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21.发明授权
公开(公告)号：US4659651A
公开(公告)日：1987-04-21
申请号：US753847
申请日：1985-07-11
申请人： Morio Yagihara , Akihiko Ikegawa
发明人： Morio Yagihara , Akihiko Ikegawa
IPC分类号： C07D409/04 , C07D239/52 , C07D239/56 , C07D249/18 , C07D257/04 , C07D335/00 , C07D335/02 , C07D409/12 , G03C1/06 , G03C1/34 , G03C7/26 , G03C7/305 , G03C1/46 , G03C1/02
CPC分类号： G03C7/30511 , G03C1/34 , Y10S430/156 , Y10S430/158 , Y10S430/16 , Y10S430/161
摘要： A silver halide photographic material comprising a support having thereon at least one light-sensitive silver halide emulsion layer having associated therewith at least one blocked photographic reagent represented by formula (I) or (II); ##STR1## wherein, A represents a moiety of a photographic reagent or a moiety of a precursor of a photographic reagent bonded to the ring containing Z through a hetero atom; Y.sup.1, and Y.sup.2 and Y.sup.3 each represents a hydrogen atom or a substituent, or Y.sup.1 and Y.sup.3 in formula (I) together form a ring; Z represents an atomic group necessary for forming a carbon ring or a heterocyclic ring; and n represents 1 or 2.The silver halide photographic material is stable under storage conditions.
摘要翻译： 一种卤化银照相材料，其包含其上具有至少一种感光卤化银乳剂层的载体，所述感光卤化银乳剂层具有至少一种由式（I）或（II）表示的封闭照相试剂。 （II）其中，A表示通过杂原子键合到含有Z的环的照相试剂或照相试剂的前体的部分的部分; Y1，Y2和Y3各自表示氢原子或取代基，或式（I）中的Y1和Y3一起形成环; Z表示形成碳环或杂环所必需的原子团; 并且n表示1或2.卤化银照相材料在储存条件下是稳定的。
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公开(公告)号：US20070274983A1
公开(公告)日：2007-11-29
申请号：US11574123
申请日：2005-08-24
IPC分类号： A61K39/395
CPC分类号： A61K31/702 , A23L33/12 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/29 , A61K31/202 , A61K31/733 , A61K35/741 , A61K39/42 , A61K2300/00 , A23V2200/324 , A23V2250/28 , A23V2250/608 , A23V2250/304 , A23V2250/1642 , A23V2250/1882 , A23V2200/3202 , A23V2200/3204
摘要： The present invention provides a method and composition for the treatment and/or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and immunoglobulin from the milk or colostrum of hyperimmunized cows.
摘要翻译： 本发明提供了用于治疗和/或预防感染的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和来自超免疫母牛的乳或初乳的免疫球蛋白。
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公开(公告)号：US06713473B1
公开(公告)日：2004-03-30
申请号：US09926355
申请日：2002-02-19
申请人： Naoyuki Nishikawa , Masaharu Sugai , Kozo Aoki , Makoto Suzuki , Akihiko Ikegawa , Kazunobu Takahashi , Fukuichi Ohsawa , Naomi Masuda , Nobukazu Kakui , Jiro Tanaka , Yuji Tabata , Kenji Asai
发明人： Naoyuki Nishikawa , Masaharu Sugai , Kozo Aoki , Makoto Suzuki , Akihiko Ikegawa , Kazunobu Takahashi , Fukuichi Ohsawa , Naomi Masuda , Nobukazu Kakui , Jiro Tanaka , Yuji Tabata , Kenji Asai
IPC分类号： A61K31403
CPC分类号： C07D231/12 , A61K31/403 , A61K31/4035 , A61K31/41 , A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/675 , C07D209/88 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/5728 , C09B57/00
摘要： A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR3—CO—, —CO—NR3— and the like (R3 represents a hydrogen atom, a lower alkyl group, a lower acyl group and the like); M represents an alkylene linking group (a carbon atom constituting the carbon chain may be replaced with a nitrogen atom, an oxygen atom and the like); X represents —S—, —O—, —NR4—, —NR5—CO— and the like (R4 and R5 represent a hydrogen atom, a lower alkyl group and the like) or a single bond; Y represents an alkyl group, an aryl group, an amino group, an aromatic heterocyclic group and the like; R1 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower acyl group; and R21, R22 and R23 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like] or a salt thereof. The compound is useful as an active ingredient of medicaments for diseases in which neuropeptide Y is involved, ingestion control for hyperphagia and the like.
