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21.发明授权
公开(公告)号：US5839443A
公开(公告)日：1998-11-24
申请号：US648561
申请日：1996-05-16
申请人： Eric Rose , David Stern , Ann Marie Schmidt , Talia Spanier
发明人： Eric Rose , David Stern , Ann Marie Schmidt , Talia Spanier
CPC分类号： A61M1/3675 , A61K38/4846 , G01N33/86 , G01N2333/9645
摘要： This invention provides an assay to monitor antithrombic activity of a Factor IXa compound infused into circulation of a patient which includes: (a) obtaining Factor IXa-deficient plasma; (b) mixing the plasma from step (a) with diatomaceous and with plasma from the patient; (c) incubating the mixture with a source of lipid and calcium chloride under conditions suitable for clot formation; and (d) measuring time necessary for clot formation in the incubate, thereby monitoring the antithrombic activity of the Factor IXa compound infused into the circulation of the patient.
摘要翻译： 本发明提供了监测注射到患者循环中的因子IXa化合物的抗血栓活性的测定法，其包括：（a）获得因子IXa缺陷血浆; （b）将来自步骤（a）的血浆与硅藻土和来自患者的血浆混合; （c）在适合凝块形成的条件下将混合物与脂质和氯化钙源一起孵育; 和（d）测量培养物中凝块形成所需的时间，从而监测输注到患者循环中的因子IXa化合物的抗血栓活性。
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公开(公告)号：US5631734A
公开(公告)日：1997-05-20
申请号：US195889
申请日：1994-02-10
申请人： David Stern , Peter Fiekowsky
发明人： David Stern , Peter Fiekowsky
CPC分类号： G01N21/6458 , G01N21/6428 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , G01N2021/174
摘要： Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light from a light source 100 and detecting the photons from the light fluoresced therefrom, and repeating the steps of exposure and detection until the substrate 230 is completely examined. The resulting data can be used to determine binding affinity of the targets to specific polymer sequences.
摘要翻译： 荧光标记的靶结合到在已知位置处与聚合物序列合成的底物230。 通过将衬底230的选定区域暴露于来自光源100的光并从其发荧光的光检测光子并且重复曝光和检测的步骤直到基片230被完全检查来检测靶。 所得数据可用于确定靶向特定聚合物序列的结合亲和力。
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公开(公告)号：US09767342B2
公开(公告)日：2017-09-19
申请号：US12780825
申请日：2010-05-14
申请人： David Stern , Chuan Gao , Melvin Yamamoto , Devin Nguyen
发明人： David Stern , Chuan Gao , Melvin Yamamoto , Devin Nguyen
CPC分类号： G06K9/00134 , G01N21/6452 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/361 , Y10T29/49826
摘要： In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array. The method utilizes obtaining the best z position of the fiducials and using a surface fitting algorithm to produce a surface fit profile. One or more surface non-flatness parameters can be adjusted to improve the flatness image of the array surface to be imaged.
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24.发明授权Recommending items to users utilizing a bi-linear collaborative filtering model 有权使用双线性协同过滤模型向用户推荐项目公开(公告)号：US08781915B2
公开(公告)日：2014-07-15
申请号：US12253854
申请日：2008-10-17
申请人： Ralf Herbrich , Thore Graepel , David Stern
发明人： Ralf Herbrich , Thore Graepel , David Stern
IPC分类号： G06Q10/00
CPC分类号： G06Q30/0633 , G06Q30/02 , G06Q30/0203
摘要： A recommender system may be used to predict a user behavior that a user will give in relation to an item. In an embodiment such predictions are used to enable items to be recommended to users. For example, products may be recommended to customers, potential friends may be recommended to users of a social networking tool, organizations may be recommended to automated users or other items may be recommended to users. In an embodiment a memory stores a data structure specifying a bi-linear collaborative filtering model of user behaviors. In the embodiment an automated inference process may be applied to the data structure in order to predict a user behavior given information about a user and information about an item. For example, the user information comprises user features as well as a unique user identifier.
