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公开(公告)号：US10400245B2
公开(公告)日：2019-09-03
申请号：US15485338
申请日：2017-04-12
Applicant: Dow AgroSciences LLC
Inventor： Manju Gupta , Sandeep Kumar , Wei Chen
Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a Zea mays GRMZM2G047720 promoter. Some embodiments relate to a Zea mays GRMZM2G047720 promoter that functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a Zea mays GRMZM2G047720 3′UTR that functions in plants to terminate transcription of operably linked nucleotide sequences.
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22.发明授权公开(公告)号：US10344289B2
公开(公告)日：2019-07-09
申请号：US14538609
申请日：2014-11-11
Applicant: Dow AgroSciences LLC , Sangamo BioSciences, Inc.
Inventor： Manju Gupta , Asha M. Palta , Stephen Novak , Fyodor Urnov , Sunita Gopalan
Abstract: The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes.
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公开(公告)号：US10030247B2
公开(公告)日：2018-07-24
申请号：US14587750
申请日：2014-12-31
Applicant: Dow AgroSciences LLC
Inventor： Sandeep Kumar , Manju Gupta , Terry R. Wright , Susan M. Jayne , Doug A. Smith , Diaa Alabed
IPC: C12N15/82
CPC classification number: C12N15/8216
Abstract: The Zea mays c.v. B73 Ubiquitin-1 (Z. mays c.v. B73 Ubi-1) promoter drives high levels of constitutive transgene expression in plants. Repeated use of the same Z. mays c.v. B73 Ubi-1 promoter in multi-gene constructs may also lead to gene silencing, thereby making transgenic products less efficacious. Provided are gene regulatory promoter elements, constructs, and methods for expressing a transgene in plant cells and/or plant tissues using gene regulatory elements from the Ubi-1 promoter of a different Z. mays genotype, Z. mays c.v. Hi-II.
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公开(公告)号：US10023921B2
公开(公告)日：2018-07-17
申请号：US14547589
申请日：2014-11-19
Applicant: Pioneer Hi-Bred International, Inc. , Dow Agrosciences LLC , E. I. Du Pont De Nemours and Company
Inventor： Eric Barbour , James Wayne Bing , Guy A. Cardineau , Robert F. Cressman, Jr. , Manju Gupta , Mary E. Hartnett Locke , David Hondred , Joseph W. Keaschall , Michael G. Koziel , Terry EuClaire Meyer , Daniel Moellenbeck , Kenneth Edwin Narva , Wilas Nirunsuksiri , Stephen W. Ritchie , Marjorie L. Rudert , Craig D. Sanders , Aihua Shao , Steven Jeffrey Stelman , David S. Stucker , Laura Ann Tagliani , William M. Van Zante
IPC: C12Q1/68 , C12N15/82 , C12Q1/6895 , C12Q1/686
Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize TC1507 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
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25.发明申请公开(公告)号：US20180163217A1
公开(公告)日：2018-06-14
申请号：US15882609
申请日：2018-01-29
Applicant: Dow AgroSciences LLC , Sangamo Therapeutics, Inc.
Inventor： Noel Cogan , John Forster , Matthew Hayden , Tim Sawbridge , German Spangenberg , Steven R. Webb , Manju Gupta , W. Michael Ainley , Matthew J. Henry , Jeffrey C. Miller , Dmitry Y. Guschin
CPC classification number: C12N15/79 , C12N9/22 , C12N15/63 , C12N15/8241 , C12N15/8247
Abstract: A method of gene editing or gene stacking within a FAD3 loci by cleaving, in a site directed manner, a location in a FAD3 gene in a cell, to generate a break in the FAD3 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.
