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公开(公告)号:US12110549B2
公开(公告)日:2024-10-08
申请号:US17822117
申请日:2022-08-24
Applicant: 10x Genomics, Inc.
Inventor: Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo , Stephane Claude Boutet , Sarah Taylor , Niranjan Srinivas
IPC: C12Q1/68 , C12Q1/6806 , C12Q1/683 , C12Q1/6874
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.
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公开(公告)号:US20190367966A1
公开(公告)日:2019-12-05
申请号:US16375102
申请日:2019-04-04
Applicant: 10X Genomics, Inc.
Inventor: Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez
IPC: C12Q1/6806 , G01N33/53 , G01N33/58 , C12Q1/6804 , G01N33/50 , C12N15/10
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including characterization of major histocompatibility complex (MHC) molecules. The compositions, methods, systems, and devices disclosed herein generally describe peptides and barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing MHC molecules from one or more cells.
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公开(公告)号:US10480029B2
公开(公告)日:2019-11-19
申请号:US15933299
申请日:2018-03-22
Applicant: 10X GENOMICS, INC.
Inventor: Zachary Bent , Josephine Harada , Christopher Hindson , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Solongo Batjargal Ziraldo
IPC: C12Q1/68 , C12Q1/6874 , C12Q1/683 , C12Q1/6806
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号:US20190338353A1
公开(公告)日:2019-11-07
申请号:US16426762
申请日:2019-05-30
Applicant: 10X GENOMICS, INC.
Inventor: Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo
IPC: C12Q1/6874 , C12N15/10 , C12Q1/683 , C12Q1/6806 , C12Q1/6804
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.
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公开(公告)号:US20180282803A1
公开(公告)日:2018-10-04
申请号:US15933299
申请日:2018-03-22
Applicant: 10X GENOMICS, INC.
Inventor: Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo
IPC: C12Q1/6874 , C12Q1/683 , C12Q1/6806
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号:US10011872B1
公开(公告)日:2018-07-03
申请号:US15720085
申请日:2017-09-29
Applicant: 10X GENOMICS, INC.
Inventor: Phillip Belgrader , Zachary Bent , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry
IPC: C12Q1/68 , C12Q1/6874 , C12Q1/6806 , C12Q1/683
CPC classification number: C12Q1/6874 , C12N15/1075 , C12Q1/6804 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179 , C12Q2525/179 , C12Q2535/122 , C12Q2563/131 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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公开(公告)号:US20180179590A1
公开(公告)日:2018-06-28
申请号:US15720085
申请日:2017-09-29
Applicant: 10X GENOMICS, INC.
Inventor: Phillip Belgrader , Zachary Bent , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q1/683 , C12Q2525/191 , C12Q2537/143 , C12Q2563/179
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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