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    DENTAL INSERT FOR CONNECTING A DENTAL IMPLANT TO A DENTAL ABUTMENT
    21.
    发明申请
    DENTAL INSERT FOR CONNECTING A DENTAL IMPLANT TO A DENTAL ABUTMENT 审中-公开

    公开(公告)号：US20190314122A1

    公开(公告)日：2019-10-17

    申请号：US16472526

    申请日：2017-12-20

    Applicant: UNIVERSITÄT BASEL

    Inventor： Stefan STÜBINGER ,  Markus LINK

    IPC: A61C8/00

    Abstract: A dental insert for connecting a dental implant to a dental abutment includes a dental abutment having at least two interfaces. A first interface of the at least two interfaces is formed in interaction with the abutment for fixing the dental insert to the implant by a latching and/or clamping connection. A second interface of the at least two interfaces is formed for fixing the dental insert to the dental abutment.

    ALLELE EDITING AND APPLICATIONS THEREOF
    23.
    发明申请
    ALLELE EDITING AND APPLICATIONS THEREOF 审中-公开

    公开(公告)号：US20190136263A1

    公开(公告)日：2019-05-09

    申请号：US16096074

    申请日：2017-04-25

    Applicant: UNIVERSITÄT BASEL

    Inventor： Mara KORNETE ,  Lukas JEKER

    IPC: C12N15/90 ,  A61K35/28 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0789 ,  C12N5/0783

    Abstract: The invention relates to a method to determine a homology directed repair (HDR) event within a eukaryotic cell, wherein the cell expresses a first isoform of a surface protein, which is different from a second isoform of said surface protein with regard to an amino acid marker. The method comprises the steps of inducing a DNA double strand break, providing a HDR template DNA construct comprising the amino acid marker corresponding to the second isoform of the surface protein and subsequently determining the expression of the first or second isoform of said surface protein on said cell, wherein expression of the second isoform indicates a successful HDR event. The invention also relates to a method for editing a genomic location of interest within a eukaryotic cell, and to a method of selectively depleting or enriching an edited cell in a composition of non-edited and edited cells.

    COMPUTER SYSTEM AND METHOD FOR IMPROVED GLOSS REPRESENTATION IN DIGITAL IMAGES
    24.
    发明申请
    COMPUTER SYSTEM AND METHOD FOR IMPROVED GLOSS REPRESENTATION IN DIGITAL IMAGES 审中-公开

    公开(公告)号：US20190080509A1

    公开(公告)日：2019-03-14

    申请号：US16190856

    申请日：2018-11-14

    Applicant: Universität Basel

    Inventor： Andrea BIANCO ,  Peter FORNARO

    IPC: G06T15/50

    Abstract: A computer-implemented image processing method, system, and computer program product for representation of static objects in a digital target image including a plurality of target pixels. The method includes at least receiving a plurality of digital source images of the static objects, computing diffuse components for target pixels of surface elements by computing for each target pixel of the surface elements a set of diffuse reflection coefficients from a best-fit function when fitted into reflected light intensity values of corresponding source pixels of the source images under different illumination angles, generating normal vectors for the target pixels by using the computed diffuse reflection coefficients, and determining glossy coefficients for the target pixels of the one or more surface elements as the distances between the corresponding best-fit function values and the reflected light intensity values of the corresponding source pixels for the different illumination angles.

    LOSSLESS CRYO-GRID PREPARATION STAGE FOR HIGH-RESOLUTION ELECTRON MICROSCOPY
    26.
    发明申请
    LOSSLESS CRYO-GRID PREPARATION STAGE FOR HIGH-RESOLUTION ELECTRON MICROSCOPY 审中-公开

