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21.发明申请Multipole ion guide interface for reduced background noise in mass spectrometry 有权多极离子导向接口，用于降低质谱中的背景噪音公开(公告)号：US20090218486A1
公开(公告)日：2009-09-03
申请号：US11809349
申请日：2007-05-31
IPC分类号： H01J49/04
CPC分类号： H01J49/04 , H01J49/063
摘要： Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra. Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to-noise in mass spectra.
摘要翻译： 从离子源传输到用于质量分析的质谱仪的离子通常伴有起源于离子源的背景颗粒如光子，中性物质和簇或气溶胶离子。 在与质谱仪检测器的视线的较高压力区域中与背景气体分子碰撞期间，离子的散射和中和也产生背景颗粒。 在任一种情况下，这种背景颗粒在质谱中产生噪声。 提供了一种设备和方法，其中多极离子导向器被配置为有效地将离子传输通过多个真空级，同时防止在离子源和离子传输途径中产生的背景颗粒到达检测器，从而改善信号到 在质谱中不存在。
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公开(公告)号：US20080142704A1
公开(公告)日：2008-06-19
申请号：US11965448
申请日：2007-12-27
IPC分类号： H01J49/00
CPC分类号： H01J49/167
摘要： An improved sample introduction probe is disclosed for the production of ions from liquid sample solutions in an electrospray ion source. Nebulization of a liquid sample emerging from the end of an inner flow tube is pneumatically assisted by gas flowing from the end of an outer gas flow tube essentially coaxial with the inner sample flow tube. The disclosed probe provides for adjustment of the relative axial positions of the ends of the liquid and gas flow tubes without degrading the precise concentricity between the inner and outer tubes. Additionally, the terminal portion of the outer gas flow tube may be fabricated either from a conductive or dielectric material, thereby allowing the pneumatic nebulization and electrospray processes to be optimized separately and independently. Hence, the disclosed invention provides a pneumatically-assisted electrospray probe with improved mechanical and operational stability, reliability, reproducibility, and ease of use compared to prior art probes
摘要翻译： 公开了用于在电喷雾离子源中从液体样品溶液中产生离子的改进的样品引入探针。 从内流管端部出现的液体样品的雾化由气体从与内部样品流管同轴的外部气体流管的端部流动的气体辅助。 所公开的探针提供了调节液体和气体流管的端部的相对轴向位置，而不会降低内管和外管之间的精确同心度。 此外，外部气体流动管的端子部分可以由导电材料或介电材料制成，从而允许气动雾化和电喷雾工艺被独立地和独立地优化。 因此，与现有技术的探针相比，所公开的发明提供了具有改善的机械和操作稳定性，可靠性，再现性和易用性的气动辅助电喷雾探针
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公开(公告)号：US07375319B1
公开(公告)日：2008-05-20
申请号：US11500055
申请日：2006-08-07
IPC分类号： H01J49/04
CPC分类号： H01J49/0463 , H01J49/145
摘要： Atmospheric pressure, intermediate pressure and vacuum laser desorption ionization methods and ion sources are configured to increase ionization efficiency and the efficiency of transmitting ions to a mass to charge analyzer or ion mobility analyzer. An electric field is applied in the region of a sample target to accumulate ions generated from a local ion source on a solid or liquid phase sample prior to applying a laser desorption pulse. The electric field is changed just prior to or during the desorption laser pulse to promote the desorption of charged species and improve the ionization efficiency of desorbed sample species. After a delay, the electric field may be further changed to optimize focusing and transmission of ions into a mass spectrometer or ion mobility analyzer. Charged species may also be added to the region of the laser desorbed sample plume to promote ion-molecule reactions between the added ions and desorbed neutral sample species, increasing desorbed sample ionization efficiency and/or creating desired production species. The cycling of electric field changes is repeated in a timed sequence with one or more desorption laser pulse occurring per electric field change cycle. Embodiments of the invention comprise atmospheric pressure, intermediate pressure and vacuum pressure laser desorption ionization source methods and devices for increasing the analytical flexibility and improving the sensitivity of mass spectrometric analysis.
