公开(公告)号：US07078461B2

公开(公告)日：2006-07-18

申请号：US10431956

申请日：2003-05-08

申请人： Donald A. Tomalia ,  Istvan J. Majoros

发明人： Donald A. Tomalia ,  Istvan J. Majoros

IPC分类号： C08L67/00 ,  C08G63/48

CPC分类号： C08L79/02 ,  C08L2205/02 ,  C12N15/895 ,  C08L2666/20

摘要： The present invention relates to compositions and methods involving biocompatible dendrimers. In particular, the present invention provides dendrimeric copolymers with poly(propyleneimine) (POPAM) interiors and poly(amidoamine) (PAMAM) exteriors for use in transfection and imaging applications.

摘要翻译： 本发明涉及涉及生物相容性树枝状大分子的组合物和方法。 特别地，本发明提供了用于转染和成像应用的聚（丙烯亚胺）（POPAM）内部和聚（酰氨基胺）（PAMAM）外观的树枝状聚合物。

公开(公告)号：US06475994B2

公开(公告)日：2002-11-05

申请号：US09219907

申请日：1998-12-23

申请人： Donald A. Tomalia ,  Lajos Balogh

发明人： Donald A. Tomalia ,  Lajos Balogh

IPC分类号： A61K3170

CPC分类号： C08G83/003 ,  B01J13/02 ,  C12N15/895 ,  Y10S977/914 ,  Y10S977/916

摘要： A gene transfection particle includes a polymer, a support particle conjugated with the dendritic polymer, and genetic material conjugated with the dendritic polymer. The gene transfection particles are highly efficient and are capable of delivering higher quantities of genetic materials to cells, with reduced cell damage. A gene transfection method involves bombarding cells with conjugates of polymers and genetic material, with or without a support particle.

摘要翻译： 基因转染颗粒包括聚合物，与树枝状聚合物共轭的载体颗粒和与树枝状聚合物共轭的遗传物质。 基因转染颗粒是高效的，并且能够向细胞递送更多量的遗传物质，具有降低的细胞损伤。 基因转染方法包括用聚合物和遗传物质的共轭物轰击细胞，具有或不具有支持物质。

公开(公告)号：US5731095A

公开(公告)日：1998-03-24

申请号：US735883

申请日：1996-10-23

申请人： Larry A. Milco ,  Donald A. Tomalia

发明人： Larry A. Milco ,  Donald A. Tomalia

IPC分类号： C08F2/16 ,  C08F8/30 ,  C08G83/00 ,  C09D201/00 ,  B32B27/06 ,  C08F2/32 ,  C08F20/00

CPC分类号： C08G83/003 ,  C08F8/30 ,  C09D201/005 ,  Y10S977/754 ,  Y10T428/31794

摘要： A water-soluble or water-dispersible fluorine-containing dendritic polymer surfactant having at least one terminal fluorocarbon moiety and at least one terminal anionic moiety, and which is suitable for use in preparing protective coating compositions is disclosed. The water-soluble or water-dispersible fluorine-containing dendritic polymer surfactants are represented by the general formula: ##STR1## where D represents a dendritic polymer, R.sub.F represents a fluorocarbon containing moiety, A.sup.- represents an anionic containing moiety, C.sup.+ represents a cation, T represents a terminal group of the dendritic polymer which has not been functionalized with a fluorocarbon or anionic moiety, n and m are at least each at least one, and the sum of n+m+q is the total number of terminal groups on the dendritic polymer. Also disclosed is a coating composition capable of forming a highly crosslinked, non-stick, protective coating. The coating composition includes a water-soluble or water-dispersible fluorine-containing dendritic polymer surfactant having at least one terminal fluorocarbon moiety and at least one terminal anionic moiety, an oxazoline crosslinking agent, and a water-based solvent.

摘要翻译： 公开了具有至少一个末端碳氟化合物部分和至少一个末端阴离子部分并且适合用于制备保护性涂料组合物的水溶性或水分散性含氟树枝状聚合物表面活性剂。 水溶性或水分散性的含氟树枝状高分子表面活性剂由以下通式表示：其中D表示树枝状聚合物，RF表示含氟碳的部分，A-表示含阴离子的部分，C +表示阳离子 ，T表示尚未用碳氟化合物或阴离子部分官能化的树枝状聚合物的末端基团，n和m至少分别为至少一个，n + m + q的总和为 树枝状聚合物。 还公开了能够形成高度交联，不粘的保护涂层的涂料组合物。 涂料组合物包括具有至少一个末端碳氟化合物部分和至少一个末端阴离子部分，恶唑啉交联剂和水基溶剂的水溶性或水分散性含氟树枝状聚合物表面活性剂。

