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21.
公开(公告)号:US20120295842A1
公开(公告)日:2012-11-22
申请号:US13339448
申请日:2011-12-29
申请人: Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
发明人: Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
CPC分类号: C07D487/04
摘要: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐,酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号:US20110124073A1
公开(公告)日:2011-05-26
申请号:US12860799
申请日:2010-08-20
申请人: Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
发明人: Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
CPC分类号: C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要: The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
摘要翻译: 本公开确定了赋予工程生物体的改善的工业适应性的途径和机制。 它还公开了具有改善的工业适应性的工程生物。 公开了合成生物工程模块,其提供轻捕获,二氧化碳固定,NADH生产,NADPH生产,耐热性,pH耐受性,烟气耐受性,耐盐性,营养独立性和近红外吸光度。 所公开的工程生物体可以包括这些模块中的一个或多个。 还提供了使用工程生物体产生感兴趣的碳基产物,生物质或药剂的方法。
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公开(公告)号:US20090213131A1
公开(公告)日:2009-08-27
申请号:US12200704
申请日:2008-08-28
申请人: Tony DeRose , Mark Meyer , Tom Sanocki , Brian Green
发明人: Tony DeRose , Mark Meyer , Tom Sanocki , Brian Green
IPC分类号: G09G5/00
CPC分类号: G06T13/00 , G06T13/20 , G06T13/40 , G06T17/20 , G06T2213/00
摘要: Mesh data and other proximity information from the mesh of one model can be transferred to the mesh of another model, even with different topology and geometry. A correspondence can be created for transferring or sharing information between points of a source mesh and points of a destination mesh. Information can be “pushed through” the correspondence to share or otherwise transfer data from one mesh to its designated location at another mesh. Correspondences can be authored on a source mesh by drawing or placing one or more geometric primitives (e.g., points, lines, curves, volumes, etc.) at the source mesh and corresponding geometric primitives at the destination mesh. A collection of “feature curves” may be placed to partition the source and destination meshes into a collection of “feature regions” resulting in partitions or “feature curve networks” for constructing correspondences between all points of one mesh and all points of another mesh.
摘要翻译: 即使具有不同的拓扑和几何形状,网格数据和一个模型的网格的其他邻近信息也可以传输到另一个模型的网格中。 可以创建用于在源网格的点和目标网格的点之间传送或共享信息的通信。 信息可以“推”通信,以共享或以其他方式将数据从一个网格传输到另一个网格的指定位置。 可以通过在源网格上绘制或放置一个或多个几何基元(例如,点,线,曲线,体积等)并在目的地网格上对应的几何图元来在源网格上创作对应关系。 可以将“特征曲线”的集合放置成将源网格和目的网格划分为“特征区域”的集合,从而产生分区或“特征曲线网络”,用于构建一个网格的所有点与另一个网格的所有点之间的对应关系。
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公开(公告)号:US20070232627A1
公开(公告)日:2007-10-04
申请号:US11613810
申请日:2006-12-20
申请人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号: A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20070079971A1
公开(公告)日:2007-04-12
申请号:US11561671
申请日:2006-11-20
申请人: Brian Green
发明人: Brian Green
IPC分类号: A62C37/08
摘要: A sprinkler head assembly includes a sprinkler head body, a frame including a pair of arms extending from the body from opposed sides of the body, and a deflector mounted to the frame spaced from the outlet opening of the sprinkler head body for deflecting fire extinguishing liquid flowing from the outlet opening. The sprinkler head assembly is adapted to direct a greater proportion of the fire extinguishing liquid from one side of the sprinkler body than the other side of the sprinkler body.
摘要翻译: 一种喷洒头组件,包括一喷洒头主体,一框架,包括一对从本体的主体相对侧延伸的臂,以及安装在与喷洒头主体出口开口隔开的框架上的偏转器,用于偏转灭火液体 从出口开口流出。 喷洒头组件适于从喷洒器主体一侧的喷射器主体的另一侧引导更大比例的灭火液。
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公开(公告)号:USD525670S1
公开(公告)日:2006-07-25
申请号:US29232468
申请日:2005-06-17
申请人: Brian Green
设计人: Brian Green
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公开(公告)号:US20060031779A1
公开(公告)日:2006-02-09
申请号:US11140597
申请日:2005-05-26
申请人: David Theurer , Bernd Christiansen , Brian Green , Klaus Schauser , Thorsten Von Eicken , Albert Alexandrov , Rafael Saavedra
发明人: David Theurer , Bernd Christiansen , Brian Green , Klaus Schauser , Thorsten Von Eicken , Albert Alexandrov , Rafael Saavedra
IPC分类号: G06F3/00
CPC分类号: G06F3/1454 , G09G5/14 , G09G2310/04 , G09G2340/10 , H04L12/1813
摘要: The present invention relates to systems and methods for providing screen sharing techniques to selectively share portions of the screen between a source node and a consumer node. The source node, such as the computer of a presenter of an online meeting, may transmit screen data to a consumer node, such as the computer of an attendee of the online meeting. The consumer or attendee computer uses the screen data to display the screen of the source or presenter's computer. The techniques of the present invention provide a mechanism for not sharing a selective portion of the presenter's screen during screen sharing. So, although a certain element may be displayed on the screen of the presenter, the present invention prevents an attendee from viewing the user interface element in the screen share session.
