公开(公告)号：US20130062677A1

公开(公告)日：2013-03-14

申请号：US13228767

申请日：2011-09-09

申请人： Zhengwen Li ,  Damon B. Farmer ,  Michael P. Chudzik ,  Keith Kwong Hon Wong ,  Jian Yu ,  Zhen Zhang ,  Chengwen Pei

发明人： Zhengwen Li ,  Damon B. Farmer ,  Michael P. Chudzik ,  Keith Kwong Hon Wong ,  Jian Yu ,  Zhen Zhang ,  Chengwen Pei

IPC分类号： H01L21/20 ,  H01L27/06

CPC分类号： H01L27/10829 ,  H01L21/84 ,  H01L27/10861 ,  H01L27/1203 ,  H01L28/91 ,  H01L29/945

摘要： A memory device, and a method of forming a memory device, is provided that includes a capacitor with a lower electrode of a metal semiconductor alloy. In one embodiment, the memory device includes a trench present in a semiconductor substrate including a semiconductor on insulating (SOI) layer on top of a buried dielectric layer, wherein the buried dielectric layer is on top of a base semiconductor layer. A capacitor is present in the trench, wherein the capacitor includes a lower electrode of a metal semiconductor alloy having an upper edge that is self-aligned to the upper surface of the base semiconductor layer, a high-k dielectric node layer, and an upper electrode of a metal. The memory device further includes a pass transistor in electrical communication with the capacitor.

摘要翻译： 提供一种存储器件和形成存储器件的方法，其包括具有金属半导体合金的下电极的电容器。 在一个实施例中，存储器件包括存在于半导体衬底中的沟槽，其包括在掩埋介电层顶部上的绝缘（SOI）半导体层，其中所述掩埋介电层位于基底半导体层的顶部。 电容器存在于沟槽中，其中电容器包括金属半导体合金的下电极，其具有与基底半导体层的上表面自对准的上边缘，高k电介质节点层和上层 金属电极。 存储器件还包括与电容器电连通的传输晶体管。

公开(公告)号：US20120119302A1

公开(公告)日：2012-05-17

申请号：US12944018

申请日：2010-11-11

申请人： Chengwen Pei ,  Jeffrey B. Johnson ,  Zhengwen Li ,  Jian Yu

发明人： Chengwen Pei ,  Jeffrey B. Johnson ,  Zhengwen Li ,  Jian Yu

IPC分类号： H01L23/532 ,  H01L21/28 ,  H01L29/78

CPC分类号： H01L21/76879 ,  H01L21/26586 ,  H01L21/28518 ,  H01L21/76805 ,  H01L23/485 ,  H01L29/41766 ,  H01L29/517 ,  H01L29/66545 ,  H01L29/66636 ,  H01L2924/0002 ,  H01L2924/00

摘要： An electrical structure is provided that includes a dielectric layer present on a semiconductor substrate and a via opening present through the dielectric layer.An interconnect is present within the via opening. A metal semiconductor alloy contact is present in the semiconductor substrate. The metal semiconductor alloy contact has a perimeter defined by a convex curvature relative to a centerline of the via opening. The endpoints for the convex curvature that defines the metal semiconductor alloy contact are aligned to an interface between a sidewall of the via opening, a sidewall of the interconnect and an upper surface of the semiconductor substrate.

摘要翻译： 提供一种电结构，其包括存在于半导体衬底上的电介质层和通过电介质层存在的通路开口。 在通孔开口内存在互连。 在半导体衬底中存在金属半导体合金接触。 金属半导体合金触点具有由相对于通孔开口的中心线的凸曲面限定的周长。 限定金属半导体合金触点的凸曲率的端点与通孔开口的侧壁，互连的侧壁和半导体衬底的上表面之间的界面对准。

公开(公告)号：US20110090898A1

公开(公告)日：2011-04-21

申请号：US12582653

申请日：2009-10-20

申请人： Vipul Patel ,  Scott Miller ,  Mehul Shah ,  Jian Yu

发明人： Vipul Patel ,  Scott Miller ,  Mehul Shah ,  Jian Yu

IPC分类号： H04L12/66 ,  H04W4/12

CPC分类号： H04L12/66 ,  H04L65/4015 ,  H04L65/4069 ,  H04N21/4782 ,  H04N21/4788

摘要： Methods and apparatus for providing unified access to interactive media applications and services in a network. In one embodiment, the network comprises a content-based network such as a cable television or satellite network, and the applications are disposed at the network headend. A servlet is provided to facilitate communication between the applications and client devices. The servlet acts as a proxy for applications utilizing a different content format than the client devices. The applications obtain data from e.g., an internet host server via a gateway device. The client application(s) may comprise Enhanced TV Binary Interchange Format (EBIF) pages, and are configured so as to permit use via a common interface (e.g., the user's set top box and television display). These client applications enable a user to, for example, search the internet for data relating to displayed content, post and navigate micro-blogs, instant messaging or SMS, making telephone calls (e.g., VoIP), address/contact management, or provide the user with additional information about a product or service. An application providing internet content to the client device is also provided.

