公开(公告)号：US20130274116A1

公开(公告)日：2013-10-17

申请号：US13896293

申请日：2013-05-16

Applicant: Matthew Rabinowitz ,  Allison Rayan ,  George Gemelos ,  Milena Banjevic ,  Zachary Demko

Inventor： Matthew Rabinowitz ,  Allison Rayan ,  George Gemelos ,  Milena Banjevic ,  Zachary Demko

IPC: C12Q1/68

CPC classification number: G16B30/00 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06N7/005 ,  G16B20/00 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.

Abstract translation: 本文公开了用于在非侵入性产前诊断的上下文中确定胎儿中染色体的拷贝数的方法。 在一个实施方案中，分析来自含有胎儿DNA和母体DNA的遗传物质的样品的测量的遗传数据以及来自胎儿的生物亲本的遗传数据，并确定感兴趣的染色体的拷贝数。 在一个实施方案中，使用单核苷酸多态性（SNP）微阵列以及亲本基因组数据测量母体血清，并且使用染色体拷贝数的确定来进行与胎儿有关的临床决定。

公开(公告)号：US20130261004A1

公开(公告)日：2013-10-03

申请号：US13846160

申请日：2013-03-18

Applicant: Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

Inventor： Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6876 ,  C12Q2600/156 ,  G16B10/00

Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

Abstract translation: 本文公开了非侵入性产前亲子鉴定的方法。 该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。 这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

公开(公告)号：US20130178373A1

公开(公告)日：2013-07-11

申请号：US13791397

申请日：2013-03-08

Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Zachary Demko ,  Matthew Hill ,  Bernhard Zimmermann ,  Johan Baner

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6827 ,  C12Q1/6862 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/18 ,  G06F19/24 ,  C12Q2537/161 ,  C12Q2537/165

Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US20120122701A1

公开(公告)日：2012-05-17

申请号：US13335043

申请日：2011-12-22

Applicant: Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

Inventor： Allison Ryan ,  Styrmir Sigurjonsson ,  Milena Banjevic ,  George Gemelos ,  Matthew Hill ,  Johan Baner ,  Matthew Rabinowitz ,  Zachary Demko

IPC: C12Q1/68 ,  G01N33/53 ,  G01N21/64 ,  C40B20/00

CPC classification number: C12Q1/6869 ,  C12Q1/6876 ,  C12Q2600/156 ,  G06F19/14

Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

Abstract translation: 本文公开了非侵入性产前亲子鉴定的方法。 该方法使用从怀孕母亲获得的血浆进行的遗传测量，以及所称父亲的遗传测量以及母亲的遗传测量，以确定所称父亲是否是胎儿的生物之父。 这通过基于信息学的方法来实现，该方法可以将母体血浆中发现的胎儿DNA的遗传指纹与所称父亲的遗传指纹进行比较。

公开(公告)号：US08106828B1

公开(公告)日：2012-01-31

申请号：US12209971

申请日：2008-09-12

Applicant: Ju-Yong Do ,  Andy Lee ,  David Gotwisner ,  Dimitri Rubin ,  Matthew Rabinowitz

Inventor： Ju-Yong Do ,  Andy Lee ,  David Gotwisner ,  Dimitri Rubin ,  Matthew Rabinowitz

IPC: G01S3/02

CPC classification number: H04H60/51 ,  G01S5/0252 ,  H04B17/27 ,  H04N21/25841 ,  H04W64/00

Abstract: An apparatus for location identification using broadcast wireless signal signatures includes a receiver to receive first measurements of a plurality of wireless television signals. The first measurements are made by a remote device receiving the plurality of wireless television signals. In addition, the apparatus includes a processor to select one or more of a plurality of possible locations of the remote device based on the first measurements and a plurality of associations each associating one of the possible locations with expected values. Moreover, the receiver receives second measurements of the wireless television signals made by one or more monitor units, and the processor generates the expected values for the first measurements and the associations based on the second measurements and the locations of the one or more monitor units.

