公开(公告)号：US20150306082A1

公开(公告)日：2015-10-29

申请号：US14794094

申请日：2015-07-08

Applicant: EMORY UNIVERSITY ,  MERCER UNIVERSITY ,  UNION UNIVERSITY

Inventor： Jack L. Arbiser ,  J. Philip Bowen ,  E. Blake Watkins

IPC: A61K31/445 ,  A61K45/06

CPC classification number: A61K31/445 ,  A61K45/06 ,  C07D211/10 ,  C07D211/22 ,  C07D211/40 ,  A61K2300/00

Abstract: This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure relates to compounds of the following formula: or salts, esters or prodrugs thereof as described herein.

Abstract translation: 本公开内容涉及与其相关的依卡鲁汀衍生物，药物组合物和治疗用途。 在某些实施方案中，本公开涉及如本文所述的下式的化合物或其盐，酯或前药。

公开(公告)号：US20250027902A1

公开(公告)日：2025-01-23

申请号：US18909305

申请日：2024-10-08

Applicant: AUBURN UNIVERSITY ,  MERCER UNIVERSITY

Inventor： Masoud MAHJOURI-SAMANI ,  Michael C. HAMILTON ,  Marcelo A. KURODA ,  Sahar HASIM ,  Parvin FATHI-HAFSHEJANI

IPC: G01N27/414

Abstract: In at least one illustrative embodiment, a field-effect transistor biosensor for detection of a pathogen includes a substrate and a channel formed from a two-dimensional monolayer or few-layer metal chalcogenide that is functionalized with a biorecognition element. The biorecognition element may be an antibody, such as an antibody for the SARS-COV-2 spike protein. A method for manufacturing the biosensor includes depositing an amorphous two-dimensional material on the substrate with pulsed laser ablation, crystallizing the amorphous two-dimensional material to generate a two-dimensional monolayer coupled to the substrate, and activating a surface of the two-dimensional material with the biorecognition element after crystallizing the amorphous two-dimensional material. The composition of the two-dimensional material may be tuned. The substrate may be photolithographically patterned. Other embodiments are described and claimed.

公开(公告)号：US12123845B2

公开(公告)日：2024-10-22

申请号：US17522421

申请日：2021-11-09

Applicant: AUBURN UNIVERSITY ,  MERCER UNIVERSITY

Inventor： Masoud Mahjouri-Samani ,  Michael C. Hamilton ,  Marcelo Kuroda ,  Sahar Hasim ,  Parvin Fathi-Hafshejani

IPC: G01N27/414

CPC classification number: G01N27/4145

Abstract: In at least one illustrative embodiment, a field-effect transistor biosensor for detection of a pathogen includes a substrate and a channel formed from a two-dimensional monolayer or few-layer metal chalcogenide that is functionalized with a biorecognition element. The biorecognition element may be an antibody, such as an antibody for the SARS-CoV-2 spike protein. A method for manufacturing the biosensor includes depositing an amorphous two-dimensional material on the substrate with pulsed laser ablation, crystallizing the amorphous two-dimensional material to generate a two-dimensional monolayer coupled to the substrate, and activating a surface of the two-dimensional material with the biorecognition element after crystallizing the amorphous two-dimensional material. The composition of the two-dimensional material may be tuned. The substrate may be photolithographically patterned. Other embodiments are described and claimed.

公开(公告)号：US20240246973A1

公开(公告)日：2024-07-25

申请号：US18435838

申请日：2024-02-07

Applicant: The Corporation of Mercer University

Inventor： Clinton E. Canal ,  Nader Moniri ,  Yiming Chen

IPC: C07D471/08 ,  C07D211/32 ,  C07D223/04 ,  C07D471/04 ,  C07D491/18

CPC classification number: C07D471/08 ,  C07D211/32 ,  C07D223/04 ,  C07D471/04 ,  C07D491/18

Abstract: Compounds, such as cathinone derivatives, and pharmaceutical formulations that include the compounds. The compounds may have a first selectivity for a first receptor subtype that is at least 10 times greater than a second selectivity for a second receptor subtype from the same class of receptors. Methods of treating patients, which may include administering to a patient a pharmaceutical formulation that includes a compound, such as a cathinone derivative.

公开(公告)号：US11298641B2

公开(公告)日：2022-04-12

申请号：US16422546

申请日：2019-05-24

Applicant: The Corporation of Mercer University

Inventor： Adam Mitchell Kiefer ,  Laura Waneta Lackey

IPC: B01D45/08 ,  B01D53/00

Abstract: Mercury capture systems are disclosed. Methods of making and using mercury capture systems are also disclosed.

