公开(公告)号：US09138596B2

公开(公告)日：2015-09-22

申请号：US11895022

申请日：2007-08-22

申请人： John Foley ,  Craig Stolen ,  Mark Schwartz

发明人： John Foley ,  Craig Stolen ,  Mark Schwartz

IPC分类号： A61N5/06 ,  A61B5/04 ,  A61B5/00

CPC分类号： A61N5/0622 ,  A61B5/04012 ,  A61B5/418 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/063 ,  A61N2005/0651

摘要： The invention provides a cardiac rhythm management system for stimulating a heart having photosensitive tissue, vectors useful to photosensitize cells expressing the vectors, and methods for light induced depolarization of cells.

公开(公告)号：US08311620B2

公开(公告)日：2012-11-13

申请号：US11895025

申请日：2007-08-22

申请人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

发明人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

IPC分类号： A61B5/04 ,  A61K9/22

CPC分类号： A61N1/3621 ,  A61M5/14276 ,  A61N1/0568 ,  A61N1/0587 ,  A61N1/3962

摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.

摘要翻译： 本发明提供一种心律管理系统，其包括程序化以检测和分类快速性心律失常的快速性心律失常检测和分类电路，构造成递送或调节适于终止或预防心房颤动（AF）的表达盒的生物治疗递送装置，以及 耦合到快速心律失常检测和分类电路的控制电路和生物治疗递送装置。 还提供了一种用于具有心血管系统的身体的可植入医疗装置，其包括可植入装置主体，该可植入装置主体至少包括构造成在心血管系统中的心血管部分，以及结合到可植入装置的心血管部分中的表达盒 身体，选择表达终止或预防AF的基因产物的表达盒。 还提供了采用特定表达盒来预防，抑制或治疗房颤的方法。

公开(公告)号：US08072346B2

公开(公告)日：2011-12-06

申请号：US12421210

申请日：2009-04-09

申请人： Timothy Hall ,  Mark Schwartz

发明人： Timothy Hall ,  Mark Schwartz

IPC分类号： G08B5/22

CPC分类号： G08G1/087

摘要： Various approaches for activating a traffic control preemption system. A light bar includes a support structure and a plurality of LED modules individually mounted on the support structure. Each LED module includes a plurality of LED groups, and in at least one of the plurality of LED modules, at least one LED group in the module is an infrared (IR) LED group, and at least one LED group in the module is a visible light LED group. A controller is coupled to each module. The controller is configured to trigger an IR light pulse pattern at a first level of IR radiant power from the at least one IR LED group. The pulse pattern and first level of IR radiant power activate preemption in a traffic control preemption system.

摘要翻译： 用于激活流量控制抢占系统的各种方法。 灯条包括支撑结构和分别安装在支撑结构上的多个LED模块。 每个LED模块包括多个LED组，并且在所述多个LED模块中的至少一个中，所述模块中的至少一个LED组是红外（IR）LED组，并且所述模块中的至少一个LED组是 可见光LED组。 控制器耦合到每个模块。 控制器被配置为以至少一个IR LED组的IR辐射功率的第一水平触发IR光脉冲模式。 脉冲模式和红外辐射功率的第一级激活流量控制抢占系统中的抢占。

公开(公告)号：US20110068951A1

公开(公告)日：2011-03-24

申请号：US12142421

申请日：2008-06-19

申请人： Mark Schwartz ,  Charles Meyer

发明人： Mark Schwartz ,  Charles Meyer

IPC分类号： G08G1/087

CPC分类号： G08G1/087

摘要： Various approaches for a traffic control preemption system that includes a receiver, a light emitter, and control circuitry. The receiver includes a photodetector and circuitry that produces a number of electrical pulses in response to each detected light pulse. For each detected light pulse the number of electrical pulses represents a level of radiant power of the light pulse, and a threshold number of electrical pulses and an activation frequency at which the threshold number of electrical pulses is repeated activates preemption. The control circuitry is coupled to the light emitter and controls the light emitter to emit bursts of light pulses. Each burst includes at least two light pulses and a frequency of light pulses in each burst and a frequency of the bursts cause the receiver to produce at least the threshold number of electrical pulses at the activation frequency and activate the preemption.