摘要翻译： 大气压力，中压和真空激光解吸电离方法和离子源被配置为增加电离效率和将离子传输到质量计量分析器或离子迁移率分析仪的效率。 在样品靶的区域内施加电场，以在施加激光解吸脉冲之前，在固相或液相样品上积聚从局部离子源产生的离子。 电场在解吸激光脉冲之前或期间改变，以促进带电物质的解吸附并提高解吸样品的离子化效率。 延迟后，可以进一步改变电场以优化离子聚焦和传输到质谱仪或离子迁移率分析仪中。 带电物质也可以添加到激光解吸的样品羽毛的区域中，以促进添加的离子和解吸的中性样品物质之间的离子 - 分子反应，增加解吸的样品离子化效率和/或产生所需的生产物质。 以定时序列重复电场变化的循环，每个电场变化周期发生一个或多个解吸激光脉冲。 本发明的实施例包括大气压力，中压和真空压力激光解吸电离源的方法和装置，用于增加分析灵活性并提高质谱分析的灵敏度。
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公开(公告)号：US07176455B1
公开(公告)日：2007-02-13
申请号：US11135926
申请日：2005-05-23
申请人： Craig M. Whitehouse , Erol Gulcicek
发明人： Craig M. Whitehouse , Erol Gulcicek
IPC分类号： H01J49/00
CPC分类号： H01J49/063 , H01J49/0481
摘要： A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide an and qn values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.
摘要翻译： 在一个泵送阶段开始并连续延伸到一个或多个后续泵送阶段的多极离子导向器已经被并入到大气压离子源质谱仪系统中。 从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并且使用多极离子导向器以高效率聚焦到质量分析器中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 可以使用多极离子导向DC偏移电位来调整平均离子能量，并且可以设置离子导向器以减小或扩大范围 将通过离子导向器传输的离子质量。 多极离子导向器和多泵级多极离子导向器的这些特性用于提高大气压离子源质谱仪器的性能和降低成本。
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公开(公告)号：US07019285B2
公开(公告)日：2006-03-28
申请号：US09808468
申请日：2001-03-14
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.
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公开(公告)号：US06541768B2
公开(公告)日：2003-04-01
申请号：US09813396
申请日：2001-03-21
IPC分类号： B01D5944
CPC分类号： H01J49/107 , H01J49/0009 , H01J49/0431 , H01J49/165
摘要： Multiple sample introduction means have been configured in Atmospheric Pressure Ion sources which are interfaced to mass analyzers. Different samples can be introduced through multiple Electrospray (ES) or Atmospheric Pressure Chemical Ionization (APCI) probes individually or simultaneously and ionized. The gas phase ion mixture resulting from individual solutions sprayed from multiple ES or APCI probe inputs is mass analyzed. In this manner a calibration solution can be introduced through one ES or APCI probe while one or more sample solutions are spray from additional probes. Simultaneous spraying of calibration and sample solutions, results in an acquired mass spectrum containing peaks of ions with known molecular weights as well as sample related peaks. The calibration peaks can be used as an internal calibration standard during data analysis. Acquisition of mass spectra containing internal calibration peaks can be achieved by spraying different solutions simultaneously from multiple inlet probes without having to mix calibration and sample solutions in the liquid phase. Arrangements of ES and APCI probes can be configured in one API source chamber and the solution flow through any combination of ES or APCI probes can be switched on or off during an analytical run. A single mass analyzer can serve as a detector for multiple separation systems each delivering sample solution through separate ES or APCI inlet probes into an atmospheric pressure ion source.
