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209 条记录 (耗时 0.032 秒)

    Anthrax antitoxins
    21.
    发明申请
    Anthrax antitoxins 失效
    炭疽毒素

    公开(公告)号：US20070172500A1

    公开(公告)日：2007-07-26

    申请号：US11340424

    申请日：2006-01-26

    申请人： John Young ,  Heather Scobie ,  G. Jonah Rainey ,  Kenneth Bradley

    发明人： John Young ,  Heather Scobie ,  G. Jonah Rainey ,  Kenneth Bradley

    IPC分类号： A61K39/07 ,  C07H21/04 ,  C07K14/32 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C07K16/1278 ,  A61K38/00 ,  C07K14/705 ,  C07K14/78

    摘要： The present invention provides compositions useful in preparing and/or serving as antitoxins against Bacillus anthracis, the causative agent of anthrax. The present invention also provides polypeptides and polynucleotides relating to the capillary morphogenisis gene 2 (CMG-2), vectors containing the polynucleotides and polypeptides, and host cells containing related polynucleotide molecules, all used in association with the treatment of, or the research and development of treatments for anthrax. The present invention also relates to methods for identifying molecules that bind CMG-2 and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明提供了可用于制备和/或用作抗炭疽杆菌（Anthracis）的抗毒素的组合物，炭疽芽孢杆菌的致病因子。 本发明还提供了与毛细血管形成形成发生基因2（CMG-2）相关的多肽和多核苷酸，含有多核苷酸和多肽的载体，以及包含相关多核苷酸分子的宿主细胞，所有这些都与治疗或研究和开发相结合 的炭疽治疗。 本发明还涉及用于鉴定结合CMG-2的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Receptor for B. anthracis toxin
    23.
    发明申请
    Receptor for B. anthracis toxin 审中-公开
    炭疽杆菌毒素受体

    公开(公告)号：US20070117159A1

    公开(公告)日：2007-05-24

    申请号：US11483872

    申请日：2006-07-10

    申请人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    发明人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    IPC分类号： G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C07K14/74 ,  C07K14/32 ,  C12N15/74

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Carrier for ammunition handling system
    24.
    发明申请
    Carrier for ammunition handling system 失效
    运载火箭弹药处理系统

    公开(公告)号：US20060230915A1

    公开(公告)日：2006-10-19

    申请号：US11108114

    申请日：2005-04-18

    申请人： John Young ,  Valery Soroka

    发明人： John Young ,  Valery Soroka

    IPC分类号： F41F5/00

    CPC分类号： F41A9/30 ,  F41A9/79

    摘要： The invention provides an ammunition carrier for retaining ammunition. The ammunition carrier includes a stationary carrier body portion disposed about a space in which to retain the ammunition; and a rotating carrier body portion disposed about the space and pivotally. attached to the stationary carrier body portion. The stationary carrier body portion and the rotating carrier body portion collectively form a cover assembly to secure the ammunition. The ammunition carrier further includes a locking mechanism, the locking mechanism pivotally attached to the rotating carrier body portion, the locking mechanism (1) engageable, in an engaged position, with the stationary carrier body portion so as to prevent rotation of the rotating carrier body portion relative to the stationary carrier body portion; and (2) disengageable, in a disengaged position, with the stationary carrier body portion so as to allow rotation of the rotating carrier body portion relative to the stationary carrier body portion.

    摘要翻译： 本发明提供了用于保留弹药的弹药载体。 弹药载体包括固定载体主体部分，围绕保留弹药的空间设置; 以及旋转的承载体本体部分，围绕该空间设置并且枢转。 附接到固定载体主体部分。 固定的载体主体部分和旋转载体主体部分共同形成盖组件以固定弹药。 所述弹药托架还包括锁定机构，所述锁定机构可旋转地附接到所述旋转载体主体部分，所述锁定机构（1）可在所述固定载体主体部分处于接合位置接合，以防止所述旋转载体主体 相对于固定载体主体部分的部分; 和（2）在分离位置与固定的承载体主体部分脱离接合，以允许旋转的承载体主体部分相对于固定的承载体主体部分旋转。

    Fungicidal gel and method for controlling nail fungi
    25.
    发明申请
    Fungicidal gel and method for controlling nail fungi 失效

