公开(公告)号：US06774107B1

公开(公告)日：2004-08-10

申请号：US09936737

申请日：2001-09-17

申请人： Wolfgang Strittmatter ,  Detlef Güssow ,  Uwe Hofmann ,  Jürgen Hemberger ,  Zisi Fotev ,  Bernhard Scheuble

发明人： Wolfgang Strittmatter ,  Detlef Güssow ,  Uwe Hofmann ,  Jürgen Hemberger ,  Zisi Fotev ,  Bernhard Scheuble

IPC分类号： A61K3817

CPC分类号： C07K14/43536 ,  A61K38/00

摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

摘要翻译： 描述了从药用水蛭Hirudo medicinalis的唾液中分离的天然存在的蛋白质，其与胶原强烈结合，从而作为天然血小板粘附到胶原的抑制剂。 蛋白质的分子量约为12,000，是酸性等电点，含有六个半胱氨酸。 对蛋白质进行测序，并从H. medicinalis cDNA文库克隆该基因。 公开了通过重组技术生产这种多肽的方法。 重组和天然存在的蛋白质是胶原依赖性血小板粘附的有效抑制剂，因此可用于治疗与心脏病和循环系统疾病有关的各种病症。 此外，该蛋白质可用于包被天然或人造胶原表面，以使其对细胞不粘附并阻止细胞的活化。

公开(公告)号：US06224751B1

公开(公告)日：2001-05-01

申请号：US09293860

申请日：1999-04-16

申请人： Uwe Hofmann ,  Erik Fischer

发明人： Uwe Hofmann ,  Erik Fischer

IPC分类号： B01D2700

CPC分类号： C02F1/003 ,  C02F2209/445 ,  C02F2307/04

摘要： A water purifying device that has a collecting jug for purified water, in which a funnel with a filter cartridge filled with purifying medium is fitted in a removable manner, the jug can be closed at the top with a lid. Grips for removing the lid are arranged on the lid, and an indicator is provided for indicating the exhaustion of the purifying medium. The indicator is inexpensive, easily readable and reliably functioning to show the state of exhaustion of the purifying medium. The indicator is secured in an aperture in the top surface of the lid, an indicator panel of which can be seen externally from above and which, by an electronic, battery driven circuit, shows only the respective state of time elapsed, without cooperating with separate signaling.

摘要翻译： 一种净水装置，其具有用于净化水的收集罐，其中具有填充有净化介质的滤筒的漏斗以可移除的方式安装，所述罐可以在顶部用盖封闭。 用于移除盖的夹具布置在盖上，并且提供指示器以指示净化介质的耗尽。 指示剂便宜，易于阅读和可靠地起作用以显示净化介质的耗尽状态。 指示器固定在盖的顶表面中的孔中，其指示板可以从上方看到，并且由电子的电池驱动电路仅显示相应的经过时间的状态，而不与单独的 信令。

公开(公告)号：US5829739A

公开(公告)日：1998-11-03

申请号：US738427

申请日：1996-10-25

申请人： Uwe Hofmann

发明人： Uwe Hofmann

IPC分类号： B65G49/07 ,  G11B5/84 ,  B25B1/20

CPC分类号： G11B5/84

摘要： A device is provided which supports plate-like objects and, while supporting the objects, changes the distance between the objects. The device comprises at least one elongated carrier having movable interconnected spacers. The spacers support the plate-like objects substantially parallel with respect to each other. The spacers can be shifted axially on the carrier between positions between positions of minimum and maximum distance.