摘要翻译： 在大气压离子源中配置了多个样品引入装置，它们与大量分析仪接口。 可以通过多个电喷雾（ES）或大气压化学电离（APCI）探针单独或同时引入不同的样品并进行电离。 对从多个ES或APCI探针输入喷射的各溶液产生的气相离子混合物进行质量分析。 以这种方式，可以通过一个ES或APCI探针引入校准溶液，同时从另外的探针喷射一种或多种样品溶液。 同时喷射校准和样品溶液，得到包含已知分子量的离子峰以及样品相关峰的获得质谱。 在数据分析期间，校准峰可用作内部校准标准。 通过从多个入口探针同时喷射不同的溶液而无需在液相中混合校准和样品溶液，可以获得含有内部校准峰的质谱。 可以在一个API源室中配置ES和APCI探针的安排，并且可以在分析运行期间打开或关闭通过ES或APCI探针的任意组合的溶液流。 单个质量分析仪可用作多个分离系统的检测器，每个分离系统将样品溶液通过单独的ES或APCI入口探针输送到大气压离子源。
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公开(公告)号：US06337480B1
公开(公告)日：2002-01-08
申请号：US09632572
申请日：2000-08-04
申请人： Bruce A. Andrien, Jr. , Craig M. Whitehouse , Michael A. Sansone , Denise M. Sauro , Glenn P. Whitehouse
发明人： Bruce A. Andrien, Jr. , Craig M. Whitehouse , Michael A. Sansone , Denise M. Sauro , Glenn P. Whitehouse
IPC分类号： H01J4904
CPC分类号： H01J49/167
摘要： An Electrospray probe which includes a replaceable or disposable micron size diameter Electrospray tip used for low flow rate Electrospray has been developed. The Electrospray probe assembly combines the use of a low pressure gas and electric fields to initiate and sustain the Electrospray process at low liquid flow rates. The operational flow rates of this probe range from below 25 nL/min to over 1 &mgr;L/min, with total sample volume loaded ranging from less than 1 &mgr;L to over 20 &mgr;L. The Electrospray probe assembly includes axial and radial adjustment of the Electrospray tip position relative to the sampling orifice into vacuum and that tip position can be locked in place. The replaceable microtip can be safely removed from the Electrospray (ES) chamber without turning off high voltage within the ES chamber. Telescoping support ways have been included to prevent ES tip damage by guiding the Electrospray probe tip during removal from and insertion into the ES chamber. The replaceable microtip is held in a fixed position during operation with a collet assembly which also provides electrical contact with coated microtips. The replaceable microtip ES probe assembly is compatible with microtips that are metal or coated or uncoated glass materials. For uncoated glass microtips the ES probe assembly accommodates a wire electrical contact which is installed in the replaceable microtip bore.
摘要翻译： 已经开发了一种电喷探针，其包括用于低流速电喷雾的可替换或一次性微米尺寸直径的电喷雾尖端。 电喷雾探针组件结合了低压气体和电场的使用，以低液体流速启动和维持电喷雾过程。 该探头的操作流量范围从低于25 nL / min到超过1μL/ min，总样品体积加载范围从小于1μL到20μL。 电喷雾探针组件包括相对于采样孔将电喷雾头部位置轴向和径向调节成真空并且尖端位置可以锁定就位。 可以从电喷雾（ES）室中安全地移除可更换的微尖端，而不会关闭ES室内的高压。 通过引导电喷雾探针尖端从ES腔中取出并插入ES腔，已经包括伸缩支撑方式来防止ES尖端损伤。 在使用夹套组件的操作期间，可替换的微尖头保持在固定位置，其还提供与涂覆的微尖端的电接触。 可替换的微尖头ES探针组件与金属或涂层或未涂覆的玻璃材料的微尖头兼容。 对于未涂覆的玻璃微尖头，ES探头组件可容纳安装在可更换微型钻孔中的电线触点。
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公开(公告)号：US06188066B1
公开(公告)日：2001-02-13
申请号：US09373337
申请日：1999-08-12
申请人： Craig M. Whitehouse , Erol Gulcicek
发明人： Craig M. Whitehouse , Erol Gulcicek
IPC分类号： B01D5944
CPC分类号： B01D59/44 , H01J49/0481 , H01J49/063
摘要： A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide an and qn values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.
