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29 条记录 (耗时 0.015 秒)

    Bone marrow-derived neuronal cells
    22.
    发明申请
    Bone marrow-derived neuronal cells 审中-公开
    骨髓来源的神经元细胞

    公开(公告)号：US20060194316A1

    公开(公告)日：2006-08-31

    申请号：US10353742

    申请日：2003-01-27

    申请人： Juan Sanchez-Ramos ,  Shijie Song ,  William Janssen ,  Paul Sanberg ,  Thomas Freeman

    发明人： Juan Sanchez-Ramos ,  Shijie Song ,  William Janssen ,  Paul Sanberg ,  Thomas Freeman

    IPC分类号： A61K35/30 ,  C12N5/08

    CPC分类号： C12N5/0619 ,  A61K35/12 ,  A61K2035/124 ,  C12N2500/46 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/385 ,  C12N2501/392 ,  C12N2502/08 ,  C12N2506/1353

    摘要： Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

    摘要翻译： 骨髓基质细胞（BMSC）在体外和体内分化成神经元样表型，植入正常或去神经支配的大鼠纹状体。 BMSC没有保留在移植物的位点，而是迁移到整个大脑，并以各种建筑模式整合到特定的脑区域。 BMSC最有序的整合是在小脑浦肯野细胞的层流分布中，其中BMSC衍生的细胞采用浦肯野表型。 BMSC表现出位点依赖性分化，并表达了几种神经元标志物，包括神经元特异性核蛋白，酪氨酸羟化酶和钙结合蛋白。 BMSC可用于靶向神经修复和基因治疗策略中的特定脑核。

    Promotion of brain self-repair mechanisms by stereotaxic micro-stimulation
    23.
    发明授权
    Promotion of brain self-repair mechanisms by stereotaxic micro-stimulation 有权
    通过立体定位微刺激促进大脑自我修复机制

    公开(公告)号：US08452408B1

    公开(公告)日：2013-05-28

    申请号：US12491893

    申请日：2009-06-25

    申请人： Shijie Song ,  Juan Sanchez-Ramos

    发明人： Shijie Song ,  Juan Sanchez-Ramos

    IPC分类号： A61N1/36

    CPC分类号： A61B17/0642 ,  A61B17/0682 ,  A61B2017/0641

    摘要： A method of treating neurological deficit in which the brain area affected is focally and precisely stimulated by the transient insertion and subsequent removal of a micro-needle. This insertion and subsequent removal of the micro-needle induces endogenous stem cells to proliferate, migrate and promote the brain's self-repair mechanisms. The micro-needle stimulation causes the birth of new neural cells within the brain as well as mobilizes bone marrow derived cells with a neuronal phenotype to migrate to the site of stimulation to repair and replace damaged neural cells. By repairing and/or replacing injured or dead cells, this approach will slow down the degenerative course of the disease and may result in reversal of symptoms.

    摘要翻译： 一种治疗神经功能缺损的方法，其中受影响的脑区域通过瞬时插入并随后移除微针而被焦点和精确地刺激。 这种插入和随后的微针移除诱导内源性干细胞增殖，迁移和促进大脑的自我修复机制。 微针刺激导致脑内新神经细胞的诞生以及用神经元表型动员骨髓来源的细胞迁移到刺激部位以修复和替代受损的神经细胞。 通过修复和/或更换受伤或死细胞，这种方法将减缓疾病的退行过程，并可能导致症状的逆转。

    Oxygen producing non-polluting engine
    25.
    发明授权
    Oxygen producing non-polluting engine 有权
    生产氧气的无污染发动机

    公开(公告)号：US07350482B1

    公开(公告)日：2008-04-01

    申请号：US11065679

    申请日：2005-02-24

    申请人： Juan Sanchez, Jr.

    发明人： Juan Sanchez, Jr.

    IPC分类号： F03C5/00

    CPC分类号： F02M25/12 ,  Y02T10/121

    摘要： A non-polluting engine that produces mechanical, rotary motion, and produces oxygen as a principle gaseous byproduct. The engine employs a fuel mixture that includes two components that together produce oxygen. The fuel mixture is introduced to a combustion chamber where it is heated to facilitate the rapid production of oxygen. The expansion of the oxygen within the combustion chamber is translated to rotary mechanical energy. The oxygen produced during the reaction is expelled from the combustion chamber and released into the atmosphere.

