公开(公告)号：US20050009047A1

公开(公告)日：2005-01-13

申请号：US10805171

申请日：2004-03-19

Applicant: Mark Erlander ,  Ranelle Salunga ,  Xiao-Jun Ma ,  Eddy Enright

Inventor： Mark Erlander ,  Ranelle Salunga ,  Xiao-Jun Ma ,  Eddy Enright

IPC: C12P19/34 ,  C12Q1/68

CPC classification number: C12Q1/6851 ,  C12Q2521/119 ,  C12Q2521/131 ,  C12Q2521/107 ,  C12Q2521/101 ,  C12Q2525/173

Abstract: The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.

Abstract translation: 本发明提供了扩增核酸分子的方法。 提供了使用寡核苷酸，DNA和RNA聚合酶扩增靶多核苷酸（包括mRNA）的方法。 本发明还提供了用于实施该方法的组合物和试剂盒，以及使用扩增产物的方法。

公开(公告)号：US09856533B2

公开(公告)日：2018-01-02

申请号：US10773761

申请日：2004-02-06

Applicant: Mark G. Erlander ,  Xiao-Jun Ma ,  Dennis C. Sgroi

Inventor： Mark G. Erlander ,  Xiao-Jun Ma ,  Dennis C. Sgroi

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: Methods and compositions are provided for the identification of expression signatures in ER+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to treatment with tamoxifen or another antiestrogen agent against breast cancer The signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with breast cancer with tamoxifen or another antiestrogen agent against breast cancer. Additional methods and compositions are provided for predicting responsiveness to tamoxifen or another antiestrogen agent against breast cancer in cases of breast cancer by use of three biomarkers. Two biomarkers display increased expression correlated with tamoxifen response while the third biomarker displays decreased expression correlated with tamoxifen response.

公开(公告)号：US09635075B2

公开(公告)日：2017-04-25

申请号：US12660962

申请日：2010-03-08

Applicant: Xiao Jun Ma ,  Jun Li ,  Lin Du ,  Jian Ping Song

Inventor： Xiao Jun Ma ,  Jun Li ,  Lin Du ,  Jian Ping Song

IPC: H04L12/28 ,  H04L29/06 ,  H04N21/235 ,  H04N21/435 ,  H04N21/438 ,  H04N21/4782 ,  H04N21/482 ,  H04N21/858

CPC classification number: H04L65/4076 ,  H04L65/4084 ,  H04N21/235 ,  H04N21/435 ,  H04N21/4383 ,  H04N21/4782 ,  H04N21/482 ,  H04N21/8586

Abstract: A user assigns a major and minor channel number combination to a media service which does not have such a pre-existing combination, where such a media service is accessed by using such a channel combination without having to resort to the typical means of accessing the media service, such as using a web site URL or radio frequency. Optionally, the invention will automatically update the minor numbers associated with a media service when older versions of the media service become unavailable.

公开(公告)号：US09338485B2

公开(公告)日：2016-05-10

申请号：US13320940

申请日：2010-05-11

Applicant: Xiao Jun Ma ,  Jun Li ,  Junbiao Zhang

Inventor： Xiao Jun Ma ,  Jun Li ,  Junbiao Zhang

IPC: G06F15/16 ,  H04N21/2365 ,  H04N21/21 ,  H04N21/23 ,  H04N21/242 ,  H04N21/2665

CPC classification number: H04N21/2365 ,  H04N21/21 ,  H04N21/23 ,  H04N21/242 ,  H04N21/2665

Abstract: A method for distributing a multimedia content to at least two rendering devices, wherein said multimedia content comprises at least two elementary contents, the method comprises the steps of receiving first information including information indicating for each of said at least two elementary contents a destination rendering device and a starting time; for each rendering device associated with said multimedia content, sending corresponding information indicating starting time for at least one elementary content destined to the rendering device; receiving said multimedia content; and sending said at least two elementary contents of said multimedia content to their corresponding destination rendering devices based on information indicating destination rendering device for each of said at least two elementary contents.

Abstract translation: 一种用于将多媒体内容分发到至少两个呈现设备的方法，其中所述多媒体内容包括至少两个基本内容，所述方法包括以下步骤：接收包括针对所述至少两个基本内容中的每一个指示目的地呈现设备的信息的第一信息 和开始时间; 对于与所述多媒体内容相关联的每个呈现设备，发送指示用于到达所述呈现设备的至少一个基本内容的开始时间的相应信息; 接收所述多媒体内容; 以及基于针对所述至少两个基本内容中的每一个的指示目的地呈现设备的信息，将所述多媒体内容的所述至少两个基本内容发送到其对应的目的地呈现设备。

