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公开(公告)号：US20160319010A1
公开(公告)日：2016-11-03
申请号：US15198696
申请日：2016-06-30
Applicant: AbbVie Inc.
Inventor： Boris Labkovsky , Tariq Ghayur , Georgeen Gaza-Bulseco , Pratibha Mishra , Subramanya Hegde , Sudha Krishnan
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K2039/505 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/77 , Y02A50/386
Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.
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公开(公告)号：US20160280791A1
公开(公告)日：2016-09-29
申请号：US15075630
申请日：2016-03-21
Applicant: AbbVie Inc.
Inventor： Tariq Ghayur , Jijie Gu , Carrie L. Goodreau
CPC classification number: C07K16/2863 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: Engineered multivalent and multispecific binding proteins that bind two different (e.g., nonoverlapping) epitopes of the same receptor or two different receptors expressed on the same cell are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US09409986B2
公开(公告)日：2016-08-09
申请号：US14133380
申请日：2013-12-18
Applicant: AbbVie, Inc.
Inventor： Chengbin Wu , Dominic J. Ambrosi , Chung-ming Hsieh , Tariq Ghayur
IPC: A61K38/00 , C07K14/545 , C07K16/24 , A61K39/395 , A61K47/48 , A61K45/06 , G01N33/68 , A61K9/00
CPC classification number: C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481
Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质及其在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途， 和组合物。
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公开(公告)号：US09345702B2
公开(公告)日：2016-05-24
申请号：US14535070
申请日：2014-11-06
Applicant: AbbVie Inc.
Inventor： Steven Elmore , Andrew Souers , Lichun Wang , Tariq Ghayur , Stuart J. Perper
IPC: A61K31/496 , A61K31/5377
CPC classification number: A61K31/5377 , A61K31/496
Abstract: This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-xL.
Abstract translation: 本发明涉及用选择性抑制Bcl-2抗凋亡蛋白活性的化合物治疗系统性红斑狼疮和干燥综合征的方法。 具体地，本发明涉及用选择性抑制Bcl-2蛋白活性的化合物治疗，对抑制其它BCL-2家族蛋白（包括Bcl-xL）活性的亲和性较小。
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公开(公告)号：US20160101109A1
公开(公告)日：2016-04-14
申请号：US14972429
申请日：2015-12-17
Applicant: AbbVie Inc.
Inventor： Philip Bardwell , Tariq Ghayur
IPC: A61K31/5377 , A61K45/06 , A61K31/495
CPC classification number: A61K31/5377 , A61K31/495 , A61K31/496 , A61K31/635 , A61K45/06
Abstract: Methods of preventing or treating arthritis is disclosed.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20160032000A1
公开(公告)日：2016-02-04
申请号：US14720592
申请日：2015-05-22
Applicant: AbbVie Inc.
Inventor： Tariq Ghayur , Alfred Hahn , Bernhard Mueller
CPC classification number: C07K16/2869 , A61K39/3955 , A61K45/06 , A61K47/6843 , A61K47/6845 , A61K47/6849 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/248 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/525 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US20150104452A1
公开(公告)日：2015-04-16
申请号：US14301305
申请日：2014-06-10
Applicant: AbbVie Inc.
Inventor： Tariq Ghayur , Edward B. Reilly , Andrew Phillips , Randy L. Bell , Yingchun Li , Hua Ying , Susan E. Morgan-Lappe , Gillian A. Kingsbury , Jieyi Wang , Suzanne M. Norvell , Junjian Liu
CPC classification number: C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58 , Y10S435/81
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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28.发明申请公开(公告)号：US20150056202A1
公开(公告)日：2015-02-26
申请号：US14224894
申请日：2014-03-25
Applicant: AbbVie, Inc.
Inventor： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。
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29.发明申请PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开PROSTAGLANDIN E2双变量域免疫球蛋白及其用途公开(公告)号：US20150017095A1
公开(公告)日：2015-01-15
申请号：US14327306
申请日：2014-07-09
Applicant: AbbVie Inc.
Inventor： Tariq Ghayur , Jijie Gu , Peter Isakson
CPC classification number: C07K16/468 , A61K38/00 , A61K45/06 , A61K47/6879 , A61K51/109 , C07K16/22 , C07K16/24 , C07K16/26 , C07K16/2863 , C07K16/2866 , C07K16/44 , C07K2317/31 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/6869 , G01N33/74 , G01N33/88 , G01N2333/4709 , G01N2333/48 , G01N2333/525 , G01N2333/5443 , G01N2333/545 , G01N2333/7155 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/478 , Y02A50/481
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US20140271458A1
公开(公告)日：2014-09-18
申请号：US14211604
申请日：2014-03-14
Applicant: AbbVie Inc.
Inventor： Tariq Ghayur , JiJie Gu , Maria Harris , Carrie Goodreau , Sonal Saluja
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K47/6879 , C07K16/244 , C07K16/245 , C07K2317/31 , C07K2317/626 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , G01N33/6869 , G01N2333/54 , G01N2333/545
Abstract: Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
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