利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

39 条记录 (耗时 0.028 秒)

    Treatment of neurologic disorders with inhibitors of 11beta-HSD1
    23.
    发明申请
    Treatment of neurologic disorders with inhibitors of 11beta-HSD1 审中-公开
    用11beta-HSD1抑制剂治疗神经障碍

    公开(公告)号：US20050137209A1

    公开(公告)日：2005-06-23

    申请号：US11016387

    申请日：2004-12-17

    申请人： Donna Oksenberg ,  Mehrdad Shamloo ,  Roman Urfer

    发明人： Donna Oksenberg ,  Mehrdad Shamloo ,  Roman Urfer

    IPC分类号： A61K31/496

    CPC分类号： A61K31/496

    摘要： Methods and compositions for the treatment of neurologic disorders involving neuronal death, including but not limited to focal or global ischemia of the brain and central nervous system. In vivo inhibition of 11 beta hydroxysteroid dehydrogenase 1 (HSD1) is shown to be neuroprotective in these conditions. HSD1 inhibitors are administered alone or in combination with additional agents for prophylaxis or therapy.

    摘要翻译： 用于治疗涉及神经元死亡的神经障碍的方法和组合物，包括但不限于脑和中枢神经系统的局灶性或全身缺血。 在这些条件下，11β羟基类固醇脱氢酶1（HSD1）的体内抑制显示为神经保护作用。 HSD1抑制剂单独施用或与额外的预防或治疗剂组合施用。

    Sigma ligands for neuronal regeneration and functional recovery
    24.
    发明申请
    Sigma ligands for neuronal regeneration and functional recovery 失效
    Sigma配体用于神经元再生和功能恢复

    公开(公告)号：US20050059689A1

    公开(公告)日：2005-03-17

    申请号：US10868423

    申请日：2004-06-14

    申请人： Donna Oksenberg ,  Roman Urfer

    发明人： Donna Oksenberg ,  Roman Urfer

    IPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/438 ,  A61K31/473 ,  A61K31/485 ,  A61K31/495 ,  A61K38/17 ,  C07D295/096 ,  G06F21/00 ,  H04L29/06

    CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

    摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably SA-4503, or salts, or solvates thereof These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

    摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用配体用于σ受体，其中配体优选为SA-4503，或其盐或溶剂合物。这些分子可单独递送或与治疗或预防神经变性疾病如由缺血性卒中引起的神经变性疾病 ，糖尿病性周围神经病变，癌症治疗诱发的神经病，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

    Sigma ligands for neuronal regeneration and functional recovery
    25.
    发明申请
    Sigma ligands for neuronal regeneration and functional recovery 审中-公开
    Sigma配体用于神经元再生和功能恢复

    公开(公告)号：US20050032827A1

    公开(公告)日：2005-02-10

    申请号：US10868267

    申请日：2004-06-14

    申请人： Donna Oksenberg ,  Roman Urfer

    发明人： Donna Oksenberg ,  Roman Urfer

    IPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/438 ,  A61K31/473 ,  A61K31/485 ,  A61K31/495 ,  A61K38/17 ,  C07D295/096 ,  G06F21/00 ,  H04L29/06

    CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

    摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably siramesine, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

    摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选是sirameine，或其盐或溶剂化物。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

    METHODS AND COMPOSITIONS FOR THE PROTECTION OF SENSORY CELLS
    28.
    发明申请
    METHODS AND COMPOSITIONS FOR THE PROTECTION OF SENSORY CELLS 审中-公开
    用于保护感染细胞的方法和组合物

    公开(公告)号：US20170072015A1

    公开(公告)日：2017-03-16

    申请号：US15123238

    申请日：2015-03-03

    申请人： Lawrence M. Schwartz ,  Gerald Commissiong ,  David A. Lowe ,  Roman Urfer

    发明人： Lawrence M. Schwartz ,  Gerald Commissiong ,  David A. Lowe ,  Roman Urfer

    IPC分类号： A61K38/18

    CPC分类号： A61K38/185

    摘要： Disclosed herein are methods of treating or preventing cell death-related sensory cell loss in a subject in need thereof, the method comprising administering an effective amount of one or more neuroprotective peptides to the subject. Also disclosed are methods of treating or preventing drug-induced ototoxicity in a subject in need thereof, the method comprising administering an effective amount of one or more neuroprotective peptides to the subject.

    摘要翻译： 本文公开了在有需要的受试者中治疗或预防细胞死亡相关的感觉细胞损失的方法，所述方法包括给受试者施用有效量的一种或多种神经保护肽。 还公开了在有需要的受试者中治疗或预防药物诱导的耳毒性的方法，所述方法包括向受试者施用有效量的一种或多种神经保护肽。

    Treatment methods using NGF variants
    29.
    发明授权
    Treatment methods using NGF variants 有权
    使用NGF变体的治疗方法

    公开(公告)号：US08101571B2

    公开(公告)日：2012-01-24

    申请号：US12254458

    申请日：2008-10-20

    申请人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

    发明人： Leonard G. Presta ,  Roman Urfer ,  John W. Winslow

    IPC分类号： A61K38/18

    CPC分类号： C07K14/48 ,  A61K38/00

    摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.

    摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。

    Sigma ligands for neuronal regeneration and functional recovery
    30.
    发明申请
    Sigma ligands for neuronal regeneration and functional recovery 审中-公开
    Sigma配体用于神经元再生和功能恢复

    公开(公告)号：US20110015209A1

    公开(公告)日：2011-01-20

    申请号：US12923504

    申请日：2010-09-24

    申请人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

    发明人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

    IPC分类号： A61K31/495 ,  A61P25/00

    CPC分类号： A61K31/00 ,  A61K31/438 ,  A61K31/495 ,  C07D295/096

    摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by multiple sclerosis. In other methods, the sigma receptor ligands are administered after MS to facilitate functional recovery. The administration of the sigma receptor ligands causes fasted functional recovery.

    摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可单独递送或与治疗或预防神经变性疾病如由多发性硬化引起的疾病的药物组合递送。 在其他方法中，σ受体配体在MS后施用以促进功能恢复。 σ受体配体的施用引起禁食功能恢复。