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公开(公告)号：US09259398B1
公开(公告)日：2016-02-16
申请号：US12324618
申请日：2008-11-26
Applicant: Kyle Klein , Katsuyuki Murase , Jinping Wan , Dariush Davalian
Inventor： Kyle Klein , Katsuyuki Murase , Jinping Wan , Dariush Davalian
CPC classification number: A61K31/00 , A61K9/1075 , A61K38/00 , A61K39/44 , A61K47/183
Abstract: A composition of bioactive agent-loaded micelles with tissue-targeting properties and methods of using the same are disclosed.
Abstract translation: 公开了具有组织靶向特性的生物活性剂负载胶束的组合物及其使用方法。
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22.发明申请Drug Delivery System And Method Of Treatment Of Vascular Diseases Using Photodynamic Therapy 审中-公开药物输送系统及使用光动力疗法治疗血管疾病的方法公开(公告)号：US20120310142A1
公开(公告)日：2012-12-06
申请号：US13572507
申请日：2012-08-10
Applicant: Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
Inventor： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
IPC: A61M37/00
CPC classification number: A61K31/409 , A61K9/0009 , A61K9/0019 , A61K9/1272 , A61K9/5146 , A61K41/0071 , A61L29/16 , A61L2300/224 , A61L2300/626 , A61M25/0045 , A61M25/10 , A61M2025/105 , A61M2025/1086
Abstract: This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.
Abstract translation: 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。
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23.发明申请POLY(AMIDE) AND POLY(ESTER-AMIDE) POLYMERS AND DRUG DELIVERY PARTICLES AND COATINGS CONTAINING SAME 有权聚（酰胺）和聚（酰胺）聚合物和药物递送颗粒和包含它们的涂料公开(公告)号：US20110311596A1
公开(公告)日：2011-12-22
申请号：US13221767
申请日：2011-08-30
Applicant: Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
Inventor： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
IPC: A61K9/14 , A61K47/34 , A61K31/436 , A61K31/675 , B82Y5/00
CPC classification number: C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
Abstract: The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
Abstract translation: 本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。
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公开(公告)号：US20100323019A1
公开(公告)日：2010-12-23
申请号：US12806790
申请日：2010-08-19
Applicant: Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
Inventor： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
IPC: A61K9/14 , A61K38/18 , A61K33/26 , A61K31/517 , A61K31/41 , A61K31/436 , A61P13/12 , A61P3/10
CPC classification number: A61K9/1647 , A61K9/0019 , A61K9/5031
Abstract: Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
Abstract translation: 公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。
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公开(公告)号：US07824601B1
公开(公告)日：2010-11-02
申请号：US11940158
申请日：2007-11-14
Applicant: John Stankus , Syed F. A. Hossainy , Jinping Wan
Inventor： John Stankus , Syed F. A. Hossainy , Jinping Wan
CPC classification number: A61F2/86 , A61L31/14 , B32B1/08 , D01D5/0069 , D01F1/10 , D04H1/728 , D04H1/76
Abstract: Medical devices, such as stents, including a fibrous layer including particles are disclosed. Methods of forming such medical devices using electrospinning are disclosed.
Abstract translation: 公开了包括包括颗粒的纤维层在内的医疗装置，例如支架。 公开了使用静电纺丝形成这种医疗装置的方法。
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Patent Agency Ranking
26.发明申请Poly(Amide) And Poly(Ester-Amide) Polymers And Drug Delivery Particles And Coatings Containing Same 有权聚（酰胺）和聚（酯 - 酰胺）聚合物和药物递送颗粒和包含它们的涂料公开(公告)号：US20090324671A1
公开(公告)日：2009-12-31
申请号：US12165173
申请日：2008-06-30
Applicant: Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
Inventor： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
CPC classification number: C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
Abstract: The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
Abstract translation: 本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。
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公开(公告)号：US20080200377A1
公开(公告)日：2008-08-21
申请号：US11676175
申请日：2007-02-16
Applicant: Mikael O. Trollsas , Thierry Glauser , Michael Ngo , Jinping Wan
Inventor： Mikael O. Trollsas , Thierry Glauser , Michael Ngo , Jinping Wan
CPC classification number: A61K9/0019 , A61K9/5031 , A61K47/34
Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid, wherein the activated diamine comprises a product of a diol and an amino acid. A method including combining a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid; and forming particles of the combination suitable for delivery through a blood vessel.