    摘要翻译： 一种无污染的发动机，产生机械，旋转运动，并产生氧气作为主要气态副产物。 发动机采用的燃料混合物包括两个共同产生氧气的组分。 将燃料混合物引入燃烧室，在其中加热燃料，以促进氧的快速生成。 燃烧室内氧气的膨胀转化为旋转机械能。 在反应过程中产生的氧气从燃烧室排出并释放到大气中。

    Apparatus and method for authenticating a user when accessing to multimedia services
    26.
    发明申请
    Apparatus and method for authenticating a user when accessing to multimedia services 有权
    用于在访问多媒体业务时认证用户的装置和方法

    公开(公告)号：US20070130471A1

    公开(公告)日：2007-06-07

    申请号：US10595110

    申请日：2003-08-26

    申请人： John Walker Pina ,  Juan Sanchez Herrero

    发明人： John Walker Pina ,  Juan Sanchez Herrero

    IPC分类号： H04L9/00

    CPC分类号： H04L63/0815 ,  H04L63/0853 ,  H04L65/1016 ,  H04L67/04 ,  H04L67/14 ,  H04L67/306 ,  H04W12/06

    摘要： An inter-domain authentication mechanism is provided for carrying out a cross-domain authentication for a given user between an access network domain and a Multimedia domain. The authentication mechanism is applicable where a user has been authenticated by the access network and may be implemented as a dedicated Multimedia Authentication device in close co-operation with a subscriber server, or be fully integrated in the subscriber server. The authentication mechanism is arranged for re-using authentication data between different networks, or between different technological domains, and with help from other entities of a Multimedia domain according to present standards.

    摘要翻译： 提供域间认证机制，用于对接入网域和多媒体域之间的给定用户进行跨域认证。 认证机制适用于用户已经被接入网络认证，并且可以被实现为与订户服务器紧密合作的专用多媒体认证设备，或者完全集成在订户服务器中。 认证机制被安排用于根据现行标准在不同网络之间或不同技术领域之间以及多媒体域的其他实体的帮助下重新使用认证数据。

    Protection against ischemia and reperfusion injury
    28.
    发明申请
    Protection against ischemia and reperfusion injury 失效
    防止缺血和再灌注损伤

    公开(公告)号：US20050222038A1

    公开(公告)日：2005-10-06

    申请号：US11141670

    申请日：2005-05-31

    申请人： Peter Oeltgen ,  Paul Bishop ,  Mark Kindy ,  Juan Sanchez

    发明人： Peter Oeltgen ,  Paul Bishop ,  Mark Kindy ,  Juan Sanchez

    IPC分类号： A61K38/08 ,  A61K38/10 ,  A61P9/00 ,  A61K31/198 ,  A61K31/416

    CPC分类号： A61K38/10 ,  A61K38/08

    摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

    摘要翻译： 使用该化合物以减少与哺乳动物器官如心脏的缺血和再灌注相关的损伤的化合物和方法。 化合物，即Deltorphin A和/或Dermorphin H，可以作为预处理策略的一部分施用，其减少损伤的程度并改善停止和恢复血流之后的器官功能。 该化合物可用于准备计划的缺血或以预防方式预期进一步的缺血事件。

    System for the induction heating of the electric plates of a cooker
    29.
    发明授权
    System for the induction heating of the electric plates of a cooker 失效
    电饭煲感应加热系统

    公开(公告)号：US4885447A

    公开(公告)日：1989-12-05

    申请号：US821061

    申请日：1986-01-21

    申请人： Juan Sanchez Gonzalez

    发明人： Juan Sanchez Gonzalez

    IPC分类号： H05B6/06

    CPC分类号： H05B6/062

    摘要： An inverter bridge of MOS technology transistors applies a series of high frequency power pulses to a disc coil in an electrically-heating of a cooker plate in order to heat a ferromagnetic container on the plate. The transistorized inverter bridge is activated by a control circuit which adjusts the triggering moment of each leg of the transistor bridge to the inductive recovery times of the disc coil and inhibits the functioning thereof in the absence of ferromagnetic load, i.e. container, on the plate. In this manner, the plate is self-igniting when a ferromagnetic container is placed thereon, thereby substantially reducing the electric power consumed in use. The control circuit for activating the transistor bridge is advantageously incorporated in a single integrated circuit in order to reduce maximumly the wiring and cost of assembly.

    摘要翻译： MOS技术晶体管的逆变桥在炊具板的电加热中将一系列高频功率脉冲施加到盘式线圈，以便加热板上的铁磁容器。 晶体管化逆变桥由一个控制电路激活，该控制电路将晶体管桥的每个支路的触发力矩调整到盘式线圈的感应恢复时间，并且在板上不存在铁磁负载（即容器）的情况下，抑制其功能。 以这种方式，当铁磁容器放置在其上时，板是自点火的，从而显着降低了使用中消耗的电力。 用于激活晶体管桥的控制电路有利地结合在单个集成电路中，以便最大限度地减少布线和组装成本。