公开(公告)号：US06870012B2

公开(公告)日：2005-03-22

申请号：US10422559

申请日：2003-04-24

Applicant: Daniel Cohn ,  Avraham Levi

Inventor： Daniel Cohn ,  Avraham Levi

IPC: C08G63/664 ,  C08G65/332 ,  C08L71/02 ,  A61K47/34 ,  C08G65/08

CPC classification number: C08G65/3324 ,  C08G63/664 ,  C08L71/02 ,  C08L2205/05 ,  C08L2666/18

Abstract: A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene oxide) unit, E is a chain extender unit, n=0-20, and m is greater than 2. The ethylene oxide:propylene oxide ratio ranges from about 0.2:1 to about 40:1. The composition has a final viscosity at a final temperature of more than twice the initial viscosity at an initial temperature wherein the final temperature is at least 10° C. higher than the initial temperature. The composition is combined with either a cellular material for tissue engineering, a cellular material for effecting repair or healing in a patient, or a bioactive agent.

Abstract translation: 具有逆热凝胶性的组合物包含具有以下结构的嵌段聚合物：其中A是聚酯单元，B是聚（环氧乙烷）单元，C是聚（环氧丙烷）单元，E是扩链剂单元，n = 0-20，m大于2.环氧乙烷：环氧丙烷的比例为约0.2:1至约40:1。 该组合物在最终温度下的初始粘度的最终粘度为初始温度的两倍，其中最终温度比起始温度高至少10℃。 组合物与用于组织工程的细胞材料，用于在患者中进行修复或愈合的细胞材料或生物活性剂组合。

公开(公告)号：US20050008609A1

公开(公告)日：2005-01-13

申请号：US10789431

申请日：2004-02-27

Applicant: Daniel Cohn ,  Alejandro Sosnik

Inventor： Daniel Cohn ,  Alejandro Sosnik

IPC: A61K9/00 ,  A61K31/74 ,  A61K47/34

CPC classification number: A61K9/0024 ,  A61K47/34

Abstract: A multi-component environmentally responsive polymeric system, having at least two environmentally responsive polymeric components capable of undergoing a transition that results in a sharp increase in viscosity in response to a change in temperature at a predetermined body site, wherein the at least two components display different reverse thermal gelation behavior in the human body.

Abstract translation: 一种多组分环境响应的聚合物体系，其具有至少两种环境响应性聚合物组分，其能够经历转变，其导致响应于在预定体部位处的温度变化引起的粘度急剧增加，其中所述至少两种组分显示 不同的反向热凝胶化行为在人体内。

公开(公告)号：US06579951B1

公开(公告)日：2003-06-17

申请号：US09587983

申请日：2000-06-06

Applicant: Daniel Cohn ,  Avraham Levi

Inventor： Daniel Cohn ,  Avraham Levi

IPC: C08G63664

CPC classification number: C08G65/3324 ,  C08G63/664 ,  C08L71/02 ,  C08L2205/05 ,  C08L2666/18

Abstract: A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure: {[An(BCB)An]}m wherein A is a polyester unit, B is a poly(ethylene oxide) unit, C is a poly(propylene oxide unit, E is a chain extender or crosslinking agent unit, n ranges from 0 to 20, and m is greater than 2, said block polymer possessing an EO (ethylene xide):PO (propylene oxide) ratio ranging from about 0.2:1 to about 40:1, said composition having a final viscosity at a final temperature of more than twice the initial viscosity at an initial temperature, said final temperature being at least 10° C. higher than said initial temperature.

Abstract translation: 具有逆热凝胶性的组合物包含具有以下结构的嵌段聚合物：其中A是聚酯单元，B是聚（环氧乙烷）单元，C是聚（环氧丙烷单元，E是增链剂或交联剂单元 ，n为0至20，m大于2，所述嵌段聚合物具有EO（乙烯基）：PO（环氧丙烷）比为约0.2:1至约40:1，所述组合物具有最终粘度 在初始温度下的初始粘度的两倍以上的最终温度下，所述最终温度比所述初始温度高至少10℃。

公开(公告)号：US06211249B1

公开(公告)日：2001-04-03

申请号：US09006664

申请日：1998-01-13

Applicant: Daniel Cohn ,  Theodor Stern ,  Avraham Levi

Inventor： Daniel Cohn ,  Theodor Stern ,  Avraham Levi

IPC: A61K4734

CPC classification number: C08G69/44 ,  A61L31/06 ,  C08G63/08 ,  C08G63/664 ,  C08L67/04 ,  C08L77/12

Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and bum dressings and producing biodegradable articles, among numerous others.