公开(公告)号：US20210100880A1

公开(公告)日：2021-04-08

申请号：US17107468

申请日：2020-11-30

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  A61K39/155 ,  C12N7/00 ,  A61K39/165 ,  A61K39/095 ,  A61K9/00 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  C12N15/88 ,  A61K9/16 ,  C12N5/071

Abstract: A method for producing at least one microneedle containing a vaccine for transdermal delivery of the vaccine to a patient includes preparing microparticles or nanoparticles of encapsulated vaccine by preparing a solution comprising a vaccine antigen and a biocompatible polymer matrix; and spray drying the solution to form the microparticles or nanoparticles. The method includes the further steps of preparing a film composition including at least one pre-polymer solution; preparing a suspension comprising the microparticles or nanoparticles and the film composition; loading the suspension into a 3D printer; printing, via the 3D printer, at least one microneedle made from the suspension; and, converting the pre-polymer solution into a cross-linked biopolymer by exposing the at least one microneedle to UV light. Also disclosed are microneedles containing a vaccine for transdermal delivery.

公开(公告)号：US20220287818A1

公开(公告)日：2022-09-15

申请号：US17693533

申请日：2022-03-14

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Joanna L. Thomas ,  Sagar G. Patel

IPC: A61F2/04 ,  A61F2/82

Abstract: Stents are disclosed. The stents provide novel stent designs that can, in some cases, span bifurcations in a duct, such as the extrahepatic bile duct (EHBD) (e.g., where the right hepatic duct meets the left hepatic duct), without impeding bile flow from either duct branch. Methods of making and using stents are also disclosed.

公开(公告)号：US20220056029A1

公开(公告)日：2022-02-24

申请号：US17407438

申请日：2021-08-20

Applicant: The Corporation of Mercer University

Inventor： Clinton E. Canal ,  Nader Moniri ,  Yiming Chen

IPC: C07D471/08 ,  C07D211/32 ,  C07D223/04 ,  C07D471/04 ,  C07D491/18

Abstract: Compounds, such as cathinone derivatives, and pharmaceutical formulations that include the compounds. The compounds may have a first selectivity for a first receptor subtype that is at least 10 times greater than a second selectivity for a second receptor subtype from the same class of receptors. Methods of treating patients, which may include administering to a patient a pharmaceutical formulation that includes a compound, such as a cathinone derivative.

公开(公告)号：US20180303918A1

公开(公告)日：2018-10-25

申请号：US16017542

申请日：2018-06-25

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  A61K39/155 ,  A61K9/16 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  C12N15/88 ,  C12N7/00 ,  C12N5/071 ,  A61K39/165 ,  A61K9/00 ,  A61K39/095 ,  A61K31/727 ,  A61K31/7088 ,  A61K48/00

CPC classification number: A61K39/00 ,  A61K9/0021 ,  A61K9/1652 ,  A61K9/5161 ,  A61K9/5169 ,  A61K9/5192 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  A61K39/0008 ,  A61K39/0011 ,  A61K39/095 ,  A61K39/155 ,  A61K39/165 ,  A61K48/00 ,  A61K2039/52 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/55594 ,  A61K2039/57 ,  C12N5/0677 ,  C12N7/00 ,  C12N15/88 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2760/18434 ,  C12N2760/18534

Abstract: A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.

公开(公告)号：US10004790B2

公开(公告)日：2018-06-26

申请号：US14874978

申请日：2015-10-05

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'Souza

IPC: A61K48/00 ,  A61K39/00 ,  A61K39/155 ,  C12N7/00 ,  A61K39/165 ,  A61K39/39 ,  A61K39/095 ,  A61K9/00 ,  A61K9/16 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  C12N15/88

CPC classification number: A61K39/00 ,  A61K9/0021 ,  A61K9/1652 ,  A61K9/5161 ,  A61K9/5169 ,  A61K9/5192 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  A61K39/0008 ,  A61K39/0011 ,  A61K39/095 ,  A61K39/155 ,  A61K39/165 ,  A61K48/00 ,  A61K2039/52 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/55594 ,  A61K2039/57 ,  C12N5/0677 ,  C12N7/00 ,  C12N15/88 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2760/18434 ,  C12N2760/18534

Abstract: A method of transdermal delivery of a vaccine, comprising preparing microparticles of encapsulated vaccine by spray drying a mixture of the vaccine and at least one polymer, and injecting the microparticles transdermally using a microneedle delivery apparatus.