摘要翻译： 提供了一种支撑板状物体的装置，并且在支撑物体的同时改变对象之间的距离。 该装置包括至少一个具有可移动互连间隔件的细长载体。 间隔件相对于彼此基本平行地支撑板状物体。 间隔件可以在最小和最大距离的位置之间的位置之间在载体上轴向移动。

公开(公告)号：US09737853B2

公开(公告)日：2017-08-22

申请号：US14232026

申请日：2012-06-29

申请人： Bernd Christner ,  Uwe Hofmann ,  Tobias Peters

发明人： Bernd Christner ,  Uwe Hofmann ,  Tobias Peters

IPC分类号： B01D53/94 ,  F01N3/20 ,  F01N9/00 ,  B01D53/00

CPC分类号： B01D53/9431 ,  F01N3/208 ,  F01N9/00 ,  F01N2610/02 ,  F01N2900/1818 ,  Y02T10/24 ,  Y02T10/47

摘要： A determination of a quality of a reducing agent solution containing ammonia used to reduce nitrogen oxides involves actuating a metering unit that delivers metered quantities of reducing agent solution into an engine's discharged exhaust gas and determining an efficiency value that is at least correlated with the efficiency of the SCR catalytic converter and comparing the efficiency value to a predefinable limit value. If an efficiency value not corresponding to proper functioning of the SCR exhaust emission control system is identified by the comparison, a switch is made to a diagnostic mode in a second method step. If a predefinable deviation of the efficiency value from a limit value is identified after expiration of the second method step time period, a third method step is performed for conditioning the SCR catalytic converter. A fourth step involves an adaptation mode in which a deviation from the efficiency value is determined.

公开(公告)号：US09353664B2

公开(公告)日：2016-05-31

申请号：US12992787

申请日：2009-07-22

申请人： Bernd Christner ,  Uwe Hofmann ,  Alexander Kaiser ,  Markus Paule

发明人： Bernd Christner ,  Uwe Hofmann ,  Alexander Kaiser ,  Markus Paule

IPC分类号： F01N3/035 ,  F01N3/20 ,  F01N9/00

CPC分类号： F01N3/208 ,  F01N3/035 ,  F01N9/005 ,  F01N2560/021 ,  F01N2560/025 ,  F01N2560/06 ,  F01N2560/08 ,  F01N2560/14 ,  F01N2570/10 ,  F01N2570/14 ,  F01N2610/02 ,  F01N2900/0402 ,  F01N2900/0421 ,  F01N2900/1621 ,  F01N2900/1622 ,  Y02A50/2325 ,  Y02T10/24 ,  Y02T10/47

摘要： In a system with an SCR catalytic converter, a correction by a changeable long term adaption factor to a target dosing rate is provided for the model dosing rate and a correction by a changeable short term adaption factor to an assumed actual filling state for the ammonia filling level value. A dosing unit controllable by a control unit adds an ammonia-containing reducing agent to the exhaust gas and an exhaust gas enriched with ammonia according to the dosing is fed to the SCR catalytic converter. An ammonia filling level value for a filling level of ammonia stored in the SCR catalytic converter and a model dosing rate for dosing the reducing agent into the exhaust gas are calculated by a computer model.

摘要翻译： 在具有SCR催化转化器的系统中，通过改变的长期适应因子到目标给药速率的校正被提供用于模型给药速率，并且通过可变的短期适应因子校正到用于氨灌装的假设的实际填充状态 水平值。 由控制单元控制的计量单元向排气添加含氨还原剂，并且根据给料将富含氨的废气供给SCR催化转化器。 通过计算机模型计算用于存储在SCR催化转化器中的氨的填充水平的氨填充水平值和用于将还原剂计量到排气中的模型计量速率。

公开(公告)号：US07981633B2

公开(公告)日：2011-07-19

申请号：US11995742

申请日：2006-07-07

申请人： Tanja Henzler ,  Bjoern Hock ,  Andree Blaukat ,  Uwe Hofmann

发明人： Tanja Henzler ,  Bjoern Hock ,  Andree Blaukat ,  Uwe Hofmann

IPC分类号： C12Q1/48

CPC分类号： C12Q1/485

摘要： The present invention relates to methods for measuring the autophosphorylation of one or more tyrosine kinases and use of such methods in profiling kinase inhibitors and activators. As a representative example, the method comprises inducing kinase autophosphorylation activity in cells in presence and in absence of a kinase inhibitor, lysing the cells, capturing the tyrosine kinase in the cell lysate by adding a plurality of tyrosine kinase specific binding proteins which are associated with unique dyes, adding a phosphotyrosine specific antibody tagged with a marker which is distinguishable from the unique dyes, and identifying the autophosphorylated tyrosine kinase by detecting the unique dye and the marker. Alternately, the tyrosine kinases themselves could be coupled to the unique dyes. The present invention also relates to kits and compositions for carrying out the above-described methods.

