摘要:
A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.
摘要:
An assembly for filtering water includes a housing, a water inlet for supplying unfiltered water to the housing, and a water filter including an outer casing attached to the housing in communication with the water inlet and a filter medium within the outer casing, the water filter filtering the unfiltered water through filter medium to provide filtered water. A water outlet is attached to the housing for transferring filtered water from the outer casing to a device via the housing. Some sort of indicia is located on the outer casing, and an optical device detects a feature of the indicia to determine if the water filter is properly installed in the housing. Related refrigeration appliances incorporating such devices are also disclosed.
摘要:
The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal DNA in a maternal sample or apoptic DNA in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.
摘要:
In certain embodiments, the invention provides amplification methods in which nucleotide tag(s) and a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.
摘要:
New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
摘要:
Apparatus and methodologies are provided to improve the refrigeration system by precisely controlling refrigerator compartment and heat exchanger temperatures through continuous modulation of device speeds or positions to match capacity with instantaneous load. A controller in a refrigerator is configured to provide a plurality of control loops to control various operational aspects of selected components in the refrigerator. A first loop controls the operating speed of a compressor based on temperature of the evaporator or based on the desired speed of an evaporator fan. A second control loop controls speed of an evaporator fan to maintain a prescribed freezer compartment temperature. A third control loop maintains a prescribed temperature in a fresh food compartment. In certain embodiments selected of the control loops may be thermodynamically coupled by way of thermal interaction between the various cooled compartments rather than being electrically coupled. The control loops may be individually configured as one of a proportional, proportional-integral, or proportional-integral-derivative control loop.
摘要:
A consumer refrigeration appliance, such as a refrigerator, includes a refrigeration system charged with a refrigerant and further having a compressor, a condenser, an expansion device, and an evaporator. At least one of the evaporator or condenser is a spine fin heat exchanger having a defined length of tube with a spine fine material configured around at least a portion of tube. The tube has a reduced refrigerant side diameter that provides a reduced refrigerant side area defined by the tube length and refrigerant side diameter. The refrigeration system has a reduced refrigerant charge mass.
摘要:
An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
摘要:
An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.