公开(公告)号：US5714166A

公开(公告)日：1998-02-03

申请号：US400203

申请日：1995-03-07

申请人： Donald A. Tomalia ,  James R. Baker ,  Roberta C. Cheng ,  Anna U. Bielinska ,  Michael J. Fazio ,  David M. Hedstrand ,  Jennifer A. Johnson ,  Donald A. Kaplan, deceased ,  Scott L. Klakamp ,  William J. Kruper, Jr. ,  Jolanta Kukowska-Latallo ,  Bartley D. Maxon ,  Lars T. Piehler ,  Ian A. Tomlinson ,  Larry R. Wilson ,  Rui Yin ,  Herbert M. Brothers, II

发明人： Donald A. Tomalia ,  James R. Baker ,  Roberta C. Cheng ,  Anna U. Bielinska ,  Michael J. Fazio ,  David M. Hedstrand ,  Jennifer A. Johnson ,  Donald A. Kaplan, deceased ,  Scott L. Klakamp ,  William J. Kruper, Jr. ,  Jolanta Kukowska-Latallo ,  Bartley D. Maxon ,  Lars T. Piehler ,  Ian A. Tomlinson ,  Larry R. Wilson ,  Rui Yin ,  Herbert M. Brothers, II

IPC分类号： C12N15/02 ,  A01N25/10 ,  A61K20060101 ,  A61K31/70 ,  A61K38/00 ,  A61K39/385 ,  A61K39/44 ,  A61K45/00 ,  A61K47/34 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K51/00 ,  C07C211/29 ,  C07C233/11 ,  C07C237/20 ,  C07K20060101 ,  C07K14/525 ,  C07K14/535 ,  C07K14/54 ,  C07K14/555 ,  C07K17/06 ,  C07K17/08 ,  C08G73/00 ,  C08G83/00 ,  C08L101/00 ,  C12N20060101 ,  C12N5/10 ,  C12N15/09 ,  C12N15/57 ,  C12N15/87 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  A61K31/74 ,  A61K9/14 ,  A61K31/785

CPC分类号： A01N25/10 ,  A61K47/48192 ,  A61K47/48207 ,  A61K47/4823 ,  A61K47/48961 ,  A61K49/085 ,  A61K49/124 ,  B82Y5/00 ,  C07C211/29 ,  C07C233/11 ,  C07C237/20 ,  C08G83/003 ,  C08L101/005 ,  C12N15/87 ,  Y10S424/16

摘要： Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.

摘要翻译： 已经制备了由载体材料可以是生物反应调节剂的至少一种携带材料的至少一个单元组成的树枝状聚合物共轭物。 缀合物还可以存在目标导向剂，并且当其存在时，所携带的材料可以是生物活性剂。 优选的树枝状聚合物是与生物反应调节剂复合的致密星形聚合物。 这些共轭物和配合物由于其独特的特性而具有特别有利的性质。

公开(公告)号：US5393795A

公开(公告)日：1995-02-28

申请号：US259089

申请日：1994-06-13

申请人： David M. Hedstrand ,  Donald A. Tomalia

发明人： David M. Hedstrand ,  Donald A. Tomalia

IPC分类号： C08J9/12 ,  C08G73/02 ,  C08J9/00 ,  C08L101/00 ,  C08G6/00

CPC分类号： C08J9/0061 ,  C08G73/028 ,  C08J2479/00

摘要： Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents in forming a polymer blend.

摘要翻译： 通过用能够提供疏水性外壳的疏水基团加成改性的密集星形聚合物或树枝状大分子在形成聚合物共混物时用作分子成核剂。

公开(公告)号：US4694064A

公开(公告)日：1987-09-15

申请号：US834993

申请日：1986-02-28

申请人： Donald A. Tomalia ,  Pamela M. Kirchhoff

发明人： Donald A. Tomalia ,  Pamela M. Kirchhoff

IPC分类号： C08G73/00 ,  C08G63/44 ,  C08G65/28 ,  C08G65/38 ,  C08G69/00 ,  C08G69/02 ,  C08G73/02 ,  C08G75/00 ,  C08G75/02 ,  C08G75/20 ,  C08G83/00 ,  C08G69/10

CPC分类号： C08G83/003 ,  C08G73/02 ,  Y10S424/16

摘要： Rod-shaped dendrimers having a plurality of dendritic branches emanating from an essentially linear core are prepared by first reacting a linear polyfunctional core compound such as a polyethyleneimine with a first dendritic branching reactant such as an ester of an unsaturated carboxylic acid, e.g., methyl acrylate, and then successively reacting the resulting product with a second dendritic branching reactant such as ethylenediamine and then with the first or another dendritic branching reactant.The rod-shaped dendrimers are useful in the production of molecular composites and as crystallinity modifiers for polymeric materials.

公开(公告)号：US4600535A

公开(公告)日：1986-07-15

申请号：US659201

申请日：1984-10-09

申请人： Donald A. Tomalia ,  Larry R. Wilson

发明人： Donald A. Tomalia ,  Larry R. Wilson

IPC分类号： C07D257/02

CPC分类号： C07D257/02

摘要： Cyclic peptides, such as 1,4,8,11-tetraazacyclotetradecane-5,12-dione, that are useful chelation agents for metals are prepared by contacting an acrylic acid ester and a 1,2-alkylenediamine.

