公开(公告)号：US10953350B2

公开(公告)日：2021-03-23

申请号：US15960483

申请日：2018-04-23

Applicant: InnovaPrep LLC

Inventor： David Scott Alburty ,  Michael Lee Hornback ,  Bryan Charles Long ,  Andrew Edward Page

IPC: A47G19/22 ,  B01D19/00 ,  G01N1/40 ,  G01N1/42 ,  C12H1/18 ,  A23L5/20 ,  G01N33/14

Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.

公开(公告)号：US09593359B2

公开(公告)日：2017-03-14

申请号：US14084385

申请日：2013-11-19

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: C12Q1/24 ,  G01N1/40

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  C12Q1/24 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。

公开(公告)号：US20140231256A1

公开(公告)日：2014-08-21

申请号：US14058193

申请日：2013-10-18

Applicant: InnovaPrep LLC

Inventor： Zachary Allen Packingham ,  Andrew Edward Page ,  David Scott Alburty ,  Steven Dale Graham ,  Alec Douglas Adolphson

IPC: G01N1/40

CPC classification number: G01N1/405 ,  B01D61/20 ,  B01D61/22 ,  B01D63/082 ,  B01D63/088 ,  B01D2315/08 ,  B01D2319/06 ,  B01D2321/02 ,  G01N1/40 ,  G01N1/4055 ,  G01N1/4077 ,  G01N2001/4016 ,  G01N2001/4038 ,  G01N2001/4088

Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.

Abstract translation: 本公开提供了用于从流体样品分级和浓缩颗粒的装置，系统和方法。 这包括一个包含分级过滤器的筒，该过滤器具有一系列减小孔径的多孔表面，用于从流体样品捕获颗粒; 以及与所述盒流体连通的渗透压力源; 其中所述颗粒从所述多孔表面洗脱并以减少的流体体积分配。

公开(公告)号：US11839837B2

公开(公告)日：2023-12-12

申请号：US17209420

申请日：2021-03-23

Applicant: InnovaPrep LLC

Inventor： David Scott Alburty ,  Michael Lee Hornback ,  Bryan Charles Long ,  Andrew Edward Page

IPC: A47G19/22 ,  B01D19/00 ,  G01N1/40 ,  G01N1/42 ,  C12H1/18 ,  A23L5/20 ,  G01N33/14

CPC classification number: B01D19/0073 ,  A23L5/21 ,  A47G19/22 ,  A47G19/2233 ,  B01D19/00 ,  C12H1/18 ,  G01N1/4005 ,  G01N1/4055 ,  G01N1/42 ,  G01N33/146 ,  A23V2002/00

Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.

公开(公告)号：US20230358153A1

公开(公告)日：2023-11-09

申请号：US18135104

申请日：2023-04-14

Applicant: INNOVAPREP LLC

Inventor： Steven D. Graham ,  Alec Adolphson ,  Bryan Long

IPC: F01N1/08 ,  F01N1/10 ,  F01N13/00

CPC classification number: F01N1/083 ,  F01N1/10 ,  F01N13/002

Abstract: Devices, systems and methods are described for reducing noise emitted from active aerosol and bioaerosol collection devices. The system includes a noise reducing muffler between the collection component and the air mover and a noise reducing baffle at the outlet of the air mover. The muffler reduces higher frequency noises emitted from the air mover inlet while the baffle reduces lower frequency noises emitted from the air mover outlet. Placement of the muffler between the collection component and the air mover eliminates the potential for loss of particles to the muffler prior to collection.

公开(公告)号：US20230146816A1

公开(公告)日：2023-05-11

申请号：US17984204

申请日：2022-11-09

Applicant: INNOVAPREP LLC

Inventor： Michael Fischer ,  Bryan Long ,  Steven D. Graham ,  Sidney J. Spry ,  Alec Adolphson ,  John D. Birkenholz ,  Andrew E. Page ,  David S. Alburty

IPC: B01L3/00

CPC classification number: B01L3/505

Abstract: Devices, systems, and methods are disclosed which relate to using a use large area surface sampler with invertible bag for collection of biological and non-biological particles prior to subsequent analysis. The large area surface sampler with invertible bag uses an inverted bag with bonded sampling material to first serve as a sampling device followed by the bag being turned right side out and the captured particles being extracted inside of the bag. The device includes measures for sealing liquid in the sampling material using a protective cup at time of manufacture. This enables users to simply remove the protective cup and perform wet surface sampling prior to turning the bag right side out and removing captured particles from the sampling material with repeated compressions. The described device, systems and methods allow users to capture and elute surface samples for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required.

公开(公告)号：US20180304176A1

公开(公告)日：2018-10-25

申请号：US15960483

申请日：2018-04-23

Applicant: InnovaPrep LLC

Inventor： David Scott Alburty ,  Michael Lee Hornback ,  Bryan Charles Long ,  Andrew Edward Page

IPC: B01D19/00 ,  G01N1/40 ,  G01N1/42 ,  G01N33/14 ,  C12H1/18 ,  A23L5/20

CPC classification number: B01D19/0073 ,  A23L5/21 ,  A23V2002/00 ,  C12H1/18 ,  G01N1/4055 ,  G01N1/42 ,  G01N33/146

Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.

公开(公告)号：US20170153164A1

公开(公告)日：2017-06-01

申请号：US15431655

申请日：2017-02-13

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/10 ,  G01N1/14 ,  G01N1/40

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N1/34 ,  G01N1/4077 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

公开(公告)号：US09574977B2

公开(公告)日：2017-02-21

申请号：US14191205

申请日：2014-02-26

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/34 ,  G01N1/40

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N1/34 ,  G01N1/4077 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 一次性吸头包括用于吸取样品并连接到浓缩单元的流体端口。

公开(公告)号：US20160302776A1

公开(公告)日：2016-10-20

申请号：US15132046

申请日：2016-04-18

Applicant: InnovaPrep LLC

Inventor： Alec D. Adolphson ,  Ann K. Packingham ,  Andrew E. Page ,  David S. Alburty ,  Zachary A. Packingham ,  John D. Birkenholz ,  Michael F. Fischer

IPC: A61B10/02 ,  A61B10/00

CPC classification number: A61B10/02 ,  A61B10/0096 ,  A61B2010/0216

Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.

Abstract translation: 公开了涉及使用湿泡沫洗脱来从拭子和擦拭物去除颗粒的装置，系统和方法。 这允许用户从表面捕获颗粒，并通过洗脱到小样本体积中进行回收，以便随后检测人类临床，兽医，食品安全，制药，疫情调查，取证，生物识别和生物恐怖反应，环境监测和其他应用，其中收集 需要表面和人体或动物的样品。 更具体地，拭子或擦拭物用于以目前市售的拭子和擦拭巾的标准方式收集样品; 例如食品工厂中的食物制备表面，制药设备中的生产设备，用于在生物恐怖事件应答期间收集干粉，以及用于收集诸如鼻，喉，鼻咽和伤口的临床样品。