公开(公告)号：US06307048B1

公开(公告)日：2001-10-23

申请号：US09442511

申请日：1999-11-18

Applicant: Shen-Chun Kuo ,  Charles F. Bernard ,  Frank Xing Chen ,  Donald Hou ,  Agnes S. Kim-Meade ,  George G. Wu

Inventor： Shen-Chun Kuo ,  Charles F. Bernard ,  Frank Xing Chen ,  Donald Hou ,  Agnes S. Kim-Meade ,  George G. Wu

IPC: C07D40102

CPC classification number: C07D401/04 ,  C07D401/14 ,  Y02P20/55

Abstract: Disclosed is a process for preparing a compound of the formula: wherein X1, X2, X3, X4, and X5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula wherein X1, X2, X3, X4, and X5 are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having the formula wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase.

Abstract translation: 公开了一种制备下式化合物的方法：其中X 1，X 2，X 3，X 4和X 5独立地选自H，卤素，烷基，烷氧基，芳基和芳氧基，R是保护基 其中具有如下定义的具有如下定义的化合物：（a）非亲核性强碱;（b）手性氨基醇（其中R 1，R 2，R 3，X 4， ; 和（c）具有甲醛的化合物L是离去基团，R如上定义。 通过该方法制备的化合物是制备法呢基蛋白转移酶抑制剂的化合物的有用中间体。

公开(公告)号：US6096883A

公开(公告)日：2000-08-01

申请号：US210921

申请日：1998-12-14

Applicant: George G. Wu ,  Xing Chen ,  Yee-Shing Wong ,  Doris P. Schumacher ,  Martin Steinman

Inventor： George G. Wu ,  Xing Chen ,  Yee-Shing Wong ,  Doris P. Schumacher ,  Martin Steinman

IPC: C07D205/08

CPC classification number: C07D205/08

Abstract: The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R.sub.1, .sub.2 and R.sub.3 are as defined in the specification,

Abstract translation: 本发明涉及式的中间体，所述中间体可用于制备下式化合物的方法，其中Bn是苄基，R1,2和R3如说明书中所定义，

公开(公告)号：US5756301A

公开(公告)日：1998-05-26

申请号：US25557

申请日：1993-03-03

Applicant: Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

Inventor： Bernard F. Erlanger ,  Jyh-Gang Leu ,  Bi-Xing Chen

IPC: C07K16/16 ,  C07K16/42 ,  G01N33/53 ,  G01N33/574 ,  G01N33/92 ,  G01N33/567

CPC classification number: C07K16/16 ,  C07K16/4208 ,  G01N33/5308 ,  G01N33/57415 ,  G01N33/57449 ,  G01N33/92

Abstract: The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No. HB11281 and 29B7B3C, having ATCC Accession No. HB11280. The present invention also provides a method for detecting the presence of taxol or a taxol-like substance in a sample, a method for screening for a ligand in a subject which is not being treated with taxol, an endogenous taxol-like substance in human serum detected by this screening method, a method of quantitatively determining the amount of taxol or taxol-like substance in a biological fluid sample and a kit for assaying for taxol or a taxol-like substance in a sample.

Abstract translation: 本发明提供了能够结合紫杉醇和紫杉醇样物质的两种单克隆抗体，其由具有ATCC登录号HB11281和ATCCB2B3C的具有ATCC登录号HB11280的69E4A8E的杂交瘤产生。 本发明还提供了一种用于检测样品中紫杉醇或类紫杉醇样物质的存在的方法，用于筛选未用紫杉醇处理的受试者中的配体的方法，人血清中的内源性紫杉醇样物质 通过该筛选方法检测生物流体样品中紫杉醇或类紫杉醇样物质的量的定量方法和用于测定样品中紫杉醇或类紫杉醇样物质的试剂盒。

公开(公告)号：US5581350A

公开(公告)日：1996-12-03

申请号：US471997

申请日：1995-06-06

Applicant: Xing Chen ,  Philip D. Flanner, III ,  Kiron B. Malwankar ,  Jennming Chen