    公开(公告)号：US20180209881A1

    公开(公告)日：2018-07-26

    申请号：US15742532

    申请日：2015-07-06

    Applicant: UNIVERSITÄT BASEL

    Inventor： Stefan Alexander ARNOLD ,  Thomas BRAUN ,  Henning STAHLBERG

    IPC: G01N1/42 ,  H01J37/20

    CPC classification number: G01N1/42 ,  H01J37/20

    Abstract: The invention relates to a preparation system for preparing a sample for electron microscopy, comprising:—a liquid handling system (0) comprising a dispensing head (1), wherein said liquid handling system (0) is configured to aspirate and dispense a volume of a sample via the dispensing head (1),—a support structure (2) that is configured to accommodate the sample, a temperature-controlled stage (4) that is configured to keep said support structure (2) at a pre-defined temperature when the support structure (2) is arranged on the temperature-controlled stage (4), a first adapter (3) configured to hold said support structure (2), a transfer mechanism (60) that is configured to be connected to the first adapter (3) holding the support structure (2) and to move said support structure (2) into a container (8) containing a liquid cryogen (80) so that the sample on the support structure (2) contacts the cryogen (80). Furthermore, the invention relates to a corresponding method.

    METHOD AND DEVICE FOR CONTROLLING A SCANNING PROBE MICROSCOPE
    27.
    发明申请
    METHOD AND DEVICE FOR CONTROLLING A SCANNING PROBE MICROSCOPE 有权
    用于控制扫描探针显微镜的方法和装置

    公开(公告)号：US20150369838A1

    公开(公告)日：2015-12-24

    申请号：US14651233

    申请日：2013-12-12

    Applicant: UNIVERSITÄT BASEL

    Inventor： Roderick LIM ,  Marija PLODINEC ,  Marko LOPARIC ,  Pascal OEHLER ,  Leon CAMENZIND

    IPC: G01Q20/00 ,  G01Q10/00

    CPC classification number: G01Q20/00 ,  G01Q10/00 ,  G01Q10/065 ,  G01Q30/06

    Abstract: The present invention relates to a method for controlling a scanning probe microscope having a probe (2) with a tip (21) for interacting with a sample (4), and a nanoscanner (1) for retaining the sample (4) or the probe (2), comprising the steps of monitoring the extension of the piezo element (1) along a first direction (R) along which the tip (21) is moved towards the sample (4), and adjusting the level of the probe (2) along the first direction (R) by means of an additional actuator (3), when the nanoscanner (1) exhibits an extension below or above a threshold value. The invention further relates to a device (100) for controlling a scanning probe microscope.

    Abstract translation: 本发明涉及一种用于控制扫描探针显微镜的方法，所述扫描探针显微镜具有带有用于与样品（4）相互作用的尖端（21）的探针（2）和用于保持样品（4）或探针 （2），包括以下步骤：沿尖端（21）朝向样品（4）移动的第一方向（R）监测压电元件（1）的延伸，并且调节探针（2）的水平 ）当所述纳米扫描仪（1）展现出低于或高于阈值的延伸时，通过附加致动器（3）沿所述第一方向（R）。 本发明还涉及一种用于控制扫描探针显微镜的装置（100）。

    DEVICE FOR MODELLING A BLOOD LABYRINTH BARRIER
    29.
    发明公开
    DEVICE FOR MODELLING A BLOOD LABYRINTH BARRIER 审中-公开

    公开(公告)号：US20240141269A1

    公开(公告)日：2024-05-02

    申请号：US18548738

    申请日：2022-03-08

    Applicant: UNIVERSITÄT BASEL

    Inventor： Vesna PETKOVIC ,  Marijana SEKULIC

    IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06

    CPC classification number: C12M21/08 ,  C12M23/16 ,  C12M25/04 ,  C12M29/10

    Abstract: A device is disclosed for modelling a blood labyrinth barrier of a human ear that includes a first fluid channel and a second fluid channel, and a membrane separating the first and second fluid channels. The membrane has a luminal side in the first fluid channel and an abluminal side in the second fluid channel, endothelial cells attached to the luminal side of the membrane, pericytes attached to the abluminal side of the membrane, and perivascular macrophage-type melanocytes arranged in the second fluid channel. A method of preparing such device is also disclosed. As well, a device with two fluid channels and a membrane as described above is disclosed, wherein the endothelial cells, pericytes and perivascular macrophage-type melanocytes are arranged in two fluid containers.

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