摘要翻译： 用于包括接收器，发光器和控制电路的交通控制抢占系统的各种方法。 接收器包括光电检测器和响应于每个检测到的光脉冲而产生多个电脉冲的电路。 对于每个检测到的光脉冲，电脉冲数表示光脉冲的辐射功率的水平，并且电脉冲的阈值数量和重复阈值电脉冲的激活频率激活抢占。 控制电路耦合到光发射器并且控制光发射器发射一束光脉冲。 每个脉冲串包括至少两个光脉冲和每个脉冲串中的光脉冲的频率，并且脉冲串的频率使接收器产生至少在激活频率处的阈值数量的电脉冲并激活抢占。

公开(公告)号：US20090054943A1

公开(公告)日：2009-02-26

申请号：US11895025

申请日：2007-08-22

申请人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

发明人： Jihong Qu ,  Haris J. Sih ,  Mark Schwartz ,  Prashant Sinha

IPC分类号： A61N1/05 ,  A61N1/18 ,  A61N1/362

CPC分类号： A61N1/3621 ,  A61M5/14276 ,  A61N1/0568 ,  A61N1/0587 ,  A61N1/3962

摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.

摘要翻译： 本发明提供一种心律管理系统，其包括程序化以检测和分类快速性心律失常的快速性心律失常检测和分类电路，构造成递送或调节适于终止或预防心房颤动（AF）的表达盒的生物治疗递送装置，以及 耦合到快速心律失常检测和分类电路的控制电路和生物治疗递送装置。 还提供了一种用于具有心血管系统的身体的可植入医疗装置，其包括可植入装置主体，该可植入装置主体至少包括构造成在心血管系统中的心血管部分，以及结合到可植入装置的心血管部分中的表达盒 身体，选择表达终止或预防AF的基因产物的表达盒。 还提供了采用特定表达盒来预防，抑制或治疗房颤的方法。

公开(公告)号：US20070161912A1

公开(公告)日：2007-07-12

申请号：US11329346

申请日：2006-01-10

申请人： Yunlong Zhang ,  Mark Schwartz

发明人： Yunlong Zhang ,  Mark Schwartz

IPC分类号： A61B5/02 ,  A61B5/00 ,  A61B5/103

CPC分类号： A61B5/103 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/6862 ,  A61B5/6869 ,  A61B5/6876 ,  A61B2562/0219

摘要： A method involves implantably detecting changes in posture of a patient's body. Baroreflex responses to the posture changes are determined. An autonomic tone of the patient is determined based on the baroreflex responses. Based on the autonomic tone, various patient susceptibilities to disease may be determined, including susceptibilities to heart disease, arrhythmia, and/or sudden cardiac death.

摘要翻译： 一种方法包括可植入地检测患者身体姿势的变化。 确定对姿势变化的反射反应。 基于压力反射响应来确定患者的自主神经。 基于自主语调，可以确定各种患者对疾病的敏感性，包括对心脏病的易感性，心律失常和/或心脏猝死。

公开(公告)号：US20070008174A1

公开(公告)日：2007-01-11

申请号：US11154348

申请日：2005-06-16

申请人： Mark Schwartz

发明人： Mark Schwartz

IPC分类号： G08G1/00

CPC分类号： G08G1/087

摘要： A remotely-activated vehicle priority system includes a control center, a vehicle-priority communication device, at least one receiver, and a phase selector. The control center transmits an activation message. The vehicle-priority communication device is mounted to a vehicle and is communicatively coupled to the control center. In response to the activation message, the vehicle-priority communication device transmits a priority preemption request. Transmission of the priority preemption request in response to the activation message prevents improper activation, either intentional or unintentional, of the vehicle priority system by an operator of the vehicle. The receiver is situated at a traffic signal and receives the priority preemption request. The phase selector issues, responsive to the priority preemption request, a command to a controller of the traffic signal. The command selects a phase for the traffic signal.

