公开(公告)号：US08241348B2

公开(公告)日：2012-08-14

申请号：US12728755

申请日：2010-03-22

申请人： Daniel L. Cox

发明人： Daniel L. Cox

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2002/91566 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0036

摘要： An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for rupturing a fibrous cap to controllably release vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by links. The stent includes struts and links of varying strengths about the circumference of the stent. The weaker struts and links require less force to open and, hence, may apply more stress to rupture the fibrous cap while the stronger struts and links protect the healthy portions of the body lumen. In another embodiment, the stent may include stress concentrators positioned on outer surfaces of the links. The stress concentrators are aligned with the fibrous cap prior to stent expansion so that upon stent expansion, the stress concentrators induce stress to rupture the fibrous cap, thereby releasing the vulnerable plaque.

摘要翻译： 可扩张支架植入体腔，例如冠状动脉，外周动脉或其他体腔，用于破裂纤维帽以可控制地释放易受伤害的斑块。 本发明提供一种血管内支架，其具有通过连杆连接的多个圆柱形环。 支架包括围绕支架圆周的不同强度的支柱和连杆。 较弱的支柱和连接件需要较小的打开力，因此可能施加更多的应力来破坏纤维帽，而较强的支柱和连接件保护身体内腔的健康部分。 在另一个实施例中，支架可以包括定位在链节的外表面上的应力集中器。 应力集中器在支架膨胀之前与纤维帽对准，因此在支架膨胀时，应力集中器会引起应力使纤维帽破裂，从而释放易损斑块。

公开(公告)号：US08187324B2

公开(公告)日：2012-05-29

申请号：US11445694

申请日：2006-06-01

申请人： William E. Webler ,  Daniel L. Cox ,  Richard Newhauser

发明人： William E. Webler ,  Daniel L. Cox ,  Richard Newhauser

IPC分类号： A61F2/24

CPC分类号： A61B17/00234 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00477 ,  A61B2017/00783 ,  A61B2017/00991 ,  A61B2017/0427 ,  A61F2/2451 ,  A61F2/91 ,  A61F2002/30545 ,  A61F2002/828 ,  A61F2250/001 ,  A61F2250/0065

摘要： A medical device that can be used for treating a defective heart valve. One aspect of the invention pertains to a longitudinally adjustable medical device that comprises a distal portion, a proximal portion, and a cord member. The distal portion comprises a distal anchoring member, a distal telescope, and a distal backbone. The proximal portion comprises a proximal anchoring member, a proximal telescope, and a proximal backbone. The distal backbone and the proximal backbone are configured to provide a structural support to the device while providing flexibility to the device. The cord member is disposed within the device and used to facilitate longitudinal adjustment for the device.

摘要翻译： 可用于治疗有缺陷心脏瓣膜的医疗器械。 本发明的一个方面涉及一种可纵向调节的医疗装置，其包括远侧部分，近端部分和绳部件。 远端部分包括远端锚固构件，远端望远镜和远端骨架。 近端部分包括近端锚固构件，近端望远镜和近端骨架。 远端骨干和近端骨架被构造成为装置提供结构支撑，同时为装置提供灵活性。 帘线构件设置在装置内并用于促进装置的纵向调节。

公开(公告)号：US08100855B2

公开(公告)日：2012-01-24

申请号：US11901575

申请日：2007-09-17

申请人： Paul M. Consigny ,  William E. Webler ,  Gustavo D. Cipolla ,  Gordon Stewart ,  Benny Serna ,  Daniel L. Cox

发明人： Paul M. Consigny ,  William E. Webler ,  Gustavo D. Cipolla ,  Gordon Stewart ,  Benny Serna ,  Daniel L. Cox

IPC分类号： A61M31/00

CPC分类号： A61M25/104 ,  A61B17/22 ,  A61B2017/22042 ,  A61B2017/22051 ,  A61B2017/22084 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1081

摘要： Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

摘要翻译： 公开了用于在处理部位洗脱试剂的系统，装置和方法。 这些装置包括可扩张框架和至少一个膜片。 膜可以携带一种药剂在治疗部位洗脱。 在给药期间，膜可允许血液在治疗部位流动。

公开(公告)号：US20100174303A1

公开(公告)日：2010-07-08

申请号：US12728755

申请日：2010-03-22

申请人： Daniel L. Cox

发明人： Daniel L. Cox

IPC分类号： A61B17/22 ,  A61F2/82

CPC分类号： A61F2/915 ,  A61F2002/91566 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0036

摘要： An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for rupturing a fibrous cap to controllably release vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by links. The stent includes struts and links of varying strengths about the circumference of the stent. The weaker struts and links require less force to open and, hence, may apply more stress to rupture the fibrous cap while the stronger struts and links protect the healthy portions of the body lumen. In another embodiment, the stent may include stress concentrators positioned on outer surfaces of the links. The stress concentrators are aligned with the fibrous cap prior to stent expansion so that upon stent expansion, the stress concentrators induce stress to rupture the fibrous cap, thereby releasing the vulnerable plaque.

