公开(公告)号：US20100216726A1

公开(公告)日：2010-08-26

申请号：US12712042

申请日：2010-02-24

申请人： Kouki FUCHINO ,  R. Richard Goehring ,  Akira Matsumura ,  Bin Shao ,  Yoshiyuki Taoda ,  Naoki Tsuno ,  John William Frank Whitehead ,  Jiangchao Yao

发明人： Kouki FUCHINO ,  R. Richard Goehring ,  Akira Matsumura ,  Bin Shao ,  Yoshiyuki Taoda ,  Naoki Tsuno ,  John William Frank Whitehead ,  Jiangchao Yao

IPC分类号： A61K38/05 ,  C07D401/04 ,  A61K31/498 ,  A61P3/04 ,  A61P13/06 ,  A61P9/12 ,  A61P25/08 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P1/12 ,  C07D413/14 ,  A61K31/5377 ,  C07D471/04 ,  C07D491/113 ,  C07D451/14

CPC分类号： C07D451/14 ,  A61K31/498 ,  C07D401/04 ,  C07D401/14 ,  C07D451/04 ,  C07D471/08 ,  C07D471/14 ,  C07D487/04 ,  C07D498/08 ,  C07D519/00

摘要： The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

摘要翻译： 本发明涉及取代的喹喔啉型哌啶化合物，包含有效量的取代的喹喔啉型哌啶化合物的组合物和治疗或预防诸如疼痛的病症的方法，包括向有需要的动物施用有效量 的取代的喹喔啉型哌啶化合物。

公开(公告)号：US20100311792A1

公开(公告)日：2010-12-09

申请号：US12599608

申请日：2008-09-26

申请人： Bin Shao ,  Jiangchao Yao

发明人： Bin Shao ,  Jiangchao Yao

IPC分类号： A61K31/4468 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06 ,  C07D405/12 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/453 ,  A61P29/00 ,  A61P25/18 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P9/06 ,  A61P9/12 ,  G01N33/53

CPC分类号： C07D211/58 ,  C07D401/04

摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1，R2，R3，Z和q如说明书所述定义。 本发明还涉及使用式I化合物来治疗对阻断钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US20090298878A1

公开(公告)日：2009-12-03

申请号：US12373328

申请日：2007-07-12

申请人： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

发明人： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

IPC分类号： A61K31/445 ,  C07D211/98 ,  G01N23/00 ,  C07D401/12

CPC分类号： C07D211/72 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

摘要： The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

摘要翻译： 本发明涉及式（I）的肟化合物及其药学上可接受的盐，前药或溶剂化物，其中X是氢，任选取代的芳基，任选取代的杂芳基等; Y是CO，SO2，CR3R4等; Z是任选取代的低级烷基，任选取代的芳基等; W是任选取代的低级亚烷基或任选取代的低级亚烯基，R 3和R 4各自独立地是氢，低级烷基等; p是0,1或2，q是0,1或2.本发明还涉及使用式I化合物来治疗，预防或改善对阻断钙通道有响应的病症，特别是N型 钙通道。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US20160204717A1

公开(公告)日：2016-07-14

申请号：US14623025

申请日：2015-02-16

申请人： Xing Li ,  Yong Feng ,  Bin Shao

发明人： Xing Li ,  Yong Feng ,  Bin Shao

IPC分类号： H02N2/18

CPC分类号： H02N2/181

摘要： An impedance matching circuit is provided for use with a piezotransducer that includes a parasitic capacitor comprising: an inductor coupled in parallel with the parasitic capacitor; a peak and valley detection circuit configured to detect output voltage waveform peaks and valleys; a first switch circuit configured to bias flip the output voltage waveform at a selectable first time relative to a detected peak and at a selectable first time relative to a detected valley; a second switch circuit configured to couple the inductor to the energy storage circuit at a selectable second time following each output voltage bias flip; an energy monitoring circuit to provide an indication of energy flow from the inductor to the energy storage circuit following each output voltage bias flip; and a maximum power point tracking (MPPT) circuit configured to select the first time and the second time based at least in part upon the indicated energy flow.

