公开(公告)号：US10987493B2

公开(公告)日：2021-04-27

申请号：US15544946

申请日：2016-02-19

Applicant: NIPRO CORPORATION

Inventor： Yoshihiko Sano ,  Katsuhiro Hiejima

IPC: A61M25/09

Abstract: Provided is a guide wire having a novel structure, with which it is possible to improve production efficiency and to effectively prevent large irregularities from forming on an outer circumferential surface of a core wire. Further provided is a guide wire having a novel structure, with which it is possible to more meticulously set bending rigidity to a distal end portion thereof. In a guide wire having a coil externally mounted about a distal end portion of a core wire, a proximal end portion of the coil is integrally joined to the core wire during formation of the coil. Furthermore, in a guide wire having a coil externally mounted about a distal end portion of a core wire, a cross-sectional shape of a wire that constitutes the coil varies in a lengthwise direction of the coil.

公开(公告)号：US20200375767A1

公开(公告)日：2020-12-03

申请号：US16495021

申请日：2018-03-22

Applicant: NIPRO CORPORATION

Inventor： Koji AKIMOTO

IPC: A61F2/88 ,  A61F2/915

Abstract: A stent having a line-shaped body that extends helically in a circumferential direction while reciprocating in an axial direction by continuously alternating straight parts and curved parts, wherein the plurality of straight parts in the line-shaped body have a substantially constant thickness throughout the entire stent, and a certain number of the plurality of curved parts in the line-shaped body have different thicknesses.

公开(公告)号：US20200179662A1

公开(公告)日：2020-06-11

申请号：US16793164

申请日：2020-02-18

Applicant: NIPRO CORPORATION

Inventor： Yoshihiko SANO ,  Yasushi OOYAMA ,  Katsuhiro HIEJIMA

IPC: A61M25/10 ,  A61F2/958

Abstract: To provide a new balloon catheter enabling formation of, with high dimensional accuracy and excellent shape adaptability with respect to a balloon, an additional structure such as a blade and a reinforcement member to be additionally provided to the balloon. In this balloon catheter 10 provided with an expandable/contractible balloon 14 on the distal end side of a catheter 12, an additional structure 36 having a prescribed pattern is formed through electroforming or the like directly onto an inner circumferential surface 34 and/or an outer circumferential surface 82 of the balloon 14.

公开(公告)号：US20200166525A1

公开(公告)日：2020-05-28

申请号：US16631619

申请日：2018-07-24

Applicant: Toru HASEGAWA ,  NIPRO CORPORATION

Inventor： Toru HASEGAWA ,  Hiroshi YOSHIDA ,  Yoshinori KOSOKU

IPC: G01N33/68 ,  G01N33/74 ,  G16H50/30 ,  A61B5/055 ,  A61B6/03

Abstract: Provided is a method for aiding diagnosis of a neurodegenerative disease in a subject with a light physical burden. The method for aiding diagnosis of the neurodegenerative disease, comprising: a first assessment step of assessing a risk of the neurodegenerative disease based on an amount of homocysteine acid in a biological sample obtained from the subject; a second assessment step of assessing a risk of the neurodegenerative disease based on an amount of an inflammatory factor, a pituitary gland secretion, or an autonomic nerve secretion in the biological sample obtained from the subject or based on a measured value obtained from a brain image of the subject; and a step of determining whether the subject has the neurodegenerative disease based on the results of the first assessment and the second assessment.

公开(公告)号：US10507163B2

公开(公告)日：2019-12-17

申请号：US16057915

申请日：2018-08-08

Applicant: NIPRO CORPORATION

Inventor： Kazuaki Uetake ,  Naohisa Katayama

IPC: B65B47/00 ,  A61J1/03 ,  B65D75/32 ,  B29C51/42 ,  B65B47/04 ,  B29C51/10

Abstract: A method of manufacturing a PTP sheet for pharmaceutical drug packaging from which a solid pharmaceutical drug is easily taken out and in which a pocket portion is hard to be accidentally damaged. The PTP sheet has a first sheet from which a pocket portion capable of housing a solid pharmaceutical drug protrudes to the side of an upper surface and a second sheet which is stuck to a lower surface of the first sheet and which closes an opening of the pocket portion. The pocket portion has a peripheral wall portion having a peripheral surface continuous with the upper surface and a top portion having a top surface continuous with the peripheral surface of the peripheral wall portion. A wall thickness of the peripheral wall portion is smaller than a wall thickness of the top portion.