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Patent Agency Ranking
26.发明授权公开(公告)号：US09832942B2
公开(公告)日：2017-12-05
申请号：US14614284
申请日：2015-02-04
Applicant: Dow AgroSciences LLC
Inventor： Xueyi Hu , Mandy Lynne Sullivan-Gilbert , Manju Gupta , Steven Arnold Thompson
CPC classification number: A01H1/02 , A01H1/04 , A01H5/10 , C12N9/0071 , C12N9/0083 , C12N15/8247 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Y114/19001
Abstract: The present invention provides methods of marker-assisted selection for high oleic/low linolenic traits in canola and in other oil seed crop species, as well as isolated nucleic acids for use as molecular markers in such methods. In particular, molecular markers and Brassica nucleic acid corresponding to fad2 and fad3 gene mutations are disclosed. The markers of the present invention are highly useful for the direct selection of desirable fad2 and fad3 alleles during marker-assisted trait introgression and breeding. In one aspect of the embodiment, two single nucleotide polymorphism (SNP) markers are provided that correspond to the alleles. Thus, the present invention advantageously permits one of skill in the art to breed for the molecular markers described herein, or derivatives thereof, rather than breeding for a high oleic/low linolenic phenotype.
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公开(公告)号：US20170298373A1
公开(公告)日：2017-10-19
申请号：US15453121
申请日：2017-03-08
Applicant: Dow AgroSciences LLC
Inventor： Manju Gupta , Sandeep Kumar , Shavell Gorman , Andrew F. Worden
CPC classification number: C12N15/8225 , C12N15/113 , C12N15/8223 , C12N15/8286 , Y02A40/162
Abstract: This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a Zea mays GRMZM2G138258 promoter. Some embodiments relate to a Zea mays GRMZM2G138258 promoter that functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a Zea mays GRMZM2G138258 3′UTR that functions in plants to terminate transcription of operably linked nucleotide sequences.
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公开(公告)号：US09777286B2
公开(公告)日：2017-10-03
申请号：US14505055
申请日：2014-10-02
Applicant: Dow AgroSciences LLC
Inventor： Manju Gupta , Sandeep Kumar , Navin Elango , Karthik Narayna Muthuraman , Jeffrey Beringer , Huixia Wu , Nagesh Sardesai
IPC: C12N15/82
CPC classification number: C12N15/8227 , C12N15/8216 , C12N15/8222
Abstract: Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using Zea mays metallothionein-like gene regulatory elements.
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公开(公告)号：US20170081675A1
公开(公告)日：2017-03-23
申请号：US15266348
申请日：2016-09-15
Applicant: Dow AgroSciences LLC
Inventor： Manju Gupta , Sara Bennett , Andrew F. Worden
IPC: C12N15/82
CPC classification number: C12N15/8216 , C07K14/415 , C12N15/8205 , C12N15/8222 , C12N15/8241 , C12N15/8273 , C12N15/8274 , C12N15/8286
Abstract: This disclosure concerns compositions and methods for promoting transcription and translation of a nucleotide sequence in a plant or plant cell, employing a 3′UTR from Arabidopsis thaliana Ubiquitin C9 gene. Some embodiments relate to a 3′ UTR from a Arabidopsis thaliana Ubiquitin C9 gene that functions in plants to terminate transcription of operably linked nucleotide sequences.
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30.发明授权公开(公告)号：US09422569B2
公开(公告)日：2016-08-23
申请号：US13674606
申请日：2012-11-12
Applicant: Dow AgroSciences LLC
Inventor： Sandeep Kumar , Diaa Alabed , Terry Wright , Manju Gupta
IPC: C12N15/82
CPC classification number: C12N15/8216 , C12N15/8222 , C12N15/8286 , Y02A40/162
Abstract: Provided are constructs and methods for expressing multiple genes in plant cells and/or plant tissues. The constructs provided comprise at least one bidirectional promoter link to multiple gene expression cassettes. In some embodiments, the constructs and methods provided employ a bidirectional promoter based on a minimal core promoter element from a Zea mays Ubiquitin-1 gene, or a functional equivalent thereof. In some embodiments, the constructs and methods provided allow expression of genes between three and twenty.
Abstract translation: 提供了用于在植物细胞和/或植物组织中表达多个基因的构建体和方法。 所提供的构建物包含至少一个与多个基因表达盒的双向启动子连接。 在一些实施方案中，提供的构建体和方法使用基于来自玉米泛素-1基因的最小核心启动子元件或其功能等同物的双向启动子。 在一些实施方案中，提供的构建体和方法允许在3至20个之间表达基因。
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