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公开(公告)号：US11099194B2
公开(公告)日：2021-08-24
申请号：US15641203
申请日：2017-07-03
申请人： ASTUTE MEDICAL, INC.
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.
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公开(公告)号：US20180067131A1
公开(公告)日：2018-03-08
申请号：US15818632
申请日：2017-11-20
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Angiopoietin-related protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparin-binding growth factor 1, Angiopoietin-related protein 6, Proepiregulin, Probetacellulin, Amphiregulin, Angiogenin, Thrombospondin-2, and Collagen alpha-1(XVIII) chain as diagnostic and prognostic biomarkers in renal injuries.
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23.发明申请公开(公告)号：US20170248615A1
公开(公告)日：2017-08-31
申请号：US15595691
申请日：2017-05-15
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/54306 , G01N2333/4706 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect Chitinase-3-like protein 1 as a predictive biomarker in renal injuries.
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公开(公告)号：US09696322B2
公开(公告)日：2017-07-04
申请号：US15174559
申请日：2016-06-06
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , G01N33/70 , G01N2333/4703 , G01N2333/4745 , G01N2333/65 , G01N2333/8146 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G06F19/00 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.
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公开(公告)号：US20150293131A1
公开(公告)日：2015-10-15
申请号：US14390338
申请日：2013-04-02
IPC分类号： G01N33/92 , G01N33/74 , G01N33/573 , G01N33/68
CPC分类号： G01N33/92 , G01N33/573 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6893 , G01N33/74 , G01N2333/4745 , G01N2800/26 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients and in patients at risk for sepsis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.
摘要翻译： 本发明涉及用于监测，诊断，预后和确定败血症患者和患有败血症风险的患者的治疗方案的方法和组合物。 特别地，本发明涉及使用检测一种或多种生物标志物作为这些患者中的诊断和预后生物标志物测定的测定法。
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公开(公告)号：US20150241415A1
公开(公告)日：2015-08-27
申请号：US14421099
申请日：2013-08-09
申请人： ASTUTE MEDICAL, INC. , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Kai Singbartl , John A. Kellum, JR.
IPC分类号： G01N33/53
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect hyaluronic acid as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient.
摘要翻译： 本发明涉及用于监测，诊断，预后和确定败血症患者治疗方案的方法和组合物。 特别地，本发明涉及使用检测透明质酸作为脓毒症患者肾损伤的诊断和预后生物标志物测定的测定法。
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公开(公告)号：US20150177260A1
公开(公告)日：2015-06-25
申请号：US14416988
申请日：2013-07-22
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68 , G06F19/00 , G01N33/573
CPC分类号： G01N33/6893 , G01N33/573 , G01N33/6869 , G01N2333/47 , G01N2333/70503 , G01N2333/7155 , G01N2333/96433 , G01N2800/26 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G16H40/63 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients and in patients at risk for sepsis. In particular, the invention relates to using assays that detect one or more of WAP four-disulfide core domain protein 2, Hepatitis A virus cellular receptor 1, Interleukin-1 receptor-like 1, and Proprotein convertase subtilisin/kexin type 9 as diagnostic and prognostic in such patients.
摘要翻译： 本发明涉及用于监测，诊断，预后和确定败血症患者和患有败血症风险的患者的治疗方案的方法和组合物。 特别地，本发明涉及使用检测WAP四 - 二硫键核心结构域蛋白2，甲型肝炎病毒细胞受体1，白介素-1受体样1和Proprotein转化酶枯草杆菌蛋白酶/ kexin 9中的一种或多种作为诊断和 这种患者的预后。
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28.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20150038595A1
公开(公告)日：2015-02-05
申请号：US14131566
申请日：2012-07-05
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , G01N33/74 , G01N33/743 , G01N2333/47 , G01N2333/4727 , G01N2333/4756 , G01N2333/575 , G01N2333/635 , G01N2333/765 , G01N2333/96433 , G01N2333/96463 , G01N2800/347 , G01N2800/50 , G01N2800/54 , G01N2800/56 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Serum albumin, Protein S100-B, Glial cell line-derived neurotrophic factor, Resistin, Serum amyloid A protein, Hydrocortisone, Parathyroid hormone, and Tissue Plasminogen Activator as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自以下的肾损伤标记物：血清白蛋白，蛋白质S100-B，胶质细胞系衍生的神经营养因子，抗性蛋白，血清淀粉样蛋白A蛋白，氢化可的松 ，甲状旁腺激素和组织纤溶酶原激活剂作为肾损伤的诊断和预后生物标志物。
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公开(公告)号：US20220236286A1
公开(公告)日：2022-07-28
申请号：US17710832
申请日：2022-03-31
申请人： ASTUTE MEDICAL, INC.
发明人： Joseph Anderberg , Paul McPherson , Jeff Gray , Kevin Nakamura , James Patrick Kampf , Thomas Kwan
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.
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公开(公告)号：US11209443B2
公开(公告)日：2021-12-28
申请号：US16679486
申请日：2019-11-11
申请人： ASTUTE MEDICAL, INC.
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.
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