公开(公告)号：US06307048B1

公开(公告)日：2001-10-23

申请号：US09442511

申请日：1999-11-18

申请人： Shen-Chun Kuo ,  Charles F. Bernard ,  Frank Xing Chen ,  Donald Hou ,  Agnes S. Kim-Meade ,  George G. Wu

发明人： Shen-Chun Kuo ,  Charles F. Bernard ,  Frank Xing Chen ,  Donald Hou ,  Agnes S. Kim-Meade ,  George G. Wu

IPC分类号： C07D40102

CPC分类号： C07D401/04 ,  C07D401/14 ,  Y02P20/55

摘要： Disclosed is a process for preparing a compound of the formula: wherein X1, X2, X3, X4, and X5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula wherein X1, X2, X3, X4, and X5 are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having the formula wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase.

摘要翻译： 公开了一种制备下式化合物的方法：其中X 1，X 2，X 3，X 4和X 5独立地选自H，卤素，烷基，烷氧基，芳基和芳氧基，R是保护基 其中具有如下定义的具有如下定义的化合物：（a）非亲核性强碱;（b）手性氨基醇（其中R 1，R 2，R 3，X 4， ; 和（c）具有甲醛的化合物L是离去基团，R如上定义。 通过该方法制备的化合物是制备法呢基蛋白转移酶抑制剂的化合物的有用中间体。

公开(公告)号：US6096883A

公开(公告)日：2000-08-01

申请号：US210921

申请日：1998-12-14

申请人： George G. Wu ,  Xing Chen ,  Yee-Shing Wong ,  Doris P. Schumacher ,  Martin Steinman

发明人： George G. Wu ,  Xing Chen ,  Yee-Shing Wong ,  Doris P. Schumacher ,  Martin Steinman

IPC分类号： C07D205/08

CPC分类号： C07D205/08

摘要： The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R.sub.1, .sub.2 and R.sub.3 are as defined in the specification,

摘要翻译： 本发明涉及式的中间体，所述中间体可用于制备下式化合物的方法，其中Bn是苄基，R1,2和R3如说明书中所定义，

公开(公告)号：US5756301A

公开(公告)日：1998-05-26

申请号：US25557

申请日：1993-03-03

申请人： Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

发明人： Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

IPC分类号： C07K16/16 ,  C07K16/42 ,  G01N33/53 ,  G01N33/574 ,  G01N33/92 ,  G01N33/567

CPC分类号： C07K16/16 ,  C07K16/4208 ,  G01N33/5308 ,  G01N33/57415 ,  G01N33/57449 ,  G01N33/92

摘要： The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No. HB11281 and 29B7B3C, having ATCC Accession No. HB11280. The present invention also provides a method for detecting the presence of taxol or a taxol-like substance in a sample, a method for screening for a ligand in a subject which is not being treated with taxol, an endogenous taxol-like substance in human serum detected by this screening method, a method of quantitatively determining the amount of taxol or taxol-like substance in a biological fluid sample and a kit for assaying for taxol or a taxol-like substance in a sample.

摘要翻译： 本发明提供了能够结合紫杉醇和紫杉醇样物质的两种单克隆抗体，其由具有ATCC登录号HB11281和ATCCB2B3C的具有ATCC登录号HB11280的69E4A8E的杂交瘤产生。 本发明还提供了一种用于检测样品中紫杉醇或类紫杉醇样物质的存在的方法，用于筛选未用紫杉醇处理的受试者中的配体的方法，人血清中的内源性紫杉醇样物质 通过该筛选方法检测生物流体样品中紫杉醇或类紫杉醇样物质的量的定量方法和用于测定样品中紫杉醇或类紫杉醇样物质的试剂盒。