Abstract translation: 本发明涉及基于AB聚酯聚醚或相关二嵌段和三嵌段的新型生物可吸收聚合物组合物。 根据本发明的组合物可以用于医疗应用中，例如用于减少或防止医疗程序如手术之后的粘附形成，用于生产包括支架和移植物的外科用品，作为涂层，密封剂，润滑剂，作为瞬时屏障 身体，用于控制身体中生物活性剂释放的材料，用于伤口和烧伤敷料以及生产可生物降解的制品等等。

公开(公告)号：US20210184887A1

公开(公告)日：2021-06-17

申请号：US17166850

申请日：2021-02-03

Applicant: Harish Balasubramaniam ,  Daniel Cohn ,  Magnus Eriksson ,  Oren Haggai ,  Robert Hughes ,  Idan Zalitzky

Inventor： Harish Balasubramaniam ,  Daniel Cohn ,  Magnus Eriksson ,  Oren Haggai ,  Robert Hughes ,  Idan Zalitzky

IPC: H04L12/40 ,  H04L29/06 ,  H04W76/10 ,  H04W28/20

Abstract: This disclosure describes systems, methods, and devices related to label based isochronous connection update. A central Bluetooth low energy (BLE) device may send a plurality of labels to a peripheral BLE device during a setup of a BLE communication to notify the peripheral BLE device of one or more labels to be used during the BLE communication. The central BLE device may determine a channel variation between the central BLE device and the peripheral BLE device. The central BLE device may send a first label to the peripheral BLE device to indicate an isochronous (ISO) parameter update that will occur at a first time offset based on the channel variation. The central BLE device may implement the isochronous parameter update at the first time offset based on the channel variation.

公开(公告)号：US09526813B2

公开(公告)日：2016-12-27

申请号：US13383588

申请日：2010-07-13

Applicant: Daniel Cohn ,  Itai Pelled ,  Randa Abbas ,  Ram Malal

Inventor： Daniel Cohn ,  Itai Pelled ,  Randa Abbas ,  Ram Malal

IPC: A61M29/04 ,  A61L31/06 ,  A61F2/945

CPC classification number: A61L31/06 ,  A61F2/945 ,  C08L67/04

Abstract: Novel medical devices and uses thereof for lining a blood vessel and/or treating an aneurysm are disclosed herein. The device comprises a non-metallic expandable tubular structure, implantable in a body vessel and being made, at least in part, from a polymeric system characterized by a stiffness which changes upon stimulation under physiological conditions. Novel polymeric systems are further disclosed herein, which are configured to produce a polymeric material upon stimulation under physiological conditions, such that a stiffness of said polymeric material is higher than a stiffness of said system. Uses of polymer systems in the manufacture of a device are further disclosed.

Abstract translation: 本文公开了用于衬里血管和/或治疗动脉瘤的新型医疗装置及其用途。 该装置包括可植入体内容器中的至少部分由聚合体系制成的非金属可膨胀管状结构，其特征在于在生理条件下刺激时改变的刚度。 本文进一步公开了新型聚合物体系，其被配置为在生理条件下刺激时产生聚合物材料，使得所述聚合物材料的刚度高于所述系统的刚度。 进一步公开了聚合物体系在制造装置中的用途。

公开(公告)号：US08837428B2

公开(公告)日：2014-09-16

申请号：US13036958

申请日：2011-02-28

Applicant: Daniel Cohn

Inventor： Daniel Cohn

IPC: H04W4/00 ,  H04W36/00

CPC classification number: H04W36/0072 ,  H04W36/0038 ,  H04W36/0044 ,  H04W36/0055

Abstract: A method and system are provided for enabling an MS operative in a multi-layer wireless network, to be handed over to a target BS associated with another one of the multi-layers. By the method provided, if it is required that the MS which has not yet been provided with information that relates to a potential target BS associated with a layer different from the one with which its currently serving BS, be handed over to such a target BS, then upon receiving an acknowledgement from the target BS indicating its capability to provide service to the MS, a message is transmitted to the MS that comprises information to enable the MS to perform a fast network re-entry in order to communicate with the target BS. Next, a handover procedure between the MS and the target BS is initiated, during which the MS performs a fast network re-entry.