摘要翻译： 由式（I）表示的化合物[A表示5-至7-元烃环基团; L代表-NR 3 -CO - ， - CO-NR 3 - 等（R 3表示氢原子，低级烷基，低级酰基等）。 M表示亚烷基连接基（构成碳链的碳原子可以被氮原子，氧原子等取代）; X表示-S - ， - O - ，-NR 4 - ， - NR 5 -CO-等（R 4和R 5表示氢原子，低级烷基等） ）或单一债券; Y表示烷基，芳基，氨基，芳香族杂环基等; R 1表示低级烷基，低级烯基，低级炔基或低级酰基; R 21，R 22和R 23表示氢原子，羟基，低级烷基等〕或其盐。 该化合物可用作其中涉及神经肽Y的疾病的药物的活性成分，用于食欲摄入的摄取控制等。
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公开(公告)号：US5618831A
公开(公告)日：1997-04-08
申请号：US242834
申请日：1994-05-16
申请人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
发明人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： A61K31/541 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506
摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译： 一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。 （I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。
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公开(公告)号：US5384234A
公开(公告)日：1995-01-24
申请号：US85174
申请日：1993-07-02
申请人： Fumitaka Ueda , Junji Nishigaki , Akihiko Ikegawa
发明人： Fumitaka Ueda , Junji Nishigaki , Akihiko Ikegawa
CPC分类号： G03C1/29 , G03C1/14 , G03C7/30529
摘要： The present invention provides a silver halide color photographic photosensitive material which has high saturation, excellent color reproduction and excellent graininess, the material comprising a silver halide emulsion layer which imparts an interlayer effect to a red sensitive silver halide emulsion layer is spectrally sensitized with a sensitizing dye represented by formula (I) and contains a development inhibitor releasing compound represented by formula (II). ##STR1##
摘要翻译： 本发明提供了一种具有高饱和度，优异色彩再现性和优异颗粒性的卤化银彩色照相感光材料，包含赋予红色感光卤化银乳剂层的层间效应的卤化银乳剂层的材料用敏化剂进行光谱增感 由式（I）表示的染料并含有由式（II）表示的显影抑制剂释放化合物。 （I）
（II） -
公开(公告)号：US5290676A
公开(公告)日：1994-03-01
申请号：US944314
申请日：1992-09-14
CPC分类号： G03C5/50 , G03C1/0051 , G03C1/035 , G03C1/14
摘要： Disclosed herein is a silver halide photographic light-sensitive material having at least one silver halide emulsion layer formed on a support. Said light-sensitive material having at least one layer contains a regular silver halide emulsion, a tabular silver halide emulsion containing tabular silver halide grains having an average diameter/average thickness ratio of 2 or more, which occupy 50% or more of the total projected area of all silver halide grains, and a silver halide emulsion containing internal latent-image silver halide grains each chemically sensitized to the depth of less than 0.02 .mu.m from the surface of the grain. Each of these emulsions contains at least one methine compound represented by the following formula (I): ##STR1## where R.sup.1 is --(CH.sub.2).sub.r --CONHSO.sub.2 --R.sub.3 or --(CH.sub.2).sub.s --SO.sub.2 NHCO--R.sub.4, where R.sup.3 and R.sup.4 are an alkyl group, r and s are an integer ranging from 1 to 5; R.sup.2 is a sulfoalkyl group; Z.sup.1 and Z.sup.2 are non-metal atom groups required for forming a 5- or 6-membered heterocyclic group; p and q are 0 or 1; L.sub.1, L.sub.2 and L.sub.3 are methine groups; and m is 0, 1 or 2, wherein said at least one methine compound has been added at 50.degree. C. or more in any step from a step of preparing of the emultion to a step of coating of the emulsion.
摘要翻译： 本文公开了一种卤化银照相感光材料，其在载体上形成有至少一个卤化银乳剂层。 具有至少一层的所述感光材料含有规则的卤化银乳剂，包含平均直径/平均厚度比为2或更大的片状卤化银颗粒的片状卤化银乳剂，其占总投影的50％或更多 所有卤化银颗粒的面积，以及含有内部潜像卤化银颗粒的卤化银乳剂，其每一种化学增感剂从晶粒表面的深度小于0.02（my）m。 这些乳液中的每一种含有至少一种下式（I）表示的次甲基化合物：（*化学结构*）式（I）其中R1为 - （CH2）r-CONHSO2-R3或 - （CH2）s-SO2NHCO- R4，其中R3和R4是烷基，r和s是1至5的整数; R2是磺基烷基; Z1和Z2是形成5或6元杂环基团所需的非金属原子团; p和q为0或1; L1，L2和L3是次甲基; 并且m为0,1或2，其中所述至少一种次甲基化合物在从制备所述乳液的步骤到所述乳液的涂布步骤的任何步骤中以50℃以上加入。
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公开(公告)号：US5213952A
公开(公告)日：1993-05-25
申请号：US607186
申请日：1990-10-31
申请人： Shigeru Kuwashima , Akihiko Ikegawa
发明人： Shigeru Kuwashima , Akihiko Ikegawa
CPC分类号： G03C7/3003 , G03C1/48584 , G03C7/3924 , G03C2001/03541 , G03C7/00 , Y10S430/141
摘要： A method of forming a direct positive color image by imagewise exposing a photographic material having at least one emulsion layer which contains previously non-fogged internal latent image-type silver halide grains, on a support, followed by color-developing the exposed material during or after fogging thereof, wherein the photographic material contains a color sensitizing dye and at least one compound or salt thereof which satisfies the condition-1 as defined in the specification. With the image formed by the method having an elevated maximum image density with a lowered minimum image density, and with the iamge-forming method displaying extremely excellent color reproducibility.