公开(公告)号：US08832519B2

公开(公告)日：2014-09-09

申请号：US12734536

申请日：2008-11-04

Applicant: Jun Li ,  Xiao Jun Ma ,  Huan Qiang Zhang ,  Charles Chuanming Wang

Inventor： Jun Li ,  Xiao Jun Ma ,  Huan Qiang Zhang ,  Charles Chuanming Wang

IPC: H03M13/00 ,  H04L12/801 ,  H04L1/00 ,  H04L29/06 ,  H04L29/14

CPC classification number: H04L1/0041 ,  H04L47/10 ,  H04L65/605 ,  H04L69/40 ,  H04L2001/0098

Abstract: A method for Forward Error Correction (FEC) encoding in a transmitter, the method comprising: receiving a data stream from a data source; generating a first Forward Error Correction data for respective data block with a first block size of the data stream; and generating a second Forward Error Correction data for respective data block with a second block size of the data stream, wherein the second block size is different with the first block size and wherein the data blocks of the first block size form the data stream, and the data blocks with the second block size form the data stream.

Abstract translation: 一种在发射机中进行前向纠错（FEC）编码的方法，所述方法包括：从数据源接收数据流; 为所述数据流的第一块大小生成相应数据块的第一前向纠错数据; 以及生成具有所述数据流的第二块大小的相应数据块的第二前向纠错数据，其中所述第二块大小与所述第一块大小不同，并且其中所述第一块大小的数据块形成所述数据流，以及 具有第二块大小的数据块形成数据流。

公开(公告)号：US20140178869A1

公开(公告)日：2014-06-26

申请号：US13843408

申请日：2013-03-15

Applicant: Xiao-Jun MA ,  Yuling LUO ,  Raymond Tubbs

Inventor： Xiao-Jun MA ,  Yuling LUO ,  Raymond Tubbs

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C07K16/00 ,  C07K2317/515 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: The invention provides a method for detecting immunoglobulin light chain restriction and clonality in B cells by obtaining a sample of B cells from a subject; conducting a duplex in situ hybridization assay on the sample using (i) at least one probe set which is designed to specifically hybridize to immunoglobulin kappa chain constant region (IGKCR) RNA; and (ii) at least one probe set which is designed to specifically hybridize to immunoglobulin lambda chain constant region (IGLCR) RNA; detecting signal associated with hybridized IGKCR probe and signal associated with hybridized IGLCR probe in a population of B cells in the sample; and determining a pattern of signal associated with hybridized IGKCR probe and hybridized IGLCR probe within individual cells in the B cell population, wherein the pattern of signal within individual cells indicates the presence or absence of light chain restriction and clonality of the B cells.

Abstract translation: 本发明提供一种通过从受试者获得B细胞样品来检测B细胞中免疫球蛋白轻链限制和克隆性的方法; 使用（i）设计为与免疫球蛋白κ恒定区（IGKCR）RNA特异性杂交的至少一个探针组进行样品上的双链原位杂交测定; 和（ii）设计成与免疫球蛋白λ链恒定区（IGLCR）RNA特异性杂交的至少一个探针组; 检测与杂交的IGKCR探针相关的信号和与样品中B细胞群中的杂交IGLCR探针相关的信号; 以及确定在B细胞群体中的各个细胞内与杂交的IGKCR探针和杂交的IGLCR探针相关联的信号模式，其中各个细胞内的信号模式指示存在或不存在B细胞的轻链限制和克隆。

公开(公告)号：US20130262554A1

公开(公告)日：2013-10-03

申请号：US13991283

申请日：2010-12-07

Applicant: Jianfeng Chen ,  Ning Liao ,  Xiao Jun Ma

Inventor： Jianfeng Chen ,  Ning Liao ,  Xiao Jun Ma

IPC: H04L29/06

CPC classification number: H04L65/80 ,  H04L45/123 ,  H04L45/24 ,  H04L65/4076 ,  H04L65/605 ,  H04N21/4126 ,  H04N21/4307 ,  H04N21/43637 ,  H04N21/44227

Abstract: A method and an apparatus for managing content distribution over multiple terminal devices in collaborative media system are provided. In the collaborative media system, a first media data is transmitted over a first channel path to a first media terminal and a second media data relevant to the first media data is transmitted over a second channel to a second media terminal. The method comprises: detecting a quality of the first media data on the first channel path and that of the second media data on the second channel path; upon detection the quality of the first media data being lower than a first predetermined value and that of the second media data being greater than a second predetermined value, transmitting the second media data over the second channel path, instead of the first media data over the first channel path, to the first media terminal (S204).

