公开(公告)号：US08272411B2

公开(公告)日：2012-09-25

申请号：US12534730

申请日：2009-08-03

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: B65B55/08 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/18 ,  A61J1/2037 ,  A61J1/2041 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2207/00 ,  B65B3/003 ,  B65D47/248

Abstract: A lyophilization device configured for use in a lyophilization process has a body defining a chamber for receiving a liquid to be lyophilized, and a stopper creating a liquid-tight seal between the chamber and ambient atmosphere to form a sealed, empty sterile chamber. The stopper is adapted so that the chamber may be sterile filled with the substance through the stopper. A fluid passageway is formed through the stopper, through which the chamber is evacuated. The substance is lyophilized, the fluid passageway is closed, and the lyophilized substance is hermetically sealed within the chamber.

Abstract translation: 构造成用于冻干过程的冻干装置具有限定用于接收要冷冻干燥的液体的室的主体和在室与环境大气之间形成液密密封的塞子，以形成密封的空的无菌室。 塞子适于使得腔室可以通过止动器无菌地填充物质。 通过塞子形成流体通道，通过该塞子抽空腔室。 物质被冻干，流体通道关闭，冻干物质密封在腔室内。

公开(公告)号：US20120227359A1

公开(公告)日：2012-09-13

申请号：US13454910

申请日：2012-04-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/02

CPC classification number: B65B31/024 ,  A61L2/04 ,  A61L2/081 ,  A61L2/087 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/182 ,  B65B5/045 ,  B65B7/02 ,  B65B55/02 ,  B65B55/08 ,  B65B55/16 ,  B65B69/0033 ,  B65B69/0066

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

Abstract translation: 无菌外壳包含定义窗口的传输模块。 端口覆盖窗口，以将密封和无菌环境保持在外壳内部。 安装在端口上的滑动加热切割元件用于对连接到端口的无菌转移袋组件的一部分进行消毒和切断。 优选地，当端口打开时，无菌转移袋组件的切除部分被固定到端口。 滑动切割元件保持延伸和加热，以防止端口打开时的污染。 此外，加热元件安装在窗口周围，以便在端口打开时围绕开口消毒。

公开(公告)号：US08251235B2

公开(公告)日：2012-08-28

申请号：US12259284

申请日：2008-10-27

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Willey

Inventor： Daniel Py ,  Julian Chan ,  Jeffrey Willey

IPC: A61J9/00

CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及包含用于在储存期间气密地密封室内的产品的主密封件的容器盖。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。

公开(公告)号：US20120186697A1

公开(公告)日：2012-07-26

申请号：US13419204

申请日：2012-03-13

Applicant: Daniel Py ,  Norbert Assion ,  Nathaniel Houle ,  Debashis Sahoo ,  M. Jeffrey Willey ,  EriC E. Hartman ,  John Guthy

Inventor： Daniel Py ,  Norbert Assion ,  Nathaniel Houle ,  Debashis Sahoo ,  M. Jeffrey Willey ,  EriC E. Hartman ,  John Guthy

IPC: B65B1/04 ,  B65D51/18

CPC classification number: B65B55/10 ,  B65B3/003 ,  B65B7/2842 ,  B65B51/22 ,  B65B55/025 ,  B65D51/002 ,  B65D51/18 ,  B65D2251/0015 ,  B65D2251/0078

Abstract: A container and method are provided for storing fat containing liquid products. The container includes a body defining a storage chamber for receiving the product, and a container closure. A first material portion forms at least most of the surface area overlying the storage chamber that can contact any product therein. Neither the body nor the first material portion leach more than a predetermined amount of leachables into the product or undesirably alter a taste profile thereof. A needle penetrable and thermally resealable second material portion either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area overlying the storage chamber that can contact any product therein in comparison to the first material portion. A sealing portion is engageable with the body to form a substantially dry hermetic seal between the container closure and body.

Abstract translation: 提供容器和方法来储存含有液体产品的脂肪。 容器包括限定用于接收产品的储存室的主体和容器封闭件。 第一材料部分形成至少大部分覆盖储存室的表面区域，该表面区域可接触其中的任何产品。 身体和第一材料部分都不会将超过预定量的可浸出物浸入产品中或者不期望地改变其味道特征。 针可穿透和可热再密封的第二材料部分（i）覆盖在第一材料部分上并且不能接触储存室内的任何产品，或（ii）形成覆盖存储室的基本上较小的表面区域，其可以与其中的任何产品接触 到第一材料部分。 密封部分可与主体接合以在容器封闭件和主体之间形成基本上干燥的气密密封。

