公开(公告)号：US20230284944A1

公开(公告)日：2023-09-14

申请号：US18198085

申请日：2023-05-16

Applicant: Dexcom, Inc.

Inventor： Shanger Wang ,  Devon M. Headen ,  Sebastian Bohm ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Jiong Zou

IPC: A61B5/1486 ,  A61B5/00 ,  C12Q1/00 ,  A61B5/145 ,  C12Q1/54

CPC classification number: A61B5/14865 ,  A61B5/0022 ,  C12Q1/006 ,  C12Q1/002 ,  A61B5/14532 ,  A61B5/14546 ,  C12Q1/54 ,  G01N27/3271

Abstract: Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

公开(公告)号：US20230138407A1

公开(公告)日：2023-05-04

申请号：US18091658

申请日：2022-12-30

Applicant: DexCom, Inc.

Inventor： Jiong Zou ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Shanger Wang

IPC: G01N27/327 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20220214300A1

公开(公告)日：2022-07-07

申请号：US17560566

申请日：2021-12-23

Applicant: DEXCOM, INC.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: G01N27/327 ,  C08G18/08 ,  C08G18/48 ,  C08G18/40 ,  C08G18/38 ,  C08G18/12 ,  C08G18/44 ,  C08G18/75 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US20200205705A1

公开(公告)日：2020-07-02

申请号：US16728945

申请日：2019-12-27

Applicant: DexCom, Inc.

Inventor： Ted Tang Lee ,  Anna Leigh Davis ,  Peter C. Simpson ,  Liang Wang ,  Shanger Wang ,  Jiong Zou ,  Stephen J. Vanslyke ,  Rui Ma ,  Wenjie Lan

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1473

Abstract: Various examples described herein are directed to systems, apparatuses, and methods for mitigating break-in in an analyte sensor. An example analyte sensor system comprises an analyte sensor applicator comprising a needle; an analyte sensor comprising at least a working electrode and a reference electrode, the analyte sensor positioned at least partially within a lumen of the needle; and a hydrating agent positioned within the lumen of the needle to at least partially hydrate the needle.

公开(公告)号：US20180199873A1

公开(公告)日：2018-07-19

申请号：US15874503

申请日：2018-01-18

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Devon M. Headen ,  Sebastian Bohm ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Jiong Zou

IPC: A61B5/1486 ,  G01N27/327 ,  A61B5/00 ,  C12Q1/00 ,  C12Q1/54

CPC classification number: A61B5/14865 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/125 ,  A61B2562/164 ,  C12Q1/002 ,  C12Q1/006 ,  C12Q1/54 ,  G01N27/3271

Abstract: Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

公开(公告)号：US20170188916A1

公开(公告)日：2017-07-06

申请号：US15395892

申请日：2016-12-30

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: A61B5/145 ,  C12N11/08 ,  G01N33/66 ,  C12Q1/00

CPC classification number: G01N27/3273 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/12 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  C08G18/0828 ,  C08G18/12 ,  C08G18/3857 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4833 ,  C08G18/755 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12N11/08 ,  C12Q1/002 ,  C12Q1/006 ,  G01N27/3275 ,  G01N33/66 ,  C08G18/3234

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US12089933B2

公开(公告)日：2024-09-17

申请号：US17895755

申请日：2022-08-25

Applicant: DexCom, Inc.

Inventor： Sebastian Bohm ,  Pradnya Prakash Samant ,  Jiong Zou

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US20240090802A1

公开(公告)日：2024-03-21

申请号：US18241655

申请日：2023-09-01

Applicant: DexCom, Inc.

Inventor： Devon M. Headen ,  Joshua Ray Windmiller ,  Avid Najdahmadi ,  Sylvie Liong ,  Peter C. Simpson ,  Shannon Reuben Woodruff ,  Christina Rodriguez ,  Jiong Zou

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14546

Abstract: A continuous (multi-)analyte sensor device is provided, comprising a (multi-)analyte sensor operably coupled to a signal transducer, the (multi-)analyte sensor comprising at least one membrane, the least one membrane comprising a least one first transducing element, and at least one of a mediator and/or a regenerative cofactor.

公开(公告)号：US20230073214A1

公开(公告)日：2023-03-09

申请号：US17945585

申请日：2022-09-15

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Mahender Nath Avula ,  Chris Dring ,  Ted Tang Lee ,  Xiangyou Liu ,  Shane Richard Parnell ,  Jiong Zou

IPC: A61K9/00 ,  A61B5/145 ,  A61B5/1486 ,  A61K31/573

Abstract: The present disclosure relates generally to bioactive releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel bioactive releasing membranes, to devices and implantable devices including these membranes, methods for forming the bioactive releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.

公开(公告)号：US20220296867A1

公开(公告)日：2022-09-22

申请号：US17697701

申请日：2022-03-17

Applicant: DexCom, Inc.

Inventor： Mahender Nath Avula ,  Chris Dring ,  Ted Tang Lee ,  Xiangyou Liu ,  Shane Richard Parnell ,  Shanger Wang ,  Jiong Zou

IPC: A61M31/00 ,  A61B5/145

Abstract: The present disclosure relates generally to drug releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel drug releasing membranes, to devices and implantable devices including these membranes, methods for forming the drug releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.