公开(公告)号：US20070074972A1

公开(公告)日：2007-04-05

申请号：US11522815

申请日：2006-09-13

Applicant: Hany Nassef ,  Hou-Pu Chou ,  Michael Lucero ,  Andrew May ,  Kathy Yokobata

Inventor： Hany Nassef ,  Hou-Pu Chou ,  Michael Lucero ,  Andrew May ,  Kathy Yokobata

IPC: C07K1/26

CPC classification number: G01N33/54366 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00389 ,  B01J2219/00398 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N33/5302

Abstract: A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.

Abstract translation: 微流体装置适于执行许多同时结合测定，包括但不限于免疫学实验，例如ELISA测定，初级和次级抗体之间的最小串扰。

公开(公告)号：US20060032477A1

公开(公告)日：2006-02-16

申请号：US10919419

申请日：2004-08-16

Applicant: Andrew May

Inventor： Andrew May

IPC: F02D41/04

CPC classification number: F02D41/3047 ,  F02D19/10 ,  F02D41/0025 ,  F02D41/008 ,  F02D41/3094 ,  Y02T10/36

Abstract: An engine system includes a first fuel regulator adapted to control an amount of a first fuel supplied to the engine, a second fuel regulator adapted to control an amount of a second fuel supplied to the engine concurrently with the first fuel being supplied to the engine, and a controller coupled to at least the second fuel regulator. The controller is adapted to determine the amount of the second fuel supplied to the engine in a relationship to the amount of the first fuel supplied to the engine to operate in igniting the first fuel at a specified time in steady state engine operation and adapted to determine the amount of the second fuel supplied to the engine in a manner different from the relationship at steady state engine operation in transient engine operation.

Abstract translation: 发动机系统包括适于控制供应到发动机的第一燃料的量的第一燃料调节器，适于控制与供应给发动机的第一燃料同时供应给发动机的第二燃料的量的第二燃料调节器， 以及耦合到至少第二燃料调节器的控制器。 控制器适于确定供应给发动机的第二燃料的量与供应给发动机的第一燃料的量相关联，以在稳定状态的发动机运行中在指定时间点燃第一燃料以操作，并适于确定 在瞬时发动机运转中以与稳态发动机运转的关系不同的方式供给发动机的第二燃料的量。

公开(公告)号：US06883318B2

公开(公告)日：2005-04-26

申请号：US10424246

申请日：2003-04-28

Applicant: Oliver A. Warner ,  Mark A. Zurawski ,  Andrew May

Inventor： Oliver A. Warner ,  Mark A. Zurawski ,  Andrew May

IPC: F02D13/04 ,  F02B33/44

CPC classification number: F02D13/04

Abstract: A method of controlling an internal combustion engine when the engine is operating in an engine braking mode is provided. The engine operates in the engine braking mode and an exhaust valve for the cylinder is prematurely opened to dissipate power. The method includes controlling airflow to at least one cylinder based on a comparison of a desired mass airflow rate and an actual mass airflow rate such that the actual mass airflow rate tracks the desired mass airflow rate.

Abstract translation: 提供了一种当发动机以发动机制动模式操作时控制内燃机的方法。 发动机在发动机制动模式下工作，并且用于气缸的排气阀被过早地打开以消散功率。 该方法包括基于所需质量气流速率和实际质量气流速率的比较来控制至少一个气缸的气流，使得实际质量气流速率跟踪期望的质量气流速率。

公开(公告)号：US06305167B1

公开(公告)日：2001-10-23

申请号：US09540017

申请日：2000-03-31

Applicant: Steve Miller Weisman, II ,  Admir Kreso ,  Andrew May

Inventor： Steve Miller Weisman, II ,  Admir Kreso ,  Andrew May

IPC: F02B3724

CPC classification number: F02D41/0052 ,  F02B37/24 ,  G01F1/36 ,  G01F1/42 ,  Y02T10/144 ,  Y02T10/47

Abstract: A method of controlling an internal combustion engine includes determining an exhaust gas recirculation (EGR) command signal based on at least one engine condition, and determining a variable geometry turbocharger (VGT) command signal based on at least one engine condition and at least partially based on the EGR command signal. Advantageously, the EGR system and VGT system may be continuously and simultaneously controlled, taking into account the effects of each system on the other, to provide improved and more precise control over engine air flow. In an alternative embodiment, an engine may be controlled with a feedback control system where engine intake chemical composition is the feedback variable.