Abstract translation: 用于使用广播无线信号签名的位置识别的装置包括接收多个无线电视信号的第一测量的接收机。 第一测量由接收多个无线电视信号的远程设备进行。 另外，该设备包括处理器，用于基于第一测量值选择远程设备的多个可能位置中的一个或多个，以及多个关联，每个关联将每个可能位置之一与期望值相关联。 此外，接收机接收由一个或多个监视器单元产生的无线电视信号的第二测量，并且处理器基于第二测量和一个或多个监视器单元的位置，产生用于第一测量和关联的期望值。

公开(公告)号：US20100292920A1

公开(公告)日：2010-11-18

申请号：US12834580

申请日：2010-07-12

Applicant: Matthew D. Pierce ,  Matthew Rabinowitz

Inventor： Matthew D. Pierce ,  Matthew Rabinowitz

IPC: G01C21/00

CPC classification number: G01S5/0036 ,  A63F2300/205 ,  G01C21/206 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/14 ,  G01S5/145 ,  G01S19/46 ,  H04N21/25841 ,  H04N21/2662 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A service depends on the location of a device. The device location is determined using DTV signals. More specifically, the device location is determined based on pseudo-ranges between the device and a plurality of digital television (DTV) transmitters and the pseudo-ranges are determined based on broadcast DTV signals received by the device from the DTV transmitters. Examples of DTV signals include the American Television Standards Committee (ATSC) signals, the European Telecommunications Standards Institute Digital Video Broadcasting-Terrestrial (DVB-T) signals and the Japanese Integrated Service Digital Broadcasting-Terrestrial (ISDB-T) signals.

Abstract translation: 服务取决于设备的位置。 设备位置使用DTV信号确定。 更具体地，基于设备和多个数字电视（DTV）发射机之间的伪距来确定设备位置，并且基于由设备从DTV发射机接收的广播DTV信号来确定伪距离。 DTV信号的示例包括美国电视标准委员会（ATSC）信号，欧洲电信标准协会数字视频广播地面（DVB-T）信号和日本综合业务数字广播地面（ISDB-T）信号。

公开(公告)号：US07463195B2

公开(公告)日：2008-12-09

申请号：US10159478

申请日：2002-05-31

Applicant: Matthew Rabinowitz ,  James J. Spilker, Jr.

Inventor： Matthew Rabinowitz ,  James J. Spilker, Jr.

IPC: G01S3/02

CPC classification number: G01S19/46 ,  A63F2300/205 ,  G01S5/0036 ,  G01S5/0054 ,  G01S5/0081 ,  G01S5/02 ,  G01S5/021 ,  G01S5/0215 ,  G01S5/0221 ,  G01S5/14 ,  G01S5/145 ,  G01S19/05 ,  G01S19/11 ,  G01S19/254 ,  G01S19/256 ,  G01S19/258 ,  H04N21/25841 ,  H04N21/2668 ,  H04N21/41422 ,  H04N21/615 ,  H04N21/8126

Abstract: A method, apparatus, and computer-readable media for determining the position of a user terminal comprises receiving at the user terminal a broadcast television signal from a television signal transmitter; determining a first pseudo-range between the user terminal and the television signal transmitter based on a known component of the broadcast television signal; receiving at the user terminal a global positioning signal from a global positioning satellite; determining a second pseudo-range between the user terminal and the global positioning satellite based on the global positioning signal; and determining a position of the user terminal based on the first and second pseudo-ranges, a location of the television signal transmitter, and a location of the global positioning satellite.

Abstract translation: 一种用于确定用户终端的位置的方法，装置和计算机可读介质包括在用户终端接收来自电视信号发射机的广播电视信号; 基于所述广播电视信号的已知分量，确定所述用户终端和所述电视信号发射机之间的第一伪距; 在用户终端接收来自全球定位卫星的全球定位信号; 基于全球定位信号确定用户终端和全球定位卫星之间的第二伪距; 以及基于第一和第二伪距，电视信号发射机的位置和全球定位卫星的位置来确定用户终端的位置。

公开(公告)号：US20070184467A1

公开(公告)日：2007-08-09

申请号：US11603406

申请日：2006-11-22

Applicant: Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

Inventor： Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: G06F19/20 ,  G06F19/18

Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell is reconstructed using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. In accordance with another embodiment of the invention, incomplete genetic data from a fetus is acquired from fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. In one embodiment, the genetic data can be reconstructed for the purposes of making phenotypic predictions. In another embodiment, the genetic data can be used to detect for aneuploides and uniparental disomy.

