公开(公告)号：US20070066615A1

公开(公告)日：2007-03-22

申请号：US10557168

申请日：2004-05-06

Applicant: Christoph Gerdes ,  Elisabeth Perzborn ,  Jens Pohlmann ,  Susanne Rohrig ,  Alexander Straub ,  Christian Thomas ,  Arounarith Tuch ,  Karl-Heinz Schlemmer

Inventor： Christoph Gerdes ,  Elisabeth Perzborn ,  Jens Pohlmann ,  Susanne Rohrig ,  Alexander Straub ,  Christian Thomas ,  Arounarith Tuch ,  Karl-Heinz Schlemmer

IPC: A61K31/5377 ,  A61K31/506 ,  A61K31/496 ,  A61K31/501

CPC classification number: C07D413/14 ,  C07D419/14

Abstract: The present invention relates to the area of blood clotting. The invention relates in particular to certain heterocyclic compounds, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases.

Abstract translation: 本发明涉及血液凝固的面积。 本发明特别涉及某些杂环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途。

公开(公告)号：US07105523B2

公开(公告)日：2006-09-12

申请号：US10432571

申请日：2001-11-09

Applicant: Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

Inventor： Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

IPC: C07D403/04 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: This invention relates to compounds of the formula wherein R1 is H or a di-C1-6-alkylaminocarbonyl raical, and R2 is a radical of the formula —O—C(X)—NR3R4 wherein X is O or S. A process for preparing such compounds, pharmaceutical compositions containing them, and methods for using them in treatment of hypertension are also disclosed and claimed.

Abstract translation: 本发明涉及下式的化合物，其中R 1是H或C 1 -C 6 - 烷基氨基羰基，R 2是 式-OC（X）-NR 3 R 4的基团其中X是O或S.制备这种化合物的方法，含有它们的药物组合物和方法 用于治疗高血压的用途也被公开并要求保护。

公开(公告)号：US20050245553A1

公开(公告)日：2005-11-03

申请号：US11175740

申请日：2005-07-05

Applicant: Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

Inventor： Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

IPC: A61K31/506 ,  A61K45/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  A61K31/513 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula —O—SO2-R3 in which R3 is optionally substituted C1-6-alkyl, optionally substituted C3-8-cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1-6-alkyl-CO— or optionally substituted C1-6-alkyl-SO2—; as well as salts, stereoisomers, tautomers, and hydrates thereof.

Abstract translation: 本发明涉及使用式（I）的吡唑吡啶衍生物治疗心血管疾病，血栓栓塞障碍，炎症和中枢神经系统疾病的方法，其中R 1是式-O的基团 其中R 3是任选取代的C 1-6 - 烷基，任选取代的C 1 -C 6 - C 3-8 - 环烷基或任选取代的苯基; R 2是H，任选取代的C 1-6 - 烷基-CO-或任选取代的C 1-6 - 烷基-S SO > 2 - ; 以及其盐，立体异构体，互变异构体及其水合物。

公开(公告)号：US06833364B1

公开(公告)日：2004-12-21

申请号：US09744703

申请日：2001-03-26

Applicant: Alexander Straub ,  Achim Feurer ,  Cristina Alonso-Alija ,  Elke Stahl ,  Johannes-Peter Stasch ,  Elisabeth Perzborn ,  Joachim Hütter ,  Klaus Dembowsky

Inventor： Alexander Straub ,  Achim Feurer ,  Cristina Alonso-Alija ,  Elke Stahl ,  Johannes-Peter Stasch ,  Elisabeth Perzborn ,  Joachim Hütter ,  Klaus Dembowsky

IPC: A61K31506

CPC classification number: C07D403/04 ,  C07D471/04

Abstract: The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R1, R2, R3, A, X and Y are each as defined, and to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.

Abstract translation: 本发明涉及通式（I）的新的取代的吡唑衍生物，其中取代基R 1，R 2，R 3，A，X和Y各自如上所定义， 制剂和用作药物，特别是用于治疗心血管疾病的药物。

公开(公告)号：US06451805B1

公开(公告)日：2002-09-17

申请号：US09297121

申请日：1999-04-23

Applicant: Alexander Straub ,  Chantal Fürstner ,  Thomas Jaetsch ,  Achim Feurer ,  Raimund Kast ,  Johannes-Peter Stasch ,  Elisabeth Perzborn ,  Joachim Hütter ,  Klaus Dembowsky

Inventor： Alexander Straub ,  Chantal Fürstner ,  Thomas Jaetsch ,  Achim Feurer ,  Raimund Kast ,  Johannes-Peter Stasch ,  Elisabeth Perzborn ,  Joachim Hütter ,  Klaus Dembowsky

IPC: A61K31506

CPC classification number: C07D405/04 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.

Abstract translation: 本发明涉及新的取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。

公开(公告)号：US06387940B1

公开(公告)日：2002-05-14

申请号：US09644179

申请日：2000-08-23

Applicant: Alexander Straub ,  Chantal Fürstner ,  Ulrich Niewöhner ,  Thomas Jaetsch ,  Achim Feurer ,  Raimund Kast ,  Johannes-Peter Stasch ,  Elisabeth Perzborn ,  Joachim Hütter ,  Klaus Dembowsky ,  Dieter Arlt

Inventor： Alexander Straub ,  Chantal Fürstner ,  Ulrich Niewöhner ,  Thomas Jaetsch ,  Achim Feurer ,  Raimund Kast ,  Johannes-Peter Stasch ,  Elisabeth Perzborn ,  Joachim Hütter ,  Klaus Dembowsky ,  Dieter Arlt

IPC: A61K314155

CPC classification number: C07D401/04 ,  C07D263/32 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.