Abstract translation: 一种包含适于引入血管的溶液的组合物，其包含包含至少一种活化二胺和至少一种活化二羧酸的处理剂和聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并将溶液引入血管中，所述溶液包含包含至少一种活化二胺和至少一种活化二羧酸的处理剂和聚合物的颗粒，其中所述活化二胺包括二醇和氨基酸的产物。 一种方法，包括将处理剂和至少一种活化二胺和至少一种活化的二羧酸的聚合物组合; 以及形成适于通过血管输送的组合颗粒。
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公开(公告)号：US09119787B2
公开(公告)日：2015-09-01
申请号：US12806790
申请日：2010-08-19
Applicant: Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
Inventor： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
CPC classification number: A61K9/1647 , A61K9/0019 , A61K9/5031
Abstract: Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
Abstract translation: 公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。
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公开(公告)号：US08802184B2
公开(公告)日：2014-08-12
申请号：US11809045
申请日：2007-05-30
Applicant: Syed F. A. Hossainy , Dariush Davalian , Jinping Wan , Troy Carter , Charles Silvis
Inventor： Syed F. A. Hossainy , Dariush Davalian , Jinping Wan , Troy Carter , Charles Silvis
IPC: A61L33/00
CPC classification number: B05D1/18 , A61F2/82 , A61F2250/0067 , A61L31/022 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/624 , A61L2400/12 , B05D3/101 , B05D2401/32 , B05D2602/00
Abstract: A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first fluid into a second fluid having a suspension of nano-constructs; and removing the stent from the second fluid and allowing the first and second fluid to be removed such that the nano-constructs are carried by the stent for in vivo application of the constructs to a target location of a mammalian subject. The nano-constructs can be attached to the surface of the stent, can be attached to a surface of the coating of the stent, can be embedded into the stent, or can be embedded into the coating.
Abstract translation: 公开了一种用纳米结构修饰诸如支架的医疗装置的方法。 该方法包括将第一流体施加到支架上; 将从第一流体湿润的支架浸入具有纳米结构物悬浮液的第二流体中; 以及从所述第二流体移除所述支架并且允许所述第一和第二流体被移除，使得所述纳米构建体由所述支架承载以用于体内施用所述构建体到哺乳动物受试者的目标位置。 纳米结构可以连接到支架的表面，可以附着在支架的涂层表面，可以嵌入到支架中，或者可以嵌入到涂层中。
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30.发明申请Drug Delivery System and Method of Treatment of Vascular Diseases Using Photodynamic Therapy 审中-公开药物输送系统和使用光动力疗法治疗血管疾病的方法公开(公告)号：US20100331819A1
公开(公告)日：2010-12-30
申请号：US12491063
申请日：2009-06-24
Applicant: Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
Inventor： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
IPC: A61M25/00 , A61K9/127 , A61K9/14 , A61K31/409 , A61K31/555 , A61K31/197 , A61K31/22 , A61P35/00
CPC classification number: A61K31/409 , A61K9/0009 , A61K9/0019 , A61K9/1272 , A61K9/5146 , A61K41/0071 , A61L29/16 , A61L2300/224 , A61L2300/626 , A61M25/0045 , A61M25/10 , A61M2025/105 , A61M2025/1086
Abstract: This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site.
Abstract translation: 本发明涉及光动力治疗（PDT），更具体地涉及通过将负载PDT的纳米颗粒（例如脂质体，聚合物囊泡，胶束和聚合物纳米颗粒）递送到患病血管组织中的动脉粥样硬化斑块的PDT。 本发明提供用于递送多种药物并将药物递送至特定目标部位的方法和制剂。
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