公开(公告)号：US08767049B2

公开(公告)日：2014-07-01

申请号：US12506521

申请日：2009-07-21

申请人： Arash Kheradvar ,  Michael A. Sutton

发明人： Arash Kheradvar ,  Michael A. Sutton

IPC分类号： H04N13/02 ,  G01J5/04

CPC分类号： A61B5/1107 ,  A61B5/05

摘要： In accordance with one embodiment of the present disclosure, a method for deformation mapping of a tissue is provided. The method includes utilizing a device to measure transient three-dimensional deformations in a tissue sample. The device comprises a non-contacting, high-speed stereo imaging apparatus and a mechanism for digital image correlation. The method further includes identifying regions of the tissue that are prone to damage based upon the deformations.

摘要翻译： 根据本公开的一个实施例，提供了一种用于组织的变形映射的方法。 该方法包括利用装置来测量组织样本中的瞬时三维变形。 该装置包括非接触式高速立体成像装置和用于数字图像相关的机构。 该方法还包括基于变形来识别容易损坏的组织区域。

公开(公告)号：US20090164003A1

公开(公告)日：2009-06-25

申请号：US12341170

申请日：2008-12-22

申请人： Arash Kheradvar

发明人： Arash Kheradvar

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2230/0008 ,  A61F2230/0078 ,  A61F2230/0095

摘要： In accordance with one embodiment of the present disclosure, a prosthetic valve is provided. The prosthetic valve includes an annulus, a pair of leaflets, and a pair of support elements. The annulus has a generally saddle-shape formed by a movable pair of first portions separated from each other by a movable pair of second portions. The pair of leaflets extend from the annulus and are separated from each other by the pair of support elements. The first portions of the annulus and the second portions of the annulus are configured to move back and forth from being generally concave to being generally convex such that any movement of the first portions of the annulus occurs at generally the same time as any movement of the second portions of the annulus.

摘要翻译： 根据本公开的一个实施例，提供了一种人造瓣膜。 假体瓣膜包括环状物，一对传单和一对支撑元件。 所述环形体通常由可移动的一对第二部分彼此分开的可移动的一对第一部分形成。 一对传单从环形部分延伸，并通过一对支撑元件彼此分开。 环的第一部分和环的第二部分被配置为从大体上凹入到前后大体上是凸起的，使得环的第一部分的任何运动通常发生在任何运动的同时 环的第二部分。

公开(公告)号：US08936650B2

公开(公告)日：2015-01-20

申请号：US13427807

申请日：2012-03-22

申请人： Seyedhamed Alavi ,  Arash Kheradvar

发明人： Seyedhamed Alavi ,  Arash Kheradvar

IPC分类号： A61F2/02 ,  C12N5/02 ,  C12N5/071 ,  A61L27/54 ,  C12N5/00 ,  A61F2/24 ,  A61L27/34 ,  A61L27/38 ,  A61L27/56 ,  A61L27/04

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2415 ,  A61F2/90 ,  A61F2240/001 ,  A61K35/12 ,  A61L27/047 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/3886 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/18 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0691 ,  C12N2501/15 ,  C12N2533/10 ,  C12N2533/54 ,  C08L89/06

摘要： Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.

摘要翻译： 描述的是足够强的足以抵抗存在于身体内部的力的支架，同时具有生物相容的表面。 支架由一层由多层生物基质紧密封闭的网状物（例如不锈钢或镍钛诺）形成。 生物基质可以包括三层，直接形成在金属网上的第一层（平滑肌细胞），形成在第一层上的第二层（成纤维细胞/肌成纤维细胞）和形成在第一层上的第三层（内皮细胞） 第二层。 支架可以形成为作为各种组织操作，例如心脏瓣膜或血管移植物。 例如，网孔和相应的生物基质可以形成为小叶，使得支架可用作组织心脏瓣膜。

公开(公告)号：US08900862B2

公开(公告)日：2014-12-02

申请号：US13427843

申请日：2012-03-22

申请人： Sayedhamed Alavi ,  Arash Kheradvar

发明人： Sayedhamed Alavi ,  Arash Kheradvar

IPC分类号： C12N5/071 ,  A61F2/06 ,  A61F2/24 ,  A61L27/34 ,  C12N5/00 ,  A61L27/54 ,  A61L27/38 ,  A61L27/56 ,  A61L27/04

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2415 ,  A61F2/90 ,  A61F2240/001 ,  A61K35/12 ,  A61L27/047 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/3886 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/18 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0691 ,  C12N2501/15 ,  C12N2533/10 ,  C12N2533/54 ,  C08L89/06

摘要： Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.

摘要翻译： 描述的是足够强的足以抵抗存在于身体内部的力的支架，同时具有生物相容的表面。 支架由一层由多层生物基质紧密封闭的网状物（例如不锈钢或镍钛诺）形成。 生物基质可以包括三层，直接形成在金属网上的第一层（平滑肌细胞），形成在第一层上的第二层（成纤维细胞/肌成纤维细胞）和形成在第一层上的第三层（内皮细胞） 第二层。 支架可以形成为作为各种组织操作，例如心脏瓣膜或血管移植物。 例如，网孔和相应的生物基质可以形成为小叶，使得支架可用作组织心脏瓣膜。

公开(公告)号：US20120244617A1

公开(公告)日：2012-09-27

申请号：US13427843

申请日：2012-03-22

申请人： Seyedhamed Alavi ,  Arash Kheradvar

发明人： Seyedhamed Alavi ,  Arash Kheradvar

IPC分类号： C12N5/0775 ,  C12N5/071

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2415 ,  A61F2/90 ,  A61F2240/001 ,  A61K35/12 ,  A61L27/047 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/3886 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/18 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0691 ,  C12N2501/15 ,  C12N2533/10 ,  C12N2533/54 ,  C08L89/06

摘要： Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.

