中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

11 records (took 0.014 seconds)

    Promotion of brain self-repair mechanisms by stereotaxic micro-stimulation
    1.
    发明授权
    Promotion of brain self-repair mechanisms by stereotaxic micro-stimulation 有权
    通过立体定位微刺激促进大脑自我修复机制

    公开(公告)号：US08452408B1

    公开(公告)日：2013-05-28

    申请号：US12491893

    申请日：2009-06-25

    Applicant: Shijie Song ,  Juan Sanchez-Ramos

    Inventor： Shijie Song ,  Juan Sanchez-Ramos

    IPC: A61N1/36

    CPC classification number: A61B17/0642 ,  A61B17/0682 ,  A61B2017/0641

    Abstract: A method of treating neurological deficit in which the brain area affected is focally and precisely stimulated by the transient insertion and subsequent removal of a micro-needle. This insertion and subsequent removal of the micro-needle induces endogenous stem cells to proliferate, migrate and promote the brain's self-repair mechanisms. The micro-needle stimulation causes the birth of new neural cells within the brain as well as mobilizes bone marrow derived cells with a neuronal phenotype to migrate to the site of stimulation to repair and replace damaged neural cells. By repairing and/or replacing injured or dead cells, this approach will slow down the degenerative course of the disease and may result in reversal of symptoms.

    Abstract translation: 一种治疗神经功能缺损的方法，其中受影响的脑区域通过瞬时插入并随后移除微针而被焦点和精确地刺激。 这种插入和随后的微针移除诱导内源性干细胞增殖，迁移和促进大脑的自我修复机制。 微针刺激导致脑内新神经细胞的诞生以及用神经元表型动员骨髓来源的细胞迁移到刺激部位以修复和替代受损的神经细胞。 通过修复和/或更换受伤或死细胞，这种方法将减缓疾病的退行过程，并可能导致症状的逆转。

    Bone marrow cells as a source of neurons for brain and spinal cord repair
    3.
    发明授权
    Bone marrow cells as a source of neurons for brain and spinal cord repair 有权
    骨髓细胞作为脑和脊髓修复神经元的来源

    公开(公告)号：US06528245B2

    公开(公告)日：2003-03-04

    申请号：US09307824

    申请日：1999-05-07

    Applicant: Juan Sanchez-Ramos ,  Shijie Song ,  William Janssen ,  Paul Sanberg ,  Thomas Freeman

    Inventor： Juan Sanchez-Ramos ,  Shijie Song ,  William Janssen ,  Paul Sanberg ,  Thomas Freeman

    IPC: A01N102

    CPC classification number: C12N5/0619 ,  A61K35/12 ,  A61K2035/124 ,  C12N2500/46 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/385 ,  C12N2501/392 ,  C12N2502/08 ,  C12N2506/1353

    Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

    Abstract translation: 骨髓基质细胞（BMSC）在体外和体内分化成神经元样表型，植入正常或去神经支配的大鼠纹状体。 BMSC没有保留在移植物的位点，而是迁移到整个大脑，并以各种建筑模式整合到特定的脑区域。 BMSC最有序的整合是在小脑浦肯野细胞的层流分布中，其中BMSC衍生的细胞采用浦肯野表型。 BMSC表现出位点依赖性分化，并表达了几种神经元标志物，包括神经元特异性核蛋白，酪氨酸羟化酶和钙结合蛋白。 BMSC可用于靶向神经修复和基因治疗策略中的特定脑核。

    DIVALENT-METAL COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION
    5.
    发明申请
    DIVALENT-METAL COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION 有权
    用于通过NASAL INSUFFLATION将组合物输送到中央神经系统的金属包覆纳米颗粒

    公开(公告)号：US20140248364A1

    公开(公告)日：2014-09-04

    申请号：US14343534

    申请日：2012-09-14

    Applicant: Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Shyam S. Mohapatra ,  Subhra Mohapatra

    Inventor： Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Shyam S. Mohapatra ,  Subhra Mohapatra

    IPC: A61K9/00 ,  A61K9/51 ,  A61K47/48 ,  A61K31/7088

    CPC classification number: C12N15/113 ,  A61K9/0043 ,  A61K9/1075 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/50 ,  A61K9/501 ,  A61K9/5115 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/541 ,  A61K47/547 ,  A61K47/6939 ,  A61K48/00 ,  A61K49/1881 ,  C12N15/88 ,  C12N15/895 ,  C12N2310/14 ,  C12N2320/32

    Abstract: The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs. The present disclosure encompasses embodiments of nanoparticle-based compositions and methods for the use thereof for the delivery of genes, oligonucleotides, including but not limited to small interfering RNA, and other small molecule drugs, into the brain by nasal insufflation.

    Abstract translation: 本公开的组合物和方法特别针对在嗅觉神经末端表达的二价金属转运蛋白，以将二价阳离子包被或含阳离子的纳米颗粒转运到脑的所有区域。 已经发现，这种含二价阳离子的纳米颗粒，包括那些包含锰的纳米颗粒对金属转运受体蛋白质具有亲和力。 虽然这种受体对锰具有特殊的亲和力，但是预期其它二价离子（包括镁，钙等）也可以结合到这种受体上，导致纳米颗粒转运到细胞质细胞质中。 因此，已经开发了纳米颗粒，作为胃肠外递送基因，蛋白质和药物的载体。 本公开涵盖了基于纳米颗粒的组合物的实施方案及其用于通过鼻吹气将基因，寡核苷酸（包括但不限于小干扰RNA和其它小分子药物）递送至脑中的方法。

    Bone marrow-derived neuronal cells
    6.
    发明申请
    Bone marrow-derived neuronal cells 审中-公开
    骨髓来源的神经元细胞

    公开(公告)号：US20060194316A1

    公开(公告)日：2006-08-31

    申请号：US10353742

    申请日：2003-01-27

    Applicant: Juan Sanchez-Ramos ,  Shijie Song ,  William Janssen ,  Paul Sanberg ,  Thomas Freeman

    Inventor： Juan Sanchez-Ramos ,  Shijie Song ,  William Janssen ,  Paul Sanberg ,  Thomas Freeman

    IPC: A61K35/30 ,  C12N5/08

    CPC classification number: C12N5/0619 ,  A61K35/12 ,  A61K2035/124 ,  C12N2500/46 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/385 ,  C12N2501/392 ,  C12N2502/08 ,  C12N2506/1353

    Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

    Abstract translation: 骨髓基质细胞（BMSC）在体外和体内分化成神经元样表型，植入正常或去神经支配的大鼠纹状体。 BMSC没有保留在移植物的位点，而是迁移到整个大脑，并以各种建筑模式整合到特定的脑区域。 BMSC最有序的整合是在小脑浦肯野细胞的层流分布中，其中BMSC衍生的细胞采用浦肯野表型。 BMSC表现出位点依赖性分化，并表达了几种神经元标志物，包括神经元特异性核蛋白，酪氨酸羟化酶和钙结合蛋白。 BMSC可用于靶向神经修复和基因治疗策略中的特定脑核。

Patent Agency Ranking