    公开(公告)号：US20060018850A1

    公开(公告)日：2006-01-26

    申请号：US10894769

    申请日：2004-07-20

    申请人： John Young ,  Alberto Hoyo

    发明人： John Young ,  Alberto Hoyo

    IPC分类号： A61K8/25

    CPC分类号： A61K8/042 ,  A61K8/0291 ,  A61K8/25 ,  A61K9/7015 ,  A61K35/08 ,  A61Q3/00

    摘要： A gel formulation is combined with a fungicidal concentrate which is a liquid mixture of about 1.2 to 16 ml parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 16 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943, together with one liter of a gel formulation ingredient containing 10% by weight urea, based on the weight of the gel formulation. The fungicidal liquid concentrate is applied directly to a fungal nail to soften the fungal nail and control the growth of fungi.

    Super collapsible and compactable portable potty trainer
    26.
    发明申请
    Super collapsible and compactable portable potty trainer 失效
    超级可折叠紧凑的便携式教练机

    公开(公告)号：US20050268388A1

    公开(公告)日：2005-12-08

    申请号：US10860239

    申请日：2004-06-03

    申请人： John Young

    发明人： John Young

    IPC分类号： A47K11/02 ,  A47K13/00 ,  A47K13/06

    CPC分类号： A47K13/06

    摘要： A collapsible, portable, light weight, reusable, machine washable potty training device that may carried inconspicuously into any private or public restroom and that may be consistently fitted onto a conventional toilet seat effortlessly, with the use of minimum stall space, to teach children to use toilets.

    摘要翻译： 可折叠，便携，重量轻，可重复使用的可机洗便盆训练装置，可以不拘一格地携带到任何私人或公共厕所中，并且可以使用最小的档位空间轻轻松松地安装在常规的马桶座上，教孩子们 使用厕所。

    Receptor for B. anthracis toxin
    27.
    发明申请
    Receptor for B. anthracis toxin 失效
    炭疽杆菌毒素受体

    公开(公告)号：US20050196407A1

    公开(公告)日：2005-09-08

    申请号：US11047278

    申请日：2005-01-31

    申请人： John Young ,  Kenneth Bradley ,  R. John Collier ,  Jeremy Mogridge

    发明人： John Young ,  Kenneth Bradley ,  R. John Collier ,  Jeremy Mogridge

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/07 ,  C07H21/04 ,  C07K14/32 ,  C12N1/21

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells—minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Surgical system for retracting and severing tissue
    29.
    发明申请
    Surgical system for retracting and severing tissue 审中-公开
    用于收缩和切断组织的手术系统

    公开(公告)号：US20050096646A1

    公开(公告)日：2005-05-05

    申请号：US10699133

    申请日：2003-10-31

    申请人： Parris Wellman ,  Simon Cohn ,  John Young

    发明人： Parris Wellman ,  Simon Cohn ,  John Young

    IPC分类号： A61B17/00 ,  A61B17/02 ,  A61B17/22 ,  A61B17/32 ,  A61B18/14 ,  A61B1/32

    CPC分类号： A61B17/22031 ,  A61B17/00008 ,  A61B17/0218 ,  A61B17/320016 ,  A61B18/1445 ,  A61B2017/00969 ,  A61B2017/320044

    摘要： A surgical system that includes a surgical device comprising a tube having a first lumen and an opening disposed at a distal end thereof, the tube movable between a rear position and a forward position. A retractor comprising a shaft, a working head at a distal end of the shaft defining a working space, and at least one manipulator disposed within the working space. The retractor is releasably engagable with the surgical device, such that, when the retractor is engaged with the surgical device and the shaft is in the rear position, the tube is disposed at a location proximal to the at least one manipulator, and when the retractor is engaged with the surgical device and the tube is in the forward position the tube is disposed beneath at least one manipulator.

    摘要翻译： 一种手术系统，其包括外科装置，其包括具有第一内腔和设置在其远端的开口的管，所述管可在后部位置和向前位置之间移动。 一种牵引器，包括轴，位于所述轴的远端的工作头限定工作空间，以及设置在所述工作空间内的至少一个操纵器。 牵开器可释放地与外科装置接合，使得当牵开器与手术装置接合并且轴处于后部位置时，管被设置在靠近至少一个操纵器的位置处，并且当牵开器 与外科装置接合，并且管处于向前位置，管设置在至少一个操纵器下方。