摘要翻译： 推荐系统可以用于预测用户将相对于项目给出的用户行为。 在一个实施例中，这样的预测用于使得可以向用户推荐项目。 例如，产品可能会推荐给客户，潜在的朋友可能会推荐给社交网络工具的用户，组织可能会推荐给自动化用户或其他项目可能推荐给用户。 在一个实施例中，存储器存储指定用户行为的双线性协同过滤模型的数据结构。 在该实施例中，自动推理过程可以应用于数据结构，以便预测给定关于用户的信息的用户行为和关于项目的信息。 例如，用户信息包括用户特征以及唯一的用户标识符。
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公开(公告)号：US08589317B2
公开(公告)日：2013-11-19
申请号：US12970158
申请日：2010-12-16
IPC分类号： G06F15/18
CPC分类号： G06N99/005 , G06N3/08
摘要： Many computing scenarios involve the classification of content items within one or more categories. The content item set may be too large for humans to classify, but an automated classifier (e.g., an artificial neural network) may not be able to classify all content items with acceptable accuracy. Instead, the automated classifier may calculate a classification confidence while classifying respective content items. Content items having a low classification confidence may be sent to a human classifier, and may be added, along with the categories identified by the human classifier, to a training set. The automated classifier may then be retrained using the training set, thereby incrementally improving the classification confidence of the automated classifier while conserving the involvement of human classifiers. Additionally, human classifiers may be rewarded for classifying the content items, and the costs of such rewards may be considered while selecting content items for the training set.
摘要翻译： 许多计算场景包括对一个或多个类别内的内容项进行分类。 内容项集合可能太大以致人类不能进行分类，但是自动分类器（例如，人造神经网络）可能不能够以可接受的准确度对所有内容项进行分类。 相反，自动分类器可以在分类各个内容项目时计算分类置信度。 具有低分类置信度的内容项目可以被发送到人类分类器，并且可以与人类分类器识别的类别一起被添加到训练集合中。 然后可以使用训练集再次训练自动分类器，从而逐渐改进自动分类器的分类置信度，同时节省人类分类器的参与。 此外，可以奖励人类分类器对内容项进行分类，并且可以在选择训练集的内容项时考虑这种奖励的成本。
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公开(公告)号：US08351026B2
公开(公告)日：2013-01-08
申请号：US11379641
申请日：2006-04-21
申请人： David Stern
发明人： David Stern
IPC分类号： G01N21/00
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456
摘要： An embodiment of a system for acquiring images of a probe array is described that comprises a first light emitting diode that provides light comprising a first range of wavelengths outside of an excitation spectrum; a second light emitting diode that provides light comprising a second range of wavelengths inside of the excitation spectrum; and a detector that detects one or more wavelengths in the first range of wavelengths, wherein the first range of wavelengths comprise light wavelengths emitted from fluorescent molecules associated with one or more probes of the probe array in response to the second range of wavelengths and wavelengths reflected from one or more reflective elements associated with the probe array.
摘要翻译： 描述了一种用于获取探针阵列的图像的系统的实施例，其包括提供包含激发光谱外的第一波长范围的光的第一发光二极管; 第二发光二极管，其提供包含激发光谱内的第二波长范围的光; 以及检测器，其检测所述第一波长范围中的一个或多个波长，其中所述第一波长范围包括响应于所述第二波长和波长范围反射的与所述探针阵列的一个或多个探针相关联的荧光分子发射的光波长 来自与探针阵列相关联的一个或多个反射元件。
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公开(公告)号：US20120253770A1
公开(公告)日：2012-10-04
申请号：US13513816
申请日：2010-11-15
IPC分类号： G06G7/57
CPC分类号： G01V11/00 , E21B43/00 , E21B43/16 , E21B47/00 , G01V1/282 , G01V99/005 , G01V2210/66 , G01V2210/663 , G05B13/024 , G06F17/18 , G06F17/50 , G06F17/5009 , G06F2217/16 , G06Q10/063
摘要： A method for matching production history to flow simulations includes identifying a plurality of parameters that control an objective function measuring the mismatch between a flow simulation response in a parameter subspace and a production history. A value is calculated for an objective function and for a static measurement at each of a plurality of experiments in the parameter subspace. These results are used to develop a mathematical relationship between one or more static measurements and the objective function. During subsequent adjustment of the simulation model, a target window in the objective function is identified, and flow simulations are performed for each modified model that is predicted from the static geologic measurement to produce an objective function within the window. An objective function of each flow simulation to the production history is calculated and the procedure is iterated until the objective function is within a target range.
