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1.发明申请SYSTEM AND METHOD FOR SYNCHRONIZING THE PROFILE OF A USER IN SOCIAL NETWORKS AND THE USER'S PERSONAL CONTACT CARD (PCC) 审中-公开用于在社交网络和用户的个人联系卡（PCC）中同步用户配置文件的系统和方法公开(公告)号：US20130110776A1
公开(公告)日：2013-05-02
申请号：US13696523
申请日：2010-05-07
申请人： Jose Luis Nunez Diaz , Eduardo Fullea Carrera , Rafael Moron Abad , Jose Juan Sanchez Dasi , Bienvenido Gomez Carreno
发明人： Jose Luis Nunez Diaz , Eduardo Fullea Carrera , Rafael Moron Abad , Jose Juan Sanchez Dasi , Bienvenido Gomez Carreno
IPC分类号： G06F17/30
CPC分类号： G06F16/27 , H04L67/06 , H04L67/1095 , H04L67/306 , H04M7/0024 , H04M2203/655 , H04W4/21 , H04W4/50
摘要： The method and system for synchronizing social networks and Personal Contact Cards (PCC) update the profile of a user published in an Open Mobile Alliance Converged Address Book (OMA CAB) system with the information published and updated on one or more social networks to which the user subscribes, by means of synchronization by polling or synchronization by subscription/notification. To do so, the user sends prior authorization to access the user profile published in the social network to a telecommunication services provider operating the OMA CAB system.
摘要翻译： 用于同步社交网络和个人接触卡（PCC）的方法和系统更新在开放移动联盟聚合通信簿（OMA CAB）系统中公布的用户的简档，其中在一个或多个社交网络上发布和更新的信息， 用户通过轮询或通过订阅/通知的同步进行同步。 为此，用户发送事先授权，将在社交网络中发布的用户简档访问操作OMA CAB系统的电信服务提供商。
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2.发明申请Human Cord Blood as a Source of Neural Tissue Repair of the Brain and Spinal Cord 有权人类脐带血作为脑和脊髓神经组织修复的来源公开(公告)号：US20070237751A1
公开(公告)日：2007-10-11
申请号：US11558411
申请日：2006-11-09
CPC分类号： A61K35/30 , A61K35/12 , A61K35/51 , A61K2035/124 , C12N5/0618 , C12N2501/13 , C12N2501/385 , C12N2506/1369
摘要： The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord.
摘要翻译： 本发明涉及来自供体或患者的脐带血细胞用于提供可用于移植的神经细胞。 根据本发明的分离的细胞可以用于实现神经组织，特别是脑和脊髓的组织的自体和同种异体移植和修复，并且治疗脑和脊髓的神经变性疾病。
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公开(公告)号：US20070220005A1
公开(公告)日：2007-09-20
申请号：US11569371
申请日：2004-05-26
IPC分类号： G06F17/30
CPC分类号： H04L67/24 , H04L67/306 , H04W4/08 , H04W4/10 , H04W8/186 , H04W8/20 , H04W76/45 , H04W84/08 , H04W88/18
摘要： The present invention addresses the management of user groups, user contact lists, and user access lists in a telecom-communication system whereby a user access to a group and list management server for creating, deleting or modifying a group, contact list and access list in terms of group policies and members. User groups, user contact lists, and user access lists are operated without any validation other than being syntactically correct, and without taking into consideration the users access capabilities, the users privacy, and even the user existence. In particular, the telecommunication system may comprise a number of networks operated by different network operators where the users hold subscriptions. The present invention offers a new interface between a group management server and a subscriber server of a network operator where the users hold their subscriptions, so that user policies in the subscriber server govern operations on groups, contact lists and access lists.
摘要翻译： 本发明解决了电信通信系统中的用户组，用户联系人列表和用户访问列表的管理，由此用户访问组和列表管理服务器以创建，删除或修改组，联系人列表和访问列表 团体政策和成员的条款。 用户组，用户联系人列表和用户访问列表在没有任何验证的情况下运行，而不是在语法上正确，并且不考虑用户访问功能，用户隐私，甚至用户存在。 特别地，电信系统可以包括由用户持有订阅的不同网络运营商操作的多个网络。 本发明提供组管理服务器和用户持有其订阅的网络运营商的订户服务器之间的新接口，使得订户服务器中的用户策略控制对组，联系人列表和访问列表的操作。
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公开(公告)号：US20070167903A1
公开(公告)日：2007-07-19
申请号：US11160180
申请日：2005-06-13
IPC分类号： A61N1/30
CPC分类号： A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/327
摘要： In accordance with the present invention is provided a novel tri-pronged electrode that produces minimal damage to deep brain or spinal cord regions. The apparatus and associated method of the present invention provides for a single insertion of a novel probe effective for both delivery of DNA and delivery of therapeutic electroporating current, thereby minimizing the potential damage to the nervous system.