Abstract translation: 提供了一种方法和系统，用于使在多层无线网络中操作的MS能够切换到与多层中的另一个相关联的目标BS。 通过所提供的方法，如果要求尚未提供与与其当前服务BS不同的层相关联的潜在目标BS的信息的MS被移交给这样的目标BS ，然后在从目标BS接收到指示其向MS提供服务的能力的确认时，向MS发送包括信息的消息，以使MS能够执行快速网络重新进入，以便与目标BS通信 。 接下来，启动MS与目标BS之间的切换过程，在此期间MS执行快速网络重入。

公开(公告)号：US20120327762A1

公开(公告)日：2012-12-27

申请号：US13311128

申请日：2011-12-05

Applicant: Daniel Cohn ,  Rafi Ram

Inventor： Daniel Cohn ,  Rafi Ram

IPC: H04J3/22 ,  H04L1/00

CPC classification number: H04J3/14 ,  H04L45/12 ,  H04L45/22 ,  H04L45/28 ,  H04L45/50

Abstract: A system and method for selecting MPLS network transport entities between a first endpoint and a second endpoint are presented. Working and protection entities are selected from a set of available entities based upon minimizing the probability of simultaneous failure and/or minimizing a cost function base upon one or more metrics.

Abstract translation: 提出了一种用于在第一端点和第二端点之间选择MPLS网络传输实体的系统和方法。 基于一个或多个度量基于最小化同时故障的概率和/或使成本函数最小化，从一组可用实体中选择工作和保护实体。

公开(公告)号：US20110120569A1

公开(公告)日：2011-05-26

申请号：US12951377

申请日：2010-11-22

Applicant: Leslie Bromberg ,  Daniel Cohn

Inventor： Leslie Bromberg ,  Daniel Cohn

IPC: G05D11/00

CPC classification number: F02D19/084 ,  B60K15/04 ,  B60K2015/03118 ,  B60K2015/03131 ,  B60K2015/03157 ,  B60K2015/0319 ,  B60K2015/0321 ,  B60K2015/03348 ,  B60K2015/0467 ,  F02D19/0649 ,  F02D19/0665 ,  F02D19/0678 ,  F02D19/0689 ,  F02D19/081 ,  F02D19/087 ,  F02M25/0228 ,  F02M37/0094 ,  Y02T10/36 ,  Y10T137/2514

Abstract: A fuel tank system for gasoline or flexible gasoline/ethanol powered vehicles that use independently controlled direct ethanol injection to provide a large on-demand octane boost is disclosed. The on-demand octane boost is used when needed to prevent knock. The ethanol can be in the form of 100% ethanol or E85 (a 85% ethanol, 15% gasoline mixture) and is stored in a second tank that is separate from the tank that which contains the primary fuel. The primary fuel can be gasoline, E85, ethanol or a mix of these fuels. The fuel tank system enables convenient, quick, flexible and minimal cost refueling of the separate fuel tank. A range of fueling options is available to provide the driver with the maximum freedom to choose fuels depending upon price and availability. Valves may be utilized to direct the flow in fuel to the various tanks.

Abstract translation: 公开了一种用于汽油或柔性汽油/乙醇动力车辆的燃料箱系统，其使用独立控制的直接乙醇喷射来提供大的按需辛烷值提升。 当需要时，使用按需辛烷值提升来防止爆震。 乙醇可以是100％乙醇或E85（85％乙醇，15％汽油混合物）的形式，并且储存在与包含主要燃料的罐分开的第二罐中。 主要燃料可以是汽油，E85，乙醇或这些燃料的混合物。 燃油箱系统可以方便，快速，灵活和最小化单独燃油箱的加油。 提供一系列加油选项可为司机提供根据价格和可用性选择燃料的最大自由度。 阀可用于将燃料中的流引导到各种罐。

公开(公告)号：US07879356B2

公开(公告)日：2011-02-01

申请号：US09804745

申请日：2001-03-13

Applicant: Daniel Cohn ,  Theodor Stern ,  Avraham Levi

Inventor： Daniel Cohn ,  Theodor Stern ,  Avraham Levi

IPC: A61K9/14 ,  A61K47/00 ,  A61K47/30 ,  C08G63/08

CPC classification number: C08G69/44 ,  A61L31/06 ,  C08G63/08 ,  C08G63/664 ,  C08L67/04 ,  C08L77/12

Abstract: The present invention relates to novel bioabsorbable polymeric compositions based upon AB polyester polyether or related diblocks and triblocks. Compositions according to the present invention may be used in medical applications, for example, for reducing or preventing adhesion formation subsequent to medical procedures such as surgery, for producing surgical articles including stents and grafts, as coatings, sealants, lubricants, as transient barriers in the body, for materials which control the release of bioactive agents in the body, for wound and burn dressings and producing biodegradable articles, among numerous others.

Abstract translation: 本发明涉及基于AB聚酯聚醚或相关二嵌段和三嵌段的新型生物可吸收聚合物组合物。 根据本发明的组合物可以用于医疗应用中，例如用于减少或防止医疗程序如手术之后的粘附形成，用于生产包括支架和移植物的外科用品，作为涂层，密封剂，润滑剂，作为瞬时屏障 用于控制身体中生物活性剂释放的材料，用于伤口和烧伤敷料以及生产可生物降解的制品等等。