摘要翻译： 通过使丙烯酸酯和1,2-亚烷基二胺接触来制备用作金属螯合剂的环状肽，例如1,4,8,11-四氮杂环十四烷-5,12-二酮。

公开(公告)号：US4256855A

公开(公告)日：1981-03-17

申请号：US961159

申请日：1978-11-16

申请人： Thomas A. Chamberlin ,  Donald A. Tomalia

发明人： Thomas A. Chamberlin ,  Donald A. Tomalia

IPC分类号： B01D53/14 ,  B01J45/00 ,  C02F1/28 ,  C07D323/00 ,  C08F16/26 ,  C08F20/28 ,  C08F20/06 ,  C08F24/00

CPC分类号： C02F1/285 ,  B01D53/1493 ,  B01J45/00 ,  C07D323/00 ,  C08F16/26 ,  C08F20/28

摘要： Compounds represented by the formula ##STR1## and addition polymers thereof where m is an integer from 2 to about 10, x--is chlorine, hydroxy, carboxy or--AC--R).dbd.CH.sub.2--R is hydrogen or methyl, --R' is an ethylene or propylene group and--AC--R).dbd.CH.sub.2is one of ##STR2## These compounds and their addition polymers form complexes with alkali metal or alkaline earth metal salts and permit the concentration of aqueous solutions of said salts. For example, a compound of the formula ##STR3## is polymerized with an azobis(isobutyronitrile) catalyst to form addition polymers of the repeating unit ##STR4## When cross-linked, rendering it water-insoluble, such an addition polymer concentrates an aqueous solution of sodium chloride when contacted with same at about 0.degree. C.

摘要翻译： 由下式表示的化合物及其加成聚合物，其中m为2至约10的整数，x为氯，羟基，羧基或-AC-R）= CH 2 -R为氢或甲基，-R'为 乙烯或丙烯基和-AC-R）= CH 2是这些化合物及其加成聚合物与碱金属或碱土金属盐形成络合物并允许浓缩所述盐的水溶液。 例如，将式（IMAGE）化合物与偶氮双（异丁腈）催化剂聚合以形成重复单元的加成聚合物。当交联时，使其不溶于水，这种加成聚合物将水溶液 的氯化钠在约0℃下与其接触

公开(公告)号：US3996237A

公开(公告)日：1976-12-07

申请号：US489302

申请日：1974-07-17

申请人： Donald A. Tomalia

发明人： Donald A. Tomalia

IPC分类号： C07D263/10 ,  C08F20/36 ,  C07D265/08 ,  C07D263/12

CPC分类号： C08F20/36 ,  C07D263/10

摘要： New esters are described having the formula ##STR1## wherein R is a chemical bond or an inert linking group such as alkylene, oxa-alkylene, thia-alkylene, arylene, alkenylene or the like, R' and R" are H or lower alkyl and n is 2-3. They are made by the reaction of a bis-oxazoline or -oxazine with an equimolar amount of an acrylic acid: ##STR2## The compounds (I) are acrylic esters and are polymerizable and copolymerizable by the same general techniques used with other acrylic esters, thus producing solid resins useful as molding and coating materials. The oxazoline and oxazine rings in such resins are reactive with carboxyl groups; hence, the resins can be mixed with carboxy-containing polymers to form mixtures that readily cure upon mmold heat treatment to form hard, water-resistant and solvent-resistant, infusible resins.

摘要翻译： 描述了新的酯，其具有式（I）其中R是化学键或惰性连接基团如亚烷基，氧杂 - 亚烷基，硫杂 - 亚烷基，亚芳基，亚烯基等，R'和R“是 H或低级烷基，n为2-3。 它们通过双恶唑啉或 - 恶嗪与等摩尔量的丙烯酸的反应制备：化合物（I）是丙烯酸酯，并且可通过与其它丙烯酸酯一起使用的相同的一般技术进行聚合和共聚， 从而生产用作成型和涂覆材料的固体树脂。 这些树脂中的恶唑啉和恶嗪环与羧基反应; 因此，树脂可与含羧基的聚合物混合形成混合物，该混合物可以在多种金属热处理下容易固化以形成耐硬，耐水和耐溶剂的不熔树脂。

公开(公告)号：US06995234B2

公开(公告)日：2006-02-07

申请号：US10682646

申请日：2003-10-09

申请人： Donald A. Tomalia ,  Lajos Balogh

发明人： Donald A. Tomalia ,  Lajos Balogh

IPC分类号： C08K3/00 ,  C08J9/00

CPC分类号： B82Y30/00 ,  C08G83/003 ,  C08J3/02 ,  C08J2300/00 ,  C08J2300/202 ,  Y10S977/753 ,  Y10S977/754 ,  Y10S977/788 ,  Y10S977/835

摘要： In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.