摘要翻译： 阻抗匹配电路被提供用于包括寄生电容器的压电传感器，该寄生电容器包括：与寄生电容器并联耦合的电感器; 峰值谷检测电路，被配置为检测输出电压波形峰谷; 第一开关电路，被配置为将输出电压波形相对于检测到的峰值在可选择的第一时间相对于相对于检测到的谷值在可选择的第一时间进行偏置翻转; 第二开关电路，被配置为在每个输出电压偏置翻转之后的可选择的第二时间将所述电感器耦合到所述能量存储电路; 能量监测电路，用于在每个输出电压偏置翻转之后提供从电感器到能量存储电路的能量流的指示; 以及配置为至少部分地基于所指示的能量流来选择第一时间和第二时间的最大功率点跟踪（MPPT）电路。

公开(公告)号：US20150280554A1

公开(公告)日：2015-10-01

申请号：US14229048

申请日：2014-03-28

申请人： Hua-Jung Yang ,  Bin Shao ,  Suyi Yao ,  Yanfeng Lu

发明人： Hua-Jung Yang ,  Bin Shao ,  Suyi Yao ,  Yanfeng Lu

IPC分类号： H02M3/156 ,  H02J7/00 ,  H02J1/00

CPC分类号： H02M3/156 ,  H02J1/00 ,  H02J1/102 ,  H02J7/00 ,  H02J7/345 ,  H02M1/36 ,  Y10T307/313

摘要： An apparatus comprises an output port for a circuit load, a first input port for an energy harvest source, an input/output port a second energy source, a first circuit path from the energy harvest source to the second energy source at the input/output port and to the variable load at the output port, a second circuit path from the second energy source to the output port, a cold start circuit that produces a first voltage level at the output port by charging a capacitor at the output port using energy of the energy harvest source, and a main converter circuit that produces a second regulated voltage level at the input/output port using energy of the energy harvest source when the voltage at the output port capacitor is above a specified voltage value and uses the energy of the capacitor at the output port during startup of the main converter circuit.

摘要翻译： 一种装置包括用于电路负载的输出端口，用于能量收集源的第一输入端口，第二能量源的输入/输出端口，输入/输出端处的能量收集源至第二能量源的第一电路路径 端口和输出端口处的可变负载，从第二能量源到输出端口的第二电路路径，冷启动电路，其通过在输出端口处对电容器充电而在输出端口处产生第一电压电平， 能量收集源和主转换器电路，其在输出端口电容器处的电压高于指定电压值时使用能量收集源的能量在输入/输出端口处产生第二调节电压电平，并且使用 在主转换器电路启动期间输出端口处的电容器。

公开(公告)号：US20150214835A1

公开(公告)日：2015-07-30

申请号：US14182913

申请日：2014-02-18

申请人： Bin Shao

发明人： Bin Shao

IPC分类号： H02M3/04

CPC分类号： H02M3/158 ,  H02J7/34 ,  H02J7/35 ,  H02M2001/0045

摘要： An apparatus comprises a switching power circuit and a control circuit. The switching power converter circuit includes an output port for electrical coupling to a variable load, an input port for electrically coupling to a first energy source, wherein the energy density of the first energy source is insufficient to meet a peak energy requirement of the variable load, an input/output port for electrical coupling to a second energy source, and one inductor electrically coupled to the input port and a circuit node, wherein the electrical coupling is non-switchable. The control circuit is configured to charge the inductor using the first energy source via the input port, to provide energy from the inductor to the load via the output port, and to provide both of, via the input/output port, energy from the inductor to the second energy source and energy from the second energy source to the variable load.

摘要翻译： 一种装置包括开关电源电路和控制电路。 开关功率转换器电路包括用于电耦合到可变负载的输出端口，用于电耦合到第一能量源的输入端口，其中第一能量源的能量密度不足以满足可变负载的峰值能量需求 ，用于电耦合到第二能量源的输入/输出端口，以及电耦合到所述输入端口和电路节点的一个电感器，其中所述电耦合是不可切换的。 控制电路被配置为经由输入端口使用第一能量源对电感器充电，以经由输出端口从电感器向负载提供能量，并且通过输入/输出端口提供来自电感器的能量 到第二能量源和从第二能量源到可变负载的能量。