公开(公告)号：US5721248A

公开(公告)日：1998-02-24

申请号：US644880

申请日：1996-05-10

Applicant: Alexander Straub ,  Siegfried Goldmann ,  Jurgen Stoltefuss ,  Martin Bechem ,  Klaus Dembowsky ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

Inventor： Alexander Straub ,  Siegfried Goldmann ,  Jurgen Stoltefuss ,  Martin Bechem ,  Klaus Dembowsky ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/455 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  C07C45/71 ,  C07C45/74 ,  C07C47/546 ,  C07C47/575 ,  C07C49/835 ,  C07C323/09 ,  C07C323/62 ,  C07D209/08 ,  C07D209/44 ,  C07D209/48 ,  C07D211/84 ,  C07D211/90 ,  C07D215/14 ,  C07D241/42 ,  C07D241/48 ,  C07D307/79 ,  C07D311/04 ,  C07D311/08 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/32 ,  C07D311/42 ,  C07D311/58 ,  C07D311/76 ,  C07D333/54 ,  C07D333/62 ,  C07D335/06 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  C07F9/24 ,  A61K31/47

CPC classification number: C07D307/79 ,  C07C323/62 ,  C07C45/71 ,  C07C45/74 ,  C07C47/575 ,  C07C49/835 ,  C07D209/48 ,  C07D211/90 ,  C07D215/14 ,  C07D241/48 ,  C07D311/18 ,  C07D311/32 ,  C07D311/58 ,  C07D311/76 ,  C07D333/54 ,  C07D333/62 ,  C07D335/06 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07F9/242

Abstract: The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

Abstract translation: 本发明涉及在描述中给出的通式（I）的新的4-双环取代的二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。

公开(公告)号：US5412099A

公开(公告)日：1995-05-02

申请号：US103871

申请日：1993-08-06

Applicant: Siegfried Goldmann ,  Horst Boshagen ,  Jurgen Stoltefuss ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

Inventor： Siegfried Goldmann ,  Horst Boshagen ,  Jurgen Stoltefuss ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

IPC: C07D263/56 ,  C07D263/57 ,  C07D277/66 ,  C07D413/04 ,  C07D417/04 ,  C07D491/04

CPC classification number: C07D263/57 ,  C07D277/66 ,  C07D413/04 ,  C07D417/04 ,  C07D491/04

Abstract: Intermediate compounds of formula IIR.sup.3 --CHO (II)wherein R.sup.3 is ##STR1## and R.sup.6 and R.sup.7 are as defined in the specification, are useful to make compounds having cardiovascular activity.

Abstract translation: 式II的中间体化合物R3-CHO（II）其中R3为本文所述，R6和R7如本说明书中所定义，可用于制备具有心血管活性的化合物。

公开(公告)号：US5410055A

公开(公告)日：1995-04-25

申请号：US230579

申请日：1994-04-21

Applicant: Alexander Straub ,  Jurgen Stoltefuss ,  Siegfried Goldmann ,  Rainer Gross ,  Martin Bechem ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

Inventor： Alexander Straub ,  Jurgen Stoltefuss ,  Siegfried Goldmann ,  Rainer Gross ,  Martin Bechem ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

IPC: A61K31/455 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/50 ,  A61P9/04 ,  C07D213/75 ,  C07D237/28 ,  C07D401/04 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D519/00 ,  C07D409/04

CPC classification number: C07D401/04 ,  C07D471/04 ,  C07D491/04

Abstract: The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and intermediates thereof and to their use in medicaments, in particular in compositions having positively inotropic action.

Abstract translation: 本发明涉及通式Ⅰ的新的4-噌啉基和4-萘啶基 - 二氢吡啶，其中R1至R5具有说明书中给出的含义，其制备方法及其中间体以及它们的 用于药物，特别是在具有正性肌力作用的组合物中。

公开(公告)号：US5380851A

公开(公告)日：1995-01-10

申请号：US6432

申请日：1993-01-21

Applicant: Jurgen Stoltefuss ,  Siegfried Goldmann ,  Alexander Straub ,  Horst Boshagen ,  Martin Bechem ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

Inventor： Jurgen Stoltefuss ,  Siegfried Goldmann ,  Alexander Straub ,  Horst Boshagen ,  Martin Bechem ,  Rainer Gross ,  Siegbert Hebisch ,  Joachim Hutter ,  Howard-Paul Rounding

IPC: A61K31/47 ,  A61K31/445 ,  A61K31/4709 ,  A61P9/00 ,  A61P9/04 ,  C07D20060101 ,  C07D211/90 ,  C07D215/12 ,  C07D215/14 ,  C07D215/48 ,  C07D261/06 ,  C07D261/08 ,  C07D401/04 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D215/00 ,  C07D215/16 ,  C07D409/06

CPC classification number: C07D401/04 ,  C07D215/14

Abstract: The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

Abstract translation: 本发明涉及新的2-氨基-5-氰基-4-喹啉-1,4-二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。