摘要翻译： 本发明涉及用于测量一种或多种酪氨酸激酶的自磷酸化的方法以及在分析激酶抑制剂和激活剂中使用这些方法。 作为代表性实例，该方法包括在存在和不存在激酶抑制剂的情况下诱导细胞中的激酶自磷酸化活性，裂解细胞，通过添加多个与酪氨酸激酶特异性结合蛋白相关的酪氨酸激酶特异性结合蛋白来捕获细胞裂解物中的酪氨酸激酶 添加标记有与独特染料不同的标记的磷酸酪氨酸特异性抗体，并通过检测独特的染料和标记来鉴定自磷酸化酪氨酸激酶。 或者，酪氨酸激酶本身可以与独特的染料偶联。 本发明还涉及用于实施上述方法的试剂盒和组合物。

公开(公告)号：US20110113752A1

公开(公告)日：2011-05-19

申请号：US12992787

申请日：2009-07-22

申请人： Bernd Christner ,  Uwe Hofmann ,  Alexander Kaiser ,  Markus Paule

发明人： Bernd Christner ,  Uwe Hofmann ,  Alexander Kaiser ,  Markus Paule

IPC分类号： F01N3/10

CPC分类号： F01N3/208 ,  F01N3/035 ,  F01N9/005 ,  F01N2560/021 ,  F01N2560/025 ,  F01N2560/06 ,  F01N2560/08 ,  F01N2560/14 ,  F01N2570/10 ,  F01N2570/14 ,  F01N2610/02 ,  F01N2900/0402 ,  F01N2900/0421 ,  F01N2900/1621 ,  F01N2900/1622 ,  Y02A50/2325 ,  Y02T10/24 ,  Y02T10/47

摘要： In a system with an SCR catalytic converter, a correction by a changeable long term adaption factor to a target dosing rate is provided for the model dosing rate and a correction by a changeable short term adaption factor to an assumed actual filling state for the ammonia filling level value. A dosing unit controllable by a control unit adds an ammonia-containing reducing agent to the exhaust gas and n exhaust gas enriched with ammonia according to the dosing is fed to the SCR catalytic converter. An ammonia filling level value for a filling level of ammonia stored in the SCR catalytic converter and a model dosing rate for dosing the reducing agent into the exhaust gas are calculated by a computer model.

摘要翻译： 在具有SCR催化转化器的系统中，通过改变的长期适应因子到目标给药速率的校正被提供用于模型给药速率，并且通过可变的短期适应因子校正到用于氨灌装的假设的实际填充状态 水平值。 由控制单元控制的计量单元向排气添加含氨还原剂，并且根据给料将富含氨的废气送入SCR催化转化器。 通过计算机模型计算用于存储在SCR催化转化器中的氨的填充水平的氨填充水平值和用于将还原剂计量到排气中的模型计量速率。

公开(公告)号：US20100326051A1

公开(公告)日：2010-12-30

申请号：US12675930

申请日：2008-08-13

申请人： Michael-Rainer Busch ,  Dirk Herbstritt ,  Uwe Hofmann

发明人： Michael-Rainer Busch ,  Dirk Herbstritt ,  Uwe Hofmann

IPC分类号： F01N9/00

CPC分类号： F01N9/00 ,  F01N3/208 ,  F01N9/005 ,  F01N11/00 ,  F01N2560/021 ,  F01N2560/026 ,  F01N2610/02 ,  F01N2900/1402 ,  F01N2900/1622 ,  Y02T10/24 ,  Y02T10/47