摘要翻译： 根据本发明，提供了一种新颖的三足电极，其对深部脑脊髓区域或脊髓区域产生最小的损伤。 本发明的装置和相关方法提供了一种新型探针的单次插入，其对于递送DNA和递送治疗性电穿孔电流有效，从而最小化对神经系统的潜在损伤。
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公开(公告)号：US20050091805A1
公开(公告)日：2005-05-05
申请号：US11005185
申请日：2004-12-06
申请人： Luis Armela , Juan Sanchez , William Clune , Jefferson Davis , Christopher Gallant , Melissa Spezzafero , Mark Clarner , William Huber , David Kraus , George Provost , Howard Kingsford , Michel Labrecque
发明人： Luis Armela , Juan Sanchez , William Clune , Jefferson Davis , Christopher Gallant , Melissa Spezzafero , Mark Clarner , William Huber , David Kraus , George Provost , Howard Kingsford , Michel Labrecque
CPC分类号： B29C43/222 , A44B18/0049 , A44B18/0065 , A61F13/625 , B29C43/46 , B29C67/0044 , B29C2043/461 , B29C2043/465 , B29L2031/729 , Y10T24/2717 , Y10T24/2742 , Y10T24/2783 , Y10T24/2792 , Y10T428/24008 , Y10T428/24017 , Y10T428/24182
摘要： A method of forming a fastener is provided, including (a) forming, from a thermoformable material, a preform product having a sheet-form base and an array of preform stems integrally molded with and extending from the base to corresponding terminal ends; (b) heating the terminal ends of the stems to a predetermined softening temperature, while maintaining the sheet-form base and a lower portion of each stem at a temperature lower than the softening temperature; and (c) contacting the terminal ends with a contact surface that is at a predetermined forming temperature, lower than the softening temperature, to deform the terminal ends to form heads therefrom that overhang the sheet-form base. Fasteners and other methods of forming them are also provided.
摘要翻译： 提供了一种形成紧固件的方法，包括（a）从可热成型材料形成具有片状基底和与基底整体模塑并从基底延伸到相应末端的预成型体棒阵列的预制品; （b）将茎的末端加热至预定的软化温度，同时将片状基底和每个茎的下部保持在低于软化温度的温度; 和（c）使终端与接触表面接触，所述接触表面处于低于软化温度的预定的形成温度，以使端部端部变形，从而形成从其延伸到片状基底的头部。 还提供了紧固件和其它形成方法。
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6.发明授权公开(公告)号：US06528245B2
公开(公告)日：2003-03-04
申请号：US09307824
申请日：1999-05-07
IPC分类号： A01N102
CPC分类号： C12N5/0619 , A61K35/12 , A61K2035/124 , C12N2500/46 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/385 , C12N2501/392 , C12N2502/08 , C12N2506/1353
摘要： Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.
摘要翻译： 骨髓基质细胞（BMSC）在体外和体内分化成神经元样表型，植入正常或去神经支配的大鼠纹状体。 BMSC没有保留在移植物的位点，而是迁移到整个大脑，并以各种建筑模式整合到特定的脑区域。 BMSC最有序的整合是在小脑浦肯野细胞的层流分布中，其中BMSC衍生的细胞采用浦肯野表型。 BMSC表现出位点依赖性分化，并表达了几种神经元标志物，包括神经元特异性核蛋白，酪氨酸羟化酶和钙结合蛋白。 BMSC可用于靶向神经修复和基因治疗策略中的特定脑核。
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7.发明申请MANGANESE ION COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION 有权用于通过NASAL INSUFFLATION将组合物输送到中央神经系统的锰离子涂覆的纳米颗粒公开(公告)号：US20160312222A1
公开(公告)日：2016-10-27
申请号：US15162872
申请日：2016-05-24
IPC分类号： C12N15/113 , A61K9/107 , A61K9/50 , A61K31/713 , A61K9/00 , A61K9/16
CPC分类号： C12N15/113 , A61K9/0043 , A61K9/1075 , A61K9/1611 , A61K9/1652 , A61K9/1658 , A61K9/50 , A61K9/501 , A61K9/5115 , A61K31/7088 , A61K31/713 , A61K47/541 , A61K47/547 , A61K47/6939 , A61K48/00 , A61K49/1881 , C12N15/88 , C12N15/895 , C12N2310/14 , C12N2320/32
摘要： The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs. The present disclosure encompasses embodiments of nanoparticle-based compositions and methods for the use thereof for the delivery of genes, oligonucleotides, including but not limited to small interfering RNA, and other small molecule drugs, into the brain by nasal insufflation.
