公开(公告)号：US20150024039A1

公开(公告)日：2015-01-22

申请号：US14506038

申请日：2014-10-03

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Dariush Davalian ,  Stephen Pacetti ,  Florian Niklas Ludwig ,  Syed Faiyaz Ahmed Hossainy ,  Irina Astafieva ,  Kimchi Tran

IPC: A61K9/00

CPC classification number: A61K9/0019 ,  A61F2/95 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/62 ,  A61M25/0084 ,  A61M25/104 ,  A61M2025/105

Abstract: This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents.

Abstract translation: 本发明涉及增强血管对治疗剂的渗透性的方法。

公开(公告)号：US20140330360A1

公开(公告)日：2014-11-06

申请号：US14333344

申请日：2014-07-16

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： John E. Papp ,  Syed Faiyaz Ahmed Hossainy ,  Michael Ngo ,  Chad Abunassar ,  Boris Anukhin ,  Mikael Trollsas ,  Lewis B. Schwartz

IPC: A61F2/90 ,  A61F2/958

CPC classification number: A61F2/915 ,  A61F2/86 ,  A61F2/89 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/826 ,  A61F2002/9155 ,  A61F2002/91591 ,  A61F2210/00 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2240/001 ,  B29C35/0805 ,  B29C65/64 ,  B29C66/1248 ,  B29C66/71 ,  B29C2035/0838 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7534

Abstract: Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

公开(公告)号：US08753709B2

公开(公告)日：2014-06-17

申请号：US13722644

申请日：2012-12-20

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Yiwen Tang ,  Homayon Askaryar ,  Qing Lin ,  Thierry Glauser

IPC: A61L31/16 ,  A61F2/82 ,  A61L31/10 ,  B05D5/00

CPC classification number: B05D5/00 ,  A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/02

Abstract: Methods for making coatings on an implantable device, such as a drug-eluting stent. The coatings comprise a polymer and a drug in a crystalline or partially crystalline form. In addition, implantable devices produced by the methods and methods of using the coated implantable devices are described.

Abstract translation: 在可植入装置（例如药物洗脱支架）上制备涂层的方法。 涂层包含聚合物和结晶或部分结晶形式的药物。 此外，描述了通过使用涂覆的可植入装置的方法和方法制造的可植入装置。

公开(公告)号：US20140107592A1

公开(公告)日：2014-04-17

申请号：US14106029

申请日：2013-12-13

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Florencia Lim ,  Michael Ngo ,  Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/604 ,  C08L67/04

Abstract: The present invention provides a coating comprising a reservoir layer comprising a terpolymer comprising caprolactone and glycolide and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.

Abstract translation: 本发明提供一种包含储层的涂层，其包含含有己内酯和乙交酯的三元共聚物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用的方法。

公开(公告)号：US09358268B2

公开(公告)日：2016-06-07

申请号：US14299771

申请日：2014-06-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Deborah Kilpatrick ,  Syed Faiyaz Ahmed Hossainy ,  Irina Astafieva ,  Florian N. Ludwig ,  Paul M. Consigny ,  Jeffrey T. Ellis ,  Florencia Lim

IPC: A61K38/17 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16 ,  A61M1/34

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/1275 ,  A61K9/1617 ,  A61K9/1658 ,  A61M1/3472 ,  A61M1/3486 ,  A61M2202/0456 ,  A61K2300/00

Abstract: A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.

Abstract translation: 一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。 包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。 包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。 一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

公开(公告)号：US09101697B2

公开(公告)日：2015-08-11

申请号：US14251489

申请日：2014-04-11

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Eugene Michal ,  Thierry Glauser ,  Connie Kwok ,  Stephen Dirk Pacetti

IPC: A61K31/44 ,  A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

Abstract translation: 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。

公开(公告)号：US20150151030A1

公开(公告)日：2015-06-04

申请号：US14605666

申请日：2015-01-26

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Lothar W. Kleiner ,  John Stankus ,  Nam D. Pham ,  Michael H. Ngo ,  Bozena Zofia Maslanka ,  Syed Faiyaz Ahmed Hossainy ,  Mikael Trollsas ,  Yiwen Tang

IPC: A61L31/16 ,  A61L31/14 ,  A61L31/10 ,  A61K31/436 ,  A61K47/34

CPC classification number: A61L31/16 ,  A61K31/436 ,  A61K47/34 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/416 ,  C08L67/04

Abstract: The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.

Abstract translation: 本发明涉及涂覆有具有可调谐疏水性的聚合物的可植入医疗装置及其在治疗血管疾病中的用途。

公开(公告)号：US20150142099A1

公开(公告)日：2015-05-21

申请号：US14603087

申请日：2015-01-22

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： John S. Stankus ,  Hugh Zhao ,  Mikael Trollsas ,  Syed Faiyaz Ahmed Hossainy ,  Michael H. Ngo ,  Yunbing Wang ,  Benny Serna

IPC: A61F2/86

CPC classification number: A61F2/86 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2210/0019 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/006 ,  A61F2250/001 ,  A61L31/041 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/16 ,  C08L67/04

Abstract: Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.

Abstract translation: 公开了具有高压碎可恢复性，高抗断裂性和由于在生理条件下的自膨胀性能而减少或无反冲的生物可吸收支架。 支架由PLLA和橡胶状聚合物如聚己内酯的无规共聚物制成。

公开(公告)号：US20150132249A1

公开(公告)日：2015-05-14

申请号：US14590590

申请日：2015-01-06

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Gina Zhang ,  Jessica Renee DesNoyer ,  Gordon Stewart ,  Maricela Kezis ,  Syed Faiyaz Ahmed Hossainy

IPC: A61K47/48 ,  C08G69/44 ,  A61K31/436

CPC classification number: A61K31/436 ,  A61K9/0019 ,  A61K47/595 ,  A61L24/001 ,  A61L24/046 ,  A61L2430/36 ,  C08G69/44 ,  Y10S977/906 ,  C08L77/12

Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.

Abstract translation: 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。

公开(公告)号：US08999369B2

公开(公告)日：2015-04-07

申请号：US13961772

申请日：2013-08-07

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： David C. Gale ,  Yunbing Wang ,  Syed Faiyaz Ahmed Hossainy ,  Bin Huang ,  Garth L. Wilkes ,  Vincent J. Gueriguian

IPC: A61F2/82 ,  A61L31/12 ,  A61L31/14 ,  B29C47/00

CPC classification number: A61F2/82 ,  A61L31/127 ,  A61L31/128 ,  A61L31/148 ,  B29C47/0007 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  Y10S977/753 ,  Y10S977/776 ,  Y10S977/831 ,  Y10S977/931

Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices, such as stents are disclosed. A suspension solution is formed including a fluid, a biodegradable polymer, and bioceramic particles. The biodegradable polymer and particles are precipitated from the suspension to form a mixture. A composite is formed by combining the mixture with another polymer and a scaffolding is formed from the composite.

Abstract translation: 公开了与聚合物 - 生物陶瓷复合植入式医疗装置（例如支架）相关的方法和装置。 形成包括流体，可生物降解的聚合物和生物陶瓷颗粒的悬浮液。 生物降解聚合物和颗粒从悬浮液中沉淀形成混合物。 通过将混合物与另一种聚合物组合形成复合材料，并且由复合材料形成脚手架。