公开(公告)号：US5581350A

公开(公告)日：1996-12-03

申请号：US471997

申请日：1995-06-06

申请人： Xing Chen ,  Philip D. Flanner, III ,  Kiron B. Malwankar ,  Jennming Chen

发明人： Xing Chen ,  Philip D. Flanner, III ,  Kiron B. Malwankar ,  Jennming Chen

IPC分类号： G01N21/21 ,  G01J4/00

CPC分类号： G01N21/211 ,  G01N21/274 ,  G01N2021/213

摘要： A method for calibrating an ellipsometer, and an ellipsometer including a processor programmed to control the analyzer, polarizer, and other ellipsometer components, and to process the data measured by the ellipsometer to perform the calibration method automatically. Where the ellipsometer's polarizer rotates and the analyzer remains fixed during measurement, the method determines coarse approximations of values A.sub.0 and P.sub.0, and then processes reflectivity data obtained at two or more analyzer angles to determine refined approximations of the values A.sub.0 and P.sub.0, where P.sub.0 is the angle of the polarizer's optical axis at an initial time, and A.sub.0 is the offset of the actual orientation angle of the analyzer from a nominal analyzer angle. Preferably the ellipsometer is a spectroscopic ellipsometer, the reflectivity data determine a tan.psi. spectrum and a cos.DELTA. spectrum for each of the analyzer angles, and the coarse approximations of A.sub.0 and P.sub.0 are refined by processing the reflectivity data by performing regression on A.sub.0 and P.sub.0 until the differences among the tan.psi. and cos.DELTA. spectra for several analyzer angles are minimized. Where the ellipsometer's analyzer rotates and the polarizer remains fixed during measurement, the method coarsely determines values A'.sub.0 and P'.sub.0, and then processes reflectivity data obtained at two or more polarizer angles to determine refined approximations of the values A'.sub.0 and P'.sub.0, where P'.sub.0 is the angle of the analyzer's optical axis at an initial time, and A'.sub.0 is the offset of the actual orientation angle of the polarizer from a nominal polarizer angle.

摘要翻译： 用于校准椭偏仪的方法以及椭圆计，其包括被编程为控制分析仪，偏振器和其它椭偏仪组件的处理器，并且处理由椭偏仪测量的数据以自动执行校准方法。 在测量期间，椭偏仪偏振器旋转并且分析仪保持固定，该方法确定值A0和P0的粗近似值，然后处理在两个或更多分析器角度获得的反射率数据，以确定值A0和P0的精确近似，其中P0为 偏振器的光轴在初始时的角度，A0是分析仪的实际取向角与标称分析仪角度的偏移。 优选地，椭偏仪是分光椭偏仪，反射率数据确定每个分析器角度的tan psi光谱和cosDDTA光谱，并且通过在A0和P0上进行回归处理反射率数据来改善A0和P0的粗略近似 直到几个分析仪角度的tan psi和cos DELTA光谱之间的差异最小化。 在椭偏仪的分析仪旋转和偏振器在测量期间保持固定的情况下，该方法粗略地确定值A'0和P'0，然后处理在两个或多个偏振器角度处获得的反射率数据，以确定值A'0和P的精确近似 '0，其中P'0是初始时分析仪的光轴的角度，A'0是偏振器与标称偏振器角度的实际定向角的偏移。

公开(公告)号：US10662552B1

公开(公告)日：2020-05-26

申请号：US15240168

申请日：2016-08-18

申请人： Xing Chen

发明人： Xing Chen

IPC分类号： D01D5/00 ,  B33Y10/00 ,  B33Y30/00

摘要： The invention provides a method for producing fibers, the method having the steps of producing electrospun fiber; and directing the fiber to a plurality of targets, whereby only one of the targets is grounded at any one time. Also provided is a system for producing anisotropic fibers having a reservoir of electrospun fiber constituent' wherein an egress point of the reservoir is electrically charged; a plurality of electrodes opposed to the egress point, wherein only one of the electrodes is grounded at any one time while the remaining electrodes are at an initial floating voltage state; and a target substrate disposed between the egress point and the plurality of electrodes.

公开(公告)号：US09620839B2

公开(公告)日：2017-04-11

申请号：US15082901

申请日：2016-03-28

申请人： Xing Chen ,  Ziyao Zhou

发明人： Xing Chen ,  Ziyao Zhou

IPC分类号： H01P1/387

CPC分类号： H01P1/387 ,  B82Y30/00

摘要： A nonreciprocal device is described. It includes a housing, a waveguide layer and at least one layer of magnetic nanofiber composite. The magnetic nanofiber composite layer is made up of a polymer base layer, a dielectric matrix comprising magnetic nanofibers. The nanofibers have a high aspect ratio and wherein said dielectric matrix is embedded in the polymer base layer.

公开(公告)号：US09302912B2

公开(公告)日：2016-04-05

申请号：US13432415

申请日：2012-03-28

申请人： Ken Tran ,  Feng Tian ,  Xing Chen ,  Franklin Lee

发明人： Ken Tran ,  Feng Tian ,  Xing Chen ,  Franklin Lee

IPC分类号： H05B37/00 ,  C01B13/11

CPC分类号： H01J37/248 ,  C01B13/115 ,  C01B2201/90

摘要： Improvements in the supply of high-frequency electrical power to ozone-producing cells can be accomplished using the systems and techniques described herein. Application of a DC-DC converter operating at a switching frequency substantially greater than a load frequency, supports generation of a high-voltage AC for powering such cells, while allowing for reductions in component size and reductions in a quality factor of a load tuning circuit. Controllable power inverters used in obtaining one or more of the switching and load frequencies can be controlled using feedback techniques to provide stable, high-quality power to ozone-producing cells under variations in one or more of externally supplied power and load conditions. An inrush protection circuit can also be provided to selectively introduce a current-limiting resistance until an input DC bus has been sufficiently initialized as determined by measurements obtained from the DC bus. The current limiting resistance can be a positive-temperature coefficient thermistor.