Abstract translation: 提供了一种用于在协作媒体系统中的多个终端设备上管理内容分发的方法和装置。 在协作媒体系统中，第一媒体数据通过第一信道路径发送到第一媒体终端，并且与第一媒体数据相关的第二媒体数据通过第二信道发送到第二媒体终端。 该方法包括：检测第一信道路径上的第一媒体数据的质量和第二信道路径上的第二媒体数据的质量; 在检测到第一媒体数据的质量低于第一预定值并且第二媒体数据的质量大于第二预定值时，通过第二信道路径发送第二媒体数据，而不是通过第二媒体数据 第一通道路径到第一媒体终端（S204）。

公开(公告)号：US20130148501A1

公开(公告)日：2013-06-13

申请号：US13320616

申请日：2010-05-18

Applicant: Yong He ,  Xiao-Jun Ma ,  Jun Li

Inventor： Yong He ,  Xiao-Jun Ma ,  Jun Li

IPC: H04L12/56

CPC classification number: H04L47/14 ,  H04W74/085

Abstract: A method and apparatus are described including determining a target congestion index, determining a congestion index based on information from a last back-off round, comparing the target congestion index with the congestion index, performing one of increasing a triggering set size by a first factor and decreasing the triggering set size by a second factor responsive to the comparison, determining if a communications medium is idle, adjusting a back-off counter responsive to the third determining act, determining if the back-off counter is equal to a triggering point in the triggering set and transmitting data responsive to the fourth determining act.

Abstract translation: 描述了一种方法和装置，包括确定目标拥塞指标，基于来自最后回退轮的信息确定拥塞指数，将目标拥塞指数与拥塞指数进行比较，执行将触发集大小增加第一因子 以及响应于所述比较将所述触发设置大小减小第二因素，确定通信介质是否空闲，响应于所述第三确定动作来调整回退计数器，确定所述退避计数器是否等于所述触发点的触发点 响应于第四确定动作的触发设置和发送数据。

公开(公告)号：US20120072538A1

公开(公告)日：2012-03-22

申请号：US13320940

申请日：2010-05-11

Applicant: Xiao Jun Ma ,  Jun Li ,  Junbiao Zhang

Inventor： Xiao Jun Ma ,  Jun Li ,  Junbiao Zhang

IPC: G06F15/16

CPC classification number: H04N21/2365 ,  H04N21/21 ,  H04N21/23 ,  H04N21/242 ,  H04N21/2665

Abstract: A method for distributing a multimedia content to at least two rendering devices, wherein said multimedia content comprises at least two elementary contents, the method comprises the steps of receiving first information including information indicating for each of said at least two elementary contents a destination rendering device and a starting time; for each rendering device associated with said multimedia content, sending corresponding information indicating starting time for at least one elementary content destined to the rendering device; receiving said multimedia content; and sending said at least two elementary contents of said multimedia content to their corresponding destination rendering devices based on information indicating destination rendering device for each of said at least two elementary contents.

Abstract translation: 一种用于将多媒体内容分发到至少两个呈现设备的方法，其中所述多媒体内容包括至少两个基本内容，所述方法包括以下步骤：接收包括针对所述至少两个基本内容中的每一个指示目的地呈现设备的信息的第一信息 和开始时间; 对于与所述多媒体内容相关联的每个呈现设备，发送指示用于到达所述呈现设备的至少一个基本内容的开始时间的相应信息; 接收所述多媒体内容; 以及基于针对所述至少两个基本内容中的每一个的指示目的地呈现设备的信息，将所述多媒体内容的所述至少两个基本内容发送到其对应的目的地呈现设备。

公开(公告)号：US20120071343A1

公开(公告)日：2012-03-22

申请号：US13236889

申请日：2011-09-20

Applicant: XIAO-JUN MA ,  Xingyong Wu ,  Yuling Luo

Inventor： XIAO-JUN MA ,  Xingyong Wu ,  Yuling Luo

IPC: C40B30/04 ,  C12Q1/42 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (PHACTR1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (SPP1), preferentially expressed antigen in melanoma (PRAME), growth differentiation factor 15 (GDF 15), and chemokine C-X-C motif ligand 10 (CXCL10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of PHACTR1, or fragments thereof, either alone or in combination with the detection of SPP1, PRAME, GDF15, and CXCL10, for the diagnosis or prognosis of melanoma.

Abstract translation: 本发明公开了一种用于诊断人类受试者中的黑素瘤的方法，以及用于对患有黑色素瘤复发风险的人类受试者提供预后的方法，以及用于确定人类受试者的黑色素瘤阶段的方法，包括 单独或与分泌的整联蛋白结合磷蛋白（SPP1）的表达水平相结合的磷酸酶和肌动蛋白调节物1（PHACTR1）基因或其片段的表达水平的测定步骤，优先表达黑素瘤（PRAME）抗原， ，生长分化因子15（GDF15）和趋化因子CXC基序配体10（CXCL10）基因。 此外，本发明涉及一种诊断试剂盒，其包含至少一种用于检测PHACTR1或其片段的表达的物质，或者与检测SPP1，PRAME，GDF15和CXCL10一起或与SPP1，PRAME，GDF15和CXCL10的检测结合用于诊断或预后 的黑色素瘤。