Abstract translation: 一种控制内燃机的方法包括：基于至少一个发动机状况来确定排气再循环（EGR）命令信号，以及基于至少一个发动机状况和至少部分基于所述发动机状态确定可变几何涡轮增压器（VGT）命令信号 在EGR指令信号上。 有利地，考虑到每个系统对另一个系统的影响，EGR系统和VGT系统可以被连续和同时控制，以提供对发动机气流的改进和更精确的控制。 在替代实施例中，可以用反馈控制系统来控制发动机，其中发动机进气化学成分是反馈变量。

公开(公告)号：US08157434B2

公开(公告)日：2012-04-17

申请号：US12018138

申请日：2008-01-22

Applicant: David S. Cohen ,  Jing Wang ,  Andrew May ,  Robert C. Jones ,  Hany Nassef

Inventor： David S. Cohen ,  Jing Wang ,  Andrew May ,  Robert C. Jones ,  Hany Nassef

IPC: B01F5/00

CPC classification number: B01L3/502738 ,  B01L3/5025 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0638 ,  B01L2400/0655 ,  B33Y80/00 ,  F16K99/0001 ,  F16K99/0026 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/0318 ,  Y10T137/85938

Abstract: New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.

Abstract translation: 新的高密度微流体装置和方法提供流体体积的精确计量和计量体积的有效混合。 将第一溶液引入与反应室流体连通的流动通道的段中。 第二溶液流过该段，使得第一溶液移入反应室，并且第二溶液的体积进入该室。 然后可以分离室，并且可以启动和/或检测室内的反应。 遗传分析的高通量方法可以比以前更高的精度进行。

公开(公告)号：US08108128B2

公开(公告)日：2012-01-31

申请号：US12415026

申请日：2009-03-31

Applicant: James Richard Zurlo ,  Kevin Paul Konkle ,  Andrew May

Inventor： James Richard Zurlo ,  Kevin Paul Konkle ,  Andrew May

IPC: F02B47/08 ,  F02M25/07 ,  F02D41/26

CPC classification number: F02D41/0052 ,  F02D41/187 ,  F02D2200/0411 ,  Y02T10/47

Abstract: In controlling an engine, an amount of an intake charge provided, during operation of the engine, to a combustion chamber of the engine is determined. The intake charge includes an air component, a fuel component and a diluent component. An amount of the air component of the intake charge is determined. An amount of the diluent component of the intake charge is determined utilizing the amount of the intake charge, the amount of the air component and, in some instances, the amount of the fuel component. An amount of a diluent supplied to the intake charge is adjusted based at least in part on the determined amount of diluent component of the intake charge.

Abstract translation: 在控制发动机时，确定在发动机运转期间向发动机的燃烧室提供的进气量。 进气装置包括空气部件，燃料部件和稀释剂部件。 确定进气量的空气分量的量。 使用进气量的量，空气成分的量以及在某些情况下燃料成分的量来确定进气量的稀释剂成分的量。 至少部分地基于确定的进料量的稀释剂组分的量来调节供应到进气装置的稀释剂的量。

公开(公告)号：US20100273219A1

公开(公告)日：2010-10-28

申请号：US12753703

申请日：2010-04-02

Applicant: Andrew May ,  Peilin Chen ,  Jun Wang ,  Fiona Kaper ,  Megan Anderson

Inventor： Andrew May ,  Peilin Chen ,  Jun Wang ,  Fiona Kaper ,  Megan Anderson

IPC: C12P19/34 ,  C12M1/00

CPC classification number: C12Q1/6806 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/0655 ,  C12Q1/686 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2527/143 ,  C12Q2535/122 ,  C12Q2549/119 ,  C12Q2563/179 ,  C12Q2565/629

Abstract: In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.

