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    Storage-Stable Dust-Free Homogeneous Particulate Formulation
    23.
    发明申请
    Storage-Stable Dust-Free Homogeneous Particulate Formulation 有权
    储存稳定的无尘均匀颗粒制剂

    公开(公告)号：US20140086992A1

    公开(公告)日：2014-03-27

    申请号：US14036365

    申请日：2013-09-25

    Applicant: BASF SE

    Inventor： Felicitas Guth ,  Karl Kolter ,  Michael Schönherr ,  Michael Klemens Müller

    IPC: A61K9/16

    CPC classification number: A61K9/1617 ,  A61K9/1682 ,  A61K47/22 ,  A61K47/32

    Abstract: Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.

    Abstract translation: 描述了储存稳定的无尘均匀颗粒制剂。 该制剂包含（a）至少一种水溶性维生素E衍生物，（b）至少一种亲水性聚合物，（c）任选地附加的表面活性物质，和（d）任选的另外的药物添加剂。 （a），（b），（c）和（d）的总和等于制剂重量的100％。 粒径小于100μm的细小部分小于10重量％。 还描述了制备制剂的方法，以及在药物制剂中使用该制剂作为增溶组合物。

    Use Of Polyether-Based And Vinyl Monomer-Based Copolymers As Binders For Dosing Forms Comprising Solid Active Ingredients
    24.
    发明申请
    Use Of Polyether-Based And Vinyl Monomer-Based Copolymers As Binders For Dosing Forms Comprising Solid Active Ingredients 审中-公开
    使用基于聚醚和乙烯基单体的共聚物作为包含固体活性成分的剂型的粘合剂

    公开(公告)号：US20130123373A1

    公开(公告)日：2013-05-16

    申请号：US13732833

    申请日：2013-01-02

    Applicant: BASF SE

    Inventor： Kathrin Meyer-Böhm ,  Rainer Dobrawa ,  Angelika Maschke ,  Karl Kolter

    IPC: A61K47/34 ,  A61K9/20

    CPC classification number: A61K47/34 ,  A61K9/1641 ,  A61K9/2031 ,  A61K9/2095

    Abstract: The use of water-soluble or water-dispersible copolymers which are obtained by free radical-initiated polymerization of a mixture of i) 30 to 80% by weight N-vinyllactam, ii) 10 to 50% by weight vinylacetate and iii) 10 to 50% by weight of a polyether, with the proviso that the total of i), ii) and iii) is equal to 100% by weight, as binders for producing solid active ingredient-containing dosage forms.

    Abstract translation: 使用水溶性或水分散性共聚物，其通过i）30至80重量％的N-乙烯基内酰胺的混合物的自由基引发聚合获得，ii）10至50重量％的乙酸乙烯酯和iii）10至 50重量％的聚醚，条件是i），ii）和iii）的总量等于100重量％，作为用于生产含固体活性成分的剂型的粘合剂。

    Storage-Stable Dust-Free Homogeneous Particulate Formulation Comprising At Least One Water-Soluble Vitamin E-Derivative And At Least One Hydrophilic Polymer
    29.
    发明申请
    Storage-Stable Dust-Free Homogeneous Particulate Formulation Comprising At Least One Water-Soluble Vitamin E-Derivative And At Least One Hydrophilic Polymer 有权
    储存稳定的无尘均匀颗粒配方包含至少一种水溶性维生素E衍生物和至少一种亲水性聚合物

    公开(公告)号：US20140086993A1

    公开(公告)日：2014-03-27

    申请号：US14036445

    申请日：2013-09-25

    Applicant: BASF SE

    Inventor： Felicitas Guth ,  Karl Kolter ,  Michael Schönherr ,  Franz Weber

    IPC: A61K47/22 ,  A61K47/32

    CPC classification number: A61K47/22 ,  A61K47/32

    Abstract: A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble Vitamin E-derivative and at least one hydrophilic polymer. In one embodiment the storage-stable dust-free homogeneous particle formulation, consists of (j) at least one water-soluble Vitamin E-derivative, (k) at least one hydrophilic polymer, (l) optionally additional surface-active substances, and (m) optionally additional pharmaceutical additives, with the proviso, that the sum of (a), (b), (c) and (d) equals 100% by weight of the formulation, and wherein the fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Methods of making the particulate formulation by a spray granulation process are also provided.

    Abstract translation: 包含至少一种水溶性维生素E衍生物和至少一种亲水性聚合物的储存稳定的无尘均质颗粒制剂。 在一个实施方案中，储存稳定的无尘均质颗粒制剂由（j）至少一种水溶性维生素E衍生物，（k）至少一种亲水性聚合物，（l）任选地附加的表面活性物质组成，以及 （m）任选的另外的药物添加剂，条件是（a），（b），（c）和（d）的总和等于制剂的100重量％，并且其中粒径小于 小于100重量％。 还提供了通过喷雾造粒方法制备颗粒制剂的方法。

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