摘要翻译： 可扩张支架植入体腔，例如冠状动脉，外周动脉或其他体腔，用于破裂纤维帽以可控制地释放易受伤害的斑块。 本发明提供一种血管内支架，其具有通过连杆连接的多个圆柱形环。 支架包括围绕支架圆周的不同强度的支柱和连杆。 较弱的支柱和连接件需要较小的打开力，因此可能施加更多的应力来破坏纤维帽，同时较强的支柱和连杆保护身体内腔的健康部分。 在另一个实施例中，支架可以包括定位在链节的外表面上的应力集中器。 应力集中器在支架膨胀之前与纤维帽对准，因此在支架膨胀时，应力集中器会引起应力使纤维帽破裂，从而释放易损斑块。

公开(公告)号：US07731744B1

公开(公告)日：2010-06-08

申请号：US10280632

申请日：2002-10-25

申请人： Daniel L. Cox

发明人： Daniel L. Cox

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2002/91566 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0036

摘要： An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for rupturing a fibrous cap to controllably release vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by links. The stent includes struts and links of varying strengths about the circumference of the stent. The weaker struts and links require less force to open and, hence, may apply more stress to rupture the fibrous cap while the stronger struts and links protect the healthy portions of the body lumen. In another embodiment, the stent may include stress concentrators positioned on outer surfaces of the links. The stress concentrators are aligned with the fibrous cap prior to stent expansion so that upon stent expansion, the stress concentrators induce stress to rupture the fibrous cap, thereby releasing the vulnerable plaque.

摘要翻译： 可扩张支架植入体腔，例如冠状动脉，外周动脉或其他体腔，用于破裂纤维帽以可控制地释放易受伤害的斑块。 本发明提供一种血管内支架，其具有通过连杆连接的多个圆柱形环。 支架包括围绕支架圆周的不同强度的支柱和连杆。 较弱的支柱和连接件需要较小的打开力，因此可能施加更多的应力来破坏纤维帽，同时较强的支柱和连杆保护身体内腔的健康部分。 在另一个实施例中，支架可以包括定位在链节的外表面上的应力集中器。 应力集中器在支架膨胀之前与纤维帽对齐，因此在支架膨胀时，应力集中器会引起应力使纤维帽破裂，从而释放易损斑块。

公开(公告)号：US07485143B2

公开(公告)日：2009-02-03

申请号：US10295714

申请日：2002-11-15

申请人： William E. Webler ,  Gregory Mathew Hyde ,  Christopher Feezor ,  Daniel L. Cox

发明人： William E. Webler ,  Gregory Mathew Hyde ,  Christopher Feezor ,  Daniel L. Cox

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/91 ,  A61F2002/828 ,  A61F2250/001 ,  Y10T24/39

摘要： A medical device for treating a defective heart valve. The medical device comprises a distal anchoring member for disposing in a blood vessel. A proximal anchoring member for disposing in or at an entrance of the blood vessel. A telescoping assembly coupling at a first end to the distal anchoring member and at a second end to the proximal anchoring member. The telescoping assembly is deployable into the blood vessel. The telescoping assembly reduces a distance between the distal anchoring member and the proximal anchoring member, wherein the telescoping assembly comprises of at least two members capable of sliding into each other giving the telescoping assembly adjustable lengths.

摘要翻译： 一种用于治疗有缺陷心脏瓣膜的医疗装置。 医疗装置包括用于设置在血管中的远侧锚定构件。 用于设置在血管入口处或入口处的近端锚定构件。 伸缩组件在第一端处联接到远侧锚固构件，并且在第二端处联接到近侧锚定构件。 伸缩组件可展开到血管中。 伸缩组件减小了远侧锚固构件和近侧锚固构件之间的距离，其中伸缩组件包括能够相互滑动的至少两个构件，其给予伸缩组件可调长度。

公开(公告)号：US07226477B2

公开(公告)日：2007-06-05

申请号：US10739554

申请日：2003-12-17

申请人： Daniel L. Cox

发明人： Daniel L. Cox

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  A61F2/91 ,  A61F2002/828 ,  A61F2250/001 ,  Y10T24/39

摘要： A medical device for treating a defective heart valve. The medical device comprises a delivery sheath and an implantable device moveably disposed within the delivery sheath. The implantable device further comprises a distal expandable basket, a proximal expandable basket, and a connecting member coupling at a first end to the distal expandable basket and at a second end to the proximal expandable basket. Each of the distal expandable basket and proximal expandable basket is in a collapsed state during delivery and an expanded state after deployment. An actuator is releasably coupled to the implantable device. When coupled to the implantable device, the actuator can move the implantable device in a way to allow for positioning of the distal and proximal expandable baskets.