摘要翻译： 遥控车辆优先系统包括控制中心，车辆优先通信设备，至少一个接收机和相位选择器。 控制中心发送激活消息。 车辆优先通信装置安装到车辆并且通信地耦合到控制中心。 响应于激活消息，车辆优先通信设备发送优先抢占请求。 响应于激活消息传送优先抢占请求防止车辆操作者对车辆优先权系统的有意或无意的不正当的激活。 接收机位于交通信号灯处，并接收优先抢占请求。 相位选择器响应于优先抢占请求发出一个命令给交通信号灯的控制器。 该命令选择交通信号灯的相位。

公开(公告)号：US20060273924A1

公开(公告)日：2006-12-07

申请号：US11142013

申请日：2005-06-01

申请人： Mark Schwartz

发明人： Mark Schwartz

IPC分类号： G08G1/095

CPC分类号： G08G1/087

摘要： A secure optical-communication traffic-preemption system and method is provided that securely communicates an identification code from an optical emitter to a traffic location. The optical emitter transmits light pulses that represent an encrypted code that is an encryption using a time-varying encryption key of at least an identification code. An optical detector situated at a traffic location receives the transmitted light pulses. Validation, including decryption using a time-varying decryption key, is attempted for the encrypted identification code represented within the received light pulses. In response to validating the included identification code, a traffic-preemption command is generated for a traffic light at the traffic location.

摘要翻译： 提供了一种安全的光通信流量抢占系统和方法，其将来自光发射器的识别码安全地传送到交通位置。 光发射器发送表示使用至少一个识别码的时变加密密钥的加密的加密代码的光脉冲。 位于交通位置处的光学检测器接收透射的光脉冲。 对于在接收的光脉冲内表示的加密识别码，尝试使用时变解密密钥进行验证，包括解密。 响应于验证所包括的识别码，为业务位置处的交通灯生成流量抢占命令。

公开(公告)号：US5416575A

公开(公告)日：1995-05-16

申请号：US970913

申请日：1992-11-03

申请人： Mark Schwartz ,  Paul Millman

发明人： Mark Schwartz ,  Paul Millman

IPC分类号： G01N21/27 ,  G01J1/02

CPC分类号： G01N21/278

摘要： A method and system for calibrating an optical density measurement apparatus includes a graphic display module that can be modulated under control of a microcomputer. The module is preferably a matrix-array type liquid crystal display wherein individual pixels may be selectively turned on or off to achieve a desired time course of transmittance changes in order to emulate the clot signature of a standard solution. Preferably the graphic LCD module includes a portion which provides a user interface during a calibration run.

摘要翻译： 用于校准光密度测量装置的方法和系统包括可在微型计算机的控制下进行调制的图形显示模块。 该模块优选地是矩阵阵列型液晶显示器，其中可以选择性地打开或关闭各个像素以实现透射率改变的期望时间过程，以便模拟标准溶液的凝块标记。 优选地，图形LCD模块包括在校准运行期间提供用户界面的部分。

公开(公告)号：US20130285909A1

公开(公告)日：2013-10-31

申请号：US13995266

申请日：2011-12-22

申请人： Nilesh Patel ,  Scott Kroll ,  Mark Schwartz

发明人： Nilesh Patel ,  Scott Kroll ,  Mark Schwartz

IPC分类号： G06F3/01

CPC分类号： G06F3/017 ,  G09B5/00 ,  G09B7/02

摘要： The system comprises functionality for instructors to record their lessons in an easy method while allowing them to capture their teaching techniques with a tool which improves the effectiveness of the playback, by reverse scripting of the teachers motions and use of educational tools including blackboards, whiteboards, and tablet computers among others and automating highlight of the relevant multiple media channels for best emphasis during presentation. Access to the centralized lesson database will permit students to learn from the best teachers and instructors and can execute the system right on their desktops or portable computers or access it through a dedicated website. Playback may be personalized to the needs and preferences of each student and the conceptual content is essentially highlighted in video and audio to maximize didactic effectiveness of presentation.

摘要翻译： 该系统包括用于教师以简单的方法记录他们的课程的功能，同时允许他们通过改进播放的有效性的工具来捕获他们的教学技术，通过教师动作的反向脚本和教学工具的使用，包括黑板，白板， 和平板电脑等，并自动化相关多媒体频道的亮点，以便在演示过程中获得最佳的重视。 访问集中式课程数据库将允许学生从最好的教师和教师那里学习，并可以在桌面或便携式计算机上执行系统，或通过专用网站进行访问。 播放可以根据每个学生的需求和偏好进行个性化，并且基本上在视频和音频中强调概念内容，以最大限度地提高教学效果。