公开(公告)号：US20140342366A1

公开(公告)日：2014-11-20

申请号：US14278902

申请日：2014-05-15

Applicant: Tuskegee University

Inventor： Teshome Yehualaeshet ,  Temesgen Samuel ,  Woubit Abdela ,  Tsegaye Habtemariam

IPC: C12Q1/68

CPC classification number: C12Q1/04

Abstract: The invention relates to a method of determining whether a live microbe, such as bacteria, is present in a test sample.

Abstract translation: 本发明涉及一种测定样品中是否存在活细菌如细菌的方法。

公开(公告)号：US20140147533A1

公开(公告)日：2014-05-29

申请号：US13686520

申请日：2012-11-27

Applicant: TUSKEGEE UNIVERSITY

Inventor： Sandra SOLAIMAN ,  Byeng Ryel MIN

IPC: A23K1/18 ,  A61K36/15

CPC classification number: A61K36/15 ,  A23K10/37 ,  A23K20/10 ,  A23K20/111 ,  A23K50/10 ,  Y02P60/56 ,  Y02P60/877

Abstract: Embodiments of the present invention relate to the use of tannin-containing wood products in animal feed to improve production efficiency and health of ruminants (e.g., sheep, goats, and cattle) by reducing internal parasite load, reducing methane and ammonia production in the rumen, and decreasing phosphor emissions from fecal waste. Embodiments include a domesticated ruminant feed comprising a condensed tannin. Certain embodiments relate to methods comprising administering condensed tannins to ruminant animals by incorporating pine bark or other suitable condensed tannin-containing wood products into regular animal feed.

Abstract translation: 本发明的实施方案涉及在动物饲料中使用含单宁的木制品以通过减少内部寄生虫负荷来降低反刍动物（例如绵羊，山羊和牛）的生产效率和健康，降低瘤胃中的甲烷和氨的产生 ，并减少粪便中的磷排放。 实施方案包括包含缩合单宁的驯化的反刍动物饲料。 某些实施方案涉及包括通过将松树皮或其它合适的缩合单宁含木质产品掺入常规动物饲料中来将缩合单宁投与反刍动物的方法。

公开(公告)号：US20130131266A1

公开(公告)日：2013-05-23

申请号：US13678914

申请日：2012-11-16

Applicant: TUSKEGEE UNIVERSITY

Inventor： Heshmat AGLAN

IPC: C08K3/04

CPC classification number: C08K3/04 ,  B05D1/005 ,  B82Y30/00 ,  C08J3/205 ,  C08J2379/08 ,  C08K3/041 ,  C08K7/24 ,  C08K2201/011 ,  Y10S977/742 ,  Y10S977/752 ,  Y10S977/753 ,  C08L79/08

Abstract: Structured films containing multi-walled carbon nanotubes (“MWCNTs”) have enhanced mechanical performance in terms of strength, fracture resistance, and creep recovery of polyimide (“PI”) films. Preferably, the loadings of MWCNTs can be in the range of 0.1 wt % to 0.5 wt %. The strength of the new PI films dried at 60° C. increased by 55% and 72% for 0.1 wt % MWCNT and 0.5 wt % MWCNT loadings, respectively, while the fracture resistance increased by 23% for the 0.1 wt % MWCNTs and then decreases at a loading of 0.5 wt % MWCNTs. The films can be advantageously be created by managing a corresponding shift in the annealing temperature at which the maximum strength occurs as the MWCNT loadings increase.

Abstract translation: 含有多壁碳纳米管（“MWCNT”）的结构膜在聚酰亚胺（“PI”）膜的强度，耐断裂性和蠕变恢复方面具有增强的机械性能。 优选地，MWCNT的负载量可以在0.1重量％至0.5重量％的范围内。 在60℃下干燥的新PI膜的强度分别对于0.1重量％MWCNT和0.5重量％MWCNT负载分别增加了55％和72％，而0.1重量％MWCNT的耐断裂性提高了23％，然后 在负载量为0.5wt％的MWCNT时减少。 可以有利地通过管理当MWCNT负载增加时发生最大强度的退火温度的相应偏移来产生膜。

公开(公告)号：US20240197830A1

公开(公告)日：2024-06-20

申请号：US18419845

申请日：2024-01-23

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Tuskegee University ,  The University of North Carolina at Chapel Hill ,  The United Government as represented by the Department of Veterans Affairs

Inventor： Cecelia C. Yates-Binder ,  Jesse Jaynes ,  Monte S. Willis ,  Richard J. Bodnar ,  Zariel I. Johnson

IPC: A61K38/19 ,  A61P9/10 ,  A61P35/00 ,  C07K7/02 ,  C12N15/113 ,  C12N15/62 ,  C12N15/86

CPC classification number: A61K38/195 ,  A61P9/10 ,  A61P35/00 ,  C07K7/02 ,  C12N15/113 ,  C12N15/62 ,  C12N15/86

Abstract: Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.

公开(公告)号：US11918625B2

公开(公告)日：2024-03-05

申请号：US17724900

申请日：2022-04-20

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education ,  Tuskegee University

Inventor： Cecelia C. Yates-Binder ,  Jesse Jaynes

IPC: A61K38/19 ,  A61P9/10 ,  A61P35/00 ,  C07K7/02 ,  C12N15/113 ,  C12N15/62 ,  C12N15/86

CPC classification number: A61K38/195 ,  A61P9/10 ,  A61P35/00 ,  C07K7/02 ,  C12N15/113 ,  C12N15/62 ,  C12N15/86

Abstract: Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.