摘要翻译： 使用本文所述的系统和技术可以实现向产生臭氧的电池供应高频电力的改进。 以明显大于负载频率的开关频率工作的DC-DC转换器的应用支持产生用于为这样的单元供电的高压AC，同时允许减小组件尺寸并降低负载调整电路的品质因数 。 可以使用反馈技术来控制用于获得开关和负载频率中的一个或多个的可控功率逆变器，以在一个或多个外部供电和负载条件的变化下向产生臭氧的电池提供稳定的高质量功率。 还可以提供浪涌保护电路以选择性地引入限流电阻，直到输入DC总线已被充分初始化为由从DC总线获得的测量结果所确定。 限流电阻可以是正温系数热敏电阻。

公开(公告)号：US08779322B2

公开(公告)日：2014-07-15

申请号：US13336616

申请日：2011-12-23

申请人： William M. Holber ,  John A. Smith ,  Xing Chen ,  Donald K. Smith

发明人： William M. Holber ,  John A. Smith ,  Xing Chen ,  Donald K. Smith

IPC分类号： B23K10/00 ,  H01H1/34

CPC分类号： H01J37/32174 ,  H01J37/321

摘要： A method and apparatus for processing metal bearing gases involves generating a toroidal plasma in a plasma chamber. A metal bearing gas is introduced into the plasma chamber to react with the toroidal plasma. The interaction between the toroidal plasma and the metal bearing gas produces at least one of a metallic material, a metal oxide material or a metal nitride material.

摘要翻译： 用于处理金属轴承气体的方法和装置涉及在等离子体室中产生环形等离子体。 将金属轴承气体引入到等离子体室中以与环形等离子体反应。 环形等离子体和金属承载气体之间的相互作用产生金属材料，金属氧化物材料或金属氮化物材料中的至少一种。

公开(公告)号：US08749939B2

公开(公告)日：2014-06-10

申请号：US13106920

申请日：2011-05-13

申请人： Ken Tran ,  Feng Tian ,  Xing Chen

发明人： Ken Tran ,  Feng Tian ,  Xing Chen

IPC分类号： H02H3/08 ,  H02M1/38 ,  H03K17/082 ,  H02M3/337

CPC分类号： H03K17/0822 ,  H02M1/38 ,  H02M3/337 ,  H03K2217/0036

摘要： A switching apparatus includes a first transistor, a second transistor, a first circuit module, a first current sensor and a control circuit. The first transistor includes first, second and third terminals. The first terminal of the first transistor is coupled to a first power terminal. The third terminal of the first transistor includes a gate or base of the first transistor. The second transistor includes first, second and third terminals. The first terminal of the second transistor is coupled to a second power terminal. The second terminal of the second transistor is coupled to the second terminal of the first transistor. The third terminal of the second transistor includes a gate or base of the second transistor. The first circuit module includes an inductor in parallel with a diode. The first circuit module is connected between the first terminal of the second transistor and the second power terminal.

摘要翻译： 开关装置包括第一晶体管，第二晶体管，第一电路模块，第一电流传感器和控制电路。 第一晶体管包括第一，第二和第三端子。 第一晶体管的第一端子耦合到第一电源端子。 第一晶体管的第三端子包括第一晶体管的栅极或基极。 第二晶体管包括第一，第二和第三端子。 第二晶体管的第一端耦合到第二电源端子。 第二晶体管的第二端子耦合到第一晶体管的第二端子。 第二晶体管的第三端子包括第二晶体管的栅极或基极。 第一电路模块包括与二极管并联的电感器。 第一电路模块连接在第二晶体管的第一端和第二电源端之间。

公开(公告)号：US20140062285A1

公开(公告)日：2014-03-06

申请号：US13598148

申请日：2012-08-29

申请人： Xing Chen

发明人： Xing Chen

IPC分类号： H05H7/04 ,  H05H1/24

CPC分类号： H05H7/04 ,  H01J37/321 ,  H01J37/3266 ,  H01J37/32669 ,  H05H1/24

摘要： A plasma source for providing dissociated gas to semiconductor process chamber is provided. The plasma chamber can have at least one gas inlet and at least one chamber wall for containing the gas, a plurality of magnetic cores disposed relative to the plasma chamber such that the plasma chamber passes through each of the plurality of magnetic cores. A primary winding can be coupled to the plurality of magnetic cores. The plasma chamber can generate a toroidal plasma along a plane extending through the plasma chamber and which is at least substantially parallel to a top surface of a sample holder disposed within the semiconductor process chamber.

摘要翻译： 提供了一种用于向半导体处理室提供离解气体的等离子体源。 等离子体室可以具有至少一个气体入口和至少一个用于容纳气体的室壁，相对于等离子体室设置的多个磁芯，使得等离子体室通过多个磁芯中的每一个。 初级绕组可耦合到多个磁芯。 等离子体室可以沿着延伸穿过等离子体室的平面产生环形等离子体，并且其至少基本上平行于设置在半导体处理室内的样品保持器的顶表面。