摘要： The invention relates to In an operating and diagnostic method for an SCR exhaust gas aftertreatment system which has an SCR catalytic converter with ammonia storage capacity, a signal of an exhaust gas sensor that is sensitive to nitrogen oxide and ammonia and is arranged downstream of the SCR catalytic converter, is measured. In a normal operating mode, ammonia is supplied to the SCR catalytic converter corresponding to a filling level model for ammonia stored in the SCR catalytic converter, in such a way that the ammonia filling level of the SCR catalytic converter is held at least approximately at a predefinable nominal value (or value range). The normal operating mode is interrupted if an exhaust gas sensor signal that exceeds a predefinable first limit value, is registered, and the set urea dosing rate is increased by a predefinable degree in relation to the value provided in the normal operating mode. Thereafter, a return is made to the normal operating mode, or a switch is made to a diagnostic operating mode, as a function of the profile of the signal of the exhaust gas sensor.

摘要翻译： 本发明涉及一种SCR排气后处理系统的操作和诊断方法，该排气后处理系统具有氨储存容量的SCR催化转化器，对氮氧化物和氨敏感的排气传感器信号，并位于SCR的下游 催化转化器，测量。 在正常操作模式中，氨被提供给SCR催化转化器，该SCR催化转化器对应于存储在SCR催化转化器中的氨的填充水平模型，使得SCR催化转化器的氨填充水平保持至少约为 预定义标称值（或值范围）。 如果注册了超过预定义的第一限制值的废气传感器信号，则登记正常操作模式，并且将设定的尿素给料速率相对于在正常操作模式中提供的值增加预定的程度。 此后，作为废气传感器的信号的轮廓的函数，返回到正常操作模式，或者切换到诊断操作模式。

公开(公告)号：US20090183803A1

公开(公告)日：2009-07-23

申请号：US12336731

申请日：2008-12-17

申请人： Ralph A. Mutschler ,  Peter William Robinson ,  Derek E. Tyler ,  Andrea Kaufler ,  Hans-Achim Kuhn ,  Uwe Hofmann

发明人： Ralph A. Mutschler ,  Peter William Robinson ,  Derek E. Tyler ,  Andrea Kaufler ,  Hans-Achim Kuhn ,  Uwe Hofmann

IPC分类号： C22F1/08 ,  C22C9/06

CPC分类号： C22C9/06 ,  C22F1/08

摘要： A copper base alloy having an improved combination of yield strength and electrical conductivity consisting essentially of between about 1.0 and about 6.0 weight percent Ni, up to about 3.0 weight percent Co, between about 0.5 and about 2.0 weight percent Si, between about 0.01 and about 0.5 weight percent Mg, up to about 1.0 weight percent Cr, up to about 1.0 weight percent Sn, and up to about 1.0 weight percent Mn, the balance being copper and impurities, the alloy processed to have a yield strength of at least about 137 ksi, and an electrical conductivity of at least about 25% IACS.

摘要翻译： 具有改进的屈服强度和导电性组合的铜基合金，其基本上由约1.0至约6.0重量％的Ni，至多约3.0重量％的Co，约0.5至约2.0重量％的Si，约0.01和约 0.5重量％的Mg，至多约1.0重量％的Cr，至多约1.0重量％的Sn和至多约1.0重量％的Mn，余量为铜和杂质，所述合金被加工成具有至少约137的屈服强度 ksi，电导率为至少约25％IACS。

公开(公告)号：US07090986B2

公开(公告)日：2006-08-15

申请号：US11153433

申请日：2005-06-16

申请人： Wolfgang Strittmatter ,  Detlef Güssow ,  Uwe Hofmann ,  Jürgen Hemberger ,  Zisi Fotev ,  Bernhard Scheuble

发明人： Wolfgang Strittmatter ,  Detlef Güssow ,  Uwe Hofmann ,  Jürgen Hemberger ,  Zisi Fotev ,  Bernhard Scheuble

IPC分类号： G01N33/53

CPC分类号： C07K14/43536 ,  A61K38/00

摘要： A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.