公开(公告)号：US10420704B2

公开(公告)日：2019-09-24

申请号：US14895533

申请日：2014-06-12

Applicant: Nipro Corporation

Inventor： Kazuaki Uetake ,  Takeshi Kodai

IPC: B65B1/04 ,  A61J1/03 ,  B65D75/32 ,  B65B41/10 ,  B65B47/04 ,  B65B51/02 ,  B65B61/26 ,  B65B47/02 ,  B65B51/16 ,  B65B61/28 ,  B65B5/10 ,  B65B9/04

Abstract: A PTP sheet for pharmaceutical packaging has a first sheet in which pockets each capable of housing a solid pharmaceutical are projected to the side of a first surface which is one of a back surface and a front surface and a second sheet which is pasted to a second surface opposite to the first surface in the first sheet and covers an opening of the pocket. The second sheet has a first region having mesh-shaped grooves having a first depth in a third surface opposite to the surface to be pasted to the second surface and a second region having mesh-shaped grooves having a second depth smaller than the first depth or not having a groove.

公开(公告)号：US20190160215A1

公开(公告)日：2019-05-30

申请号：US16181885

申请日：2018-11-06

Applicant: Nipro Corporation

Inventor： Toshinari Takahashi ,  Masashi Yokota ,  Hiroshi Fukushima ,  Kimihiko Nakamura

IPC: A61M1/16 ,  B01D63/10 ,  A61M1/36 ,  B01D65/08 ,  A61M39/22

Abstract: To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter.A blood treatment filter device 20 has a filter sheet 26 through which a specific component among components forming blood is harder to pass than other components and a spacer sheet 27 through which the specific component is easier to pass than through the filter sheet 26. The filter sheet 26 has filter through-holes 39 disposed at intervals. The filter sheet 26 and the spacer sheet 27 are spirally wound in an overlapped state. The filter device 20 has seals 31 sealing both end portions in the longitudinal direction of a wound body 25 formed by the filter sheet 26 and the spacer sheet 27 which are spirally wound in a fluid-tight manner. The outer peripheral surface of the wound body 25 is formed by the filter sheet 26.

公开(公告)号：US20190134260A1

公开(公告)日：2019-05-09

申请号：US16095317

申请日：2017-04-18

Applicant: NIPRO CORPORATION

Inventor： Yusuke Nakamura ,  Yoshikatsu Sugahara ,  Kazuhisa Matsuda

IPC: A61L24/04 ,  A61L24/10 ,  A61L24/00 ,  A61L24/08

Abstract: A sheet-like hemostatic material is provided with: an adhesive layer which serves as an affixing surface to a bleeding site and which is formed from at least poly-γ-glutamic acid (γ-PGA); and a covering layer which is a sheet formed from at least one biodegradable material (covering material) other than γ-PGA, and which serves as an opposite surface to the affixing surface. At least one of the adhesive layer and the covering layer is a single sheet. If the adhesive layer is a single sheet, the adhesive layer should be a sponge-like sheet, and if the adhesive layer is a partial layer, the adhesive layer should be a sponge-like sheet or a nonporous layer. Alternatively, in another sheet-like hemostatic material, a sheet which is formed from at least poly-γ-glutamic acid (γ-PGA) and to which at least one of a saccharide and collagen has been added is provided as the adhesive layer.

公开(公告)号：US20190117700A1

公开(公告)日：2019-04-25

申请号：US16096962

申请日：2017-04-26

Applicant: Sapporo Medical University ,  Nipro Corporation

Inventor： Osamu Honmou ,  Masanori SASAKI ,  Rie MAEZAWA ,  Shinichi OKA ,  Yuko SASAKI ,  Masahito NAKAZAKI ,  Toshihiko YAMASHITA

IPC: A61K35/28 ,  A61K9/00 ,  A61P25/00

Abstract: The present invention relates to a synapse formation promoter and a brain plasticity promoter comprising CD24-negative mesenchymal stem cells prepared from a patient's own bone marrow aspirate and treatment of dementia, chronic-phase cerebral infarction, chronic-phase spinal cord injury, mental diseases, and the like using the synapse formation promoter and brain plasticity promoter.

公开(公告)号：US20190029969A1

公开(公告)日：2019-01-31

申请号：US15757757

申请日：2016-09-06

Applicant: NIPRO CORPORATION

Inventor： Naoya KOSAKA ,  Naoyuki MIYANAGA ,  Minoru HATSUSHIKA

IPC: A61K9/50 ,  A61K31/519

Abstract: A microcapsule contains a biodegradable polymer and risperidone and has a sustained release property. The biodegradable polymer contained in the microcapsule has a molecular weight corresponding to 85% or more of an initial molecular weight (Mw) of the biodegradable polymer. A method of producing the microcapsule is also disclosed. The method of producing a microcapsule has (A) a step of preparing a first phase by mixing a solution of a biodegradable polymer and a solution of risperidone which are prepared separately, (B) a step of, immediately after the preparation of the first phase, mixing the first phase with a second phase being an aqueous phase to prepare an emulsion, and (C) a step of subjecting the resulting emulsion to in-water drying.