摘要翻译： 在网络中提供对交互式媒体应用和服务的统一访问的方法和装置。 在一个实施例中，网络包括诸如有线电视或卫星网络的基于内容的网络，并且应用被布置在网络头端。 提供servlet以便于应用程序和客户端设备之间的通信。 servlet充当使用与客户端设备不同的内容格式的应用程序的代理。 应用程序通过网关设备从例如互联网主机服务器获得数据。 客户端应用可以包括增强型电视二进制交换格式（EBIF）页面，并且被配置为允许经由公共接口（例如，用户的机顶盒和电视显示器）使用。 这些客户端应用使得用户能够例如在互联网上搜索与显示的内容有关的数据，发布和浏览微博，即时消息或SMS，进行电话呼叫（例如，VoIP），地址/联系人管理，或提供 用户提供有关产品或服务的附加信息。 还提供了向客户端设备提供因特网内容的应用。

公开(公告)号：US20110045603A1

公开(公告)日：2011-02-24

申请号：US12763886

申请日：2010-04-20

申请人： Ailan Guo ,  Albrecht Moritz ,  Anthony Possemato ,  Ting-Lei Gu ,  Jian Yu ,  Charles Lawrence Farnsworth ,  Corinne Michaud ,  Hong Ren ,  Jessica Ann Cherry ,  Jing Zhou ,  Valerie Lee Goss ,  Erik Spek ,  Yu Li ,  Meghan Ann Tucker ,  John Edward Rush, II ,  Matthew Stokes ,  Klarisa Rikova

发明人： Ailan Guo ,  Albrecht Moritz ,  Anthony Possemato ,  Ting-Lei Gu ,  Jian Yu ,  Charles Lawrence Farnsworth ,  Corinne Michaud ,  Hong Ren ,  Jessica Ann Cherry ,  Jing Zhou ,  Valerie Lee Goss ,  Erik Spek ,  Yu Li ,  Meghan Ann Tucker ,  John Edward Rush, II ,  Matthew Stokes ,  Klarisa Rikova

IPC分类号： G01N33/53 ,  C07K16/18

CPC分类号： C07K16/18 ,  C07K14/47 ,  C07K16/44 ,  G01N33/6842

摘要： The invention discloses 990 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

摘要翻译： 本发明公开了在癌和白血病中鉴定的990个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

公开(公告)号：US20110021546A1

公开(公告)日：2011-01-27

申请号：US12891987

申请日：2010-09-28

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： A61K31/517 ,  C12N9/12 ,  C07K16/40 ,  C07K2/00 ,  C07H21/00 ,  G01N33/573 ,  C12Q1/68 ,  G01N33/566 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/713 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/12 ,  C12N9/1205 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/10001 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/6893 ,  G01N2333/912 ,  G01N2333/9121

摘要： In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

摘要翻译： 根据本发明，现在已经在人类实体肿瘤中鉴定了涉及染色体2的新基因缺失和易位，导致将部分间变性淋巴瘤激酶（ALK）激酶与部分二级蛋白结合的融合蛋白。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变ALK激酶多肽的载体，用于检测其的探针，分离的突变多肽，重组多肽和用于检测融合和截短的多肽的试剂。 所公开的这种新的融合蛋白的鉴定使得能够确定生物样品中这些突变型ALK激酶多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变突变型多核苷酸特征的癌症进展抑制方法 或多肽，其也由本发明提供。

公开(公告)号：US20100240034A1

公开(公告)日：2010-09-23

申请号：US12589176

申请日：2009-10-19

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N5/02

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/1205 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57484 ,  G01N2333/9121 ,  Y10T436/117497

摘要： In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

摘要翻译： 根据本发明，现在已经在人类实体肿瘤中鉴定了涉及染色体2的新基因缺失和易位，导致将部分间变性淋巴瘤激酶（ALK）激酶与部分二级蛋白结合的融合蛋白。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变ALK激酶多肽的载体，用于检测其的探针，分离的突变多肽，重组多肽和用于检测融合和截短的多肽的试剂。 所公开的这种新的融合蛋白的鉴定使得能够确定生物样品中这些突变型ALK激酶多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变突变型多核苷酸特征的癌症进展抑制方法 或多肽，其也由本发明提供。

公开(公告)号：US20090193486A1

公开(公告)日：2009-07-30

申请号：US12019766

申请日：2008-01-25

申请人： Vipul Patel ,  Jian Yu ,  Jack Miller ,  John Callahan

发明人： Vipul Patel ,  Jian Yu ,  Jack Miller ,  John Callahan

IPC分类号： H04N7/173

CPC分类号： H04N21/8133 ,  H04N5/76 ,  H04N5/765 ,  H04N5/781 ,  H04N9/8042 ,  H04N9/8205 ,  H04N21/42661 ,  H04N21/4334 ,  H04N21/4437

摘要： A video content system includes a server module, a video content network coupled to the server module, and a digital set-top terminal coupled to the video content network. The digital set-top terminal in turn includes a processor; an interface coupled to the processor and the video content network; and a memory module. The memory module has at least a partitioned hard disk with a first partition containing digital video programming received over the video content network, and a second partition containing supplemental resources.

