公开(公告)号：US20210100880A1

公开(公告)日：2021-04-08

申请号：US17107468

申请日：2020-11-30

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  A61K39/155 ,  C12N7/00 ,  A61K39/165 ,  A61K39/095 ,  A61K9/00 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  C12N15/88 ,  A61K9/16 ,  C12N5/071

Abstract: A method for producing at least one microneedle containing a vaccine for transdermal delivery of the vaccine to a patient includes preparing microparticles or nanoparticles of encapsulated vaccine by preparing a solution comprising a vaccine antigen and a biocompatible polymer matrix; and spray drying the solution to form the microparticles or nanoparticles. The method includes the further steps of preparing a film composition including at least one pre-polymer solution; preparing a suspension comprising the microparticles or nanoparticles and the film composition; loading the suspension into a 3D printer; printing, via the 3D printer, at least one microneedle made from the suspension; and, converting the pre-polymer solution into a cross-linked biopolymer by exposing the at least one microneedle to UV light. Also disclosed are microneedles containing a vaccine for transdermal delivery.

公开(公告)号：US20180303918A1

公开(公告)日：2018-10-25

申请号：US16017542

申请日：2018-06-25

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  A61K39/155 ,  A61K9/16 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  C12N15/88 ,  C12N7/00 ,  C12N5/071 ,  A61K39/165 ,  A61K9/00 ,  A61K39/095 ,  A61K31/727 ,  A61K31/7088 ,  A61K48/00

CPC classification number: A61K39/00 ,  A61K9/0021 ,  A61K9/1652 ,  A61K9/5161 ,  A61K9/5169 ,  A61K9/5192 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  A61K39/0008 ,  A61K39/0011 ,  A61K39/095 ,  A61K39/155 ,  A61K39/165 ,  A61K48/00 ,  A61K2039/52 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/55594 ,  A61K2039/57 ,  C12N5/0677 ,  C12N7/00 ,  C12N15/88 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2760/18434 ,  C12N2760/18534

Abstract: A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.

公开(公告)号：US20190060426A1

公开(公告)日：2019-02-28

申请号：US16171465

申请日：2018-10-26

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  A61K39/155 ,  A61K9/16 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  C12N15/88 ,  C12N7/00 ,  C12N5/071 ,  A61K39/165 ,  A61K9/00 ,  A61K39/095 ,  A61K31/727 ,  A61K31/7088 ,  A61K48/00

Abstract: A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.

公开(公告)号：US20170042987A1

公开(公告)日：2017-02-16

申请号：US14874978

申请日：2015-10-05

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  C12N7/00 ,  A61K9/16 ,  A61K39/39 ,  A61K39/095 ,  A61K9/00 ,  A61K39/155 ,  A61K39/165

CPC classification number: A61K39/00 ,  A61K9/0021 ,  A61K9/1652 ,  A61K9/5161 ,  A61K9/5169 ,  A61K9/5192 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  A61K39/0008 ,  A61K39/0011 ,  A61K39/095 ,  A61K39/155 ,  A61K39/165 ,  A61K48/00 ,  A61K2039/52 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/55594 ,  A61K2039/57 ,  C12N5/0677 ,  C12N7/00 ,  C12N15/88 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2760/18434 ,  C12N2760/18534

Abstract: A method of transdermal delivery of a vaccine, comprising preparing microparticles of encapsulated vaccine by spray drying a mixture of the vaccine and at least one polymer, and injecting the microparticles transdermally using a microneedle delivery apparatus.

Abstract translation: 一种疫苗的透皮递送方法，包括通过喷雾干燥疫苗和至少一种聚合物的混合物，并使用微针输送装置透皮地注射微粒来制备包封疫苗的微粒。

公开(公告)号：US20210015909A1

公开(公告)日：2021-01-21

申请号：US17034858

申请日：2020-09-28

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K39/00 ,  A61K39/155 ,  C12N7/00 ,  A61K39/165 ,  A61K39/095 ,  A61K9/00 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  C12N15/88 ,  A61K9/16 ,  C12N5/071

Abstract: An oral dissolving film containing nano- or micro-encapsulated bioactive material and methods of forming the film. The film may be prepared by dispensing a mixture of a film-forming agent, a crosslinking agent, a solution of nano- or micro-encapsulated bioactive material, and a photoinitiator into a plurality of wells in a tray using a 3D printer. The dispensed material is exposed to radiation in order to crosslink the material and form a film.

公开(公告)号：US20200016088A1

公开(公告)日：2020-01-16

申请号：US16510466

申请日：2019-07-12

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA ,  Kevin MURNANE

IPC: A61K9/51 ,  A61K38/095 ,  A61K9/00

Abstract: Compositions and methods for treating neurological disorders including Autism Spectrum disorder. The formulations include active compounds encapsulated in a nanoparticle, wherein the nanoparticle comprises a targeting ligand.

公开(公告)号：US20170157036A1

公开(公告)日：2017-06-08

申请号：US15350718

申请日：2016-11-14

Applicant: THE CORPORATION OF MERCER UNIVERSITY

Inventor： Martin J. D'SOUZA

IPC: A61K9/00 ,  A61K39/095 ,  A61K39/00 ,  C12N7/00 ,  B29C41/04 ,  A61K39/12 ,  A61K39/155 ,  A61K35/39 ,  A61M37/00 ,  B29C41/00 ,  A61K9/16 ,  A61K39/145

CPC classification number: A61K9/0021 ,  A61K9/1652 ,  A61K31/727 ,  A61K35/39 ,  A61K39/0008 ,  A61K39/0011 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/165 ,  A61K39/39 ,  A61K48/00 ,  A61K2039/52 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55594 ,  A61K2039/57 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0061 ,  B29C33/42 ,  B29C39/023 ,  B29C41/003 ,  B29C41/04 ,  B29K2029/04 ,  B29K2105/0035 ,  B29L2031/7544 ,  B29L2031/756 ,  C12N5/0677 ,  C12N7/00 ,  C12N15/88 ,  C12N2533/72 ,  C12N2533/74 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2760/16034 ,  C12N2760/16134 ,  C12N2760/18434 ,  C12N2760/18534

Abstract: A transdermal delivery system of microneedles containing a bioactive material, comprising at least one layer of a support material; at least one biodegradable needle associated with the support material, each needle comprising at least one biodegradable polymer and at least one sugar, wherein each biodegradable needle is hollow and is adapted to retain a bioactive material.