公开(公告)号：US20100038336A1

公开(公告)日：2010-02-18

申请号：US12539061

申请日：2009-08-11

申请人： Arash Kheradvar ,  Wilfried Karmaus

发明人： Arash Kheradvar ,  Wilfried Karmaus

IPC分类号： A61J9/04

CPC分类号： A61J9/04 ,  A61J9/003

摘要： In accordance with certain embodiments of the present disclosure, a nursing bottle is provided. The bottle includes a body having a hollow interior and defining an upper opening. The bottle further includes a nipple joined to the body and disposed over the upper opening. The bottle also includes a means for generating negative pressure within a portion of the interior of the body.

摘要翻译： 根据本公开的某些实施例，提供了一种护理瓶。 瓶子包括具有中空内部并限定上开口的主体。 瓶子还包括连接到主体并设置在上部开口上的乳头。 瓶子还包括用于在身体内部的一部分内产生负压的装置。

公开(公告)号：US20090292306A1

公开(公告)日：2009-11-26

申请号：US12472092

申请日：2009-05-26

申请人： Arash Kheradvar ,  Mark H. DeLegge

发明人： Arash Kheradvar ,  Mark H. DeLegge

IPC分类号： A61M29/02

CPC分类号： A61F5/0036 ,  A61M29/02

摘要： In accordance with certain embodiments of the present disclosure, a device for treatment of obesity in a patient is provided. The device comprises an inflatable material and a flexible ring-shaped member. The inflatable material is joined to the flexible ring-shaped member to define a space that is configured to be expanded when the device is inflated to a generally torus shape, the ring-shaped member defining an opening therethrough.

摘要翻译： 根据本公开的某些实施例，提供了一种用于治疗患者中的肥胖的装置。 该装置包括可膨胀材料和柔性环形构件。 可膨胀材料连接到柔性环形构件以限定被构造为当装置膨胀至大致环形形状时膨胀的空间，环形构件限定穿过其中的开口。

公开(公告)号：US08915387B2

公开(公告)日：2014-12-23

申请号：US12539061

申请日：2009-08-11

申请人： Arash Kheradvar ,  Wilfried Karmaus

发明人： Arash Kheradvar ,  Wilfried Karmaus

IPC分类号： B65B1/04 ,  A61J9/04 ,  A61J9/00

CPC分类号： A61J9/04 ,  A61J9/003

摘要： In accordance with certain embodiments of the present disclosure, a nursing bottle is provided. The bottle includes a body having a hollow interior and defining an upper opening. The bottle further includes a nipple joined to the body and disposed over the upper opening. The bottle also includes a means for generating negative pressure within a portion of the interior of the body.

摘要翻译： 根据本公开的某些实施例，提供了一种护理瓶。 瓶子包括具有中空内部并限定上开口的主体。 瓶子还包括连接到主体并设置在上部开口上的乳头。 瓶子还包括用于在身体内部的一部分内产生负压的装置。

公开(公告)号：US20120245706A1

公开(公告)日：2012-09-27

申请号：US13427807

申请日：2012-03-22

申请人： Seyedhamed Alavi ,  Arash Kheradvar

发明人： Seyedhamed Alavi ,  Arash Kheradvar

IPC分类号： A61F2/02

CPC分类号： A61F2/2418 ,  A61F2/07 ,  A61F2/2415 ,  A61F2/90 ,  A61F2240/001 ,  A61K35/12 ,  A61L27/047 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3826 ,  A61L27/3886 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/18 ,  A61L2430/20 ,  C12N5/0068 ,  C12N5/0691 ,  C12N2501/15 ,  C12N2533/10 ,  C12N2533/54 ,  C08L89/06

摘要： Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.

摘要翻译： 描述的是足够强的足以抵抗存在于身体内部的力的支架，同时具有生物相容的表面。 支架由一层由多层生物基质紧密封闭的网状物（例如不锈钢或镍钛诺）形成。 生物基质可以包括三层，直接形成在金属网上的第一层（平滑肌细胞），形成在第一层上的第二层（成纤维细胞/肌成纤维细胞）和形成在第一层上的第三层（内皮细胞） 第二层。 支架可以形成为作为各种组织操作，例如心脏瓣膜或血管移植物。 例如，网孔和相应的生物基质可以形成为小叶，使得支架可用作组织心脏瓣膜。

公开(公告)号：US20100016711A1

公开(公告)日：2010-01-21

申请号：US12506521

申请日：2009-07-21

申请人： Arash Kheradvar ,  Michael A. Sutton

发明人： Arash Kheradvar ,  Michael A. Sutton

IPC分类号： A61B5/05

CPC分类号： A61B5/1107 ,  A61B5/05

摘要： In accordance with one embodiment of the present disclosure, a method for deformation mapping of a tissue is provided. The method includes utilizing a device to measure transient three-dimensional deformations in a tissue sample. The device comprises a non-contacting, high-speed stereo imaging apparatus and a mechanism for digital image correlation. The method further includes identifying regions of the tissue that are prone to damage based upon the deformations.

摘要翻译： 根据本公开的一个实施例，提供了一种用于组织的变形映射的方法。 该方法包括利用装置来测量组织样本中的瞬时三维变形。 该装置包括非接触式高速立体成像装置和用于数字图像相关的机构。 该方法还包括基于变形来识别容易损坏的组织区域。