Inventor： Xing Chen ,  Philip D. Flanner, III ,  Kiron B. Malwankar ,  Jennming Chen

IPC: G01N21/21 ,  G01J4/00

CPC classification number: G01N21/211 ,  G01N21/274 ,  G01N2021/213

Abstract: A method for calibrating an ellipsometer, and an ellipsometer including a processor programmed to control the analyzer, polarizer, and other ellipsometer components, and to process the data measured by the ellipsometer to perform the calibration method automatically. Where the ellipsometer's polarizer rotates and the analyzer remains fixed during measurement, the method determines coarse approximations of values A.sub.0 and P.sub.0, and then processes reflectivity data obtained at two or more analyzer angles to determine refined approximations of the values A.sub.0 and P.sub.0, where P.sub.0 is the angle of the polarizer's optical axis at an initial time, and A.sub.0 is the offset of the actual orientation angle of the analyzer from a nominal analyzer angle. Preferably the ellipsometer is a spectroscopic ellipsometer, the reflectivity data determine a tan.psi. spectrum and a cos.DELTA. spectrum for each of the analyzer angles, and the coarse approximations of A.sub.0 and P.sub.0 are refined by processing the reflectivity data by performing regression on A.sub.0 and P.sub.0 until the differences among the tan.psi. and cos.DELTA. spectra for several analyzer angles are minimized. Where the ellipsometer's analyzer rotates and the polarizer remains fixed during measurement, the method coarsely determines values A'.sub.0 and P'.sub.0, and then processes reflectivity data obtained at two or more polarizer angles to determine refined approximations of the values A'.sub.0 and P'.sub.0, where P'.sub.0 is the angle of the analyzer's optical axis at an initial time, and A'.sub.0 is the offset of the actual orientation angle of the polarizer from a nominal polarizer angle.

Abstract translation: 用于校准椭偏仪的方法以及椭圆计，其包括被编程为控制分析仪，偏振器和其它椭偏仪组件的处理器，并且处理由椭偏仪测量的数据以自动执行校准方法。 在测量期间，椭偏仪偏振器旋转并且分析仪保持固定，该方法确定值A0和P0的粗近似值，然后处理在两个或更多分析器角度获得的反射率数据，以确定值A0和P0的精确近似，其中P0为 偏振器的光轴在初始时的角度，A0是分析仪的实际取向角与标称分析仪角度的偏移。 优选地，椭偏仪是分光椭偏仪，反射率数据确定每个分析器角度的tan psi光谱和cosDDTA光谱，并且通过在A0和P0上进行回归处理反射率数据来改善A0和P0的粗略近似 直到几个分析仪角度的tan psi和cos DELTA光谱之间的差异最小化。 在椭偏仪的分析仪旋转和偏振器在测量期间保持固定的情况下，该方法粗略地确定值A'0和P'0，然后处理在两个或多个偏振器角度处获得的反射率数据，以确定值A'0和P的精确近似 '0，其中P'0是初始时分析仪的光轴的角度，A'0是偏振器与标称偏振器角度的实际定向角的偏移。

公开(公告)号：US10196757B1

公开(公告)日：2019-02-05

申请号：US15203943

申请日：2016-07-07

Applicant: Xing Chen ,  Garrett L. Grocke ,  Viktor Vajda ,  Ziyao Zhou

Inventor： Xing Chen ,  Garrett L. Grocke ,  Viktor Vajda ,  Ziyao Zhou

IPC: D01D5/00

Abstract: The invention provides a system for producing nanotubes, nanofibers and nanorods, the system comprising a wire array shaped as a cylinder such that the cylinder defines a void; a first furnace positioned within the void; a second furnace positioned opposite the first furnace to define a channel adapted to receive a portion of the cylinder as the cylinder rotates about its axis; a device for depositing spun fiber onto the wire array as the cylinder rotates; and a device for removing the deposited fiber from the array after the deposited fiber is heated within the channel. The invention also provides a method for producing nanotubes, the method comprising: supplying a cylindrical wire array, wherein the array defines an internal void; positioning a first furnace within the void; positioning a second furnace opposite the first furnace so as to define a channel between the first furnace and second furnace, the channel adapted to receive a portion of the cylindrical array as the array rotates about its axis; depositing spun fiber onto the array as the array rotates; heating the deposited fiber as it enters the channel; and removing the deposited fiber as it exits the channel.

