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    Sterile de-molding apparatus and method
    21.
    发明授权
    Sterile de-molding apparatus and method 有权
    无菌脱模装置及方法

    公开(公告)号：US08181431B2

    公开(公告)日：2012-05-22

    申请号：US13012074

    申请日：2011-01-24

    Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

    Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

    IPC: B65B3/02 ,  B65B5/02

    CPC classification number: B65B3/022

    Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

    Abstract translation: 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

    Penetrable and resealable lyophilization method
    22.
    发明授权
    Penetrable and resealable lyophilization method 有权
    可穿透和可再密封的冻干方法

    公开(公告)号：US08171652B2

    公开(公告)日：2012-05-08

    申请号：US13169586

    申请日：2011-06-27

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: F26B5/04

    CPC classification number: F26B5/06

    Abstract: Device and method for lyophilizing a substance within the device and storing therein the lyophilized substance. The device defines a chamber for receiving therein the substance to be lyophilized, a penetrable and resealable portion of the device is penetrable or pierceable by a needle for filling the device with the substance, and a resulting hole therein is resealable by transmitting radiation from a radiation source thereon. A filter is connectable in fluid communication between an interior and exterior of the chamber for permitting fluid to flow therethrough in a direction from the interior to the exterior of the chamber, and for substantially preventing contaminants from flowing therethrough in a direction from the exterior to the interior of the chamber.

    Abstract translation: 用于冻结装置内的物质并在其中储存冻干物质的装置和方法。 该装置限定用于在其中容纳待冷冻干燥的物质的腔室，该装置的可穿透和可重新密封的部分可被针穿透或穿刺，用于填充该物质的装置，并且其中产生的孔可通过从辐射辐射 来源。 过滤器可连接在室的内部和外部之间的流体连通中，以允许流体从腔室的内部到外部的方向流过其中，并且用于基本上防止污染物沿着从外部到外部的方向流过 室内

    Pouch Connector and Related Method
    23.
    发明申请
    Pouch Connector and Related Method 审中-公开
    袋连接器及相关方法

    公开(公告)号：US20120097705A1

    公开(公告)日：2012-04-26

    申请号：US13279141

    申请日：2011-10-21

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: B67D7/06 ,  B65D90/00

    CPC classification number: B67D3/043 ,  B67B7/24

    Abstract: A pouch connector includes a safety cap having a cap base portion and a main connector disposed opposite the safety cap. The main connector and safety cap are configured to receive a portion of a pouch therebetween. The main connector includes a piercing member for piercing the pouch, an actuating portion for actuating the piercing member and a main connector base portion. The piercing member is configured to pierce through a portion of the pouch so as to provide fluid communication between a substance inside the pouch and the interior of the main connector. A polymeric membrane is coupled to at least one of the cap base portion and the main connector base portion.

    Abstract translation: 小袋连接器包括具有帽基部的安全帽和与安全帽相对设置的主连接器。 主连接器和安全帽被配置为在其间容纳一部分袋。 主连接器包括用于刺穿小袋的刺穿构件，用于致动刺穿构件的致动部分和主连接器基部。 刺穿构件构造成穿过袋的一部分，以便在袋内的物质和主连接器的内部之间提供流体连通。 聚合物膜联接到帽基部和主连接器基部中的至少一个。

    Sterile de-molding apparatus and method
    26.
    发明授权
    Sterile de-molding apparatus and method 有权
    无菌脱模装置及方法

    公开(公告)号：US08071009B2

    公开(公告)日：2011-12-06

    申请号：US11582291

    申请日：2006-10-17

    Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

    Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

    IPC: B29C45/04

    CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

    Abstract: An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein. A fluid source that contains or otherwise generates a fluid sterilant, such as vaporized hydrogen peroxide, is connectable in fluid communication with the fluid passageway for introducing the sterilant into the fluid passageway with at least one of the first and second mold portions in the open position, and in turn contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

    Abstract translation: 提供了用于模制无菌部件的装置和方法。 该装置具有第一模具部分和第二模具部分。 第一模具部分和第二模具部分中的至少一个限定了模腔，其被配置为容纳熔融塑料并从其形成至少一个模制部件。第一模具部分和第二模具部分中的至少一个可相对于彼此移动， 用于密封模腔或空腔并在其中模制至少一个部件的位置，以及（ii）限定第一和第二模具部分之间的流体通道并允许其中的流体灭菌剂通过的打开位置。 包含或以其它方式产生流体灭菌剂的流体源例如蒸发的过氧化氢可连接到流体通道，用于将灭菌剂引入流体通道，其中第一和第二模具部分中的至少一个处于打开位置 并且又与灭菌剂接触形成第一和第二模具部分的表面，形成流体通道并且位于与至少一个模具腔相邻但不与模具腔内的模制部件的内表面接触，以消毒 暴露的模具表面，从而防止模制部件的污染。