公开(公告)号：US08871984B2

公开(公告)日：2014-10-28

申请号：US13521044

申请日：2010-03-18

申请人： Xinde Xu ,  Bin Shao ,  Hongjuan Chao ,  Xuejun Lao ,  Xiaoxia Sun

发明人： Xinde Xu ,  Bin Shao ,  Hongjuan Chao ,  Xuejun Lao ,  Xiaoxia Sun

IPC分类号： C07C27/02 ,  C07C29/09 ,  C07C29/56 ,  C07C403/24 ,  C09B61/00

CPC分类号： C07C403/24 ,  C07C2601/16 ,  C09B61/00

摘要： The invention makes public a method for preparing xanthophyll crystals with higher content of zeaxanthin from plant oleoresin. The current methods generally are to get quite pure crystal forms of xanthophyll or zeaxanthin, and they refer to several separation steps. The invention mixes the xanthophyll diester-containing plant oleoresins and food grade alcohol solvents to form smooth solution, and then soap-dissolve the solution under an alkaline environment; then replenish organic solvents and emulsifiers into the reaction solution and drop some alkali solution into the solution to make partial xanthophyll crystals be transformed to be zeaxanthin through epimerization reaction; after the reaction is finished, add the mixed solvents of alcohol solvent and water to separate out the crystals; use the method of centrifugation or filtration to get the crystals; wash the crystals several times with the mixed solution of deionized water and alcohols to remove the impurities among the crystals; recrystallize the gained crystals with absolute ethyl alcohol, and then dry the crystals to get the products. The invention can gain mixture of crystals that contain xanthophyll and zeaxanthin at one time in quite high collection rate.

摘要翻译： 本发明公开了一种从植物油树脂制备玉米黄质含量较高的叶黄素晶体的方法。 目前的方法通常是获得相当纯的叶黄素或玉米黄质的晶体形式，它们是指几个分离步骤。 本发明混合含有叶黄素二酯的植物油树脂和食品级醇溶剂，形成光滑的溶液，然后在碱性环境下将溶液皂溶; 然后将有机溶剂和乳化剂补充到反应溶液中，并将一些碱溶液滴入溶液中，使部分叶黄素晶体通过差向异构化反应转化为玉米黄质; 反应完成后，加入醇溶剂和水的混合溶剂分离出晶体; 使用离心或过滤方法得到晶体; 用去离子水和醇的混合溶液洗涤晶体数次以除去晶体中的杂质; 用绝对乙醇重结晶获得的晶体，然后干燥晶体得到产物。 本发明可以以相当高的收集率一次获得含有叶黄素和玉米黄质的晶体的混合物。

公开(公告)号：US20140030419A1

公开(公告)日：2014-01-30

申请号：US13997273

申请日：2011-01-30

申请人： Xinde Xu ,  Bin Shao ,  Xuejun Lao

发明人： Xinde Xu ,  Bin Shao ,  Xuejun Lao

IPC分类号： A23D9/007

CPC分类号： A23D9/007 ,  A23K20/158 ,  A23K20/179 ,  A61K9/10 ,  A61K31/015 ,  A61K47/44

摘要： A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5 μm. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.

摘要翻译： 提供类胡萝卜素油悬浮液及其制备方法。 该方法包括以下步骤：a）将类胡萝卜素与有机溶剂混合，加热混合物以充分溶解类胡萝卜素，得到类胡萝卜素溶液; b）将步骤a）中得到的类胡萝卜素溶液加入到通过喷雾高速搅拌的植物油溶液中，同时在真空条件下回收喷雾过程中产生的有机溶剂，同时完成回收和喷涂，然后获得类胡萝卜素油悬浮液; 其中，类胡萝卜素油悬浮液包含平均粒度小于5um的类胡萝卜素晶体。 该方法适用于工业规模，连续操作，效率高，无需额外的类胡萝卜素晶体研磨工艺，降低类胡萝卜素油悬浮液制备过程中类胡萝卜素的降解。

