-
公开(公告)号：US07049401B1
公开(公告)日：2006-05-23
申请号：US09642853
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
-
公开(公告)号：US20060094035A1
公开(公告)日：2006-05-04
申请号：US11145307
申请日：2005-06-03
Applicant: Mark Erlander , Xiao-Jun Ma
Inventor： Mark Erlander , Xiao-Jun Ma
CPC classification number: C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , G06Q50/22 , G16B25/00 , G16B40/00
Abstract: The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
Abstract translation: 本发明提供了使用基因表达测量法在临床环境中从受试者获得的样品中分类或鉴定肿瘤的方法，例如在福尔马林固定的石蜡包埋（FFPE）样品的情况下。
-
公开(公告)号：US20060063170A1
公开(公告)日：2006-03-23
申请号：US11084582
申请日：2005-03-18
Applicant: Mark Erlander , Li Ding
Inventor： Mark Erlander , Li Ding
CPC classification number: C12Q1/6851 , C12Q1/68 , C12Q2545/101 , C12Q2545/114 , C12Q2531/113 , C12Q2525/161
Abstract: This invention relates to the determination of RNA quality, or RNA integrity, in a biological sample. The extent of RNA degradation, or retention of RNA integrity, is determined based upon the comparison of the relative amount of two sequences of a representative RNA molecule in the sample. Compositions and methods related to the determination are provided to assess RNA quality.
Abstract translation: 本发明涉及生物样品中RNA质量或RNA完整性的确定。 基于样品中代表性的RNA分子的两个序列的相对量的比较来确定RNA降解的程度或RNA完整性的保留。 提供与测定有关的组合物和方法以评估RNA质量。
-
公开(公告)号：US20050208500A1
公开(公告)日：2005-09-22
申请号：US10794263
申请日：2004-03-04
Applicant: Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
Inventor： Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
CPC classification number: C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
Abstract: The invention relates to the identification and use of gene expression profiles, or patterns, suitable for identification of populations that are positive and negative for estrogen receptor expression. The gene expression profiles may be embodied in nucleic acid expression, protein expression, or other expression formats, and may be used in the study and/or diagnosis of cells and tissue in breast cancer as well as for the study and/or determination of prognosis of a patient, including breast cancer survival.
Abstract translation: 本发明涉及鉴定和使用适合于鉴定雌激素受体表达阳性和阴性的群体的基因表达谱或模式。 基因表达谱可以体现在核酸表达，蛋白质表达或其他表达形式中，并且可以用于乳腺癌细胞和组织的研究和/或诊断以及用于预后的研究和/或测定 的患者，包括乳腺癌的存活。
-
Patent Agency Ranking
25.发明申请公开(公告)号：US20050124795A1
公开(公告)日：2005-06-09
申请号：US10661378
申请日：2003-09-12
Applicant: Adrienne Dubin , Mark Erlander , Arne Huvar , Rene Huvar , Lukas Buehler
Inventor： Adrienne Dubin , Mark Erlander , Arne Huvar , Rene Huvar , Lukas Buehler
IPC: G01N33/50 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/08 , A61P1/10 , A61P3/04 , A61P3/10 , A61P9/06 , A61P9/12 , A61P9/14 , A61P11/06 , A61P11/08 , A61P13/10 , A61P15/10 , A61P25/04 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P37/08 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/566 , A61K39/395 , C07H21/04
CPC classification number: C07K14/70571 , A61K38/00 , C07K16/286
Abstract: DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征编码人5-HT3-C的DNA。 重组蛋白能够形成生物活性的人5-HT3-C蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
-
公开(公告)号：US20050095607A1
公开(公告)日：2005-05-05
申请号：US10795092
申请日：2004-03-05
Applicant: Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
Inventor： Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
CPC classification number: C07K14/4748 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
Abstract: The invention relates to the identification and use of gene expression profiles, or patterns, suitable for identification of breast cancer patient populations with different survival outcomes. The gene expression profiles may be embodied in nucleic acid expression, protein expression, or other expression formats, and may be used in the study and/or determination of the prognosis of a patient, including breast cancer survival.
Abstract translation: 本发明涉及鉴定和使用适合于鉴定具有不同生存结果的乳腺癌患者群体的基因表达谱或模式。 基因表达谱可以体现在核酸表达，蛋白质表达或其他表达形式中，并且可以用于研究和/或确定患者的预后，包括乳腺癌存活。
-
27.发明授权公开(公告)号：US06855560B1
公开(公告)日：2005-02-15
申请号：US09642852
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC: C07K14/72 , C12N15/12 , G01N33/53 , G01N33/567
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
-
公开(公告)号：US20050014168A1
公开(公告)日：2005-01-20
申请号：US10769476
申请日：2004-01-30
Applicant: Mark Erlander , Xiao-Jun Ma , Thomas Baer
Inventor： Mark Erlander , Xiao-Jun Ma , Thomas Baer
CPC classification number: C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
Abstract: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
Abstract translation: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。
-
公开(公告)号：US20050009047A1
公开(公告)日：2005-01-13
申请号：US10805171
申请日：2004-03-19
Applicant: Mark Erlander , Ranelle Salunga , Xiao-Jun Ma , Eddy Enright
Inventor： Mark Erlander , Ranelle Salunga , Xiao-Jun Ma , Eddy Enright
CPC classification number: C12Q1/6851 , C12Q2521/119 , C12Q2521/131 , C12Q2521/107 , C12Q2521/101 , C12Q2525/173
Abstract: The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.
Abstract translation: 本发明提供了扩增核酸分子的方法。 提供了使用寡核苷酸，DNA和RNA聚合酶扩增靶多核苷酸（包括mRNA）的方法。 本发明还提供了用于实施该方法的组合物和试剂盒，以及使用扩增产物的方法。
-
-
-
-
-
-
-
-
Search Results
29
records
(took 0.036 seconds)
