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    ARRAY OF POLYMERIC HYDROGEL NANOSTRUCTURES AND THEIR USES
    25.
    发明申请
    ARRAY OF POLYMERIC HYDROGEL NANOSTRUCTURES AND THEIR USES 有权

    公开(公告)号：US20210299629A1

    公开(公告)日：2021-09-30

    申请号：US17265307

    申请日：2019-08-01

    Applicant: CORNING INCORPORATED

    Inventor： Ye Fang

    IPC: B01J19/00 ,  B01L3/00 ,  C12Q1/6874

    Abstract: A method for making a microfluidic device having one or more different patterned polymeric hydrogel nanostructure is provided. The method includes: providing a first substrate having a first patterned array of polymeric hydrogel nanostructures on a first interior surface and a peripheral surface portion; providing a second substrate having a second interior surface and a side wall with an end surface; and bonding the end surface of the second substrate to the peripheral surface portion of the first substrate such that the first and second interior surfaces define a hermetic cavity within the bonded first and second substrate. The microfluidic device can be designed to include a variety of different patterned array of polymeric hydrogel nanostructures depending on the desired application and properties for the device.

    NANO-PATTERNED SURFACES FOR MICROFLUIDIC DEVICES AND METHODS FOR MANUFACTURING THE SAME
    27.
    发明申请
    NANO-PATTERNED SURFACES FOR MICROFLUIDIC DEVICES AND METHODS FOR MANUFACTURING THE SAME 有权

    公开(公告)号：US20210213448A1

    公开(公告)日：2021-07-15

    申请号：US17251016

    申请日：2019-06-10

    Applicant: CORNING INCORPORATED

    Inventor： Donald Erwin Allen ,  Ye Fang ,  Wei Jiang ,  Jeffrey Glenn Lynn ,  Barry James Paddock ,  Ying Zhang

    IPC: B01L3/00 ,  B81B1/00 ,  B81C1/00

    Abstract: A method of making a microfluidic device (200, 201, 300) can include depositing a layer of photoresist onto a first substrate (210, 270, 310), selectively removing the photoresist to expose portions of the first substrate (210, 270, 310), etching the exposed portions of the first substrate (210, 270, 310) to form an array of nano-wells (240, 340), coating each nano-well (240, 340) with metal oxide, and coating the metal oxide on each nano-well (240, 340) with a first material to increase binding of DNA, proteins, and polynucleotides to the metal oxide. A layer of a second material can be deposited on interstitial areas between the nano-wells (240, 340) to inhibit binding of DNA, proteins, and polynucleotides to the interstitial areas. A second substrate (220, 320) can be bonded to the first substrate (210, 270, 310) to enclose the array of nano-wells (240, 340) in a cavity.

    PATTERNED FLOW CELLS FOR BIOMOLECULAR ANALYSIS
    28.
    发明申请
    PATTERNED FLOW CELLS FOR BIOMOLECULAR ANALYSIS 有权

    公开(公告)号：US20210213447A1

    公开(公告)日：2021-07-15

    申请号：US17251011

    申请日：2019-06-10

    Applicant: CORNING INCORPORATED

    Inventor： Ye Fang

    IPC: B01L3/00

    Abstract: A patterned flow cell includes a substrate (100, 200) having a patterned array of metal oxide nano-patches (104, 202). Each of the metal oxide nano-patches (104, 202) has an organophosphate coating layer (106, 206) to increase the ability of the metal oxide (104, 204) to bind with DNA, proteins, or polynucleotides. A silane coating layer (108, 208) is deposited in the interstitial spaces on the substrate (100, 200) between the metal oxide nano-patches (104, 202) to prevent the binding of polynucleotides, DNA, or proteins in the interstitial spaces.

    MICROFLUIDIC DEVICES AND METHODS FOR MANUFACTURING MICROFLUIDIC DEVICES
    29.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS FOR MANUFACTURING MICROFLUIDIC DEVICES 有权

    公开(公告)号：US20210069710A1

    公开(公告)日：2021-03-11

    申请号：US17049676

    申请日：2019-04-23

    Applicant: CORNING INCORPORATED

    Inventor： Ye Fang ,  Jin Su Kim ,  Aize Li

    IPC: B01L3/00

    Abstract: A method for manufacturing a microfluidic device (100) includes depositing a bonding layer (106) on a surface of a second glass layer (104a) of a glass substrate having a first glass layer (102) and the second glass layer (104a) fused to the first glass layer (102), such that a masked region of the surface is covered by the bonding layer, and an exposed region of the surface is uncovered by the bonding layer; removing a portion of the second glass layer corresponding to the exposed region of the surface to form a flow channel (112) in the glass substrate; and bonding a cover (108) to the glass substrate with the bonding layer (106).

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