摘要翻译： 用于将生产历史与流程模拟相匹配的方法包括识别控制参数子空间中的流动模拟响应与生产历史之间的不匹配的目标函数的多个参数。 在参数子空间中的多个实验的每一个处，针对目标函数和静态测量计算值。 这些结果用于开发一个或多个静态测量与目标函数之间的数学关系。 在仿真模型的后续调整过程中，识别目标函数中的目标窗口，并对从静态地质测量预测的每个修改后的模型进行流模拟，以在窗口内产生目标函数。 计算每个流程仿真到生产历史的目标函数，并重复该过程，直到目标函数在目标范围内。
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公开(公告)号：US08233735B2
公开(公告)日：2012-07-31
申请号：US12212320
申请日：2008-09-17
申请人： David Stern , Peter Fiekowsky
发明人： David Stern , Peter Fiekowsky
CPC分类号： G01N21/6458 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , G01N21/6428 , G01N2021/174
摘要： Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light from a light source 100 and detecting the photons from the light fluoresced therefrom, and repeating the steps of exposure and detection until the substrate 230 is completely examined. The resulting data can be used to determine binding affinity of the targets to specific polymer sequences.
摘要翻译： 荧光标记的靶结合到在已知位置处与聚合物序列合成的底物230。 通过将衬底230的选定区域暴露于来自光源100的光并从其发荧光的光检测光子并且重复曝光和检测的步骤直到基片230被完全检查来检测靶。 所得数据可用于确定靶向特定聚合物序列的结合亲和力。
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公开(公告)号：US07699059B2
公开(公告)日：2010-04-20
申请号：US10054671
申请日：2002-01-22
申请人： Michael Fonseca , Mark Allen , David Stern , Jason White , Jason Kroh
发明人： Michael Fonseca , Mark Allen , David Stern , Jason White , Jason Kroh
CPC分类号： A61B5/03 , A61B5/0002
摘要： The progress of a endovascular aneurysm repair can be monitored by inserting a pressure transducer sensor using a catheter into the sac during endovascular aneurysm repair and then using a small, hand-held read out device to measure pressure easily, safely, inexpensively and accurately. In one aspect a sensor is introduced into the body by the steps of folding or rolling the sensor into a cylinder, loading it into a catheter, and deploying into the aneurysm sac by allowing it to unroll or unfold, either by itself or facilitated by the incorporation of a super-elastic alloy component.
摘要翻译： 血管内动脉瘤修复的进展可以通过在血管内动脉瘤修复期间使用导管插入囊中的压力传感器传感器来监测，然后使用小的手持式读出装置来容易，安全，低成本且准确地测量压力。 在一个方面，通过将传感器折叠或滚动到圆柱体中，将其装载到导管中并通过允许其自身展开或展开而部署到动脉瘤囊中的步骤将传感器引入体内， 掺入超弹性合金成分。
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公开(公告)号：US07574792B2
公开(公告)日：2009-08-18
申请号：US11472905
申请日：2006-06-22
申请人： David O'Brien , Jason White , Michael Fonseca , Jason Kroh , Mark Allen , David Stern
发明人： David O'Brien , Jason White , Michael Fonseca , Jason Kroh , Mark Allen , David Stern
IPC分类号： H01F7/06
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/076 , Y10T29/49016 , Y10T29/49069 , Y10T29/49071 , Y10T29/49073
摘要： In the disclosed method of manufacturing an implantable wireless sensor, a cavity is etched in one side of a first substrate. A conductive structure are formed on the base of the cavity. A second conductive structureare formed on a surface of a second substrate, and the two substrates are mutually imposed such that the two conductive plates and coils are disposed in opposed, spaced-apart relation. A laser is then used to cut away perimeter portions of the imposed substrates and simultaneously to heat bond the two substrates together such that the cavity in the first substrate is hermetically sealed.
摘要翻译： 在所公开的制造可植入无线传感器的方法中，在第一衬底的一侧蚀刻空腔。 在空腔的基部上形成导电结构。 在第二基板的表面上形成第二导电结构，并且相互施加两个基板，使得两个导电板和线圈以相对的间隔关系设置。 然后使用激光来切除所施加的基板的周边部分，同时将两个基板热结合在一起，使得第一基板中的空腔被气密密封。
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