摘要翻译: 本发明涉及用于提供屏幕共享技术以选择性地共享源节点和消费者节点之间的屏幕的部分的系统和方法。 源节点,诸如在线会议的演示者的计算机,可以向诸如在线会议的与会者的计算机的消费者节点发送屏幕数据。 消费者或参加者计算机使用屏幕数据来显示源或演示者的计算机的屏幕。 本发明的技术提供了一种用于在屏幕共享期间不共享演示者屏幕的选择性部分的机制。 因此,尽管可以在演示者的屏幕上显示特定元素,但是本发明防止参加者在屏幕共享会话中观看用户界面元素。
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公开(公告)号:US06308429B1
公开(公告)日:2001-10-30
申请号:US09283782
申请日:1999-04-01
申请人: Brian Green , Sean Miller
发明人: Brian Green , Sean Miller
IPC分类号: G01B338
摘要: A portable gaging system is used to measure a seal gap for a vehicle door or decklid. The gaging system includes gage assemblies that are removably mounted on a door or decklid flange. The gages are spaced apart from one another about the perimeter of the door or decklid to simultaneously measure the seal gap at various locations. A probe member is supported on each of the gaging assemblies and is selectively moveable between a rest position and an actuated position by the vehicle door as the door is moved from an open to a closed position. Each of the gage assemblies has a sensor for producing an electronic signal representative of gap size based upon movement of the probe member. A portable processor unit receives and stores the electronic signals produced by each of the gage assemblies. A remote actuator is used to generate an activation signal to initiate the gap measurements. An adapter assembly can be removably mounted to the gage body to provide extended support for the probe for measuring larger gap sizes.
摘要翻译: 便携式测量系统用于测量车门或甲板车的密封间隙。 测量系统包括可移除地安装在门或甲板法兰上的量具组件。 量具相互间隔开门或甲板的周边,以同时测量各个位置处的密封间隙。 探针构件被支撑在每个测量组件上,并且当门从打开位置移动到关闭位置时,可以通过车门在静止位置和致动位置之间选择性地移动。 每个量规组件具有用于根据探针构件的移动产生代表间隙尺寸的电子信号的传感器。 便携式处理器单元接收并存储由每个量具组件产生的电子信号。 远程致动器用于产生激活信号以启动间隙测量。 适配器组件可拆卸地安装到量规体上,以为探头提供扩展的支撑以测量更大的间隙尺寸。
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29.
公开(公告)号:US08951964B2
公开(公告)日:2015-02-10
申请号:US13339448
申请日:2011-12-29
申请人: Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
发明人: Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
IPC分类号: A61K38/00 , A01N37/18 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐,酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号:US08737532B2
公开(公告)日:2014-05-27
申请号:US13485746
申请日:2012-05-31
申请人: Brian Green , Javier Elenes
发明人: Brian Green , Javier Elenes
CPC分类号: H04L25/0262 , H04H40/18 , H04L7/0029 , H04L7/005 , H04L25/05
摘要: A method and apparatus for adjusting a sample rate for an asynchronous sample rate converter is disclosed. In one embodiment, an apparatus includes an asynchronous sample rate converter (ASRC) that is configured to receive a digital data stream provided at a first sample rate. The ASRC is configured to convert the digital data stream to a second sample rate at which it is output. The apparatus also includes a sample rate estimator coupled to an interface through which samples from the digital data stream are conveyed subsequent to conversion to the second sample rate. The sample rate estimator is further coupled to the ASRC, and configured to adjust the second sample rate based on information obtained from the interface.
摘要翻译: 公开了一种用于调整异步采样率转换器采样率的方法和装置。 在一个实施例中,一种装置包括异步采样率转换器(ASRC),其被配置为接收以第一采样率提供的数字数据流。 ASRC被配置为将数字数据流转换成其输出的第二采样率。 该装置还包括耦合到接口的采样率估计器,通过该接口,来自数字数据流的样本在转换到第二采样率之后被传送。 采样率估计器还耦合到ASRC,并且被配置为基于从接口获得的信息来调整第二采样率。
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