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35 条记录 (耗时 0.039 秒)

    Fredericamycin derivatives as medicaments for treating tumours
    22.
    发明授权
    Fredericamycin derivatives as medicaments for treating tumours 失效
    弗雷德霉素衍生物作为治疗肿瘤的药物

    公开(公告)号：US07244741B2

    公开(公告)日：2007-07-17

    申请号：US10520421

    申请日：2003-07-09

    申请人： Werner Simon ,  Ulrich Abel

    发明人： Werner Simon ,  Ulrich Abel

    IPC分类号： A61K31/473 ,  C07D221/20

    CPC分类号： C07D221/20

    摘要： The invention relates to novel fredericamycin derivatives of general formula (Ia) or (Ib), to medicaments containing the fredericamycin derivatives or salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially tumor diseases.

    摘要翻译： 本发明涉及通式（Ia）或（Ib）的新型fredericamycin衍生物，涉及含有fredericamycin衍生物或其盐的药物，以及使用fredericamycin衍生物治疗疾病，特别是肿瘤疾病。

    Screw unit with transversely adjustable support sleeve
    25.
    发明授权
    Screw unit with transversely adjustable support sleeve 失效
    带横向可调支撑套筒的螺丝单元

    公开(公告)号：US6062791A

    公开(公告)日：2000-05-16

    申请号：US242149

    申请日：1999-02-09

    申请人： Werner Simon

    发明人： Werner Simon

    IPC分类号： F16B5/02 ,  F16B43/00 ,  F16B43/02

    CPC分类号： F16B5/0233

    摘要： The screw unit for the adjustable and lockable spanning of distances between structural components, brackets, and for adjusting assemblies, etc., consists of a threaded pin, which has adjusting surfaces and a central bore passing through it, and a nut, which is screwed onto the threaded pin. This nut is designed as a support sleeve with an internal thread and adjusting surfaces, into which the threaded pin can be screwed until it is more or less flush. On the end facing an adjusting collar, the support sleeve is provided with an inward-projecting, ring-shaped collar with the internal thread, whereas the free end of the threaded pin is provided with a stop element to prevent the pin from being completely unscrewed.So that the unit can be adjusted not only in the height direction but also in the direction perpendicular to that, the support sleeve is attached to a sliding support element so that it can be shifted in the direction perpendicular to the longitudinal axis of the screw unit, the support element itself being held in place on a spacer.

    摘要翻译： PCT No.PCT / EP98 / 03273。 371日期1999年2月9日 102（e）1999年2月9日PCT PCT。1998年6月2日PCT公布。 出版物WO98 / 58180 日期1998年12月23日用于可调节和可锁定的结构部件，支架和用于调整组件之间的距离的螺钉单元由具有调节表面和穿过其的中心孔的螺纹销组成， 螺母，拧在螺纹销上。 该螺母设计为具有内螺纹和调节表面的支撑套筒，螺纹销可以拧入螺母，直到其或多或少地齐平。 在面向调节环的端部，支撑套筒设置有具有内螺纹的向内突出的环形套环，而螺纹销的自由端设置有止动元件，以防止销完全拧开 。 因此，该单元不仅可以在高度方向上而且也可以在垂直于该方向的方向上进行调节，所以支撑套筒附接到滑动支撑元件，使得其能够在与螺钉单元的纵向轴线垂直的方向上移动 支撑元件本身被保持在间隔件上的适当位置。

    Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
    26.
    发明授权
    Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy 有权
    设计用于肿瘤治疗的阿片剂药物治疗细胞表面结合组分

    公开(公告)号：US09233173B2

    公开(公告)日：2016-01-12

    申请号：US13263287

    申请日：2010-04-08

    申请人： Heinz Faulstich ,  Gerhard Moldenhauer ,  Werner Simon ,  Jan Anderl ,  Christoph Müller

    发明人： Heinz Faulstich ,  Gerhard Moldenhauer ,  Werner Simon ,  Jan Anderl ,  Christoph Müller

    IPC分类号： A61K47/48 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

    CPC分类号： A61K47/48492 ,  A61K47/6831 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/92

    摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

    摘要翻译： 本发明涉及肿瘤治疗。 在一个方面，本发明涉及毒素和靶结合部分的缀合物，例如， 抗体，其可用于治疗癌症。 特别地，毒素是一种amatoxin，靶结合部分优选针对肿瘤相关抗原。 特别地，通过接头部分将该amatoxin与抗体结合。 特别地，连接体部分共价结合到位于氨苄西毒素位置的官能团，其被证明作为关于最佳抗肿瘤活性的连接子的优选位置。 在另一方面，本发明涉及包含这种靶结合部分毒素缀合物的药物组合物以及这种靶结合部分毒素缀合物用于制备这种药物组合物的用途。 靶结合部分毒素缀合物和本发明的药物组合物可用于治疗癌症。