    Sealed Containers and Methods of Filling and Resealing Same
    27.
    发明申请
    Sealed Containers and Methods of Filling and Resealing Same 审中-公开
    密封容器和填充和密封方法相同

    公开(公告)号：US20110277873A1

    公开(公告)日：2011-11-17

    申请号：US13193662

    申请日：2011-07-29

    Applicant: Daniel Py ,  Norbert M. Assion

    Inventor： Daniel Py ,  Norbert M. Assion

    IPC: B65B1/04

    CPC classification number: B65B3/003 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2096 ,  A61M2207/00 ,  A61M2209/045 ,  B65B3/027 ,  B65B7/161 ,  B65B51/10 ,  B65B55/08 ,  B65B2039/009 ,  B65D51/002

    Abstract: A container and method for filling same. The container includes a penetrable and resealable portion that is resealable, and a container body having a sealed empty chamber in fluid communication with the penetrable and resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the penetrable and resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent upward movement of the body, and applying energy to the penetrable and resealable portion to form a gas-tight seal.

    Abstract translation: 一种容器及其填充方法。 容器包括可重复密封的可穿透和可重新密封的部分，以及容器主体，其具有与可穿透和可再密封部分流体连通的密封空腔，用于在其中容纳物质。 容器还包括基部，中间部分和与基部相对于基部在中间部分的相对侧上轴向间隔开的上部。 基部和上部中的每一个限定大于中间部分的最大横向延伸尺寸的横向延伸的尺寸。 填充容器的方法包括用注射构件穿透可穿透和可重新密封的部分并将物质引入腔室中，同时接合身体的基部以基本上防止身体的向上移动并且将能量施加到 可渗透和可重新密封的部分以形成气密密封。

    Container and one-way valve assembly for storing and dispensing substances, and related method
    28.
    发明授权
    Container and one-way valve assembly for storing and dispensing substances, and related method 有权
    用于储存和分配物质的容器和单向阀组件及相关方法

    公开(公告)号：US07997447B2

    公开(公告)日：2011-08-16

    申请号：US12857114

    申请日：2010-08-16

    Applicant: Daniel Py ,  Miles J. Flamenbaum ,  Eric E. Hartman ,  Nathaniel Houle

    Inventor： Daniel Py ,  Miles J. Flamenbaum ,  Eric E. Hartman ,  Nathaniel Houle

    IPC: B67D1/00

    CPC classification number: B65D51/227 ,  B65D47/205 ,  B65D2251/0025 ,  B65D2251/0093

    Abstract: A device for storing and dispensing a substance includes a storage chamber for the substance. The container includes a passageway in fluid communication with the storage chamber. The container includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber. The device includes a one-way valve assembly including a piercing portion. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall allowing the flow of substance from the storage chamber. A removable member is disposed intermediate the valve and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed.

    Abstract translation: 用于存储和分配物质的装置包括用于物质的储存室。 容器包括与储存室流体连通的通道。 容器包括位于通道相对于储存室的相对侧上的可刺穿的壁。 该装置包括一个包括穿刺部分的单向阀组件。 所述穿刺部分和所述可刺穿壁中的至少一个在所述可刺穿部分不穿透所述可刺穿壁的第一位置与所述可刺穿部分穿透所述可刺穿壁之间允许物质流动的第二位置之间相对于另一个可移动 从储存室。 可拆卸构件设置在阀和容器之间，防止至少一个刺穿部分和可刺穿的壁移动到第二位置，直到可移除构件被移除。

    Sterile De-Molding Apparatus and Method
    29.
    发明申请
    Sterile De-Molding Apparatus and Method 有权
    无菌脱模装置及方法

    公开(公告)号：US20110113729A1

    公开(公告)日：2011-05-19

    申请号：US13012074

    申请日：2011-01-24

    Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

    Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

    IPC: B65B55/02 ,  B65B47/00 ,  B65B5/02

    CPC classification number: B65B3/022

    Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

    Abstract translation: 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

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