公开(公告)号：US09639926B1

公开(公告)日：2017-05-02

申请号：US15263626

申请日：2016-09-13

Applicant: Xing Chen ,  Ryan J. Stoddard

Inventor： Xing Chen ,  Ryan J. Stoddard

IPC: G06K9/00 ,  G06T7/00

CPC classification number: G06T7/0004 ,  G01N21/8851 ,  G01N2021/8444 ,  G06T7/12 ,  G06T7/136 ,  G06T7/168 ,  G06T2207/10061 ,  G06T2207/20061

Abstract: A system for defining structures within an image is described. The system includes reading of an input file, preprocessing the input file while preserving metadata such as scale information and then detecting features of the input file. In one version the detection first uses an edge detector followed by identification of features using a Hough transform. The output of the process is identified elements within the image.

公开(公告)号：US20170025729A1

公开(公告)日：2017-01-26

申请号：US15082901

申请日：2016-03-28

Applicant: Xing Chen ,  Ziyao Zhou

Inventor： Xing Chen ,  Ziyao Zhou

IPC: H01P1/387

CPC classification number: H01P1/387 ,  B82Y30/00

Abstract: A nonreciprocal device is described. It includes a housing, a waveguide layer and at least one layer of magnetic nanofiber composite. The magnetic nanofiber composite layer is made up of a polymer base layer, a dielectric matrix comprising magnetic nanofibers. The nanofibers have a high aspect ratio and wherein said dielectric matrix is embedded in the polymer base layer.

Abstract translation: 描述不可逆设备。 它包括壳体，波导层和至少一层磁性纳米纤维复合材料。 磁性纳米纤维复合层由聚合物基层，包含磁性纳米纤维的介电基体构成。 纳米纤维具有高纵横比，并且其中所述介电基质嵌入聚合物基层中。

公开(公告)号：US09264489B2

公开(公告)日：2016-02-16

申请号：US12594238

申请日：2008-04-04

Applicant: Li Mo ,  Weijun Lee ,  Larry Shaoyan Ma ,  Xing Chen

Inventor： Li Mo ,  Weijun Lee ,  Larry Shaoyan Ma ,  Xing Chen

IPC: H04L29/08 ,  G06Q30/04 ,  H04L29/06

CPC classification number: H04L67/104 ,  G06Q30/04 ,  H04L63/102 ,  H04L67/1093 ,  H04L67/14 ,  H04L67/306

Abstract: A peer-to-peer network comprises a plurality of intelligent terminal nodes, each intelligent terminal node being operable to establish, maintain, and tear-down communication sessions with another intelligent terminal node, a plurality of network service nodes coupled to the plurality of intelligent terminal nodes, the plurality of network service nodes comprise at least one of the plurality of intelligent terminal nodes, at least one user P2P function module operable to store, locate and distribute service resource information related to user policies, and at least one network P2P function module operable to store, locate and distribute service resource information related to operator provider policies, and operable to exert stricter security control than the at least one user P2P function module.