公开(公告)号：US08181431B2

公开(公告)日：2012-05-22

申请号：US13012074

申请日：2011-01-24

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

IPC: B65B3/02 ,  B65B5/02

CPC classification number: B65B3/022

Abstract: Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

Abstract translation: 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

公开(公告)号：US08171652B2

公开(公告)日：2012-05-08

申请号：US13169586

申请日：2011-06-27

Applicant: Daniel Py

Inventor： Daniel Py

IPC: F26B5/04

CPC classification number: F26B5/06

Abstract: Device and method for lyophilizing a substance within the device and storing therein the lyophilized substance. The device defines a chamber for receiving therein the substance to be lyophilized, a penetrable and resealable portion of the device is penetrable or pierceable by a needle for filling the device with the substance, and a resulting hole therein is resealable by transmitting radiation from a radiation source thereon. A filter is connectable in fluid communication between an interior and exterior of the chamber for permitting fluid to flow therethrough in a direction from the interior to the exterior of the chamber, and for substantially preventing contaminants from flowing therethrough in a direction from the exterior to the interior of the chamber.

Abstract translation: 用于冻结装置内的物质并在其中储存冻干物质的装置和方法。 该装置限定用于在其中容纳待冷冻干燥的物质的腔室，该装置的可穿透和可重新密封的部分可被针穿透或穿刺，用于填充该物质的装置，并且其中产生的孔可通过从辐射辐射 来源。 过滤器可连接在室的内部和外部之间的流体连通中，以允许流体从腔室的内部到外部的方向流过其中，并且用于基本上防止污染物沿着从外部到外部的方向流过 室内

公开(公告)号：US20120097705A1

公开(公告)日：2012-04-26

申请号：US13279141

申请日：2011-10-21

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B67D7/06 ,  B65D90/00

CPC classification number: B67D3/043 ,  B67B7/24

Abstract: A pouch connector includes a safety cap having a cap base portion and a main connector disposed opposite the safety cap. The main connector and safety cap are configured to receive a portion of a pouch therebetween. The main connector includes a piercing member for piercing the pouch, an actuating portion for actuating the piercing member and a main connector base portion. The piercing member is configured to pierce through a portion of the pouch so as to provide fluid communication between a substance inside the pouch and the interior of the main connector. A polymeric membrane is coupled to at least one of the cap base portion and the main connector base portion.

Abstract translation: 小袋连接器包括具有帽基部的安全帽和与安全帽相对设置的主连接器。 主连接器和安全帽被配置为在其间容纳一部分袋。 主连接器包括用于刺穿小袋的刺穿构件，用于致动刺穿构件的致动部分和主连接器基部。 刺穿构件构造成穿过袋的一部分，以便在袋内的物质和主连接器的内部之间提供流体连通。 聚合物膜联接到帽基部和主连接器基部中的至少一个。

公开(公告)号：US08112972B2

公开(公告)日：2012-02-14

申请号：US12715821

申请日：2010-03-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B51/10 ,  B65B55/02

CPC classification number: B29C67/004 ,  B29C45/006 ,  B29C45/1701 ,  B29C45/42 ,  B29C65/16 ,  B29C65/1616 ,  B29C66/001 ,  B29C66/0018 ,  B29C66/71 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/961 ,  B29C2791/005 ,  B29L2031/565 ,  B65B3/003 ,  B65B3/022 ,  B65B55/06 ,  B29C65/00 ,  B29K2023/38

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：USD652938S1

公开(公告)日：2012-01-24

申请号：US29373688

申请日：2011-03-17

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Willey

Designer： Daniel Py ,  Julian Chan ,  Jeffrey Willey

IPC: B67D7/74 ,  B67D7/78

CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

公开(公告)号：US08071009B2

公开(公告)日：2011-12-06

申请号：US11582291

申请日：2006-10-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

IPC: B29C45/04

CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

Abstract: An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein. A fluid source that contains or otherwise generates a fluid sterilant, such as vaporized hydrogen peroxide, is connectable in fluid communication with the fluid passageway for introducing the sterilant into the fluid passageway with at least one of the first and second mold portions in the open position, and in turn contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

Abstract translation: 提供了用于模制无菌部件的装置和方法。 该装置具有第一模具部分和第二模具部分。 第一模具部分和第二模具部分中的至少一个限定了模腔，其被配置为容纳熔融塑料并从其形成至少一个模制部件。第一模具部分和第二模具部分中的至少一个可相对于彼此移动， 用于密封模腔或空腔并在其中模制至少一个部件的位置，以及（ii）限定第一和第二模具部分之间的流体通道并允许其中的流体灭菌剂通过的打开位置。 包含或以其它方式产生流体灭菌剂的流体源例如蒸发的过氧化氢可连接到流体通道，用于将灭菌剂引入流体通道，其中第一和第二模具部分中的至少一个处于打开位置 并且又与灭菌剂接触形成第一和第二模具部分的表面，形成流体通道并且位于与至少一个模具腔相邻但不与模具腔内的模制部件的内表面接触，以消毒 暴露的模具表面，从而防止模制部件的污染。