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    Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
    28.
    发明授权
    Method for inhibiting the binding of low density lipoprotein to blood vessel matrix 失效
    抑制低密度脂蛋白与血管基质结合的方法

    公开(公告)号：US6156315A

    公开(公告)日：2000-12-05

    申请号：US966296

    申请日：1997-11-07

    申请人： Ira J. Goldberg ,  Sivaram Pillarisetti

    发明人： Ira J. Goldberg ,  Sivaram Pillarisetti

    IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/775 ,  C07K16/18 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K38/1709 ,  C07K14/775 ,  C12N2799/022

    摘要： This invention also provides a method of treating atherosclerosis in a subject, comprising administering to the subject an effective amount of a substance capable of binding to the amino-terminal region of apolipoprotein B, thereby treating the atherosclerosis. This invention also provides a method for inhibiting the binding of low density lipoprotein to blood vessel matrix in a subject, comprising administering to the subject an effective amount of a substance capable of competing with the amino-terminal region of apolipoprotein B for binding to blood vessel matrix, thereby inhibiting the binding of low density lipoprotein to blood vessel matrix. This invention also provides a method for identifying a compound capable of ameliorating atherosclerosis. Additionally, this invention provides a kit for inhibiting the binding of low density lipoprotein to blood vessel matrix, wherein the kit comprises a substance capable of binding to the amino-terminal region of apolipoprotein B.

    摘要翻译： 本发明还提供一种治疗受试者的动脉粥样硬化的方法，其包括向受试者施用有效量的能够结合载脂蛋白B的氨基末端区域的物质，从​​而治疗动脉粥样硬化。 本发明还提供一种抑制受试者中低密度脂蛋白与血管基质的结合的方法，其包括向受试者施用有效量的与载脂蛋白B的氨基末端区域竞争结合血管的物质 从而抑制低密度脂蛋白与血管基质的结合。 本发明还提供了鉴定能够改善动脉粥样硬化的化合物的方法。 此外，本发明提供了一种用于抑制低密度脂蛋白与血管基质结合的试剂盒，其中该试剂盒包含能够结合载脂蛋白B的氨基末端区域的物质。