Abstract translation: 在某些实施方案中，本发明提供了其中将核苷酸标签和任选的条形码核苷酸序列加入靶核苷酸序列的扩增方法。 在其它实施例中，本发明提供一种包括多个第一输入线和多个第二输入线的微流体装置。 微流体装置还包括多组第一腔室和多组第二腔室。 每组第一腔室与多个第一输入管线中的一个流体连通。 每组第二腔室与多个第二输入管线中的一个流体连通。 微流体装置还包括与多个第二输入线的第一部分流体连通的多个第一泵元件和与多个第二输入线的第二部分流体连通的多个第二泵元件。

公开(公告)号：US20090187009A1

公开(公告)日：2009-07-23

申请号：US12258246

申请日：2008-10-24

Applicant: Andrew May ,  Hany Ramez Nassef

Inventor： Andrew May ,  Hany Ramez Nassef

IPC: C07K1/00 ,  G06F15/00

CPC classification number: B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00756 ,  G01N2035/00207 ,  G01N2035/00237 ,  G16C20/10

Abstract: The present invention provides methods of and systems for translating conditions from a small-volume experiment to a larger-volume experiment.

Abstract translation: 本发明提供了将条件从小体积实验转换成大容量实验的方法和系统。

公开(公告)号：US07402999B2

公开(公告)日：2008-07-22

申请号：US11290916

申请日：2005-11-30

Applicant: Yuri Plotnikov ,  Andrew May ,  Shridhar Nath ,  Changting Wang

Inventor： Yuri Plotnikov ,  Andrew May ,  Shridhar Nath ,  Changting Wang

IPC: G01N27/72

CPC classification number: G01N27/902

Abstract: A pulsed eddy current pipeline inspection device is provided. The pulsed eddy current pipeline inspection device comprises a plurality of stages longitudinally spaced apart from each other and adapted to move between a contracted position and an expanded position, and a plurality of sensors disposed around at least a portion of a circumference of each of the plurality of stages in the contracted position with at least one gap between sensors in each of the plurality of stages in the expanded position, the plurality of sensors being arranged such that the at least one gap in a first one of the plurality of stages is aligned with a portion of a second one of the plurality of stages that has sensors disposed thereon.

Abstract translation: 提供脉冲涡流管道检查装置。 脉冲涡流管道检查装置包括彼此纵向间隔开并适于在收缩位置和扩张位置之间移动的多个级，并且多个传感器设置在多个的每个的圆周的至少一部分周围 在收缩位置的阶段中，在扩展位置的多个阶段中的每个阶段中的传感器之间具有至少一个间隙，多个传感器被布置成使得多个级中的第一级中的至少一个间隙与 多个级中的第二级的一部分具有设置在其上的传感器。

公开(公告)号：US20070120559A1

公开(公告)日：2007-05-31

申请号：US11290916

申请日：2005-11-30

Applicant: Yuri Plotnikov ,  Andrew May ,  Shridhar Nath ,  Changting Wang

Inventor： Yuri Plotnikov ,  Andrew May ,  Shridhar Nath ,  Changting Wang

IPC: G01N27/82

CPC classification number: G01N27/902

Abstract: A pulsed eddy current pipeline inspection device is provided. The pulsed eddy current pipeline inspection device comprises a plurality of stages longitudinally spaced apart from each other and adapted to move between a contracted position and an expanded position, and a plurality of sensors disposed around at least a portion of a circumference of each of the plurality of stages in the contracted position with at least one gap between sensors in each of the plurality of stages in the expanded position, the plurality of sensors being arranged such that the at least one gap in a first one of the plurality of stages is aligned with a portion of a second one of the plurality of stages that has sensors disposed thereon.

Abstract translation: 提供脉冲涡流管道检查装置。 脉冲涡流管道检查装置包括彼此纵向间隔开并适于在收缩位置和扩张位置之间移动的多个级，并且多个传感器设置在多个的每个的圆周的至少一部分周围 在收缩位置的阶段中，在扩展位置的多个阶段中的每个阶段中的传感器之间具有至少一个间隙，多个传感器被布置成使得多个级中的第一级中的至少一个间隙与 多个级中的第二级的一部分具有设置在其上的传感器。