公开(公告)号：US11878914B2

公开(公告)日：2024-01-23

申请号：US17175137

申请日：2021-02-12

Applicant: Tuskegee University

Inventor： Michael L. Curry ,  Aiesha L. Ethridge ,  Demetrius Finley

IPC: C01G3/02 ,  B01J19/24 ,  B01J19/12 ,  B22F9/24 ,  B82Y40/00 ,  B22F1/054 ,  B22F1/102

CPC classification number: C01G3/02 ,  B01J19/123 ,  B01J19/24 ,  B22F9/24 ,  B01J2219/0869 ,  B01J2219/1203 ,  B01J2219/24 ,  B22F1/054 ,  B22F1/102 ,  B22F2301/10 ,  B22F2302/25 ,  B82Y40/00 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2002/85 ,  C01P2004/01 ,  C01P2004/04 ,  C01P2004/32 ,  C01P2004/64

Abstract: This invention relates to cost-effective methods for synthesizing metallic nanoparticles in high yield using non-dendrimeric branched polymeric templates, such as branched polyethyleneimine. This invention also provides a high-throughput apparatus for synthesizing metallic nanoparticles under conditions that produce less waste than conventional nanoparticle synthesis methods. Also provided are metallic nanoparticles and multi-metallic nanoparticle compositions made by methods and high-throughput apparatus of the invention.

公开(公告)号：US20230415173A1

公开(公告)日：2023-12-28

申请号：US18102122

申请日：2023-01-27

Applicant: Tuskegee University

Inventor： John Solomon

IPC: B05B1/08 ,  B05B7/04

CPC classification number: B05B1/08 ,  B05B7/0425

Abstract: The injection system includes a Resonance Enhanced Microjet nozzle assembly. The assembly includes plates including top and bottom plates, a first inlet in the top plate and coupled to steady jet. The bottom plate includes a hollow cavity having a bottom surface. A tube within the bottom plate forms a first outlet that exits a supersonic pulsed actuation jet in the range of kHz from the bottom plate. A second outlet is in the bottom plate and positioned concentric about the tube to form a circular slit. The circular slit is directly coupled to the bottom surface of the cavity. A second inlet via a conduit is coupled to a secondary fluid stream and the cavity. The system significantly improves the mixing of an actuation jet with the steady stream injected up to 115% in comparison to a system that uses a steady actuation jet under same operating pressure.

公开(公告)号：US11661486B1

公开(公告)日：2023-05-30

申请号：US17845143

申请日：2022-06-21

Applicant: TUSKEGEE UNIVERSITY

Inventor： Vijaya K. Rangari ,  Samia Islam ,  Woubit Abebe

IPC: C08J5/00 ,  C08J5/18 ,  C08L1/04 ,  C08B15/00 ,  C08B3/12 ,  C08B37/08 ,  C08L1/10 ,  C08L5/08

CPC classification number: C08J5/18 ,  C08B3/12 ,  C08B15/005 ,  C08B37/003 ,  C08L1/04 ,  C08L1/10 ,  C08L5/08 ,  C08J2301/02 ,  C08J2401/10 ,  C08J2405/08 ,  C08L2201/06 ,  C08L2203/16 ,  C08L2205/02 ,  C08L2205/03

Abstract: A biopolymer film is provided that comprises a combination of crystalline nano cellulose (CNC)/esterified crystalline nano cellulose (ECNC) reinforced with chitosan. The two polymer components can be present in any ratio, but an approximate CNC to ECNC 70:30 ratio is preferred. The chitosan component is derived from exoskeletons of crustaceans. Also provided are methods of preparing biopolymer film and preparing food packaging components from said biopolymer film. The CNC/ECNC mixture is dissolved in an ethanol solution and the chitin is dissolved in acetic acid and mixed together to form a polymer blend.

公开(公告)号：US11447834B2

公开(公告)日：2022-09-20

申请号：US16431039

申请日：2019-06-04

Applicant: Tuskegee University

Inventor： Woubit Abebe ,  Khaled Aldhami ,  Sayma Afroj ,  Temesgen Samuel ,  Gopal Reddy

IPC: C12Q1/689 ,  B01L3/00

Abstract: Disclosed are novel genetic arrays for use in the molecular detection of multiple Salmonella serovars, common food-borne and water-borne pathogens. The arrays may be used to simultaneously detect multiple food safety Salmonella serovars. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple high-impact food-borne pathogens simultaneously. Real-time PCR assaying techniques using such serovars include microarrays.

公开(公告)号：US11078359B2

公开(公告)日：2021-08-03

申请号：US16040250

申请日：2018-07-19

Applicant: TUSKEGEE UNIVERSITY

Inventor： Vijaya Rangari ,  Boniface Tiimob

IPC: C08L67/02 ,  C08L67/04 ,  C08K5/00 ,  C08K7/00 ,  C08L77/00 ,  C08L89/00 ,  C08J5/18 ,  B82Y40/00 ,  B82Y30/00

Abstract: A biopolymer blend is provided that comprises a combination of three components: poly (butylene adipate-co-terephthalate) (PBAT); agriculture sourced polylactic acid (PLA); and engineered proteinaceous eggshell nanoparticles. The two polymer components can be present in any ratio but an approximate 70:30 ratio is preferred. The engineered proteinaceous eggshell nanoparticles are preferably about 10-25 nanometers. Also provided are methods of preparing biopolymer film and packaging components. Pelleted poly (butylene adipate-co-terephthalate) and agriculture sourced polylactic acid (PLA) are dissolved in chloroform and mixed together to form a polymer blend, and engineered proteinaceous eggshell nanoparticles are incorporated into the polymer blend, which is then extruded to create a biopolymer film or component.