Abstract translation: 用于确定有限数量的遗传数据可用的一个或一小组细胞或来自片段DNA的遗传数据的系统和方法。 使用已知方法获取和扩增目标个体的遗传数据，并且使用目标基因组与基因相关受试者的基因组之间的预期相似性重建差测量的碱基对，缺失的等位基因和缺失区域。 根据本发明的一个实施方案，使用来自一个或两个亲本的二倍体细胞的较大样本的更完整的遗传数据重建来自胚胎细胞的不完整遗传数据，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据 ，和/或从其他相关个体获取的遗传数据。 根据本发明的另一个实施方案，从胎儿细胞或从母体血液中分离的无细胞胎儿DNA获得来自胎儿的不完整遗传数据，并且使用来自较大样本的更完整的遗传数据重建不完全遗传数据 来自一个或两个父母的二倍体细胞，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据和/或从其他相关个体获取的遗传数据。 在一个实施方案中，为了进行表型预测的目的，可以重建遗传数据。 在另一个实施方案中，遗传数据可以用于检测非整倍体和单亲二倍体。

公开(公告)号：US20070178501A1

公开(公告)日：2007-08-02

申请号：US11634550

申请日：2006-12-06

Applicant: Matthew Rabinowitz ,  Jonathan Sheena ,  Zachary Demko ,  Christopher Clark ,  Nigam Shah

Inventor： Matthew Rabinowitz ,  Jonathan Sheena ,  Zachary Demko ,  Christopher Clark ,  Nigam Shah

IPC: C12Q1/68 ,  G06F19/00 ,  G06Q50/00

CPC classification number: G06Q50/22 ,  G06Q50/24

Abstract: The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.

Abstract translation: 本文描述的系统使临床医师和研究人员能够使用来自临床试验和医疗记录的综合遗传和表型数据，为每位患者做出最安全，最有效的治疗决定。 这涉及（i）为遗传，表型，临床，药代动力学，药效学和其他数据集创建标准化本体，（ii）创建翻译引擎以将异构数据集合集成到使用标准化本体的数据库中，以及（ iii）开发统计方法，使用综合数据进行数据验证和结果预测。 该系统旨在与医院和实验室中的患者电子病历（EMR）进行接口，以提取特定患者的相关数据。 该系统也可用于产生表型预测和增强的用于治疗临床医师的医学实验室报告。 该系统也可以在利用在医疗和药物临床试验中创造的大量数据的背景下使用。 本体和验证规则被设计为灵活的，以容纳不同的客户端集合。 该系统还被设计为灵活的，以便它可以改变以适应科学进步并保持最佳配置。

公开(公告)号：US20070131079A1

公开(公告)日：2007-06-14

申请号：US11554765

申请日：2006-10-31

Applicant: Guttorm Opshaug ,  David Burgess ,  George Flammer ,  Scott Furman ,  Andy Lee ,  Matthew Rabinowitz ,  Harvind Samra

Inventor： Guttorm Opshaug ,  David Burgess ,  George Flammer ,  Scott Furman ,  Andy Lee ,  Matthew Rabinowitz ,  Harvind Samra

IPC: G10H3/18

CPC classification number: G01S11/02 ,  G01S5/0263 ,  G01S5/12

Abstract: Apparatus having corresponding methods and computer-readable media comprises a receiver to receive a wireless stereo frequency-modulation (FM) signal comprising a plurality of spectral signal components including a first tone and one or more frequency bands; one or more tone generators each to generate a respective second tone based on a respective one of the frequency bands; a plurality of phase circuits each to measure a phase of a respective one of the first and second tones; and a difference element to determine a phase difference between two of the phases.

Abstract translation: 具有相应方法和计算机可读介质的装置包括：接收器，用于接收包括包括第一音调和一个或多个频带的多个频谱信号分量的无线立体声调频（FM）信号; 一个或多个音调发生器，每个音调发生器基于相应的一个频带产生相应的第二音调; 多个相位电路，各自测量第一和第二音调中的相应一个的相位; 以及差分元件，以确定两相之间的相位差。