公开(公告)号：US20120329880A1

公开(公告)日：2012-12-27

申请号：US13255271

申请日：2010-03-04

申请人： Xinde Xu ,  Guohua Wei ,  Xuebing Xiang ,  Bin Shao

发明人： Xinde Xu ,  Guohua Wei ,  Xuebing Xiang ,  Bin Shao

IPC分类号： A61K31/047 ,  A61P35/00 ,  A61K31/122 ,  A61P39/06 ,  A61K31/01 ,  A61K31/015

CPC分类号： A23L33/105 ,  A23L5/44 ,  A23L33/10 ,  A23V2002/00 ,  A23V2250/211

摘要： The present invention relates to a method of preparing for an oil suspension of carotenoid with low viscosity and high fluidity and use thereof. The method comprises the following steps: mixing carotenoid crystals with tetrahydrofuran, heating the mixture to reflux temperature 50˜70°C. under stirring to dissolve the crystal, filtering and condensing to obtain the concentrate; mixing the concentrate with ketone solvent, heating the mixture to reflux temperature 60-80□ to dissolve the concentrate, filtering, condensing, adding absolute alcohol, crystallizing under stirring at room temperature, filtering and drying in vacuum to obtain carotenoid crystals; mixing carotenoids crystals after granded with plant oil or grinding carotenoid crystals with plant oils and then adding plant oil, to obtain the oil suspension of carotenoid with low viscosity and high fluidity. While the content of carotenoid is 10.0˜45.0 wt. % in the oil suspension of carotenoid obtained from the present invention, the oil suspension of carotenoid has high fluidity at temperature 5˜25□, and in the meanwhile do not need any extra heating steps during applications.

摘要翻译： 本发明涉及一种低粘度和高流动性的类胡萝卜素油悬浮液的制备方法及其用途。 该方法包括以下步骤：将类胡萝卜素晶体与四氢呋喃混合，将混合物加热至回流温度50〜70℃。 在搅拌下溶解晶体，过滤并冷凝得到浓缩物; 将浓缩物与酮溶剂混合，将混合物加热至回流温度60-80℃以溶解浓缩物，过滤，冷凝，加入无水乙醇，在室温搅拌下结晶，过滤并真空干燥，得到类胡萝卜素晶体; 将类胡萝卜素晶体与植物油混合后，用植物油研磨类胡萝卜素晶体，然后加入植物油，得到低粘度和高流动性的类胡萝卜素油悬浮液。 而类胡萝卜素的含量为10.0〜45.0wt。 在本发明得到的类胡萝卜素的油悬浮液中，类胡萝卜素的油悬浮液在5〜25℃的温度下具有高的流动性，同时在使用过程中不需要额外的加热步骤。

公开(公告)号：US20120161728A1

公开(公告)日：2012-06-28

申请号：US12979167

申请日：2010-12-27

申请人： Jia Chen ,  Bin Shao

发明人： Jia Chen ,  Bin Shao

IPC分类号： G05F1/10

CPC分类号： H02M3/1563

摘要： Switching voltage regulator embodiments are provided with hysteretic control to thereby switch between pulse-width modulation and pulse-frequency modulation operational modes. The switching is in response to different levels of an error voltage Verr in the feedback loop of voltage regulators. The hysteretic control is configured to provide a dc hysteretic response to changes in the error voltage Verr and also an ac hysteretic response to these changes. These two responses can be independently set to thereby enhance operational speed of the voltage regulators and also enhance immunity to transient noise signals that are generated by the mode switching. The voltage regulator embodiments facilitate instant return from the pulse-frequency modulation operational mode to the pulse-width modulation operational mode so that the stability of the feedback control of the regulator is enhanced. This feature is especially useful when the feedback loop is configured to include current-mode control as it minimizes the time duration in which the feedback loop operates in a voltage-mode control. The instant return insures that the feedback loop is immediately returned to the greater stability of the current-mode control.

摘要翻译： 开关稳压器实施例具有迟滞控制，从而在脉冲宽度调制和脉冲 - 频率调制操作模式之间切换。 开关响应于电压调节器的反馈回路中的不同电平的误差电压Verr。 迟滞控制被配置为对误差电压Verr的变化提供直流迟滞响应，并且还对对这些变化的迟滞响应。 可以独立地设置这两个响应，从而提高电压调节器的操作速度，并且还增强对由模式切换产生的瞬态噪声信号的抗扰性。 电压调节器实施例便于从脉冲 - 频率调制操作模式到脉宽调制操作模式的即时返回，从而增强了调节器的反馈控制的稳定性。 当反馈回路配置为包括电流模式控制时，该功能特别有用，因为它使反馈回路在电压模式控制中工作的持续时间最小化。 即时返回确保反馈回路立即返回到电流模式控制的更大稳定性。