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31 条记录 (耗时 0.051 秒)

    Benzenesulfonamide compounds and the use thereof
    4.
    发明授权
    Benzenesulfonamide compounds and the use thereof 有权
    苯磺酰胺化合物及其用途

    公开(公告)号：US08937181B2

    公开(公告)日：2015-01-20

    申请号：US12296788

    申请日：2007-04-13

    申请人： Akira Matsumura ,  Hidenori Mikamiyama ,  Bin Shao ,  Naoki Tsuno ,  Jiangchao Yao

    发明人： Akira Matsumura ,  Hidenori Mikamiyama ,  Bin Shao ,  Naoki Tsuno ,  Jiangchao Yao

    IPC分类号： C07D211/58 ,  A61K31/4545 ,  A61K31/4468

    CPC分类号： C07D211/58 ,  A61K31/4468 ,  A61K31/4545

    摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

    摘要翻译： 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1-R3，Z，p和q如说明书所述定义。 本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。 本发明的化合物特别适用于治疗疼痛。

    OXIME COMPOUNDS AND THE USE THEREOF
    5.
    发明申请
    OXIME COMPOUNDS AND THE USE THEREOF 审中-公开
    OXIME化合物及其用途

    公开(公告)号：US20090298878A1

    公开(公告)日：2009-12-03

    申请号：US12373328

    申请日：2007-07-12

    申请人： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

    发明人： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

    IPC分类号： A61K31/445 ,  C07D211/98 ,  G01N23/00 ,  C07D401/12

    CPC分类号： C07D211/72 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

    摘要： The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

    摘要翻译： 本发明涉及式（I）的肟化合物及其药学上可接受的盐，前药或溶剂化物，其中X是氢，任选取代的芳基，任选取代的杂芳基等; Y是CO，SO2，CR3R4等; Z是任选取代的低级烷基，任选取代的芳基等; W是任选取代的低级亚烷基或任选取代的低级亚烯基，R 3和R 4各自独立地是氢，低级烷基等; p是0,1或2，q是0,1或2.本发明还涉及使用式I化合物来治疗，预防或改善对阻断钙通道有响应的病症，特别是N型 钙通道。 本发明的化合物特别适用于治疗疼痛。

    Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators
    9.
    发明授权
    Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators 有权
    取代的喹喔啉型桥接哌啶化合物作为ORL-1调节剂

    公开(公告)号：US08476271B2

    公开(公告)日：2013-07-02

    申请号：US13010632

    申请日：2011-01-20

    申请人： Naoki Tsuno ,  Jiangchao Yao

    发明人： Naoki Tsuno ,  Jiangchao Yao

    IPC分类号： A61K31/495

    CPC分类号： C07D471/08 ,  C07D403/04 ,  C07D451/14

    摘要： Compounds of Formula (I): where R1, R2, R5, a, and b are disclosed herein, and pharmaceutically acceptable derivatives thereof (a “Substituted-Quinoxaline-Type Bridged-Piperidine Compound”), compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.

    摘要翻译： 式（I）的化合物：其中R 1，R 2，R 5，a和b在此公开，及其药学上可接受的衍生物（“取代的喹喔啉型桥连哌啶化合物”），包含有效量的取代 - 喹喔啉型桥连哌啶化合物，以及治疗或预防诸如疼痛的病症的方法，包括向有需要的动物施用有效量的取代的喹喔啉型桥连哌啶化合物。