摘要翻译： 视频内容系统包括服务器模块，耦合到服务器模块的视频内容网络和耦合到视频内容网络的数字机顶终端。 数字机顶终端又包括处理器; 耦合到所述处理器和所述视频内容网络的接口; 和内存模块。 存储器模块至少具有分区硬盘，其具有包含通过视频内容网络接收的数字视频节目的第一分区，以及包含补充资源的第二分区。

公开(公告)号：US20080220505A1

公开(公告)日：2008-09-11

申请号：US11684110

申请日：2007-03-09

申请人： Jian Yu

发明人： Jian Yu

IPC分类号： C12S3/00

CPC分类号： C08G63/90 ,  C08G63/06

摘要： The present invention relates to a method to recover, purify and isolate polyhydroxyalkanoate (PHA) biopolymers from PHA-containing cell mass, which includes: (a) solubilizing the non-PHA cell mass in an acidic solution, leaving a suspension of partially crystallized PHA granules; (b) adjusting the pH of the suspension to 7-11 and separating the PHA solids from the dissolved non-PHA cellular mass; (c) re-suspending the PHA solids in a bleaching solution for decolorization; and (d) drying the resulting PHA solids. About 95% or greater of original PHA in cell mass is recovered, and the purity of PHA solids is about 97% or above. The weight average molecular mass of the purified biopolyesters is about 500 kDa or greater.

摘要翻译： 本发明涉及从含PHA的细胞团中回收，纯化和分离聚羟基链烷酸酯（PHA）生物聚合物的方法，其包括：（a）将非PHA细胞块溶解在酸性溶液中，留下部分结晶的PHA的悬浮液 颗粒; （b）将悬浮液的pH调节至7-11，并将PHA固体与溶解的非PHA细胞团分离; （c）将PHA固体重新悬浮在漂白溶液中以进行脱色; 和（d）干燥所得的PHA固体。 回收大约95％以上的原始PHA，PHA固体纯度约97％以上。 纯化的生物聚酯的重均分子量为约500kDa或更大。

公开(公告)号：US5432216A

公开(公告)日：1995-07-11

申请号：US240569

申请日：1994-05-11

申请人： Jian Yu ,  Satoshi Nagai ,  Ken-ichi Shimizu ,  Toshiaki Okuzono

发明人： Jian Yu ,  Satoshi Nagai ,  Ken-ichi Shimizu ,  Toshiaki Okuzono

IPC分类号： C08K5/10 ,  C08K5/13 ,  C08K5/3432 ,  C08K5/3435 ,  C08K5/3475 ,  C08L23/06 ,  C08L33/12 ,  C08L51/06 ,  C08L59/00 ,  C08L71/02

CPC分类号： C08L59/00 ,  C08K5/3435 ,  C08L23/06 ,  C08L33/12 ,  C08L51/06 ,  C08L71/02

摘要： A polyacetal resin composition which comprises (A) 100 parts by weight of a polyacetal resin, (B) 0.1 to 1.5 parts by weight of at least one kind selected from the group of light stabilizers represented by the following formula (1) ##STR1## wherein two X's are the same or different and each denotes a hydrogen atom or a methyl group, (C) 0.1 to 1.5 parts by weight of an ultraviolet light absorber, (D) 0.1 to 3 parts by weight of polyethylene, (E) 0.1 to 5 parts by weight of polyethylene glycol, and (F) 0.1 to 10 parts by weight of a polymer of a methacrylate ester. This polyacetal resin composition is excellent in weather resistance and molding processability.

摘要翻译： 一种聚缩醛树脂组合物，其包含（A）100重量份的聚缩醛树脂，（B）0.1〜1.5重量份的选自由下式（1）表示的光稳定剂组中的至少一种：＆lt; IMAGE＆gt; （1）其中两个X相同或不同，各自表示氢原子或甲基，（C）0.1至1.5重量份的紫外光吸收剂，（D）0.1至3重量份的聚乙烯，（ E）0.1〜5重量份的聚乙二醇，（F）0.1〜10重量份的甲基丙烯酸酯的聚合物。 该聚缩醛树脂组合物的耐候性和成型加工性优异。

公开(公告)号：USD961413S1

公开(公告)日：2022-08-23

申请号：US29828547

申请日：2022-02-28

申请人： Jian Yu

设计人： Jian Yu