摘要翻译： 本公开的组合物和方法特别针对在嗅觉神经末端表达的二价金属转运蛋白，以将二价阳离子包被或含阳离子的纳米颗粒转运到脑的所有区域。 已经发现，这种含二价阳离子的纳米颗粒，包括那些包含锰的纳米颗粒对金属转运受体蛋白质具有亲和力。 虽然这种受体对锰具有特殊的亲和力，但是预期其它二价离子（包括镁，钙等）也可以结合到这种受体上，导致纳米颗粒转运到细胞质细胞质中。 因此，已经开发了纳米颗粒，作为胃肠外递送基因，蛋白质和药物的载体。 本公开涵盖了基于纳米颗粒的组合物的实施方案及其用于通过鼻吹气将基因，寡核苷酸（包括但不限于小干扰RNA和其它小分子药物）递送至脑中的方法。
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8.发明授权Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation 有权锰离子包被的纳米颗粒，用于通过鼻吹入将组合物递送到中枢神经系统中公开(公告)号：US09375400B2
公开(公告)日：2016-06-28
申请号：US14343534
申请日：2012-09-14
IPC分类号： A61K9/00 , A61K31/7088 , A61K47/48 , A61K9/51 , A61K9/16 , A61K9/50 , A61K49/18 , C12N15/88 , C12N15/89 , A61K31/713 , A61K48/00
CPC分类号： C12N15/113 , A61K9/0043 , A61K9/1075 , A61K9/1611 , A61K9/1652 , A61K9/1658 , A61K9/50 , A61K9/501 , A61K9/5115 , A61K31/7088 , A61K31/713 , A61K47/541 , A61K47/547 , A61K47/6939 , A61K48/00 , A61K49/1881 , C12N15/88 , C12N15/895 , C12N2310/14 , C12N2320/32
摘要： The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs. The present disclosure encompasses embodiments of nanoparticle-based compositions and methods for the use thereof for the delivery of genes, oligonucleotides, including but not limited to small interfering RNA, and other small molecule drugs, into the brain by nasal insufflation.
摘要翻译： 本公开的组合物和方法特别针对在嗅觉神经末端表达的二价金属转运蛋白，以将二价阳离子包被或含阳离子的纳米颗粒转运到脑的所有区域。 已经发现，这种含二价阳离子的纳米颗粒，包括那些包含锰的纳米颗粒对金属转运受体蛋白质具有亲和力。 虽然这种受体对锰具有特殊的亲和力，但是预期其它二价离子（包括镁，钙等）也可以结合到这种受体上，导致纳米颗粒转运到细胞质细胞质中。 因此，已经开发了纳米颗粒，作为胃肠外递送基因，蛋白质和药物的载体。 本公开涵盖了基于纳米颗粒的组合物的实施方案及其用于通过鼻吹气将基因，寡核苷酸（包括但不限于小干扰RNA和其它小分子药物）递送至脑中的方法。
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公开(公告)号：US20140082075A1
公开(公告)日：2014-03-20
申请号：US13979620
申请日：2012-01-13
IPC分类号： H04L29/06
CPC分类号： H04L65/403 , H04M3/42365
摘要： This invention refers to a method for managing a converged address book capability of a user with an address book and subscribed to converged address book service characterised by defining a service tuple in a presence document stored in a presence server; setting a value of converged address book capability in the service tuple indicating whether converged address book service is supported by the user; publishing the converged address book capability of the user and a user identifier on a converged address book server; receiving updates from the presence server of converged address capabilities of the contacts of the users; and updating a network address book, stored in a converged address book XML document management server, with converged address capabilities of served users.
摘要翻译： 本发明涉及一种用于管理具有地址簿的用户的融合地址簿能力的方法，并且订阅了融合地址簿服务，其特征在于在存储在存在服务器中的存在文档中定义服务元组; 在服务元组中设置融合地址簿能力的值，指示用户是否支持融合的地址簿服务; 发布用户的融合地址簿功能和在融合地址簿服务器上的用户标识符; 从存在服务器接收用户的联系人的融合地址能力的更新; 以及融合的地址簿XML文档管理服务器中更新存储在被服务用户的融合地址能力的网络地址簿。
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公开(公告)号：US20080206206A1
公开(公告)日：2008-08-28
申请号：US11954473
申请日：2007-12-12
CPC分类号： C12N5/0619 , A61K35/12 , A61K2035/124 , C12N5/0622 , C12N2500/46 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/33 , C12N2501/385 , C12N2501/392 , C12N2506/1353
摘要： Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC administered into the ventricle did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. Treated BMSC implanted intrastriatally stayed in the cortex and the striatum, produced tyrosine hydroxylase which produces the dopamine needed in Parkinson's disease.
摘要翻译： 骨髓基质细胞（BMSC）在体外和体内分化成神经元样表型，植入正常或去神经支配的大鼠纹状体。 施用于心室的BMSC不保持局部位于移植物的位点，而是迁移到整个脑中并以各种建筑模式整合入特定的脑区域。 BMSC最有序的整合是在小脑浦肯野细胞的层流分布中，其中BMSC衍生的细胞采用浦肯野表型。 BMSC表现出位点依赖性分化，并表达了几种神经元标志物，包括神经元特异性核蛋白，酪氨酸羟化酶和钙结合蛋白。 经脊髓内植入治疗的BMSC保留在皮层和纹状体中，产生产生帕金森病所需的多巴胺的酪氨酸羟化酶。
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