公开(公告)号：US20180014765A1

公开(公告)日：2018-01-18

申请号：US15716998

申请日：2017-09-27

Applicant: DexCom, Inc.

Inventor： Mark A. Tapsak ,  Rathbun K. Rhodes ,  Mark C. Shults ,  Jason D. McClure

IPC: A61B5/1486 ,  B05D5/00 ,  B05D3/00 ,  A61L31/12 ,  B01D71/54 ,  B01D69/14 ,  A61B5/145 ,  A61B5/1473 ,  C12Q1/00 ,  B01D71/80

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1486 ,  A61B2562/028 ,  A61B2562/125 ,  A61L31/12 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  B05D3/007 ,  B05D5/00 ,  C12Q1/002 ,  C12Q1/006 ,  Y10T428/31551

Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

公开(公告)号：US20180008173A1

公开(公告)日：2018-01-11

申请号：US15711863

申请日：2017-09-21

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US09804114B2

公开(公告)日：2017-10-31

申请号：US15059086

申请日：2016-03-02

Applicant: DexCom, Inc.

Inventor： Rathbun K. Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

IPC: A61B5/05 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  C12Q1/00 ,  G01N33/487

CPC classification number: G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

公开(公告)号：US20150087943A1

公开(公告)日：2015-03-26

申请号：US14553382

申请日：2014-11-25

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K. Rhodes ,  Barbara J. Gilligan ,  Mark A. Tapsak

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0031 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/17 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract translation: 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。

公开(公告)号：US08923947B2

公开(公告)日：2014-12-30

申请号：US13949088

申请日：2013-07-23

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K. Rhodes ,  Barbara J. Gilligan ,  Mark A. Tapsak

IPC: A61B5/05 ,  C12Q1/00 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0031 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/17 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract translation: 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。

公开(公告)号：US20140128701A1

公开(公告)日：2014-05-08

申请号：US14144508

申请日：2013-12-30

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K. Rhodes

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/0004 ,  A61B5/14532 ,  A61B5/1495 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

公开(公告)号：US20130310666A1

公开(公告)日：2013-11-21

申请号：US13949088

申请日：2013-07-23

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K Rhodes ,  Barbara J. Gilligan ,  Mark A. Tapsak

IPC: A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0031 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/17 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

公开(公告)号：US20210353187A1

公开(公告)日：2021-11-18

申请号：US17390460

申请日：2021-07-30

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/15

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

公开(公告)号：US10265000B2

公开(公告)日：2019-04-23

申请号：US15668541

申请日：2017-08-03

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/15

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

公开(公告)号：US20180289294A1

公开(公告)日：2018-10-11

申请号：US16008995

申请日：2018-06-14

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.