公开(公告)号：US20080306394A1

公开(公告)日：2008-12-11

申请号：US12063097

申请日：2006-08-09

申请人： Mark J. Zdeblick ,  Timothy Robertson ,  George M. Savage

发明人： Mark J. Zdeblick ,  Timothy Robertson ,  George M. Savage

IPC分类号： A61B5/04

CPC分类号： A61B5/04011

摘要： A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.

摘要翻译： 用于测量组织中去极化波的传导速度的方法使用位于组织内的第一卫星，并且第二卫星位于组织内距离第一卫星一定距离，例如通过使用去极化波的时间 报道从每颗卫星和距离来确定波的速度。 还提供了根据本发明使用的系统和试剂盒。

公开(公告)号：US20080294218A1

公开(公告)日：2008-11-27

申请号：US11909786

申请日：2006-03-31

申请人： George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Lawrence W. Arne ,  Olivier Colliou ,  Benedict James Costello ,  Fataneh A. Omidvar

发明人： George M. Savage ,  Todd Thompson ,  Mark J. Zdeblick ,  Lawrence W. Arne ,  Olivier Colliou ,  Benedict James Costello ,  Fataneh A. Omidvar

IPC分类号： A61N1/06

CPC分类号： A61N1/3627 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/3686 ,  A61N1/37247

摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.

摘要翻译： 本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。 在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。 起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。 然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。 该系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极发射的起搏信号。

公开(公告)号：US07284441B2

公开(公告)日：2007-10-23

申请号：US11025366

申请日：2004-12-28

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： G01L9/00

CPC分类号： A61B5/0215 ,  A61B5/412 ,  A61B2562/02 ,  A61N1/3627 ,  A61N1/36564 ,  G01L9/0042 ,  G01L9/0055 ,  G01L9/045 ,  G01L9/065

摘要： Implantable pressure sensors and methods for making and using the same are provided. A feature of embodiments of the subject pressure sensors is that they are low-drift sensors. The subject sensors find use in a variety of applications.

摘要翻译： 提供了可植入压力传感器及其制造和使用方法。 目标压力传感器的实施例的特征在于它们是低漂移传感器。 主题传感器可用于各种应用。

公开(公告)号：US08558563B2

公开(公告)日：2013-10-15

申请号：US13390866

申请日：2010-08-23

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： G01R27/08 ,  A61B5/053

CPC分类号： A61B5/150229 ,  A61B5/0002 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/150305 ,  A61B5/150877 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/6833 ,  A61B5/6846 ,  A61B10/0064 ,  A61B2560/0412

摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

摘要翻译： 在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。 电阻之间以不同的频率测量阻抗。 结果，在表面下方的不同区域测量阻抗，一个区域比其他区域更深于表面下方。 在第二实施例中，微流体装置执行分析。 分析可以在粘附到表面的柔性贴片内，或者可以是植入由组织包围的液体体内的固体装置。 分析可以涉及泵送流体，或者可以涉及通过微流体通道电泳分析分析物。

公开(公告)号：US08547248B2

公开(公告)日：2013-10-01

申请号：US12063095

申请日：2006-09-01

申请人： Mark J. Zdeblick ,  Timothy Robertson

发明人： Mark J. Zdeblick ,  Timothy Robertson

IPC分类号： G08C17/00

CPC分类号： A61B5/0022 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0265 ,  A61B5/145 ,  A61B5/14535 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6862 ,  A61B5/6876 ,  A61M5/172 ,  A61N1/37217 ,  A61N1/37223 ,  G06F19/00 ,  H02J50/20 ,  Y02A90/26

摘要： The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.

摘要翻译： 本发明提供了使用能够使设备配置和应用迄今不可能的唯一格式彼此无线通信的可植入系统。 本发明的实施例提供了与可植入医疗装置交换信息的通信装置和方法。 在一些实施例中，两个可植入装置通过长波长/低频电磁波带中的准静电信号传输彼此进行通信，患者的身体用作导电介质。

公开(公告)号：US08542123B2

公开(公告)日：2013-09-24

申请号：US13564479

申请日：2012-08-01

申请人： Timothy Robertson ,  Mark J. Zdeblick

发明人： Timothy Robertson ,  Mark J. Zdeblick

IPC分类号： G08B23/00

CPC分类号： H04B5/0062 ,  A61B5/0031 ,  A61B5/073 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6861 ,  A61B2562/08 ,  A61B2562/162 ,  G06K7/10297

摘要： Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

公开(公告)号：US20120146670A1

公开(公告)日：2012-06-14

申请号：US13390866

申请日：2010-08-23

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： G01R27/08

CPC分类号： A61B5/150229 ,  A61B5/0002 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/150305 ,  A61B5/150877 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/6833 ,  A61B5/6846 ,  A61B10/0064 ,  A61B2560/0412

摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

摘要翻译： 在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。 电阻之间以不同的频率测量阻抗。 结果，在表面下方的不同区域测量阻抗，一个区域比其他区域更深于表面下方。 在第二实施例中，微流体装置执行分析。 分析可以在粘附到表面的柔性贴片内，或者可以是植入由组织包围的液体体内的固体装置。 分析可以涉及泵送流体，或者可以涉及通过微流体通道电泳分析分析物。

公开(公告)号：US08123684B2

公开(公告)日：2012-02-28

申请号：US12624241

申请日：2009-11-23

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/00

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

公开(公告)号：US07713195B2

公开(公告)日：2010-05-11

申请号：US11731090

申请日：2007-03-29

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/08

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

公开(公告)号：US20090036769A1

公开(公告)日：2009-02-05

申请号：US12171978

申请日：2008-07-11

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61B5/05

CPC分类号： A61B5/065 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/0536 ,  A61B5/1107 ,  A61B5/6851 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7264 ,  A61N1/3627 ,  A61N1/36578

摘要： Methods for locating a sensor element in vivo, e.g., during evaluation of tissue motion, such as of a cardiac tissue motion, e.g., heart wall motion, via electric tomography are provided. In the subject methods, an electric field is applied to a subject in a manner such that the sensing element is present in the applied electric field, and a property of, e.g., a change in, the applied electric field sensed by the sensing element is employed to evaluate a patient internal parameter of interest, e.g., to evaluate movement of tissue location, to evaluate a internal device parameter, such as movement thereof, etc. The invention allows for robust noise discrimination, e.g., by employing a spread spectrum applied electric field. Also provided are systems and devices for practicing the subject methods. In addition, innovative data displays and systems for producing the same are provided. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了在体内定位传感器元件的方法，例如在通过电断层摄影术来评估组织运动（例如心脏组织运动，例如心脏壁运动）期间。 在本发明的方法中，电磁场以使得感应元件存在于所施加的电场中的方式施加到被摄体，并且由感测元件感测到的所施加的电场的变化，例如变化的性质是 用于评估感兴趣的患者内部参数，例如，以评估组织位置的运动，以评估内部设备参数，例如其移动等。本发明允许鲁棒的噪声鉴别，例如通过使用扩频应用电 领域。 还提供了用于实践主题方法的系统和设备。 此外，还提供了创新的数据显示和用于生产数据的系统。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。