摘要翻译： 一种用于治疗有缺陷心脏瓣膜的医疗装置。 医疗装置包括输送鞘和可移动地设置在输送鞘内的可植入装置。 可植入装置还包括远侧可扩张篮，近端可扩张篮和连接构件，该连接构件在第一端处连接到远端可膨胀篮，并且在第二端处连接到近端可膨胀篮。 远端可膨胀篮和近端可膨胀篮中的每一个在分娩期间处于折叠状态，并在展开后处于膨胀状态。 致动器可释放地联接到可植入装置。 当联接到可植入装置时，致动器可以以允许远端和近端可扩展筐定位的方式移动可植入装置。

公开(公告)号：US07128758B2

公开(公告)日：2006-10-31

申请号：US10657768

申请日：2003-09-08

申请人： Daniel L. Cox

发明人： Daniel L. Cox

IPC分类号： A61F2/06

CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2210/0014 ,  A61L31/022 ,  A61L2400/16 ,  Y10S623/924

摘要： A medical device for use within a body lumen that is made from a binary nickel-titanium alloy that remains in its austenitic phase throughout its operational range is disclosed. The medical device, such as an intraluminal stent, is made from superelastic nickel-titanium and may optionally be alloyed with a ternary element. By adding the ternary element and/or through heat treatment, it is possible to lower the phase transformation temperature between the austenitic phase and the martensitic phase of the nickel-titanium alloy. By lowering the phase transformation temperature, the martensite deformation temperature is likewise depressed. It is possible then to depress the martensite deformation temperature below body temperature such that when the device is used in a body lumen for medical treatment, the nickel-titanium device remains completely in the austenitic phase without appearance of stress-induced martensite even if the device is placed under stress.

公开(公告)号：US06852124B2

公开(公告)日：2005-02-08

申请号：US10244198

申请日：2002-09-16

申请人： Daniel L. Cox ,  Timothy A. Limon

发明人： Daniel L. Cox ,  Timothy A. Limon

IPC分类号： A61F2/84 ,  A61F2/00 ,  A61F2/06 ,  A61F2/90

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0036

摘要： An expandable stent for implantation in a body lumen, such as an artery, is disclosed. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in the longitudinal direction. The strength of the stent at a center section or at either end can be varied by increasing the mass of the struts forming each cylindrical element in that center section or end section relative to the lower mass struts in the remaining sections of the stent. Increasing the mass of the struts can be accomplished by, for a given strut thickness, increasing the width of the strut, or increasing the length of a cylindrical element.

摘要翻译： 公开了用于植入体腔（例如动脉）中的可扩张支架。 支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准并通过一个或多个相互连接的构件相互连接，使得支架在纵向方向上是柔性的。 支架在中心部分或两端的强度可以通过增加在该中心部分或端部部分中相对于支架的其余部分中的下部质量支柱形成每个圆柱形元件的支柱的质量来改变。 对于给定的支柱厚度，可以通过增加支柱的宽度或增加圆柱形元件的长度来实现增加支柱的质量。

公开(公告)号：US06773455B2

公开(公告)日：2004-08-10

申请号：US09848819

申请日：2001-05-03

申请人： Richard T. Allen ,  Daniel L. Cox

发明人： Richard T. Allen ,  Daniel L. Cox

IPC分类号： A61F206

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013

摘要： The invention is directed to an expandable stent for implantation in a body lumen, such as a coronary artery or peripheral vein. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so as to limit longitudinal contraction during radial expansion. The individual radially expandable cylindrical elements are formed in a serpentine pattern having bends alternating in peaks and valleys designed to expand evenly under radial stress, and to maximize the overall radial expansion ratio. Each peak and valley includes reinforcing members that extend across and proximate to each bend. Sizing and construction of the struts forming the peaks and valleys can create bimodal deployment wherein the struts bend under increasing stresses to enable the stent to expand to larger diameters.

摘要翻译： 本发明涉及用于植入体腔（例如冠状动脉或外周静脉）中的可扩张支架。 支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准，并通过一个或多个相互连接的构件相互连接，以便在径向膨胀期间限制纵向收缩。 各个可径向扩张的圆柱形元件形成为具有在设计成在径向应力下均匀膨胀的峰和谷中交替弯曲的蛇形图案，并且使总的径向膨胀比最大化。 每个峰和谷包括跨越和接近每个弯曲部分的加强构件。 形成峰谷的支柱的尺寸和结构可以产生双峰部署，其中支柱在增加的应力下弯曲，以使支架能够扩展到更大的直径。