishiwata ,  Seiichi Sato ,  Mototsugu Kabeya ,  Soichi Oda ,  Makoto Suda ,  Manabu Shibasaki

    IPC: C07D40104

    CPC classification number: C07D487/04 ,  C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

    Abstract: A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

    Abstract translation: 由式（1）表示的双（5-芳基-2-吡啶基）化合物或其盐：其中A是取代或未取代的芳族烃基或取代或未取代的芳族杂环基，X是选自 由具有式（2）至（5）的部分组成的组：其中，在式（2）中，m为1或2的整数; 在式（3）中，n为1〜6的整数， 在式（4）中，R为氢或低级烷基，p为1〜6的整数。

    PAR-2 antagonists
    27.
    发明授权
    PAR-2 antagonists 失效
    PAR-2拮抗剂

    公开(公告)号：US08268789B2

    公开(公告)日：2012-09-18

    申请号：US11576304

    申请日：2005-09-30

    Applicant: Mototsugu Kabeya ,  Kyoko Yasuoka ,  Toru Kanke ,  Hiroyuki Ishiwata ,  Junya Tagashira

    Inventor： Mototsugu Kabeya ,  Kyoko Yasuoka ,  Toru Kanke ,  Hiroyuki Ishiwata ,  Junya Tagashira

    IPC: A61K38/06 ,  A61K38/02

    CPC classification number: C07K5/0827 ,  A61K38/00 ,  C07D209/14 ,  C07K5/0806 ,  C07K5/0812

    Abstract: Compounds represented by the general formula (1) or salts thereof or solvates of both; PAR-2 antagonists containing the compounds; and preventive or therapeutic agents for PAR-2 related diseases containing the antagonists as the active ingredient: (1) wherein R1 is hydrogen, halogeno, or a group represented by the general formula (2): (wherein R11 is straight-chain or branched C1-6 alkylene or the like; and R12 and R13 together with the nitrogen atom adjacent to them form a 5- to 7-membered ring); R2 is straight-chain or branched C1-6 alkyl or the like; R3 and R4 are each independently hydrogen, one to three halogen atoms, or the like; and A1-A2-A3 is a tripeptide residue composed of α-amino acids each independently selected from the group consisting of glycine, alanine, cyclohexylalanine, and so on.

    Abstract translation: 由通式（1）表示的化合物或其盐或两者的溶剂合物; 含有这些化合物的PAR-2拮抗剂; 以及含有拮抗剂作为活性成分的PAR-2相关疾病的预防或治疗剂：（1）其中R1是氢，卤素或由通式（2）表示的基团：（其中R11是直链或支链的 C 1-6亚烷基等; R 12和R 13与它们相邻的氮原子一起形成5-至7-元环）; R2是直链或支链C 1-6烷基等; R3和R4各自独立地为氢，一至三个卤素原子等; A1-A2-A3是由各自独立地选自甘氨酸，丙氨酸，环己基丙氨酸等的α-氨基酸组成的三肽残基。

Patent Agency Ranking