摘要翻译： 在一个泵送阶段开始并连续延伸到一个或多个后续泵送阶段的多极离子导向器已经被并入大气压离子源质谱仪系统中。 从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并且使用多极离子导向器以高效率聚焦到质量分析器中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 多极离子导向DC补偿电位可用于调整平均离子能量和离子导向器a和qn值可以设置为减小或扩大将通过离子导向器传输的离子质量到充电的范围。 多极离子导向器和多泵级多极离子导向器的这些特性用于提高大气压离子源质谱仪器的性能和降低成本。
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公开(公告)号：US06060705A
公开(公告)日：2000-05-09
申请号：US988491
申请日：1997-12-10
CPC分类号： H01J49/165
摘要： Improvements have been made to the Electrospray and Atmospheric Pressure Chemical Ionization source chambers interfaced to mass spectrometers to simplify source performance optimization and source operation and to improve system sensitivity. The atmospheric pressure ion source procedure for optimizing performance has been simplified by adding windows along the sides of the atmospheric pressure ionization chamber allowing direct viewing of the Electrospray and Atmospheric pressure ion sources during operation. A cylindrical lens which extends along the side walls of the atmospheric pressure chamber has been configured to be semitransparent for viewing into the chamber. This cylindrical shaped side lens is electrically isolated from the Electrospray liquid introduction needle and Electrospray chamber endplate. Improved Electrospray mass spectrometer system sensitivity can be achieved when operating the cylindrical lens with a higher potential difference between it and the Electrospray liquid introduction needle than is set between the needle and the endplate.
摘要翻译： 已经对与质谱仪连接的电喷雾和大气压化学电离源室进行了改进，以简化源性能优化和源操作，并提高系统灵敏度。 通过在大气压电离室的侧面添加窗口可简化用于优化性能的大气压离子源程序，从而可以在运行期间直接观察电喷雾和大气压离子源。 沿着大气压力室的侧壁延伸的圆柱形透镜已经被配置为半透明的，用于观察室。 该圆柱形侧透镜与电喷雾液引入针和电喷雾室终板电隔离。 当操作具有比电针与终板之间设置的电喷雾引入针之间更高的电位差的柱面透镜时，可以实现改进的电喷雾质谱系统灵敏度。
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公开(公告)号：US6040575A
公开(公告)日：2000-03-21
申请号：US235945
申请日：1999-01-22
CPC分类号： H01J49/40 , B82Y15/00 , B82Y30/00 , H01J49/0068
摘要： A Time-Of-Flight mass spectrometer is configured with a pulsing region and electronic controls to cause the directing of ions to a surface in the Time-Of-Flight pulsing region. The population of ions resulting from the collecting of said ions on or near said surface is subsequently accelerated into the Time-Of-Flight tube for mass to charge analysis. Ions produced away from said surface located in the pulsing region of a Time-Of-Flight mass spectrometer can be directed to the surface with high or low surface collisional energies. Higher energy ion collisions with the surface can result in Surface Induced Dissociation fragmentation and the resulting ion fragment population can be accelerated into Time-Of-Flight tube where the ions are mass to charge analyzed. Ion mass to charge selection can occur prior to directing ions to the pulsing region surface allowing MS/MS Time-Of-Flight mass analysis with SID. Ion to surface low energy collisions or soft landings resulting in little or no ion fragmentation provide a means for spatially focusing ions on or near the surface prior to accelerating the surface collected ions into the Time-Of-Flight tube. The apparatus and methods described in the invention result in refined control of ion fragmentation energy and improved Time-Of-Flight mass to charge analysis performance.
摘要翻译： 飞行时间质谱仪配置有脉冲区域和电子控制器，以将离子引导到飞行时间脉动区域中的表面。 随后在所述表面上或附近收集所述离子产生的离子群随后被加速到飞行时间管中用于质量进行电荷分析。 离开位于飞行时间质谱仪的脉冲区域的所述表面的离子可以被引导到具有高或低表面碰撞能量的表面。 与表面的高能离子碰撞可导致表面诱导解离破碎，并且所得到的离子片段群体可以加速到飞行时间管中，其中离子被质量分析。 在将离子引导到脉冲区域表面之前可以进行离子质量以进行电荷选择，从而允许使用SID的MS / MS飞行时间质量分析。 离子到表面的低能量碰撞或软着陆导致很少或没有离子碎裂提供了在将表面收集的离子加速到飞行时间管之前将离子空间聚焦在表面上或附近的手段。 本发明中描述的装置和方法导致离子断裂能量的精细控制和改进的飞行时间质量以进行电荷分析性能。
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