摘要翻译： 通过将具有至少一个包含先前未雾化的内部潜像型卤化银颗粒的乳剂层的照相材料成像曝光在载体上，然后在曝光材料的期间或 其雾化后，其中照相材料含有色素增感染料和至少一种满足说明书中定义的条件-1的化合物或其盐。 通过该方法形成的图像具有提高的最大图像浓度，具有降低的最小图像浓度，并且iamge形成方法显示出极好的颜色再现性。
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公开(公告)号：US4518685A
公开(公告)日：1985-05-21
申请号：US601402
申请日：1984-04-17
申请人： Morio Yagihara , Akihiko Ikegawa , Mitsunori Ono , Yuji Mihara
发明人： Morio Yagihara , Akihiko Ikegawa , Mitsunori Ono , Yuji Mihara
IPC分类号： C07C45/63 , C07D239/54 , C07D239/553 , C07D239/62 , C07D257/04 , C07D403/04 , C07D403/12 , G03C1/06 , G03C7/26 , G03C7/305 , G03C8/00 , G03C8/08 , G03C1/46 , G03C1/02
CPC分类号： C07D239/553 , C07C45/63 , C07D239/62 , C07D257/04 , C07D403/04 , C07D403/12 , G03C7/26 , G03C7/30511 , G03C8/00 , Y10S430/156 , Y10S430/158 , Y10S430/159 , Y10S430/16 , Y10S430/161
摘要： A silver halide photographic light-sensitive material which comprises a support having thereon a light-sensitive silver halide emulsion layer, wherein the photographic light-sensitive material contains a blocked photographic agent therein represented by formula (I): ##STR1## wherein A represents a photographic agent moiety which is bonded to a blocking moiety through a hetero atom or a group which is bonded to a blocking moiety through a hetero atom and capable of releasing a photographic agent upon a subsequent reaction after the group is released; Y represents a hydrogen atom or a substituent; and Z represents an atomic group necessary to form a carbocyclic ring or a heterocyclic ring.The precursor of photographic agent is completely stable during the preservation of the photographic light-sensitive material and releases a photographic agent at a desired time upon the processing of the photographic light-sensitive material. The precursor also exhibits its function to a substantial degree over a wide range of pH.
摘要翻译： 一种卤化银照相感光材料，其包含其上具有感光卤化银乳剂层的载体，其中所述摄影感光材料含有其中由式（I）表示的封闭的照相剂：其中A表示 通过杂原子键合到阻挡部分上的照相剂部分或者通过杂原子键合到阻断部分并且在释放基团后能够随后反应释放照相剂的基团; Y表示氢原子或取代基; Z表示形成碳环或杂环所必需的原子团。 摄影感光材料的保存期间，照相剂的前体是完全稳定的，并且在照相感光材料的加工过程中在所需时间内释放照相剂。 该前体也在很宽的pH范围内显着地发挥其功能。
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公开(公告)号：US20080260661A1
公开(公告)日：2008-10-23
申请号：US11573120
申请日：2005-08-10
摘要： The invention relates to the use of an UV-absorbing compound for the preparation of a cosmetic composition for protection against UV radiation said compound being represented by the general formula (I) wherein less than 10% of the total absorption between 250 and 600 nm of said UV-absorbing compound according to formula (I) is above 400 nm. The invention also relates to sunscreen compositions comprising the UV-absorbing compound according to formula (I).
摘要翻译： 本发明涉及紫外线吸收化合物用于制备用于防止紫外线辐射的化妆品组合物的用途，所述化合物由通式（I）表示，其中小于10％的总吸收在250和600nm之间 所述根据式（I）的紫外线吸收化合物高于400nm。 本发明还涉及包含根据式（I）的UV吸收化合物的防晒组合物。
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公开(公告)号：US07244859B2
公开(公告)日：2007-07-17
申请号：US10395166
申请日：2003-03-25
IPC分类号： C07C299/00 , C07D207/04
CPC分类号： C07C227/02 , C07C315/04 , C07C317/48
摘要： The invention is a method for producing δ-aminopentadienoate derivatives of formula (1), the method comprising reacting a streptocyanine derivative of formula (2) with an ester derivative of formula (3) in the presence of an organic base. In formulae (1) to (3), R1 represents an alkyl group or an aryl group; R2, R3, R4 and R5 independently represent a hydrogen atom or an alkyl group; R2 and R3, or R4 and R5 may bond to each other to form a ring; Y represents an electron attractive group; X represents an acid radical; n indicates 0 or a positive number, which is no more than 5; Y may bond to R1 to form a ring
摘要翻译： 本发明是一种生产式（1）的三氨基戊二酸衍生物的方法，该方法包括使式（2）的链花青衍生物与式（3）的酯衍生物在有机碱的存在下反应。 在式（1）至（3）中，R 1表示烷基或芳基; R 2，R 3，R 4和R 5独立地表示氢原子或烷基; R 2和R 3，或R 4和R 5可以彼此键合形成环; Y表示吸电子基团; X表示酸基; n表示0或正数，不大于5; Y可以键合至R 1以形成环
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