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21.发明授权Compositions and methods for treating malaria with cupredoxin and cytochrome 有权用氧还蛋白和细胞色素治疗疟疾的组合物和方法公开(公告)号：US07338766B2
公开(公告)日：2008-03-04
申请号：US11436590
申请日：2006-05-19
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Soo Hong
IPC分类号： C12Q1/68 , C12P21/04 , A61K38/00 , A61K38/44 , C07K14/445
CPC分类号： C07K14/195 , A61K38/00 , C07K14/35 , C07K14/80 , C12N9/0006
摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.
摘要翻译： 本发明涉及氧还蛋白和细胞色素及其分别或一起用于抑制哺乳动物红细胞和其他感染疟原虫的组织中寄生虫血症的扩散，特别是恶性疟原虫人红细胞的寄生虫血症 。 本发明提供了分离的肽，其是铜氧还蛋白或细胞色素c的变体，衍生物或结构等同物，以及可用于治疗或预防哺乳动物疟疾感染的铜氧还蛋白和/或细胞色素c或其变体，衍生物或其结构等同物的组合物。 此外，本发明提供了治疗哺乳动物患者预防或抑制哺乳动物疟疾感染生长的方法。 本发明还提供了防止昆虫载体中疟疾感染生长的方法。
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公开(公告)号：US08232244B2
公开(公告)日：2012-07-31
申请号：US12028683
申请日：2008-02-08
IPC分类号： C07K14/00
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 货物化合物可以是核酸，特别是DNA，RNA或反义词。 本发明还公开了治疗癌症和诊断癌症的方法。
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公开(公告)号：US20080226560A1
公开(公告)日：2008-09-18
申请号：US12028683
申请日：2008-02-08
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 货物化合物可以是核酸，特别是DNA，RNA或反义词。 本发明还公开了治疗癌症和诊断癌症的方法。
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公开(公告)号：US20060292136A1
公开(公告)日：2006-12-28
申请号：US11508173
申请日：2006-08-23
申请人： Ananda Chakrabarty , Tapas Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
发明人： Ananda Chakrabarty , Tapas Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
CPC分类号： C07K14/80 , A61K38/164 , A61K38/168 , A61K38/415 , C07K14/195
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
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公开(公告)号：US10086037B2
公开(公告)日：2018-10-02
申请号：US13561225
申请日：2012-07-30
IPC分类号： A61K38/00 , A61K38/16 , A61K49/00 , A61K49/04 , A61K49/08 , A61K49/14 , C07K14/21 , C07K14/415 , A61M5/00 , C07K14/00 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C12Q1/02 , C12Q1/04 , A61K47/54 , A61K47/64 , B82Y5/00
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
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公开(公告)号：US20130084247A1
公开(公告)日：2013-04-04
申请号：US13561225
申请日：2012-07-30
IPC分类号： A61K38/16 , C07K14/32 , C07K14/235 , C07K14/225 , C07K14/22 , C07K14/21 , C07K14/28 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/22 , C12Q1/02 , C12Q1/04 , A61M5/00 , C07K14/00
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译： 本发明公开了将货物化合物输送到癌细胞中的方法和材料。 货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。 货物化合物可以是核酸，特别是DNA，RNA或反义词。 本发明还公开了治疗癌症和诊断癌症的方法。
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27.发明申请COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO EPHRIN SIGNALING WITH CUPREDOXINS 有权用于治疗与丙泊酚的EPHRIN信号相关的条件的组合物和方法公开(公告)号：US20080312413A1
公开(公告)日：2008-12-18
申请号：US12130705
申请日：2008-05-30
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsento Fialho , Yonghua Zhu
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsento Fialho , Yonghua Zhu
IPC分类号： C07K14/195
CPC分类号： C07K14/21 , A61K38/164 , A61K38/168 , C07K14/195 , C07K14/705
摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof to treat cancer in mammals.
摘要翻译： 本发明涉及使用铜氧还蛋白的组合物和方法，以及干扰哺乳动物细胞中ephrin信号系统的铜氧还蛋白的变体，衍生物和结构等同物。 具体而言，本发明涉及使用铜氧还蛋白的组合物和方法，例如azurin，铁水球蛋白和质体蛋白，以及其在哺乳动物中治疗癌症的变体，衍生物和结构等价物。
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28.发明申请Compositions and methods for treating malaria with cupredoxin and cytochrome 有权用氧还蛋白和细胞色素治疗疟疾的组合物和方法公开(公告)号：US20060251669A1
公开(公告)日：2006-11-09
申请号：US11436590
申请日：2006-05-19
申请人： Ananda Chakrabarty , Tapas Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Hong
发明人： Ananda Chakrabarty , Tapas Gupta , Tohru Yamada , Anita Chaudhari , Arsenio Fialho , Chang Hong
CPC分类号： C07K14/195 , A61K38/00 , C07K14/35 , C07K14/80 , C12N9/0006
摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.
摘要翻译： 本发明涉及氧还蛋白和细胞色素及其分别或一起用于抑制哺乳动物红细胞和其他感染疟原虫的组织中寄生虫血症的扩散，特别是恶性疟原虫人红细胞的寄生虫血症 。 本发明提供了分离的肽，其是铜氧还蛋白或细胞色素c的变体，衍生物或结构等同物，以及可用于治疗或预防哺乳动物疟疾感染的铜氧还蛋白和/或细胞色素c或其变体，衍生物或其结构等同物的组合物。 此外，本发明提供了治疗哺乳动物患者预防或抑制哺乳动物疟疾感染生长的方法。 本发明还提供了防止昆虫载体中疟疾感染生长的方法。
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公开(公告)号：US20060149037A1
公开(公告)日：2006-07-06
申请号：US11244105
申请日：2005-10-06
申请人： Ananda Chakrabarty , Tapas Gupta , Tohru Yamada , Arsenio Fialho
发明人： Ananda Chakrabarty , Tapas Gupta , Tohru Yamada , Arsenio Fialho
IPC分类号： C07K14/195 , C07K14/82
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
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公开(公告)号：US20090202441A1
公开(公告)日：2009-08-13
申请号：US12338480
申请日：2008-12-18
CPC分类号： A61K47/6455 , A61K38/00 , A61K38/03 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0056 , C07K14/195 , C07K14/21 , C07K14/35 , C07K14/415 , C12N9/0004 , G01N33/5011 , G01N33/569 , G01N2510/00
摘要： The present invention discloses methods and materials for killing and/or inhibiting the growth of a cancer cell via preferential entry of a cytotoxic compound. Preferential entry of the cytotoxic compound is accomplished by the use of protein transduction domains derived from cupredoxins, including the p18 and p28 truncations of azurin.
摘要翻译： 本发明公开了通过细胞毒素化合物的优先进入来杀死和/或抑制癌细胞的生长的方法和材料。 细胞毒性化合物的优先进入是通过使用衍生自铜氧还蛋白的蛋白转导结构域，包括azurin的p18和p28截短来完成的。
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