Abstract translation: 对等网络包括多个智能终端节点，每个智能终端节点可操作以建立，维护和拆除与另一智能终端节点的通信会话，耦合到多个智能终端节点的多个网络服务节点 所述多个网络服务节点包括所述多个智能终端节点中的至少一个，至少一个用户P2P功能模块，其可操作以存储，定位和分发与用户策略相关的服务资源信息，以及至少一个网络P2P功能 模块，其可操作以存储，定位和分发与运营商提供商策略相关的服务资源信息，并且可操作以施加比所述至少一个用户P2P功能模块更严格的安全控制。

公开(公告)号：US08680777B2

公开(公告)日：2014-03-25

申请号：US13431521

申请日：2012-03-27

Applicant: Ken Tran ,  Xing Chen ,  Russell L. Newman ,  Franklin Lee

Inventor： Ken Tran ,  Xing Chen ,  Russell L. Newman ,  Franklin Lee

IPC: H05B41/16 ,  H05B41/24

CPC classification number: H05B33/0803 ,  Y02B20/348

Abstract: A power system for a dielectric barrier discharge system, such as used for generating ozone, can include a full bridge inverter stage and parallel resonant tank outputting a signal for powering a dielectric barrier discharge cell stack. The inverter stage is controlled using a combination of pulse width modulation (PWM) and frequency modulation (FM) to enable soft switching through all load conditions—from full load to light load. A current control loop error amplifier compensator can provide a duty cycle adjustment signal to a phase shift PWM controller chip that generates the switching signals for the inverter stage. A feedback signal is also used to adjust a clock frequency time constant of the PWM controller chip to provide the FM. In one embodiment, the feedback signal is an output of an inverting amplifier connected at an output of the current control loop error amplifier compensator.

Abstract translation: 用于产生臭氧的电介质阻挡放电系统的电力系统可以包括全桥逆变器级和并联谐振回路，输出用于为介质阻挡放电单元堆供电的信号。 使用脉冲宽度调制（PWM）和调频（FM）的组合来控制逆变器级，以实现从全负载到轻负载的所有负载条件下的软开关。 电流控制回路误差放大器补偿器可以向产生用于逆变器级的开关信号的相移PWM控制器芯片提供占空比调整信号。 反馈信号也用于调整PWM控制器芯片的时钟频率时间常数以提供FM。 在一个实施例中，反馈信号是在电流控制回路误差放大器补偿器的输出处连接的反相放大器的输出。

公开(公告)号：US20130257311A1

公开(公告)日：2013-10-03

申请号：US13431521

申请日：2012-03-27

Applicant: KEN TRAN ,  XING CHEN ,  RUSSELL L. NEWMAN ,  FRANKLIN LEE

Inventor： KEN TRAN ,  XING CHEN ,  RUSSELL L. NEWMAN ,  FRANKLIN LEE

IPC: H05B41/24

CPC classification number: H05B33/0803 ,  Y02B20/348

Abstract: A power system for a dielectric barrier discharge system, such as used for generating ozone, can include a full bridge inverter stage and parallel resonant tank outputting a signal for powering a dielectric barrier discharge cell stack. The inverter stage is controlled using a combination of pulse width modulation (PWM) and frequency modulation (FM) to enable soft switching through all load conditions—from full load to light load. A current control loop error amplifier compensator can provide a duty cycle adjustment signal to a phase shift PWM controller chip that generates the switching signals for the inverter stage. A feedback signal is also used to adjust a clock frequency time constant of the PWM controller chip to provide the FM. In one embodiment, the feedback signal is an output of an inverting amplifier connected at an output of the current control loop error amplifier compensator.

Abstract translation: 用于产生臭氧的电介质阻挡放电系统的电力系统可以包括全桥逆变器级和并联谐振回路，输出用于为介质阻挡放电单元堆供电的信号。 使用脉冲宽度调制（PWM）和调频（FM）的组合来控制逆变器级，以实现从全负载到轻负载的所有负载条件下的软开关。 电流控制回路误差放大器补偿器可以向产生用于逆变器级的开关信号的相移PWM控制器芯片提供占空比调整信号。 反馈信号也用于调整PWM控制器芯片的时钟频率时间常数以提供FM。 在一个实施例中，反馈信号是在电流控制回路误差放大器补偿器的输出处连接的反相放大器的输出。